Variant report

Variant	esv3331955
Chromosome Location	chr10:6653442-6664446
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	ATF3	chr10:6663485-6663746	K562	blood:	n/a	n/a
2	CEBPB	chr10:6657447-6657691	HepG2	liver:	n/a	n/a
3	E2F4	chr10:6653664-6654135	MCF10A-Er-Src	breast:	n/a	n/a
4	E2F4	chr10:6654393-6654902	MCF10A-Er-Src	breast:	n/a	n/a
5	FOS	chr10:6654281-6654588	MCF10A-Er-Src	breast:	n/a	n/a
6	FOS	chr10:6663485-6663807	MCF10A-Er-Src	breast:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
7	FOS	chr10:6663466-6663829	MCF10A-Er-Src	breast:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
8	FOS	chr10:6663471-6663830	MCF10A-Er-Src	breast:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
9	FOS	chr10:6663485-6663813	MCF10A-Er-Src	breast:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
10	FOS	chr10:6654272-6654782	MCF10A-Er-Src	breast:	n/a	n/a
11	FOS	chr10:6661783-6661874	MCF10A-Er-Src	breast:	n/a	n/a
12	FOS	chr10:6654272-6654599	MCF10A-Er-Src	breast:	n/a	n/a
13	FOS	chr10:6654259-6654588	MCF10A-Er-Src	breast:	n/a	n/a
14	FOSL2	chr10:6663419-6663739	SK-N-SH	brain:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
15	FOSL2	chr10:6661614-6661969	HepG2	liver:	n/a	n/a
16	GATA3	chr10:6663444-6663521	SH-SY5Y	brain:	n/a	chr10:6663459-6663466 chr10:6663508-6663517 chr10:6663504-6663520 chr10:6663508-6663515 chr10:6663504-6663520 chr10:6663459-6663466 chr10:6663459-6663466 chr10:6663508-6663515 chr10:6663507-6663517 chr10:6663508-6663515 chr10:6663452-6663473
17	JUN	chr10:6663612-6663814	HepG2	liver:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
18	JUN	chr10:6663503-6663800	H1-hESC	embryonic stem cell:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663648-6663656
19	JUND	chr10:6663504-6663807	K562	blood:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663646-6663657 chr10:6663648-6663656
20	JUND	chr10:6663491-6663795	Hela-S3	cervix:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663646-6663657 chr10:6663648-6663656
21	JUND	chr10:6663493-6663843	HepG2	liver:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663646-6663657 chr10:6663648-6663656
22	JUND	chr10:6663460-6663825	H1-hESC	embryonic stem cell:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663646-6663657 chr10:6663648-6663656
23	JUND	chr10:6663404-6664010	SK-N-SH	brain:	n/a	chr10:6663647-6663657 chr10:6663647-6663656 chr10:6663649-6663656 chr10:6663648-6663657 chr10:6663646-6663657 chr10:6663648-6663656
24	KAP1	chr10:6663335-6664022	HEK293	kidney:	n/a	chr10:6663649-6663658
25	KAP1	chr10:6663095-6663993	U2OS	brain:	n/a	chr10:6663649-6663658
26	MAFF	chr10:6657616-6657628	HepG2	liver:	n/a	n/a
27	MAFK	chr10:6657422-6657626	HepG2	liver:	n/a	n/a
28	MAFK	chr10:6657451-6657756	HepG2	liver:	n/a	n/a
29	MYC	chr10:6654295-6654803	MCF10A-Er-Src	breast:	n/a	n/a
30	POLR2A	chr10:6656347-6656418	K562	blood:	n/a	n/a
31	POLR2A	chr10:6656339-6656382	H1-hESC	embryonic stem cell:	n/a	n/a
32	POLR2A	chr10:6663804-6664003	K562	blood:	n/a	n/a
33	RCOR1	chr10:6663553-6663753	K562	blood:	n/a	n/a
34	STAT3	chr10:6657958-6658170	MCF10A-Er-Src	breast:	n/a	n/a
35	STAT3	chr10:6654450-6654577	MCF10A-Er-Src	breast:	n/a	n/a
36	STAT3	chr10:6654390-6654680	MCF10A-Er-Src	breast:	n/a	n/a
37	STAT3	chr10:6663564-6663714	MCF10A-Er-Src	breast:	n/a	chr10:6663647-6663656 chr10:6663648-6663657
38	ZNF384	chr10:6654338-6654482	GM12878	blood:	n/a	n/a

