Variant report

Variant	nsv577331
Chromosome Location	chr18:65709017-65978193
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	ARID3A	chr18:65845401-65845751	HepG2	liver:	n/a	n/a
2	ATF2	chr18:65816013-65816483	H1-hESC	embryonic stem cell:	n/a	n/a
3	ATF2	chr18:65816079-65816448	H1-hESC	embryonic stem cell:	n/a	n/a
4	BACH1	chr18:65815062-65815155	K562	blood:	n/a	n/a
5	BACH1	chr18:65815072-65815334	H1-hESC	embryonic stem cell:	n/a	chr18:65815167-65815181
6	BACH1	chr18:65750379-65750688	H1-hESC	embryonic stem cell:	n/a	n/a
7	CEBPB	chr18:65853355-65853605	A549	lung:	n/a	chr18:65853475-65853484 chr18:65853473-65853486 chr18:65853473-65853486 chr18:65853475-65853484 chr18:65853474-65853485 chr18:65853475-65853484
8	CEBPB	chr18:65853315-65853652	HepG2	liver:	n/a	chr18:65853475-65853484 chr18:65853473-65853486 chr18:65853473-65853486 chr18:65853633-65853644 chr18:65853475-65853484 chr18:65853474-65853485 chr18:65853475-65853484
9	CEBPB	chr18:65782253-65782566	Hela-S3	cervix:	n/a	chr18:65782418-65782427 chr18:65782416-65782429 chr18:65782417-65782428 chr18:65782418-65782427 chr18:65782418-65782427
10	CEBPB	chr18:65847731-65848188	A549	lung:	n/a	chr18:65847895-65847906
11	CEBPB	chr18:65817155-65817469	IMR90	lung:	n/a	chr18:65817299-65817310
12	CEBPB	chr18:65807481-65807802	IMR90	lung:	n/a	chr18:65807623-65807634 chr18:65807623-65807636
13	CEBPB	chr18:65803617-65803954	HepG2	liver:	n/a	chr18:65803781-65803792
14	CEBPB	chr18:65842139-65842251	HepG2	liver:	n/a	n/a
15	CEBPB	chr18:65934853-65935219	IMR90	lung:	n/a	n/a
16	CEBPB	chr18:65810301-65810569	A549	lung:	n/a	chr18:65810444-65810455 chr18:65810431-65810442
17	CEBPB	chr18:65847741-65848265	HepG2	liver:	n/a	chr18:65847895-65847906
18	CEBPB	chr18:65942834-65943277	IMR90	lung:	n/a	chr18:65943074-65943085
19	CEBPB	chr18:65782263-65782596	K562	blood:	n/a	chr18:65782418-65782427 chr18:65782416-65782429 chr18:65782417-65782428 chr18:65782418-65782427 chr18:65782418-65782427
20	CEBPB	chr18:65845425-65845698	HepG2	liver:	n/a	n/a
21	CEBPB	chr18:65853307-65853627	H1-hESC	embryonic stem cell:	n/a	chr18:65853475-65853484 chr18:65853473-65853486 chr18:65853473-65853486 chr18:65853475-65853484 chr18:65853474-65853485 chr18:65853475-65853484
22	CEBPB	chr18:65853276-65853652	ECC-1	luminal epithelium:	n/a	chr18:65853475-65853484 chr18:65853473-65853486 chr18:65853473-65853486 chr18:65853633-65853644 chr18:65853475-65853484 chr18:65853474-65853485 chr18:65853475-65853484
23	CEBPB	chr18:65764315-65764548	HepG2	liver:	n/a	chr18:65764401-65764412 chr18:65764399-65764410 chr18:65764399-65764412 chr18:65764401-65764412
24	CEBPB	chr18:65807516-65807769	K562	blood:	n/a	chr18:65807623-65807634 chr18:65807623-65807636
25	CEBPB	chr18:65942882-65943264	Hela-S3	cervix:	n/a	chr18:65943074-65943085
26	CEBPB	chr18:65930082-65930586	Hela-S3	cervix:	n/a	n/a
27	CEBPB	chr18:65782236-65782607	IMR90	lung:	n/a	chr18:65782418-65782427 chr18:65782416-65782429 chr18:65782417-65782428 chr18:65782418-65782427 chr18:65782418-65782427
28	CEBPB	chr18:65782251-65782599	A549	lung:	n/a	chr18:65782418-65782427 chr18:65782416-65782429 chr18:65782417-65782428 chr18:65782418-65782427 chr18:65782418-65782427
29	CEBPB	chr18:65905243-65905426	HepG2	liver:	n/a	n/a
30	CEBPB	chr18:65942945-65943241	HepG2	liver:	n/a	chr18:65943074-65943085
31	CEBPB	chr18:65845172-65845830	Hela-S3	cervix:	n/a	chr18:65845351-65845363
32	CEBPB	chr18:65899601-65899801	HepG2	liver:	n/a	chr18:65899704-65899715
33	CEBPB	chr18:65708741-65709031	IMR90	lung:	n/a	n/a
34	CEBPB	chr18:65887117-65887434	IMR90	lung:	n/a	n/a
35	CEBPB	chr18:65782239-65782613	HepG2	liver:	n/a	chr18:65782418-65782427 chr18:65782416-65782429 chr18:65782417-65782428 chr18:65782418-65782427 chr18:65782418-65782427
36	CEBPB	chr18:65847789-65848210	Hela-S3	cervix:	n/a	chr18:65847895-65847906
37	CEBPB	chr18:65930194-65930563	IMR90	lung:	n/a	n/a
38	CEBPB	chr18:65752628-65752702	H1-hESC	embryonic stem cell:	n/a	n/a
39	CEBPB	chr18:65914784-65914871	HepG2	liver:	n/a	n/a
40	CEBPB	chr18:65709604-65709870	IMR90	lung:	n/a	chr18:65709758-65709769
41	CEBPB	chr18:65845309-65845798	IMR90	lung:	n/a	chr18:65845351-65845363
42	CEBPB	chr18:65720620-65720828	A549	lung:	n/a	chr18:65720725-65720737
43	CEBPB	chr18:65799862-65800068	HepG2	liver:	n/a	n/a
44	CEBPB	chr18:65782254-65782597	H1-hESC	embryonic stem cell:	n/a	chr18:65782418-65782427 chr18:65782416-65782429 chr18:65782417-65782428 chr18:65782418-65782427 chr18:65782418-65782427
45	CEBPB	chr18:65934868-65935163	Hela-S3	cervix:	n/a	n/a
46	CEBPB	chr18:65957312-65957504	HepG2	liver:	n/a	chr18:65957314-65957325 chr18:65957314-65957325
47	CEBPB	chr18:65803616-65803947	A549	lung:	n/a	chr18:65803781-65803792
48	CEBPB	chr18:65807496-65807796	Hela-S3	cervix:	n/a	chr18:65807623-65807634 chr18:65807623-65807636
49	CEBPB	chr18:65845340-65845701	HepG2	liver:	n/a	chr18:65845351-65845363
50	CEBPB	chr18:65724175-65724492	IMR90	lung:	n/a	n/a

