Variant report

Variant	nsv432616
Chromosome Location	chr4:90862943-90952424
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	ARID3A	chr4:90915498-90916168	HepG2	liver:	n/a	n/a
2	ATF2	chr4:90948720-90949133	GM12878	blood:	n/a	n/a
3	BCL11A	chr4:90948808-90949047	GM12878	blood:	n/a	n/a
4	BCL11A	chr4:90948754-90949039	GM12878	blood:	n/a	n/a
5	BCL11A	chr4:90949609-90950037	GM12878	blood:	n/a	n/a
6	BHLHE40	chr4:90949419-90950090	GM12878	blood:	n/a	n/a
7	CEBPB	chr4:90919059-90919307	HepG2	liver:	n/a	chr4:90919170-90919181
8	CEBPB	chr4:90912492-90912717	A549	lung:	n/a	chr4:90912607-90912618 chr4:90912604-90912621
9	CEBPB	chr4:90909411-90909641	H1-hESC	embryonic stem cell:	n/a	n/a
10	CEBPB	chr4:90902659-90902905	HepG2	liver:	n/a	chr4:90902759-90902770
11	CEBPB	chr4:90906484-90906786	H1-hESC	embryonic stem cell:	n/a	chr4:90906618-90906629
12	CEBPB	chr4:90909401-90909715	HepG2	liver:	n/a	n/a
13	CEBPB	chr4:90909420-90909712	A549	lung:	n/a	n/a
14	CEBPB	chr4:90915689-90916023	HepG2	liver:	n/a	n/a
15	CEBPB	chr4:90919118-90919279	A549	lung:	n/a	chr4:90919170-90919181
16	CEBPB	chr4:90876132-90876407	IMR90	lung:	n/a	n/a
17	CEBPB	chr4:90876186-90876409	A549	lung:	n/a	n/a
18	CEBPB	chr4:90882186-90882605	H1-hESC	embryonic stem cell:	n/a	n/a
19	CEBPB	chr4:90919047-90919294	IMR90	lung:	n/a	chr4:90919170-90919181
20	CEBPB	chr4:90912487-90912734	HepG2	liver:	n/a	chr4:90912607-90912618 chr4:90912604-90912621
21	CEBPB	chr4:90876134-90876426	H1-hESC	embryonic stem cell:	n/a	n/a
22	CEBPB	chr4:90919120-90919207	H1-hESC	embryonic stem cell:	n/a	chr4:90919170-90919181
23	CEBPB	chr4:90906567-90906708	HepG2	liver:	n/a	chr4:90906618-90906629
24	CEBPB	chr4:90909376-90909718	IMR90	lung:	n/a	n/a
25	CEBPB	chr4:90876104-90876433	HepG2	liver:	n/a	n/a
26	CEBPB	chr4:90929334-90929504	H1-hESC	embryonic stem cell:	n/a	n/a
27	CHD2	chr4:90948731-90949063	GM12878	blood:	n/a	n/a
28	CHD2	chr4:90949359-90950066	GM12878	blood:	n/a	n/a
29	CTCF	chr4:90871020-90871170	GM12870	blood:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
30	CTCF	chr4:90952260-90952315	H1-hESC	embryonic stem cell:	n/a	n/a
31	CTCF	chr4:90871120-90871270	GM12872	blood:	n/a	chr4:90871120-90871141
32	CTCF	chr4:90946470-90946711	Medullo	brain:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
33	CTCF	chr4:90946500-90946650	HA-sp	spinal cord:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
34	CTCF	chr4:90946520-90946670	HRE	kidney:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
35	CTCF	chr4:90952280-90952430	HBMEC	blood vessel:	n/a	chr4:90952304-90952325 chr4:90952302-90952320
36	CTCF	chr4:90946460-90946610	AG04450	lung:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
37	CTCF	chr4:90946540-90946690	GM12871	blood:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
38	CTCF	chr4:90946396-90946787	GM12878	blood:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
39	CTCF	chr4:90946467-90946679	H1-hESC	embryonic stem cell:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
40	CTCF	chr4:90946500-90946650	SK-N-SH_RA	brain:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
41	CTCF	chr4:90946478-90946617	GM10266	blood:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
42	CTCF	chr4:90871040-90871190	Hela-S3	cervix:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
43	CTCF	chr4:90871069-90871154	GM10248	blood:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
44	CTCF	chr4:90871040-90871190	GM12872	blood:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
45	CTCF	chr4:90946500-90946650	NHEK	skin:	n/a	chr4:90946582-90946600 chr4:90946583-90946599 chr4:90946584-90946605 chr4:90946585-90946598
46	CTCF	chr4:90871040-90871190	HAc	cerebellar:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
47	CTCF	chr4:90952240-90952390	BJ	skin:	n/a	chr4:90952304-90952325 chr4:90952302-90952320
48	CTCF	chr4:90871080-90871230	GM12864	blood:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
49	CTCF	chr4:90871040-90871190	MCF-7	breast:	n/a	chr4:90871120-90871141 chr4:90871118-90871136 chr4:90871119-90871135
50	CTCF	chr4:90952233-90952363	Pancreas_OC	pancreas:	n/a	chr4:90952304-90952325 chr4:90952302-90952320