No.	Distal block	Cell Line	Cell type
1	chr10:6622287..6623956-chr10:6655441..6657087,2	K562	blood:
2	chr10:6614415..6616986-chr10:6653036..6655207,2	K562	blood:
3	chr10:6657794..6661242-chr10:6661759..6664532,3	K562	blood:

No.	lncRNA name	Chromosome Location	lncRNA alias
1	lnc-AL137145.1-2	chr10:6657725-6657886	ENSG00000237943.2
2	lnc-AL137145.1-2	chr10:6657968-6658414	ENSG00000237943.2
3	lnc-AL137145.1-3	chr10:6663672-6663911	XLOC_008371
4	lnc-AL137145.1-2	chr10:6657725-6657810	XLOC_008370
5	lnc-AL137145.1-3	chr10:6662881-6663135	XLOC_008371
6	lnc-AL137145.1-3	chr10:6662976-6663135	XLOC_008371
7	lnc-AL137145.1-3	chr10:6662880-6663135	ENSG00000225948.2
8	lnc-AL137145.1-2	chr10:6657968-6658273	XLOC_008370
9	lnc-AL137145.1-2	chr10:6657332-6657409	XLOC_008370
10	lnc-AL137145.1-2	chr10:6657332-6657599	ENSG00000237943.2
11	lnc-AL137145.1-2	chr10:6657725-6657921	ENSG00000237943.2
12	lnc-AL137145.1-2	chr10:6657481-6657599	ENSG00000237943.2
13	lnc-AL137145.1-2	chr10:6657968-6658359	ENSG00000237943.2
14	lnc-AL137145.1-2	chr10:6657693-6657797	FPKM1_group_2866_transcript_7
15	lnc-AL137145.1-2	chr10:6657190-6657643	FPKM1_group_2866_transcript_7
16	lnc-AL137145.1-2	chr10:6657388-6657599	XLOC_008370
17	lnc-AL137145.1-3	chr10:6663672-6663911	XLOC_008371
18	lnc-AL137145.1-3	chr10:6662507-6662895	ucscGeneNc_uc001ijl_2
19	lnc-AL137145.1-2	chr10:6657725-6657886	ENSG00000237943.2
20	lnc-AL137145.1-3	chr10:6660678-6660738	XLOC_008371
21	lnc-AL137145.1-2	chr10:6657725-6657886	XLOC_008370
22	lnc-AL137145.1-2	chr10:6657725-6657912	ENSG00000237943.2
23	lnc-AL137145.1-2	chr10:6657693-6658742	NONHSAT011239
24	lnc-AL137145.1-3	chr10:6662880-6663135	XLOC_008371
25	lnc-AL137145.1-3	chr10:6663672-6663824	ENSG00000225948.2
26	lnc-AL137145.1-2	chr10:6657190-6657643	NONHSAT011239
27	lnc-AL137145.1-3	chr10:6663672-6663824	XLOC_008371
28	lnc-AL137145.1-3	chr10:6660597-6660738	XLOC_008371
29	lnc-AL137145.1-2	chr10:6655593-6655651	ENSG00000237943.2
30	lnc-AL137145.1-3	chr10:6660678-6660738	ENSG00000225948.2

Variant related genes	Relation type
ENSG00000225948	TF binding region
ENSG00000237943	chromatin interactions
ENSG00000225948	chromatin interactions
DDX6	miRNA target sites
TOMM70A	miRNA target sites
RNF145	miRNA target sites
EPHA4	miRNA target sites

Extended variants
information (count: 479 )
Associated
traits (count: 60 )

Variant overlapped rSNPs/rCNVs (count:479 , 50 per page) page: 1 2 3 4 5 6 7 ... 10

