Variant report

Variant	nsv1048811
Chromosome Location	chr14:24445622-24500243
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:996)
CpG islands
(count:1161)
Chromatin interactive
region (count:10)
LncRNA
region (count:1)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

(count:996 , 50 per page) page: 1 2 3 4 5 6 7 ... 20

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	ARID3A	chr14:24483175-24483522	HepG2	liver:	n/a	n/a
2	ARID3A	chr14:24483172-24483507	K562	blood:	n/a	n/a
3	ATF2	chr14:24458816-24459305	GM12878	blood:	n/a	n/a
4	BACH1	chr14:24476252-24476312	H1-hESC	embryonic stem cell:	n/a	n/a
5	BACH1	chr14:24458105-24458174	H1-hESC	embryonic stem cell:	n/a	n/a
6	BATF	chr14:24458871-24459266	GM12878	blood:	n/a	n/a
7	BATF	chr14:24458905-24459223	GM12878	blood:	n/a	n/a
8	BHLHE40	chr14:24483227-24483438	K562	blood:	n/a	n/a
9	BHLHE40	chr14:24475943-24476541	HepG2	liver:	n/a	n/a
10	BHLHE40	chr14:24483187-24483465	GM12878	blood:	n/a	n/a
11	BHLHE40	chr14:24456162-24456216	HepG2	liver:	n/a	n/a
12	BRCA1	chr14:24483351-24483423	GM12878	blood:	n/a	n/a
13	CBX3	chr14:24483218-24483539	K562	blood:	n/a	n/a
14	CBX3	chr14:24483227-24483553	K562	blood:	n/a	n/a
15	CBX3	chr14:24476155-24476416	K562	blood:	n/a	n/a
16	CEBPB	chr14:24454491-24454833	Hela-S3	cervix:	n/a	chr14:24454690-24454701
17	CEBPB	chr14:24454237-24454396	HepG2	liver:	n/a	n/a
18	CEBPB	chr14:24482978-24483461	A549	lung:	n/a	n/a
19	CEBPB	chr14:24456316-24456341	HepG2	liver:	n/a	n/a
20	CEBPB	chr14:24454350-24454830	A549	lung:	n/a	chr14:24454690-24454701
21	CEBPB	chr14:24454359-24454892	IMR90	lung:	n/a	chr14:24454690-24454701
22	CEBPB	chr14:24454506-24454789	A549	lung:	n/a	chr14:24454690-24454701
23	CEBPB	chr14:24454542-24454918	MCF-7	breast:	n/a	chr14:24454690-24454701
24	CEBPB	chr14:24454258-24454790	MCF-7	breast:	n/a	chr14:24454690-24454701
25	CEBPB	chr14:24454143-24454908	A549	lung:	n/a	chr14:24454690-24454701
26	CEBPB	chr14:24454165-24454464	MCF-7	breast:	n/a	n/a
27	CEBPB	chr14:24454306-24454822	HepG2	liver:	n/a	chr14:24454690-24454701
28	CEBPD	chr14:24457723-24458280	HepG2	liver:	n/a	n/a
29	CEBPD	chr14:24475992-24476248	HepG2	liver:	n/a	n/a
30	CEBPD	chr14:24455859-24456293	HepG2	liver:	n/a	n/a
31	CEBPD	chr14:24457835-24458170	HepG2	liver:	n/a	n/a
32	CHD1	chr14:24483316-24483498	GM12878	blood:	n/a	n/a
33	CHD2	chr14:24457926-24458005	Hela-S3	cervix:	n/a	chr14:24457984-24457994
34	CHD2	chr14:24483281-24483447	GM12878	blood:	n/a	n/a
35	CTCF	chr14:24446480-24446630	GM12874	blood:	n/a	n/a
36	CTCF	chr14:24489400-24489550	GM12871	blood:	n/a	n/a
37	CTCF	chr14:24489400-24489550	MCF-7	breast:	n/a	n/a
38	CTCF	chr14:24489340-24489490	NHDF-neo	bronchial:	n/a	n/a
39	CTCF	chr14:24446515-24446688	Fibrobl	skin:	n/a	n/a
40	CTCF	chr14:24489380-24489530	GM12864	blood:	n/a	n/a
41	CTCF	chr14:24489426-24489429	Medullo	brain:	n/a	n/a
42	CTCF	chr14:24483266-24483449	MCF-7	breast:	n/a	n/a
43	CTCF	chr14:24446500-24446650	NHEK	skin:	n/a	n/a
44	CTCF	chr14:24483280-24483430	HAc	cerebellar:	n/a	n/a
45	CTCF	chr14:24446620-24446770	HCT-116	colon:	n/a	n/a
46	CTCF	chr14:24489380-24489530	GM12865	blood:	n/a	n/a
47	CTCF	chr14:24483240-24483390	GM12866	blood:	n/a	n/a
48	CTCF	chr14:24483280-24483430	RPTEC	kidney:	n/a	n/a
49	CTCF	chr14:24489260-24489410	GM12872	blood:	n/a	n/a
50	CTCF	chr14:24483300-24483450	GM12866	blood:	n/a	n/a

