Variant report

Variant	rs539310517
Chromosome Location	chr3:46735187-46735188
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:53)
CpG islands
(count:122)
Chromatin interactive
region (count:7)
LncRNA
region (count:0)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

(count:53 , 50 per page) page: 1 2

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	POLR2A	chr3:46734879-46735254	Gliobla	brain:	n/a	n/a
2	MXI1	chr3:46734398-46735402	IMR90	lung:	n/a	n/a
3	CTCF	chr3:46735040-46735190	SAEC	small airway:	n/a	chr3:46735057-46735070
4	POLR2A	chr3:46734022-46735332	ECC-1	luminal epithelium:	n/a	n/a
5	YY1	chr3:46734982-46735202	HCT-116	colon:	n/a	n/a
6	MAFK	chr3:46735003-46735188	Hela-S3	cervix:	n/a	n/a
7	POLR2A	chr3:46734609-46735623	HUVEC	blood vessel:	n/a	n/a
8	POLR2A	chr3:46734956-46735205	A549	lung:	n/a	n/a
9	POLR2A	chr3:46734964-46735194	A549	lung:	n/a	n/a
10	POLR2A	chr3:46733934-46735221	Hela-S3	cervix:	n/a	n/a
11	POLR2A	chr3:46734047-46735474	MCF10A-Er-Src	breast:	n/a	n/a
12	CCNT2	chr3:46734819-46735516	K562	blood:	n/a	n/a
13	MYC	chr3:46734918-46735195	MCF-7	breast:	n/a	n/a
14	POLR2A	chr3:46734052-46735472	MCF-7	breast:	n/a	n/a
15	SIN3A	chr3:46734127-46735397	H1-hESC	embryonic stem cell:	n/a	chr3:46735021-46735034 chr3:46735021-46735032
16	TCF12	chr3:46733842-46735352	ECC-1	luminal epithelium:	n/a	chr3:46734673-46734683 chr3:46734291-46734299
17	E2F6	chr3:46734961-46735187	K562	blood:	n/a	chr3:46735106-46735120
18	EP300	chr3:46733839-46735284	ECC-1	luminal epithelium:	n/a	n/a
19	CTCF	chr3:46735060-46735210	Hela-S3	cervix:	n/a	n/a
20	POLR2A	chr3:46734752-46735192	HUVEC	blood vessel:	n/a	n/a
21	NFIC	chr3:46733902-46735210	ECC-1	luminal epithelium:	n/a	n/a
22	E2F6	chr3:46734560-46735249	H1-hESC	embryonic stem cell:	n/a	chr3:46735106-46735120
23	TAF1	chr3:46734719-46735548	ECC-1	luminal epithelium:	n/a	n/a
24	TEAD4	chr3:46733865-46735240	ECC-1	luminal epithelium:	n/a	n/a
25	MAX	chr3:46733849-46735719	ECC-1	luminal epithelium:	n/a	chr3:46734870-46734879 chr3:46734535-46734545 chr3:46734616-46734625 chr3:46735563-46735572
26	ZNF263	chr3:46734566-46735192	HEK293-T-REx	kidney:	n/a	n/a
27	IRF1	chr3:46734983-46735433	K562	blood:	n/a	n/a
28	TEAD4	chr3:46733948-46735209	ECC-1	luminal epithelium:	n/a	n/a
29	CTCF	chr3:46735040-46735190	AG04449	skin:	n/a	chr3:46735057-46735070
30	CHD2	chr3:46733976-46735314	Hela-S3	cervix:	n/a	n/a
31	MAZ	chr3:46734593-46735696	K562	blood:	n/a	chr3:46734870-46734879 chr3:46734616-46734625 chr3:46735563-46735572
32	ZBTB7A	chr3:46733763-46736413	ECC-1	luminal epithelium:	n/a	chr3:46736311-46736318 chr3:46734540-46734549
33	MAZ	chr3:46735014-46735198	GM12878	blood:	n/a	n/a
34	POLR2A	chr3:46734097-46735270	Hela-S3	cervix:	n/a	n/a
35	MAX	chr3:46733884-46735346	ECC-1	luminal epithelium:	n/a	chr3:46734870-46734879 chr3:46734535-46734545 chr3:46734616-46734625
36	POLR2A	chr3:46734027-46735492	MCF10A-Er-Src	breast:	n/a	n/a
37	POLR2A	chr3:46733819-46735416	ECC-1	luminal epithelium:	n/a	n/a
38	POLR2A	chr3:46734787-46735524	HUVEC	blood vessel:	n/a	n/a
39	POLR2A	chr3:46734920-46735277	MCF-7	breast:	n/a	n/a
40	POLR2A	chr3:46733827-46735509	HCT-116	colon:	n/a	n/a
41	POLR2A	chr3:46734659-46735466	HCT-116	colon:	n/a	n/a
42	E2F6	chr3:46734639-46735209	A549	lung:	n/a	chr3:46735106-46735120
43	MAX	chr3:46733983-46735223	Hela-S3	cervix:	n/a	chr3:46734870-46734879 chr3:46734535-46734545 chr3:46734616-46734625
44	CTCF	chr3:46734925-46735215	K562	blood:	n/a	chr3:46735057-46735070
45	POLR2A	chr3:46734882-46735291	MCF-7	breast:	n/a	n/a
46	MAX	chr3:46734591-46735293	H1-hESC	embryonic stem cell:	n/a	chr3:46734870-46734879 chr3:46734616-46734625
47	MAX	chr3:46734834-46735270	K562	blood:	n/a	chr3:46734870-46734879
48	POLR2A	chr3:46733911-46735363	Hela-S3	cervix:	n/a	n/a
49	POLR2A	chr3:46733959-46735688	Hela-S3	cervix:	n/a	n/a
50	MAZ	chr3:46734012-46735407	Hela-S3	cervix:	n/a	chr3:46734870-46734879 chr3:46734535-46734545 chr3:46734616-46734625

