Variant report

Variant	rs7086046
Chromosome Location	chr10:46076235-46076236
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:46074816..46082903-chr10:46083299..46090228,15	K562	blood:
2	chr10:46075326..46077121-chr10:46078521..46080983,2	K562	blood:

Variant related genes	Relation type
ENSG00000165406	Chromatin interaction

Extended variants
information (count: 50 )
Associated
traits (count: 3 )

rSNPs within LD-proxies of this variant (count:40)

rs_ID	r²[population]
rs10466245	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.84[LWK][hapmap];1.00[MEX][hapmap];0.97[MKK][hapmap];1.00[TSI][hapmap];0.84[YRI][hapmap];0.86[AFR][1000 genomes];0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10793620	0.81[CEU][hapmap];0.88[GIH][hapmap]
rs10900221	0.95[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.97[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];1.00[TSI][hapmap];0.91[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10900223	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.83[YRI][hapmap];0.94[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10900224	0.86[AFR][1000 genomes];0.94[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10900229	0.81[ASW][hapmap];0.89[CEU][hapmap];1.00[CHB][hapmap];0.87[CHD][hapmap];0.86[GIH][hapmap];0.86[MEX][hapmap];0.89[TSI][hapmap];0.89[AMR][1000 genomes];0.84[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs10900230	0.85[AMR][1000 genomes];0.86[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs10900232	0.95[CEU][hapmap];1.00[CHB][hapmap];0.90[JPT][hapmap];0.85[AMR][1000 genomes];0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11239528	0.94[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.91[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];0.97[TSI][hapmap];0.86[AMR][1000 genomes];0.88[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11239532	0.85[CHD][hapmap]
rs11239535	0.81[GIH][hapmap]
rs11239536	0.87[AMR][1000 genomes];0.90[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11239538	0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239541	0.81[CEU][hapmap]
rs11239545	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.97[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];1.00[TSI][hapmap];0.92[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239549	0.95[EUR][1000 genomes]
rs11239550	0.81[CEU][hapmap];0.88[GIH][hapmap]
rs11239551	0.86[AFR][1000 genomes];0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11239569	0.88[AFR][1000 genomes];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239571	0.81[ASW][hapmap];0.95[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.84[LWK][hapmap];1.00[MEX][hapmap];0.97[MKK][hapmap];1.00[TSI][hapmap];0.84[YRI][hapmap];0.86[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12242611	0.92[AMR][1000 genomes];0.95[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs12243153	0.92[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12243845	0.84[LWK][hapmap]
rs12246131	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12249012	0.95[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12257537	1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[JPT][hapmap];0.82[LWK][hapmap];0.96[ASN][1000 genomes]
rs12257549	0.85[AFR][1000 genomes];0.89[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12269403	0.96[ASN][1000 genomes]
rs2291428	0.86[AMR][1000 genomes];0.88[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs2291429	0.88[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs3802548	0.86[AMR][1000 genomes];0.88[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs55665473	0.92[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs58865519	0.89[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs59390133	0.93[ASN][1000 genomes]
rs61854096	0.91[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs61854123	0.86[AFR][1000 genomes];0.99[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs61854156	0.84[AMR][1000 genomes];0.84[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs7076198	0.90[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs72796498	0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs970548	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.95[MEX][hapmap];1.00[TSI][hapmap];0.94[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:10 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv430166	chr10:45668894-46148794	Bivalent Enhancer Strong transcription Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Flanking Active TSS Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
2	nsv993428	chr10:45742877-46224333	Enhancers Active TSS Weak transcription ZNF genes & repeats Bivalent/Poised TSS Strong transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
3	nsv895108	chr10:45878908-46224333	Active TSS Weak transcription Enhancers ZNF genes & repeats Strong transcription Bivalent Enhancer Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	16 gene(s)	inside rSNPs	diseases
4	nsv895109	chr10:45882741-46210665	Weak transcription Strong transcription Enhancers Active TSS Genic enhancers Flanking Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	12 gene(s)	inside rSNPs	diseases
5	nsv1043536	chr10:45915941-46076235	Weak transcription Enhancers Active TSS Strong transcription ZNF genes & repeats Flanking Active TSS Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	5 gene(s)	inside rSNPs	diseases
6	nsv895112	chr10:46012620-46202216	Flanking Active TSS Weak transcription Strong transcription Enhancers Active TSS ZNF genes & repeats Bivalent/Poised TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	9 gene(s)	inside rSNPs	diseases
7	nsv1041417	chr10:46021181-46088061	Flanking Active TSS Weak transcription Enhancers Active TSS Strong transcription ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
8	nsv528750	chr10:46024620-46076235	Enhancers Weak transcription Active TSS ZNF genes & repeats Flanking Active TSS Strong transcription Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
9	nsv1052233	chr10:46024620-46088061	Enhancers Weak transcription Strong transcription ZNF genes & repeats Flanking Active TSS Active TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
10	esv2761592	chr10:46072872-46090202	Strong transcription Enhancers Flanking Active TSS Weak transcription Active TSS ZNF genes & repeats Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	4 gene(s)	inside rSNPs	diseases

mRNA abundance (count:3)