(count:1161 , 50 per page) page: 1 2 3 4 5 6 7 ... 24

No.	Chromosome Location	Cell Line	Cell type	Cell Stage
1	chr14:24473832-24473882	ovcar-3	ovarian:	n/a
2	chr14:24457509-24457559	SK-N-SH	brain:	n/a
3	chr14:24473832-24473882	ovcar-3	ovarian:	n/a
4	chr14:24457509-24457559	SK-N-SH	brain:	n/a
5	chr14:24457993-24458043	PFSK-1	brain:	n/a
6	chr14:24475906-24475956	HUVEC	blood vessel:	n/a
7	chr14:24457509-24457559	T-47D	breast:	n/a
8	chr14:24476559-24476609	BE2_C	brain:	n/a
9	chr14:24476559-24476609	PANC-1	pancreas:	n/a
10	chr14:24475906-24475956	K562	blood:	n/a
11	chr14:24458345-24458395	A549	lung:	n/a
12	chr14:24475906-24475956	HCPEpiC	choroid plexus:	n/a
13	chr14:24458014-24458064	HIPEpiC	eye:	n/a
14	chr14:24476559-24476609	GM06990	blood:	n/a
15	chr14:24458299-24458349	U87	brain:	n/a
16	chr14:24457509-24457559	GM12878	blood:	n/a
17	chr14:24454443-24454493	GM12878	blood:	n/a
18	chr14:24457915-24457965	RPTEC	kidney:	n/a
19	chr14:24458004-24458054	AoSMC	blood vessel:	n/a
20	chr14:24457915-24457965	ovcar-3	ovarian:	n/a
21	chr14:24458345-24458395	NB4	blood:	n/a
22	chr14:24478620-24478670	PFSK-1	brain:	n/a
23	chr14:24475906-24475956	SK-N-MC	brain:	n/a
24	chr14:24454443-24454493	HRPEpiC	eye:	n/a
25	chr14:24458000-24458050	BE2_C	brain:	n/a
26	chr14:24458004-24458054	SKMC	muscle:	n/a
27	chr14:24458014-24458064	NB4	blood:	n/a
28	chr14:24458099-24458149	AG04450	lung:	fetal
29	chr14:24457893-24457943	HCM	heart:	n/a
30	chr14:24476478-24476528	U87	brain:	n/a
31	chr14:24475053-24475103	HEK293	kidney:	embryo
32	chr14:24457509-24457559	H1-hESC	embryonic stem cell:	embryo
33	chr14:24458014-24458064	CMK	blood:	n/a
34	chr14:24458345-24458395	H1-hESC	embryonic stem cell:	embryo
35	chr14:24458004-24458054	A549	lung:	n/a
36	chr14:24457993-24458043	NT2-D1	testis:	n/a
37	chr14:24473832-24473882	HMEC	breast:	n/a
38	chr14:24458014-24458064	HCM	heart:	n/a
39	chr14:24458014-24458064	Hepatocyte	liver:	n/a
40	chr14:24476559-24476609	GM12892	blood:	n/a
41	chr14:24458099-24458149	MCF-7	breast:	n/a
42	chr14:24475053-24475103	HAEpiC	amniotic membrane:	n/a
43	chr14:24473832-24473882	AG09319	gingival:	n/a
44	chr14:24475053-24475103	HNPCEpiC	eye:	n/a
45	chr14:24457509-24457559	HRCEpiC	kidney:	n/a
46	chr14:24457915-24457965	GM06990	blood:	n/a
47	chr14:24457915-24457965	LNCaP	prostate:	n/a
48	chr14:24458345-24458395	Jurkat	blood:	n/a
49	chr14:24473832-24473882	HAEpiC	amniotic membrane:	n/a
50	chr14:24458014-24458064	NT2-D1	testis:	n/a