(count:122 , 50 per page) page: 1 2 3

No.	Chromosome Location	Cell Line	Cell type	Cell Stage
1	chr3:46735152-46735202	HMEC	breast:	n/a
2	chr3:46735154-46735204	HCM	heart:	n/a
3	chr3:46735154-46735204	HepG2	liver:	n/a
4	chr3:46735154-46735204	GM19239	blood:	n/a
5	chr3:46735152-46735202	AG09319	gingival:	n/a
6	chr3:46735154-46735204	SK-N-SH_RA	brain:	n/a
7	chr3:46735152-46735202	GM12892	blood:	n/a
8	chr3:46735154-46735204	SKMC	muscle:	n/a
9	chr3:46735152-46735202	AG04449	skin:	fetal
10	chr3:46735152-46735202	NHBE	bronchial:	n/a
11	chr3:46735152-46735202	GM06990	blood:	n/a
12	chr3:46735154-46735204	HEEpiC	esophagus:	n/a
13	chr3:46735152-46735202	K562	blood:	n/a
14	chr3:46735154-46735204	Jurkat	blood:	n/a
15	chr3:46735154-46735204	HCT-116	colon:	n/a
16	chr3:46735152-46735202	NH-A	brain:	n/a
17	chr3:46735152-46735202	PANC-1	pancreas:	n/a
18	chr3:46735154-46735204	A549	lung:	n/a
19	chr3:46735152-46735202	H1-hESC	embryonic stem cell:	embryo
20	chr3:46735154-46735204	HRE	kidney:	n/a
21	chr3:46735154-46735204	AoSMC	blood vessel:	n/a
22	chr3:46735154-46735204	GM06990	blood:	n/a
23	chr3:46735154-46735204	PrEC	prostate:	n/a
24	chr3:46735154-46735204	ProgFib	skin:	n/a
25	chr3:46735152-46735202	IMR90	lung:	fetal
26	chr3:46735152-46735202	NB4	blood:	n/a
27	chr3:46735154-46735204	HRCEpiC	kidney:	n/a
28	chr3:46735154-46735204	NHDF-neo	bronchial:	n/a
29	chr3:46735152-46735202	A549	lung:	n/a
30	chr3:46735152-46735202	HCM	heart:	n/a
31	chr3:46735152-46735202	SK-N-SH	brain:	n/a
32	chr3:46735152-46735202	BJ	skin:	n/a
33	chr3:46735152-46735202	HCT-116	colon:	n/a
34	chr3:46735152-46735202	HEEpiC	esophagus:	n/a
35	chr3:46735152-46735202	HEK293	kidney:	embryo
36	chr3:46735152-46735202	HUVEC	blood vessel:	n/a
37	chr3:46735152-46735202	GM12891	blood:	n/a
38	chr3:46735154-46735204	K562	blood:	n/a
39	chr3:46735154-46735204	RPTEC	kidney:	n/a
40	chr3:46735152-46735202	SK-N-SH_RA	brain:	n/a
41	chr3:46735154-46735204	BE2_C	brain:	n/a
42	chr3:46735152-46735202	HRCEpiC	kidney:	n/a
43	chr3:46735154-46735204	PFSK-1	brain:	n/a
44	chr3:46735154-46735204	SAEC	small airway:	n/a
45	chr3:46735154-46735204	HNPCEpiC	eye:	n/a
46	chr3:46735152-46735202	HPAEpiC	pulmonary alveolar:	n/a
47	chr3:46735154-46735204	IMR90	lung:	fetal
48	chr3:46735152-46735202	AG09309	skin:	n/a
49	chr3:46735152-46735202	Caco-2	colon:	n/a
50	chr3:46735152-46735202	GM12878	blood:	n/a