No.	Distal block	Cell Line	Cell type
1	chr4:90949251..90952880-chr4:91047534..91049832,6	MCF-7	breast:
2	chr4:90950024..90952887-chr4:91047925..91049735,3	MCF-7	breast:
3	chr4:90952233..90952750-chr4:91214459..91215033,2	MCF-7	breast:
4	chr4:90931435..90933735-chr4:90933990..90936566,2	MCF-7	breast:
5	chr4:90931435..90933735-chr4:90933990..90936566,2	MCF-7	breast:
6	chr4:90923727..90925753-chr4:91047906..91049514,2	MCF-7	breast:
7	chr4:90860176..90863867-chr4:90870458..90873273,3	MCF-7	breast:

Variant related genes	Relation type
MMRN1	TF binding region
ENSG00000184305	chromatin interactions
ENSG00000138722	chromatin interactions

Extended variants
information (count: 2391 )
Associated
traits (count: 90 )

Variant overlapped rSNPs/rCNVs (count:2391 , 50 per page) page: 1 2 3 4 5 6 7 ... 48

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs11937234	chr4:90862943-90862944	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
2	rs377072096	chr4:90862972-90862973	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
3	rs112689853	chr4:90862987-90862988	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
4	rs78965721	chr4:90863007-90863008	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
5	rs531071671	chr4:90863026-90863027	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
6	rs540720378	chr4:90863090-90863091	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
7	rs114618082	chr4:90863091-90863092	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
8	rs543779178	chr4:90863099-90863100	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
9	rs564675804	chr4:90863135-90863136	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
10	rs186836266	chr4:90863153-90863154	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
11	rs17016396	chr4:90863170-90863171	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
12	rs565762612	chr4:90863171-90863172	Weak transcription Enhancers	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
13	rs111576874	chr4:90863202-90863203	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
14	rs548368708	chr4:90863203-90863204	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
15	rs568269671	chr4:90863241-90863242	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
16	rs76120137	chr4:90863306-90863307	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
17	rs373400131	chr4:90863331-90863332	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
18	rs570694969	chr4:90863359-90863360	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
19	rs539805381	chr4:90863394-90863395	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
20	rs552971861	chr4:90863402-90863403	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
21	rs574153358	chr4:90863405-90863406	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
22	rs544598640	chr4:90863440-90863441	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
23	rs541930688	chr4:90863441-90863442	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
24	rs190475314	chr4:90863453-90863454	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
25	rs144048660	chr4:90863462-90863463	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
26	rs563161184	chr4:90863501-90863502	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
27	rs182211016	chr4:90863552-90863553	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
28	rs530428783	chr4:90863650-90863651	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
29	rs148525470	chr4:90863680-90863681	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
30	rs185996601	chr4:90863686-90863687	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
31	rs566440761	chr4:90863693-90863694	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
32	rs559403595	chr4:90863711-90863712	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
33	rs528150130	chr4:90863735-90863736	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
34	rs545099333	chr4:90863808-90863809	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
35	rs548307929	chr4:90863839-90863840	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
36	rs565180768	chr4:90863859-90863860	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
37	rs35148692	chr4:90863872-90863873	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
38	rs568107924	chr4:90863906-90863907	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
39	rs530720675	chr4:90863911-90863912	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
40	rs189868568	chr4:90863940-90863941	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
41	rs6837483	chr4:90863959-90863960	Weak transcription	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
42	rs539368008	chr4:90863994-90863995	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
43	rs558396221	chr4:90863999-90864000	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
44	rs116221083	chr4:90864020-90864021	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
45	rs566531538	chr4:90864022-90864023	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
46	rs535502334	chr4:90864065-90864066	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
47	rs555429868	chr4:90864107-90864108	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
48	rs575680514	chr4:90864112-90864113	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
49	rs141904326	chr4:90864113-90864114	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
50	rs558087525	chr4:90864114-90864115	Weak transcription	n/a	n/a	Overlapped CNVs	n/a