(count:10 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr14:24483165..24483827-chr14:24559565..24560642,4	MCF-7	breast:
2	chr14:24482659..24484974-chr14:24503307..24504865,2	MCF-7	breast:
3	chr14:24482858..24483785-chr14:24559502..24560237,2	K562	blood:
4	chr14:24482840..24483718-chr14:24710880..24711620,2	MCF-7	breast:
5	chr14:24482946..24483934-chr14:24503845..24504435,3	MCF-7	breast:
6	chr14:24482802..24483800-chr14:24505642..24506553,4	MCF-7	breast:
7	chr14:24452194..24454763-chr14:24457643..24460471,2	MCF-7	breast:
8	chr14:24421533..24423333-chr14:24480435..24482151,2	K562	blood:
9	chr14:24483262..24483795-chr14:24906005..24906586,2	K562	blood:
10	chr14:24476695..24479385-chr14:24563251..24564763,2	MCF-7	breast:

(count:1 , 50 per page) page: 1

No.	lncRNA name	Chromosome Location	lncRNA alias
1	lnc-NRL-1	chr14:24457938-24458048	ENSG00000215256.3

No data

Variant related genes	Relation type
DHRS4L2	TF binding region
DHRS4-AS1	TF binding region
DHRS4L2	CpG island
DHRS4-AS1	CpG island
ENSG00000129535	chromatin interactions
ENSG00000157326	chromatin interactions
ENSG00000092330	chromatin interactions
ENSG00000215256	chromatin interactions
ENSG00000187630	chromatin interactions
ENSG00000100889	chromatin interactions
ENSG00000225766	chromatin interactions

Extended variants
information (count: 2496 )
Associated
traits (count: 62 )

Variant overlapped rSNPs/rCNVs (count:2496 , 50 per page) page: 1 2 3 4 5 6 7 ... 50

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs542270862	chr14:24445654-24445655	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
2	rs187821706	chr14:24445658-24445659	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
3	rs568848784	chr14:24445662-24445663	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
4	rs369807981	chr14:24445664-24445665	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
5	rs551155801	chr14:24445686-24445687	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
6	rs564959678	chr14:24445690-24445691	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
7	rs530818379	chr14:24445700-24445701	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
8	rs539094214	chr14:24445716-24445717	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
9	rs192208630	chr14:24445731-24445732	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
10	rs535861143	chr14:24445811-24445812	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
11	rs549441321	chr14:24445817-24445818	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
12	rs566175379	chr14:24445844-24445845	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
13	rs140869150	chr14:24445882-24445883	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
14	rs2877592	chr14:24445944-24445945	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
15	rs558317236	chr14:24445980-24445981	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
16	rs578123583	chr14:24446000-24446001	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
17	rs59807795	chr14:24446001-24446002	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	mRNA abundance
18	rs4048588	chr14:24446015-24446016	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
19	rs138787577	chr14:24446018-24446019	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
20	rs573259491	chr14:24446028-24446029	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
21	rs542204198	chr14:24446036-24446037	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
22	rs145741258	chr14:24446051-24446052	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
23	rs184435902	chr14:24446071-24446072	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
24	rs2332147	chr14:24446077-24446078	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
25	rs4048589	chr14:24446079-24446080	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
26	rs544809924	chr14:24446104-24446105	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
27	rs565056587	chr14:24446105-24446106	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
28	rs4048590	chr14:24446114-24446115	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
29	rs530639596	chr14:24446117-24446118	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
30	rs146996315	chr14:24446137-24446138	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
31	rs370172229	chr14:24446147-24446148	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
32	rs561017214	chr14:24446158-24446159	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
33	rs117088686	chr14:24446161-24446162	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
34	rs3966039	chr14:24446162-24446163	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
35	rs3966040	chr14:24446164-24446165	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
36	rs113105656	chr14:24446169-24446170	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
37	rs386775663	chr14:24446173-24446174	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
38	rs200374463	chr14:24446174-24446175	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
39	rs4048591	chr14:24446180-24446181	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
40	rs535088731	chr14:24446184-24446185	Weak transcription Enhancers	n/a	n/a	Overlapped CNVs	n/a
41	rs551608254	chr14:24446218-24446219	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
42	rs374968670	chr14:24446219-24446220	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
43	rs138002405	chr14:24446232-24446233	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
44	rs201169122	chr14:24446252-24446253	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
45	rs557570623	chr14:24446269-24446270	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
46	rs573989367	chr14:24446272-24446273	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
47	rs149491291	chr14:24446321-24446322	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
48	rs80309124	chr14:24446336-24446337	Weak transcription	n/a	n/a	Overlapped CNVs	mRNA abundance
49	rs572521044	chr14:24446374-24446375	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
50	rs545445572	chr14:24446408-24446409	Enhancers Weak transcription	n/a	n/a	Overlapped CNVs	n/a