(count:7 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr3:46734848..46735671-chr3:160283077..160283853,2	Hela-S3	cervix:
2	chr3:46733801..46735413-chr3:46924430..46926212,2	MCF-7	breast:
3	chr3:46734988..46739707-chr3:46741491..46746249,8	K562	blood:
4	chr3:46727378..46730139-chr3:46733383..46735627,3	MCF-7	breast:
5	chr3:46717709..46719534-chr3:46734745..46736639,2	MCF-7	breast:
6	chr3:46733775..46736386-chr3:46933231..46935509,2	MCF-7	breast:
7	chr3:46734355..46735316-chr5:133512715..133513418,2	Hela-S3	cervix:

No data

Variant related genes	Relation type
ALS2CL	TF binding region
ALS2CL	CpG island
ENSG00000160801	Chromatin interaction
ENSG00000181585	Chromatin interaction
ENSG00000186432	Chromatin interaction
ENSG00000113558	Chromatin interaction
ENSG00000229320	Chromatin interaction
ENSG00000178038	Chromatin interaction

Extended variants
information (count: 22 )
Associated
traits (count: 0)

Variant overlapped rSNPs/rCNVs (count:22 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1007449	chr3:46652343-46986578	Bivalent Enhancer Weak transcription Transcr. at gene 5' and 3' Enhancers ZNF genes & repeats Genic enhancers Strong transcription Bivalent/Poised TSS Flanking Active TSS Flanking Bivalent TSS/Enh Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	30 gene(s)	inside rSNPs	diseases
2	nsv536554	chr3:46652343-46986578	Enhancers Weak transcription Bivalent Enhancer Genic enhancers Flanking Active TSS Flanking Bivalent TSS/Enh Strong transcription Bivalent/Poised TSS ZNF genes & repeats Active TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	30 gene(s)	inside rSNPs	diseases
3	nsv876739	chr3:46656980-46744966	Enhancers Flanking Active TSS Weak transcription Bivalent Enhancer Bivalent/Poised TSS Active TSS Strong transcription Genic enhancers Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	18 gene(s)	inside rSNPs	diseases
4	nsv876740	chr3:46656980-46748453	Active TSS Weak transcription Enhancers Bivalent Enhancer Flanking Active TSS Strong transcription Flanking Bivalent TSS/Enh Genic enhancers Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	19 gene(s)	inside rSNPs	diseases
5	nsv876741	chr3:46663372-46763839	Enhancers Flanking Active TSS Weak transcription Strong transcription Active TSS Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	19 gene(s)	inside rSNPs	diseases
6	nsv516623	chr3:46680063-46852679	Enhancers Strong transcription Genic enhancers Weak transcription Flanking Active TSS Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	19 gene(s)	inside rSNPs	diseases
7	esv2757869	chr3:46680452-46972489	Enhancers Flanking Bivalent TSS/Enh Flanking Active TSS Strong transcription Weak transcription Active TSS Bivalent Enhancer Genic enhancers ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	28 gene(s)	inside rSNPs	diseases
8	esv2759147	chr3:46680452-46972489	Genic enhancers Flanking Active TSS Enhancers Strong transcription Bivalent/Poised TSS Weak transcription Flanking Bivalent TSS/Enh Active TSS Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	28 gene(s)	inside rSNPs	diseases
9	esv1804680	chr3:46704348-46869911	Bivalent Enhancer Flanking Active TSS Weak transcription Bivalent/Poised TSS Enhancers Flanking Bivalent TSS/Enh Strong transcription Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	20 gene(s)	inside rSNPs	diseases