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr18:65183072..65183789-chr18:65819833..65820407,2	MCF-7	breast:
2	chr18:65829262..65829762-chrX:11551081..11551794,2	MCF-7	breast:

No.	lncRNA name	Chromosome Location	lncRNA alias
1	lnc-TMX3-2	chr18:65927519-65927611	NONHSAT059732
2	lnc-CCDC102B-5	chr18:65781528-65781614	ENSG00000264869.1
3	lnc-TMX3-2	chr18:65930736-65931225	NONHSAT059730
4	lnc-TMX3-2	chr18:65925576-65925802	ENSG00000264699.1
5	lnc-TMX3-2	chr18:65907358-65907379	NONHSAT059730
6	lnc-TMX3-2	chr18:65928862-65928907	ENSG00000264699.1
7	lnc-TMX3-2	chr18:65932041-65932064	ENSG00000264699.1
8	lnc-CCDC102B-5	chr18:65773447-65773611	ENSG00000264869.1
9	lnc-CCDC102B-5	chr18:65769353-65769392	ENSG00000264869.1
10	lnc-TMX3-2	chr18:65930736-65930840	ENSG00000264699.1
11	lnc-TMX3-2	chr18:65928862-65928907	NONHSAT059732
12	lnc-CCDC102B-5	chr18:65780867-65780920	ENSG00000264869.1
13	lnc-TMX3-2	chr18:65928862-65928907	NONHSAT059730
14	lnc-TMX3-2	chr18:65927518-65927611	ENSG00000264699.1
15	lnc-TMX3-2	chr18:65930736-65931225	NONHSAT059732

Variant related genes	Relation type
ENSG00000260747	TF binding region
ENSG00000264699	TF binding region
ENSG00000264869	TF binding region
ENSG00000265533	chromatin interactions

Extended variants
information (count: 5339 )
Associated
traits (count: 84 )

Variant overlapped rSNPs/rCNVs (count:5339 , 50 per page) page: 1 2 3 4 5 6 7 ... 107