Variant related diseases (count:62)

Disease	PMID	Source
Cancer	20164920	CNVD
Esophageal cancer	21851588	CNVD
Ewing''s sarcoma	21437220	CNVD
Glioblastoma multiforme	21080181	CNVD
Retinoblastoma	21504564	CNVD
High-proliferative meningiomas	17937814	CNVD
Thoracic aortic aneurysm	21092924	CNVD
Autism	22495311	CNVD
Acute lymphoblastic leukemia	20067559	CNVD
Non-small cell lung cancer	21044232	CNVD
Renal cell carcinoma	19461508	CNVD
Cancer	21637783	CNVD
Colorectal cancer	20709793	CNVD
Melanoma	18172304	CNVD
Esophageal squamous carcinoma	21637470	CNVD
Medulloblastoma	21979893	CNVD
Oral cancer	21386901	CNVD
Endometrial cancer	22040021	CNVD
Breast cancer	21264507	CNVD
Hepatocellular carcinoma	22174799	CNVD
Breast cancer	17899364	CNVD
Colorectal cancer	16774939	CNVD
Neuroblastoma	19435921	CNVD
Colorectal cancer	19359472	CNVD
Gastrointestinal stromal cancer	19259404	CNVD
Gastrointestinal stromal cancer	17535989	CNVD
Monoclonal gammopathy of undetermined significance	17077331	CNVD
Paraganglioma	17535989	CNVD
Pulmonary chondroma	17535989	CNVD
Endometrioid adenocarcinoma	16974079	CNVD
Lung cancer	16773561	CNVD
Multiple myeloma	16616336	CNVD
Cancer	17440070	CNVD
Breast cancer	16272173	CNVD
Oral squamous cell carcinoma	17134496	CNVD
Epilepsy	20736978	CNVD
Mental retardation	20736978	CNVD
severe speech impairment	20736978	CNVD
speech impairment	20736978	CNVD
Gastrointestinal stromal cancer	16982739	CNVD
small cell lung cancer	20016488	CNVD
Acute lymphoblastic leukemia	20435627	CNVD
Lung cancer	18438408	CNVD
Gastrointestinal stromal cancer	20818650	CNVD
Renal cell carcinoma	21668985	CNVD
Prostate cancer	18632612	CNVD
Hodgkin''s lymphoma	17606441	CNVD
Chronic myeloid leukemia	20724749	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Wilms tumour	21544195	CNVD
Breast cancer	21804112	CNVD
Myelofibrosis	22110671	CNVD
Breast cancer	17603634	CNVD
Esophageal cancer	20955586	CNVD
Cancer	21183584	CNVD
Leukoplakia	24403051	CNVD
Invasive pancreatic ductal carcinoma	16982739	CNVD
Breast cancer	21364760	CNVD
Breast cancer	22522925	CNVD
Pancreatic cancer	17952125	CNVD
Glioblastoma multiforme	21390271	CNVD
Non-syndromic sensorineural hearing loss	21293372	CNVD