10	nsv876742	chr3:46705369-46763839	Flanking Bivalent TSS/Enh Enhancers Weak transcription Bivalent Enhancer Genic enhancers Active TSS Flanking Active TSS Strong transcription Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	16 gene(s)	inside rSNPs	diseases
11	nsv536555	chr3:46706571-46817963	Flanking Active TSS Strong transcription Genic enhancers Bivalent Enhancer Weak transcription Enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	17 gene(s)	inside rSNPs	diseases
12	nsv536556	chr3:46706571-46849443	Genic enhancers Bivalent/Poised TSS Weak transcription Enhancers Active TSS Flanking Active TSS Flanking Bivalent TSS/Enh Strong transcription Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	18 gene(s)	inside rSNPs	diseases
13	nsv536557	chr3:46706571-46853434	Bivalent Enhancer Flanking Active TSS Weak transcription Genic enhancers Strong transcription ZNF genes & repeats Enhancers Flanking Bivalent TSS/Enh Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	19 gene(s)	inside rSNPs	diseases
14	nsv536558	chr3:46706571-47024756	Enhancers Bivalent Enhancer Active TSS Strong transcription Weak transcription Flanking Active TSS Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	35 gene(s)	inside rSNPs	diseases
15	nsv10268	chr3:46707169-46736718	Enhancers Flanking Active TSS Weak transcription Active TSS Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats Strong transcription Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	15 gene(s)	inside rSNPs	diseases
16	esv1797503	chr3:46708712-46760713	Enhancers Weak transcription Bivalent/Poised TSS Active TSS Flanking Active TSS Strong transcription Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region	16 gene(s)	inside rSNPs	diseases
17	nsv876743	chr3:46716523-46753577	Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Weak transcription Flanking Active TSS Enhancers Strong transcription Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region	15 gene(s)	inside rSNPs	diseases
18	nsv876744	chr3:46716523-46763839	Flanking Active TSS Weak transcription Flanking Bivalent TSS/Enh Bivalent Enhancer Enhancers Strong transcription ZNF genes & repeats Active TSS Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	15 gene(s)	inside rSNPs	diseases
19	nsv460525	chr3:46728659-46790397	Bivalent/Poised TSS Flanking Active TSS Bivalent Enhancer Enhancers Flanking Bivalent TSS/Enh Active TSS Weak transcription Strong transcription Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	17 gene(s)	inside rSNPs	diseases
20	nsv590179	chr3:46728659-46790397	Flanking Bivalent TSS/Enh Active TSS Weak transcription Bivalent Enhancer Flanking Active TSS Enhancers Bivalent/Poised TSS Genic enhancers Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region	17 gene(s)	inside rSNPs	diseases
21	esv1847964	chr3:46729757-46753976	Flanking Bivalent TSS/Enh Enhancers Active TSS Bivalent Enhancer Weak transcription Flanking Active TSS Strong transcription Bivalent/Poised TSS ZNF genes & repeats Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	15 gene(s)	inside rSNPs	diseases
22	esv3438151	chr3:46734173-46736721	Flanking Bivalent TSS/Enh Enhancers Bivalent/Poised TSS Active TSS Flanking Active TSS Bivalent Enhancer Weak transcription Transcr. at gene 5' and 3' Genic enhancers	TF binding region CpG island Chromatin interactive region	14 gene(s)	inside rSNPs	diseases