Variant related diseases (count:90)

Disease	PMID	Source
Acute lymphoblastic leukemia	22237106	CNVD
Glioblastoma multiforme	21080181	CNVD
Esophageal squamous carcinoma	21637470	CNVD
Chordoma	21602918	CNVD
HIV/AIDS	22032296	CNVD
Medulloblastoma	21979893	CNVD
Neuroblastoma	18923191	CNVD
Thoracic aortic aneurysm	21092924	CNVD
Intellectual disability	22102821	CNVD
Autism	22495311	CNVD
Breast cancer	21858162	CNVD
Small bowel adenocarcinoma	21586687	CNVD
Gastric cancer	21586687	CNVD
lymphocytic leukemia	21291569	CNVD
Basal cell lymphoma	16317097	CNVD
Diffuse large b-cell lymphoma	16317097	CNVD
Melanoma	18172304	CNVD
Acute lymphoblastic leukemia	20067559	CNVD
Breast cancer	17603634	CNVD
Hepatocellular carcinoma	16750200	CNVD
Myxofibrosarcoma	16751306	CNVD
Esophageal squamous carcinoma	18350619	CNVD
Parkinson disease	18923514	CNVD
Non-syndromic sensorineural hearing loss	15273396	CNVD
Cancer	21183584	CNVD
Breast cancer	16272173	CNVD
Colorectal cancer	19359472	CNVD
Malignant mesothelioma	18160781	CNVD
Medulloblastoma	18056178	CNVD
Multiple myeloma	17077331	CNVD
Pleural malignant mesothelioma	18160781	CNVD
Primary mediastinal b-cell lymphoma	17728785	CNVD
Oral squamous cell carcinoma	17134496	CNVD
4q-syndrome	17576883	CNVD
Cancer	21637783	CNVD
Non-syndromic sensorineural hearing loss	18471307	CNVD
Colorectal cancer	20709793	CNVD
Muscular dystrophy	21149563	CNVD
Endometrial cancer	22040021	CNVD
Breast cancer	21264507	CNVD
Glioblastoma multiforme	19960244	CNVD
Glioblastoma multiforme	17387387	CNVD
Hepatocellular carcinoma	22174799	CNVD
Liposarcoma	21253554	CNVD
Oligodendroglial tumors	17285580	CNVD
Cervical cancer	21062161	CNVD
Metanephric adenoma	20802469	CNVD
Breast cancer	16608533	CNVD
Adenoid cystic carcinoma	18698036	CNVD
Lung cancer	19208797	CNVD
Wilms tumour	21544195	CNVD
Breast cancer	21785460	CNVD
Chronic lymphocytic leukemia	20421269	CNVD
Myelodysplastic syndrome	21251322	CNVD
Multiple myeloma	17550852	CNVD
Lung cancer	18438408	CNVD
Chronic lymphocytic leukemia	18922857	CNVD
Cancer	22429812	CNVD
Acute lymphoblastic leukemia	20435627	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Autism	18414403	CNVD
primary effusion lymphomas	17116491	CNVD
Mental retardation	20522426	CNVD
delayed speech	20522426	CNVD
growth disorder	20522426	CNVD
Olfactory neuroblastoma	18408657	CNVD
small cell lung cancer	20016488	CNVD
Splenic marginal zone lymphoma	21957467	CNVD
Breast cancer	17133270	CNVD
Colorectal cancer	20459617	CNVD
Acute monocytic leukemia	16498392	CNVD
Multiple myeloma	16616336	CNVD
Esophageal adenocarcinoma	18820669	CNVD
High-grade prostatic intraepithelial neoplasia	16573809	CNVD
Endometrioid adenocarcinoma	16974079	CNVD
Myelofibrosis	22110671	CNVD
Parkinson disease	20877625	CNVD
Hirschsprung''s Disease	21712996	CNVD
Congenital anomalies of the kidney and urinary tract	20505237	CNVD
Breast cancer	17393978	CNVD
Ovarian cancer	21720365	CNVD
Obesity	20622171	CNVD
Hodgkin''s lymphoma	17606441	CNVD
Basal cell lymphoma	19029149	CNVD
Diffuse large b-cell lymphoma	19029149	CNVD
Parkinson disease	17953491	CNVD
Breast cancer	22522925	CNVD
Non-syndromic sensorineural hearing loss	21293372	CNVD
Non-syndromic sensorineural hearing loss	18451855	CNVD
Non-syndromic sensorineural hearing loss	22037309	CNVD

