Variant report

Variant	rs9422656
Chromosome Location	chr10:46052744-46052745
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr10:46042311..46044795-chr10:46052336..46053839,2	K562	blood:
2	chr10:46049227..46053354-chr10:46053983..46058180,6	K562	blood:
3	chr10:46047681..46050727-chr10:46051442..46055483,4	K562	blood:
4	chr10:46045209..46047210-chr10:46049150..46053014,3	K562	blood:

Extended variants
information (count: 24 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:13)

rs_ID	r²[population]
rs10751382	0.91[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs10900226	0.97[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10900227	0.94[AFR][1000 genomes];0.94[AMR][1000 genomes];1.00[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs2242332	0.90[EUR][1000 genomes]
rs2242334	0.90[EUR][1000 genomes]
rs2291427	0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs3103182	0.92[AFR][1000 genomes];1.00[AMR][1000 genomes];0.98[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs3780913	0.91[EUR][1000 genomes]
rs4540799	0.84[EUR][1000 genomes]
rs7099874	0.84[EUR][1000 genomes]
rs7896175	0.98[AFR][1000 genomes];0.92[AMR][1000 genomes];0.97[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs7920317	0.96[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9422648	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];1.00[EUR][1000 genomes];0.98[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:11 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv430166	chr10:45668894-46148794	Bivalent Enhancer Strong transcription Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Flanking Active TSS Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
2	nsv993428	chr10:45742877-46224333	Enhancers Active TSS Weak transcription ZNF genes & repeats Bivalent/Poised TSS Strong transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
3	nsv895108	chr10:45878908-46224333	Active TSS Weak transcription Enhancers ZNF genes & repeats Strong transcription Bivalent Enhancer Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	16 gene(s)	inside rSNPs	diseases
4	nsv895109	chr10:45882741-46210665	Weak transcription Strong transcription Enhancers Active TSS Genic enhancers Flanking Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	12 gene(s)	inside rSNPs	diseases
5	nsv1043536	chr10:45915941-46076235	Weak transcription Enhancers Active TSS Strong transcription ZNF genes & repeats Flanking Active TSS Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	5 gene(s)	inside rSNPs	diseases
6	nsv895111	chr10:45989745-46071900	Weak transcription Enhancers ZNF genes & repeats Active TSS Strong transcription Flanking Active TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	2 gene(s)	inside rSNPs	diseases
7	nsv895112	chr10:46012620-46202216	Flanking Active TSS Weak transcription Strong transcription Enhancers Active TSS ZNF genes & repeats Bivalent/Poised TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	9 gene(s)	inside rSNPs	diseases
8	nsv1041417	chr10:46021181-46088061	Flanking Active TSS Weak transcription Enhancers Active TSS Strong transcription ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
9	nsv528750	chr10:46024620-46076235	Enhancers Weak transcription Active TSS ZNF genes & repeats Flanking Active TSS Strong transcription Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
10	nsv1052233	chr10:46024620-46088061	Enhancers Weak transcription Strong transcription ZNF genes & repeats Flanking Active TSS Active TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
11	nsv1047117	chr10:46027942-46075946	Strong transcription Enhancers Flanking Active TSS Weak transcription Active TSS Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs9422656	ALOX5	cis	Nerve Tibial	GTEx

Chromatin state (count:69 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:46010000-46056000	Weak transcription	Esophagus	oesophagus
2	chr10:46014400-46070000	Weak transcription	Psoas Muscle	Psoas
3	chr10:46018000-46052800	Weak transcription	Primary T helper naive cells from peripheral blood	blood
4	chr10:46024400-46052800	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
5	chr10:46026200-46057600	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
6	chr10:46028200-46053000	Weak transcription	Ovary	ovary
7	chr10:46028200-46055600	Weak transcription	Pancreatic Islets	Pancreatic Islet
8	chr10:46028400-46052800	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
9	chr10:46028800-46053000	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
10	chr10:46028800-46069200	Weak transcription	Rectal Mucosa Donor 31	rectum
11	chr10:46040000-46054000	Weak transcription	Fetal Lung	lung
12	chr10:46040000-46056000	Weak transcription	Colonic Mucosa	Colon
13	chr10:46040400-46056600	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
14	chr10:46042000-46053800	Weak transcription	Gastric	stomach
15	chr10:46042000-46062600	Weak transcription	Aorta	Aorta
16	chr10:46042200-46054800	Weak transcription	Fetal Intestine Small	intestine
17	chr10:46042400-46053200	Weak transcription	Primary hematopoietic stem cells	blood
18	chr10:46043400-46053200	Weak transcription	Right Ventricle	heart
19	chr10:46043400-46057800	Weak transcription	Skeletal Muscle Male	skeletal muscle
20	chr10:46043800-46053200	Weak transcription	Skeletal Muscle Female	skeletal muscle
21	chr10:46044000-46052800	Weak transcription	Brain Anterior Caudate	brain
22	chr10:46044000-46053000	Weak transcription	iPS-15b Cell Line	embryonic stem cell
23	chr10:46044000-46053600	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
24	chr10:46044400-46057800	Weak transcription	Breast Myoepithelial Primary Cells	Breast
25	chr10:46045000-46052800	Weak transcription	K562	blood
26	chr10:46045000-46053000	Weak transcription	Thymus	Thymus
27	chr10:46045000-46058600	Weak transcription	Fetal Stomach	stomach
28	chr10:46045200-46053000	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
29	chr10:46046200-46052800	Weak transcription	Primary T cells from cord blood	blood
30	chr10:46046200-46052800	Weak transcription	Rectal Mucosa Donor 29	rectum
31	chr10:46046200-46057400	Weak transcription	Fetal Muscle Leg	muscle
32	chr10:46046400-46055400	Weak transcription	Fetal Intestine Large	intestine
33	chr10:46047000-46076400	Weak transcription	Sigmoid Colon	Sigmoid Colon
34	chr10:46048400-46052800	Weak transcription	Primary B cells from cord blood	blood
35	chr10:46049400-46052800	Weak transcription	GM12878-XiMat	blood
36	chr10:46049400-46053000	Weak transcription	Brain Cingulate Gyrus	brain
37	chr10:46049400-46053000	Weak transcription	Brain Inferior Temporal Lobe	brain
38	chr10:46049400-46053000	Weak transcription	Duodenum Mucosa	Duodenum
39	chr10:46049400-46053200	Weak transcription	Brain Substantia Nigra	brain
40	chr10:46049400-46065200	Weak transcription	Rectal Smooth Muscle	rectum
41	chr10:46050200-46052800	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
42	chr10:46050200-46053000	Weak transcription	Small Intestine	intestine
43	chr10:46050400-46055000	Enhancers	Primary monocytes fromperipheralblood	blood
44	chr10:46050800-46052800	Enhancers	Monocytes-CD14+_RO01746	blood
45	chr10:46051400-46052800	Enhancers	Primary hematopoietic stem cells short term culture	blood
46	chr10:46051600-46054400	Enhancers	Brain Hippocampus Middle	brain
47	chr10:46051800-46053000	Weak transcription	Adipose Nuclei	Adipose
48	chr10:46051800-46053200	Flanking Active TSS	HUVEC	blood vessel
49	chr10:46051800-46054200	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
50	chr10:46051800-46055600	Enhancers	Primary T helper cells PMA-I stimulated	--

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