SNP	Gene	Cis/trans	Tissue	Source
rs7086046	ALOX5	Cis_1M	lymphoblastoid	RTeQTL
rs7086046	FAM21A///FAM21B	N/A	lymphoblastoid	RTeQTL
rs7086046	ZNF485	cis	parietal	SCAN

Chromatin state (count:80 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:46047000-46076400	Weak transcription	Sigmoid Colon	Sigmoid Colon
2	chr10:46071800-46076400	Weak transcription	HUES48 Cell Line	embryonic stem cell
3	chr10:46071800-46076400	Weak transcription	HUES64 Cell Line	embryonic stem cell
4	chr10:46072000-46076400	Weak transcription	iPS-15b Cell Line	embryonic stem cell
5	chr10:46072600-46086600	Weak transcription	Small Intestine	intestine
6	chr10:46075000-46076600	Enhancers	Primary neutrophils fromperipheralblood	blood
7	chr10:46075200-46077600	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
8	chr10:46075400-46076400	Active TSS	Rectal Mucosa Donor 29	rectum
9	chr10:46075400-46076800	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Female	--
10	chr10:46075600-46076400	Active TSS	Primary T cells fromperipheralblood	blood
11	chr10:46075600-46076400	Active TSS	Primary T helper naive cells from peripheral blood	blood
12	chr10:46075600-46076400	Active TSS	Primary T helper naive cells fromperipheralblood	blood
13	chr10:46075600-46076400	Active TSS	Primary T helper cells PMA-I stimulated	--
14	chr10:46075600-46076400	Active TSS	Primary T helper 17 cells PMA-I stimulated	--
15	chr10:46075600-46076400	Active TSS	Primary T killer naive cells fromperipheralblood	blood
16	chr10:46075600-46076400	Active TSS	Duodenum Mucosa	Duodenum
17	chr10:46075600-46076800	Flanking Active TSS	Primary hematopoietic stem cells	blood
18	chr10:46075600-46076800	Flanking Active TSS	Rectal Mucosa Donor 31	rectum
19	chr10:46075800-46076400	Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
20	chr10:46075800-46076400	Active TSS	Primary B cells from peripheral blood	blood
21	chr10:46075800-46076400	Active TSS	Primary T helper memory cells from peripheral blood 2	blood
22	chr10:46075800-46076400	Active TSS	Primary T helper memory cells from peripheral blood 1	blood
23	chr10:46075800-46076400	Active TSS	Primary T killer memory cells from peripheral blood	blood
24	chr10:46075800-46076400	Active TSS	Fetal Intestine Small	intestine
25	chr10:46075800-46076400	Enhancers	Right Ventricle	heart
26	chr10:46075800-46076400	Active TSS	Stomach Mucosa	stomach
27	chr10:46075800-46076400	Active TSS	Stomach Smooth Muscle	stomach
28	chr10:46075800-46076600	Active TSS	Primary T cells effector/memory enriched fromperipheralblood	blood
29	chr10:46075800-46076600	Active TSS	Colonic Mucosa	Colon
30	chr10:46075800-46076600	Enhancers	Fetal Brain Female	brain
31	chr10:46075800-46076600	Flanking Active TSS	Fetal Thymus	thymus
32	chr10:46075800-46076600	Active TSS	Rectal Smooth Muscle	rectum
33	chr10:46075800-46076600	Active TSS	HMEC	breast
34	chr10:46075800-46076800	Flanking Active TSS	Primary T cells from cord blood	blood
35	chr10:46075800-46076800	Flanking Active TSS	Primary hematopoietic stem cells short term culture	blood
36	chr10:46075800-46076800	Enhancers	Brain Inferior Temporal Lobe	brain
37	chr10:46075800-46076800	Enhancers	Pancreas	Pancrea
38	chr10:46075800-46076800	Flanking Active TSS	Dnd41	blood
39	chr10:46075800-46077600	Enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
40	chr10:46075800-46078400	Enhancers	HepG2	liver
41	chr10:46076000-46076400	Flanking Active TSS	Brain Hippocampus Middle	brain
42	chr10:46076000-46076400	Active TSS	Fetal Intestine Large	intestine
43	chr10:46076000-46076400	Active TSS	HUVEC	blood vessel
44	chr10:46076200-46076400	Flanking Active TSS	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
45	chr10:46076200-46076400	Active TSS	Primary B cells from cord blood	blood
46	chr10:46076200-46076400	Flanking Active TSS	Primary T regulatory cells fromperipheralblood	blood
47	chr10:46076200-46076400	Active TSS	Colon Smooth Muscle	Colon
48	chr10:46076200-46076400	Active TSS	Duodenum Smooth Muscle	Duodenum
49	chr10:46076200-46076400	Active TSS	Esophagus	oesophagus
50	chr10:46076200-46076400	Flanking Active TSS	Pancreatic Islets	Pancreatic Islet

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