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs71479788	chr10:6653452-6653453	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
2	rs536669844	chr10:6653460-6653461	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
3	rs189386067	chr10:6653468-6653469	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
4	rs532872090	chr10:6653492-6653493	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
5	rs576596140	chr10:6653534-6653535	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
6	rs543937020	chr10:6653546-6653547	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
7	rs558882449	chr10:6653571-6653572	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
8	rs112629914	chr10:6653613-6653614	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
9	rs181479019	chr10:6653616-6653617	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
10	rs541321665	chr10:6653643-6653644	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
11	rs139727493	chr10:6653650-6653651	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
12	rs369763629	chr10:6653654-6653655	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
13	rs11253626	chr10:6653676-6653677	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
14	rs185811918	chr10:6653677-6653678	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
15	rs575670895	chr10:6653737-6653738	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
16	rs10904620	chr10:6653751-6653752	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
17	rs562976360	chr10:6653774-6653775	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
18	rs558054345	chr10:6653794-6653795	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
19	rs189389652	chr10:6653830-6653831	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
20	rs552293329	chr10:6653844-6653845	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
21	rs144411264	chr10:6653890-6653891	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
22	rs528306640	chr10:6653892-6653893	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
23	rs546890987	chr10:6653895-6653896	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
24	rs568341884	chr10:6653910-6653911	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
25	rs201231380	chr10:6653914-6653915	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
26	rs180963240	chr10:6653932-6653933	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	Overlapped CNVs	n/a
27	rs2387587	chr10:6653936-6653937	Weak transcription Enhancers Flanking Active TSS	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
28	rs570080575	chr10:6654023-6654024	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
29	rs548329576	chr10:6654100-6654101	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
30	rs537103439	chr10:6654111-6654112	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
31	rs559018825	chr10:6654112-6654113	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
32	rs373371055	chr10:6654136-6654137	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
33	rs577331501	chr10:6654160-6654161	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
34	rs541632399	chr10:6654195-6654196	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
35	rs372233828	chr10:6654208-6654209	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
36	rs1590659	chr10:6654215-6654216	Weak transcription Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
37	rs186424762	chr10:6654242-6654243	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
38	rs542155147	chr10:6654270-6654271	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
39	rs34879724	chr10:6654298-6654299	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
40	rs397846419	chr10:6654307-6654308	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
41	rs530527842	chr10:6654311-6654312	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
42	rs35879082	chr10:6654324-6654325	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
43	rs397743944	chr10:6654331-6654332	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
44	rs545549194	chr10:6654334-6654335	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
45	rs58684292	chr10:6654337-6654338	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
46	rs528204401	chr10:6654365-6654366	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
47	rs549775296	chr10:6654368-6654369	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
48	rs546803224	chr10:6654414-6654415	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
49	rs568302670	chr10:6654420-6654421	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
50	rs200980676	chr10:6654475-6654476	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a

Variant related diseases (count:60)

Disease	PMID	Source
Digeorge syndrome	22283845	CNVD
Cancer	21129771	CNVD
Colorectal cancer	20709793	CNVD
Wilms tumour	19047088	CNVD
Hepatocellular carcinoma	16750200	CNVD
Acute myeloid leukemia	16864856	CNVD
Cancer	21183584	CNVD
Barakat syndrome	22470819	CNVD
Melanoma	18172304	CNVD
Ovarian cancer	21720365	CNVD
Autism	18414403	CNVD
Malignant melanoma	18718029	CNVD
Breast cancer	22032731	CNVD
Medulloblastoma	16783165	CNVD
Breast cancer	17133270	CNVD
Endometrioid adenocarcinoma	16974079	CNVD
Breast cancer	17603634	CNVD
Endometrial cancer	22040021	CNVD
Glioblastoma multiforme	21080181	CNVD
Breast cancer	21264507	CNVD
Esophageal squamous carcinoma	21637470	CNVD
Phyllodes tumor	17334353	CNVD
Acute lymphoblastic leukemia	17690704	CNVD
Pancreatic endocrine tumor	17639061	CNVD
Gastric cancer	17908304	CNVD
Chordoma	21602918	CNVD
Ewing''s sarcoma	21437220	CNVD
Medulloblastoma	21979893	CNVD
Pleomorphic xanthoastrocytoma	20730472	CNVD
small cell lung cancer	20016488	CNVD
Lung cancer	18438408	CNVD
Thoracic aortic aneurysm	21092924	CNVD
low-grade B-cell lymphoma tumor	18367492	CNVD
Ewing''s sarcoma	17952124	CNVD
Oral cancer	21386901	CNVD
Breast cancer	21785460	CNVD
Acute lymphoblastic leukemia	20435627	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Prostate cancer	18632612	CNVD
Hodgkin''s lymphoma	17606441	CNVD
Breast cancer	21858162	CNVD
Breast cancer	21364760	CNVD
Acute lymphoblastic leukemia	20724749	CNVD
Autism	22495311	CNVD
Renal cell carcinoma	18765545	CNVD
lymphocytic leukemia	21291569	CNVD
Urothelial cell carcinoma	18451213	CNVD
Myelofibrosis	22110671	CNVD
Glioblastoma multiforme	22286061	CNVD
Myxofibrosarcoma	16751306	CNVD
Non-muscle invasive bladder neoplasm	19445696	CNVD
Breast cancer	20668451	CNVD
Cancer	20668451	CNVD
Lung cancer	20668451	CNVD
Ovarian cancer	20668451	CNVD
Pancreas cancer	20668451	CNVD
Prostate cancer	20668451	CNVD
Pancreatic cancer	17952125	CNVD
Breast cancer	22522925	CNVD
Mantle cell lymphoma	19029149	CNVD