Chromatin state (count:923 , 50 per page) page: 1 2 3 4 5 6 7 ... 19

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr14:24424000-24458000	Weak transcription	Primary T cells from cord blood	blood
2	chr14:24439400-24446400	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
3	chr14:24439400-24450000	Weak transcription	Rectal Mucosa Donor 31	rectum
4	chr14:24439400-24451000	Weak transcription	Rectal Mucosa Donor 29	rectum
5	chr14:24439400-24451200	Weak transcription	Pancreas	Pancrea
6	chr14:24439400-24457600	Weak transcription	Primary T helper cells fromperipheralblood	blood
7	chr14:24440000-24453600	Weak transcription	Dnd41	blood
8	chr14:24442800-24456000	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
9	chr14:24445000-24446400	Weak transcription	Primary B cells from peripheral blood	blood
10	chr14:24445200-24454600	Weak transcription	Thymus	Thymus
11	chr14:24445200-24456200	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
12	chr14:24445400-24446000	Weak transcription	Gastric	stomach
13	chr14:24446000-24446200	Enhancers	Gastric	stomach
14	chr14:24446200-24458000	Weak transcription	Gastric	stomach
15	chr14:24446400-24446600	Enhancers	Primary B cells from peripheral blood	blood
16	chr14:24446400-24446800	Enhancers	Foreskin Keratinocyte Primary Cells skin03	Skin
17	chr14:24446400-24446800	Enhancers	Monocytes-CD14+_RO01746	blood
18	chr14:24446400-24447200	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
19	chr14:24446600-24457400	Weak transcription	Primary B cells from peripheral blood	blood
20	chr14:24448000-24457400	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
21	chr14:24448400-24457400	Weak transcription	Primary T cells fromperipheralblood	blood
22	chr14:24450000-24450400	Enhancers	Primary monocytes fromperipheralblood	blood
23	chr14:24450000-24452000	Enhancers	Fetal Intestine Large	intestine
24	chr14:24450000-24452000	Enhancers	Rectal Mucosa Donor 31	rectum
25	chr14:24450400-24454200	Weak transcription	Primary monocytes fromperipheralblood	blood
26	chr14:24450400-24457400	Weak transcription	Primary hematopoietic stem cells	blood
27	chr14:24450400-24457600	Weak transcription	Duodenum Smooth Muscle	Duodenum
28	chr14:24450800-24452200	Enhancers	HepG2	liver
29	chr14:24451000-24451400	Enhancers	Fetal Intestine Small	intestine
30	chr14:24451000-24451400	Flanking Active TSS	Rectal Mucosa Donor 29	rectum
31	chr14:24451200-24451400	Enhancers	Duodenum Mucosa	Duodenum
32	chr14:24451200-24451600	Enhancers	Pancreas	Pancrea
33	chr14:24451200-24451800	Enhancers	Liver	Liver
34	chr14:24451400-24453800	Weak transcription	Fetal Intestine Small	intestine
35	chr14:24451400-24453800	Weak transcription	Fetal Thymus	thymus
36	chr14:24451400-24454400	Weak transcription	Rectal Mucosa Donor 29	rectum
37	chr14:24451600-24454600	Weak transcription	Duodenum Mucosa	Duodenum
38	chr14:24451800-24457400	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
39	chr14:24452000-24455400	Weak transcription	Fetal Intestine Large	intestine
40	chr14:24452000-24455800	Weak transcription	Rectal Mucosa Donor 31	rectum
41	chr14:24452200-24454000	Weak transcription	HepG2	liver
42	chr14:24452600-24457600	Weak transcription	Primary T helper cells PMA-I stimulated	--
43	chr14:24453600-24453800	Enhancers	Esophagus	oesophagus
44	chr14:24453600-24453800	Enhancers	Small Intestine	intestine
45	chr14:24453600-24457600	Enhancers	Dnd41	blood
46	chr14:24453800-24455200	Weak transcription	Esophagus	oesophagus
47	chr14:24453800-24456400	Enhancers	Foreskin Keratinocyte Primary Cells skin02	Skin
48	chr14:24453800-24456400	Enhancers	Fetal Intestine Small	intestine
49	chr14:24453800-24457000	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
50	chr14:24453800-24457000	Enhancers	Foreskin Keratinocyte Primary Cells skin03	Skin

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