No data

Chromatin state (count:124 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr3:46734000-46735600	Flanking Active TSS	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
2	chr3:46734000-46735600	Active TSS	Breast Myoepithelial Primary Cells	Breast
3	chr3:46734000-46735600	Active TSS	Colon Smooth Muscle	Colon
4	chr3:46734000-46736200	Flanking Active TSS	Skeletal Muscle Female	skeletal muscle
5	chr3:46734200-46735200	Active TSS	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
6	chr3:46734200-46735200	Flanking Active TSS	Primary hematopoietic stem cells	blood
7	chr3:46734200-46735200	Flanking Bivalent TSS/Enh	Foreskin Fibroblast Primary Cells skin01	Skin
8	chr3:46734200-46735200	Flanking Active TSS	Placenta Amnion	Placenta Amnion
9	chr3:46734200-46735200	Active TSS	NHDF-Ad	bronchial
10	chr3:46734200-46735400	Flanking Active TSS	H1 Derived Mesenchymal Stem Cells	ES cell derived
11	chr3:46734200-46735400	Active TSS	HMEC	breast
12	chr3:46734200-46735400	Active TSS	NHEK	skin
13	chr3:46734200-46735600	Bivalent/Poised TSS	H9 Cell Line	embryonic stem cell
14	chr3:46734200-46735600	Bivalent/Poised TSS	HUES64 Cell Line	embryonic stem cell
15	chr3:46734200-46735600	Bivalent/Poised TSS	iPS-20b Cell Line	embryonic stem cell
16	chr3:46734200-46735600	Active TSS	Psoas Muscle	Psoas
17	chr3:46734200-46735800	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Female	--
18	chr3:46734200-46735800	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
19	chr3:46734200-46735800	Flanking Active TSS	Placenta	Placenta
20	chr3:46734200-46736000	Flanking Active TSS	Stomach Smooth Muscle	stomach
21	chr3:46734400-46735200	Active TSS	ES-WA7 Cell Line	embryonic stem cell
22	chr3:46734400-46735200	Flanking Active TSS	ES-UCSF4 Cell Line	embryonic stem cell
23	chr3:46734400-46735200	Active TSS	Fetal Kidney	kidney
24	chr3:46734400-46735200	Active TSS	Small Intestine	intestine
25	chr3:46734400-46735400	Active TSS	Aorta	Aorta
26	chr3:46734400-46735400	Active TSS	Esophagus	oesophagus
27	chr3:46734400-46735400	Active TSS	Right Atrium	heart
28	chr3:46734400-46735600	Bivalent/Poised TSS	ES-I3 Cell Line	embryonic stem cell
29	chr3:46734400-46735600	Active TSS	Pancreatic Islets	Pancreatic Islet
30	chr3:46734400-46735600	Flanking Bivalent TSS/Enh	Fetal Muscle Leg	muscle
31	chr3:46734400-46735600	Active TSS	Ovary	ovary
32	chr3:46734400-46735800	Flanking Active TSS	Primary monocytes fromperipheralblood	blood
33	chr3:46734400-46735800	Flanking Bivalent TSS/Enh	Foreskin Fibroblast Primary Cells skin02	Skin
34	chr3:46734600-46735200	Active TSS	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
35	chr3:46734600-46735200	Flanking Active TSS	Primary mononuclear cells fromperipheralblood	Blood
36	chr3:46734600-46735400	Flanking Bivalent TSS/Enh	Cortex derived primary cultured neurospheres	brain
37	chr3:46734600-46735400	Active TSS	Foreskin Keratinocyte Primary Cells skin03	Skin
38	chr3:46734600-46735400	Active TSS	Colonic Mucosa	Colon
39	chr3:46734600-46735400	Active TSS	Gastric	stomach
40	chr3:46734600-46735400	Active TSS	Left Ventricle	heart
41	chr3:46734600-46735400	Active TSS	Right Ventricle	heart
42	chr3:46734600-46735400	Active TSS	Sigmoid Colon	Sigmoid Colon
43	chr3:46734600-46735400	Active TSS	Hela-S3	cervix
44	chr3:46734600-46735600	Bivalent/Poised TSS	HUES48 Cell Line	embryonic stem cell
45	chr3:46734600-46735600	Bivalent/Poised TSS	iPS-15b Cell Line	embryonic stem cell
46	chr3:46734600-46735600	Active TSS	Primary T helper memory cells from peripheral blood 2	blood
47	chr3:46734600-46735600	Active TSS	Brain Angular Gyrus	brain
48	chr3:46734600-46735800	Active TSS	A549	lung
49	chr3:46734800-46735200	Active TSS	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
50	chr3:46734800-46735200	Bivalent/Poised TSS	HUES6 Cell Line	embryonic stem cell

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