Chromatin state (count:276 , 50 per page) page: 1 2 3 4 5 6

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr4:90854000-90867000	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
2	chr4:90855000-90872400	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
3	chr4:90856400-90867000	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
4	chr4:90856800-90878200	Weak transcription	Primary hematopoietic stem cells	blood
5	chr4:90859200-90872600	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
6	chr4:90861400-90872400	Weak transcription	HUVEC	blood vessel
7	chr4:90862400-90863000	Enhancers	Fetal Brain Female	brain
8	chr4:90862800-90863200	Enhancers	Fetal Lung	lung
9	chr4:90863000-90864200	Weak transcription	Fetal Brain Female	brain
10	chr4:90863200-90864200	Weak transcription	Fetal Lung	lung
11	chr4:90864200-90864400	Enhancers	Fetal Brain Female	brain
12	chr4:90864200-90864400	Enhancers	Fetal Lung	lung
13	chr4:90867000-90867400	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
14	chr4:90867000-90868400	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
15	chr4:90867400-90872400	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
16	chr4:90868400-90875600	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
17	chr4:90869800-90870200	Enhancers	Breast Myoepithelial Primary Cells	Breast
18	chr4:90872000-90872800	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
19	chr4:90872200-90872400	Enhancers	iPS-20b Cell Line	embryonic stem cell
20	chr4:90872400-90872800	Active TSS	iPS-15b Cell Line	embryonic stem cell
21	chr4:90872400-90872800	Flanking Active TSS	iPS-20b Cell Line	embryonic stem cell
22	chr4:90872400-90873600	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
23	chr4:90872400-90873800	Enhancers	HUES48 Cell Line	embryonic stem cell
24	chr4:90872400-90874000	Enhancers	HUES6 Cell Line	embryonic stem cell
25	chr4:90872400-90874000	Enhancers	iPS-18 Cell Line	embryonic stem cell
26	chr4:90872400-90874200	Enhancers	HUES64 Cell Line	embryonic stem cell
27	chr4:90872400-90876800	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
28	chr4:90872400-90876800	Strong transcription	HUVEC	blood vessel
29	chr4:90872600-90872800	Active TSS	ES-I3 Cell Line	embryonic stem cell
30	chr4:90872600-90873600	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
31	chr4:90872800-90873000	Flanking Active TSS	ES-I3 Cell Line	embryonic stem cell
32	chr4:90872800-90874000	Enhancers	iPS-15b Cell Line	embryonic stem cell
33	chr4:90872800-90874000	Enhancers	iPS-20b Cell Line	embryonic stem cell
34	chr4:90872800-90878600	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
35	chr4:90873000-90873800	Enhancers	ES-I3 Cell Line	embryonic stem cell
36	chr4:90873600-90873800	Enhancers	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
37	chr4:90873600-90873800	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
38	chr4:90873600-90874600	Genic enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
39	chr4:90873800-90874600	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
40	chr4:90873800-90876200	Weak transcription	ES-I3 Cell Line	embryonic stem cell
41	chr4:90873800-90876200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
42	chr4:90873800-90878200	Weak transcription	HUES48 Cell Line	embryonic stem cell
43	chr4:90874000-90874200	Enhancers	H1 Cell Line	embryonic stem cell
44	chr4:90874000-90877800	Weak transcription	iPS-15b Cell Line	embryonic stem cell
45	chr4:90874000-90878200	Weak transcription	iPS-18 Cell Line	embryonic stem cell
46	chr4:90874000-90878400	Weak transcription	HUES6 Cell Line	embryonic stem cell
47	chr4:90874000-90878400	Weak transcription	iPS-20b Cell Line	embryonic stem cell
48	chr4:90874200-90876400	Weak transcription	H1 Cell Line	embryonic stem cell
49	chr4:90874200-90878200	Weak transcription	HUES64 Cell Line	embryonic stem cell
50	chr4:90874600-90875200	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--

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