Chromatin state (count:96 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:6651000-6656400	Weak transcription	H9 Cell Line	embryonic stem cell
2	chr10:6651200-6661600	Weak transcription	Skeletal Muscle Female	skeletal muscle
3	chr10:6651400-6653600	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
4	chr10:6651600-6654800	Enhancers	Primary hematopoietic stem cells short term culture	blood
5	chr10:6651600-6654800	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
6	chr10:6651800-6655400	Enhancers	Primary T helper 17 cells PMA-I stimulated	--
7	chr10:6651800-6663200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
8	chr10:6652200-6655200	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
9	chr10:6652200-6655200	Enhancers	Primary T helper cells fromperipheralblood	blood
10	chr10:6652400-6655000	Enhancers	NHEK	skin
11	chr10:6652400-6655200	Enhancers	Primary T helper memory cells from peripheral blood 1	blood
12	chr10:6652400-6655400	Enhancers	Primary T helper naive cells from peripheral blood	blood
13	chr10:6652400-6655400	Enhancers	Primary T helper cells PMA-I stimulated	--
14	chr10:6652600-6654200	Enhancers	Primary T cells fromperipheralblood	blood
15	chr10:6652600-6654800	Enhancers	Primary hematopoietic stem cells	blood
16	chr10:6652600-6654800	Enhancers	Primary T helper naive cells fromperipheralblood	blood
17	chr10:6652600-6654800	Enhancers	Primary T regulatory cells fromperipheralblood	blood
18	chr10:6652600-6654800	Enhancers	Primary T killer naive cells fromperipheralblood	blood
19	chr10:6652600-6654800	Enhancers	Foreskin Keratinocyte Primary Cells skin02	Skin
20	chr10:6652600-6654800	Enhancers	HMEC	breast
21	chr10:6652600-6655000	Enhancers	Primary T killer memory cells from peripheral blood	blood
22	chr10:6652600-6655000	Enhancers	Foreskin Keratinocyte Primary Cells skin03	Skin
23	chr10:6652800-6653800	Enhancers	Thymus	Thymus
24	chr10:6652800-6655000	Enhancers	Primary T cells effector/memory enriched fromperipheralblood	blood
25	chr10:6653000-6653800	Enhancers	Fetal Thymus	thymus
26	chr10:6653000-6654600	Enhancers	Breast Myoepithelial Primary Cells	Breast
27	chr10:6653000-6654800	Enhancers	Primary T cells from cord blood	blood
28	chr10:6653000-6654800	Enhancers	Dnd41	blood
29	chr10:6653200-6654400	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
30	chr10:6653400-6654600	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
31	chr10:6653600-6654000	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
32	chr10:6654000-6655200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
33	chr10:6654200-6654600	Weak transcription	Primary T cells fromperipheralblood	blood
34	chr10:6654600-6654800	Enhancers	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
35	chr10:6654600-6654800	Enhancers	Primary T cells fromperipheralblood	blood
36	chr10:6654600-6660200	Weak transcription	Breast Myoepithelial Primary Cells	Breast
37	chr10:6654800-6655000	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
38	chr10:6654800-6655600	Weak transcription	Primary T cells fromperipheralblood	blood
39	chr10:6654800-6663600	Weak transcription	Primary T cells from cord blood	blood
40	chr10:6654800-6665600	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
41	chr10:6655000-6663000	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
42	chr10:6655000-6677600	Weak transcription	Primary T killer memory cells from peripheral blood	blood
43	chr10:6655200-6657400	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
44	chr10:6655200-6663000	Weak transcription	Primary T helper cells fromperipheralblood	blood
45	chr10:6655400-6656200	ZNF genes & repeats	Primary T helper 17 cells PMA-I stimulated	--
46	chr10:6655400-6663000	Weak transcription	Primary T helper cells PMA-I stimulated	--
47	chr10:6655400-6667400	Weak transcription	Primary T helper naive cells from peripheral blood	blood
48	chr10:6655600-6656000	ZNF genes & repeats	Primary T cells fromperipheralblood	blood
49	chr10:6656000-6663000	Weak transcription	Primary T cells fromperipheralblood	blood
50	chr10:6656200-6656600	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--

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