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs12965454	chr18:65709017-65709018	Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	mRNA abundance
2	rs111737920	chr18:65709048-65709049	Enhancers	n/a	n/a	Overlapped CNVs	n/a
3	rs114408119	chr18:65709052-65709053	Enhancers	n/a	n/a	Overlapped CNVs	n/a
4	rs536130036	chr18:65709102-65709103	Enhancers	n/a	n/a	Overlapped CNVs	n/a
5	rs554677438	chr18:65709116-65709117	Enhancers	n/a	n/a	Overlapped CNVs	n/a
6	rs570198915	chr18:65709154-65709155	Enhancers	n/a	n/a	Overlapped CNVs	n/a
7	rs117428314	chr18:65709171-65709172	Enhancers	n/a	n/a	Overlapped CNVs	n/a
8	rs549731899	chr18:65709197-65709198	Enhancers	n/a	n/a	Overlapped CNVs	n/a
9	rs112435785	chr18:65709205-65709206	Enhancers	n/a	n/a	Overlapped CNVs	n/a
10	rs141152970	chr18:65709214-65709215	Enhancers	n/a	n/a	Overlapped CNVs	n/a
11	rs554082117	chr18:65709221-65709222	Enhancers	n/a	n/a	Overlapped CNVs	n/a
12	rs565626795	chr18:65709270-65709271	Enhancers	n/a	n/a	Overlapped CNVs	n/a
13	rs144903177	chr18:65709280-65709281	Enhancers	n/a	n/a	Overlapped CNVs	n/a
14	rs4480909	chr18:65709289-65709290	Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
15	rs181444073	chr18:65709327-65709328	Enhancers	n/a	n/a	Overlapped CNVs	n/a
16	rs138117134	chr18:65709330-65709331	Enhancers	n/a	n/a	Overlapped CNVs	n/a
17	rs369795852	chr18:65709333-65709334	Enhancers	n/a	n/a	Overlapped CNVs	n/a
18	rs373699892	chr18:65709350-65709351	Enhancers	n/a	n/a	Overlapped CNVs	n/a
19	rs148878108	chr18:65709362-65709363	Enhancers	n/a	n/a	Overlapped CNVs	n/a
20	rs577323414	chr18:65709395-65709396	Enhancers	n/a	n/a	Overlapped CNVs	n/a
21	rs186556891	chr18:65709399-65709400	Enhancers	n/a	n/a	Overlapped CNVs	n/a
22	rs566483643	chr18:65718005-65718006	Enhancers	n/a	n/a	Overlapped CNVs	n/a
23	rs140840649	chr18:65718031-65718032	Enhancers	n/a	n/a	Overlapped CNVs	n/a
24	rs377312668	chr18:65718066-65718067	Enhancers	n/a	n/a	Overlapped CNVs	n/a
25	rs8088562	chr18:65718115-65718116	Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
26	rs564263853	chr18:65718144-65718145	Enhancers	n/a	n/a	Overlapped CNVs	n/a
27	rs535321829	chr18:65718148-65718149	Enhancers	n/a	n/a	Overlapped CNVs	n/a
28	rs144360753	chr18:65718158-65718159	Enhancers	n/a	n/a	Overlapped CNVs	n/a
29	rs189856542	chr18:65718202-65718203	Enhancers	n/a	n/a	Overlapped CNVs	n/a
30	rs182381830	chr18:65718209-65718210	Enhancers	n/a	n/a	Overlapped CNVs	n/a
31	rs558078524	chr18:65718297-65718298	Enhancers	n/a	n/a	Overlapped CNVs	n/a
32	rs572913864	chr18:65718309-65718310	Enhancers	n/a	n/a	Overlapped CNVs	n/a
33	rs8092570	chr18:65718377-65718378	Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
34	rs561658407	chr18:65718444-65718445	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
35	rs8093517	chr18:65718470-65718471	Flanking Active TSS Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
36	rs189110642	chr18:65718479-65718480	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
37	rs374374573	chr18:65718489-65718490	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
38	rs529238586	chr18:65718490-65718491	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
39	rs114300418	chr18:65718510-65718511	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
40	rs193048660	chr18:65718574-65718575	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
41	rs8092880	chr18:65718590-65718591	Flanking Active TSS Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
42	rs147808800	chr18:65718613-65718614	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
43	rs549339898	chr18:65718619-65718620	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
44	rs8093030	chr18:65718668-65718669	Flanking Active TSS Enhancers	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
45	rs533248988	chr18:65718684-65718685	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
46	rs542319637	chr18:65718710-65718711	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
47	rs556878208	chr18:65718754-65718755	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
48	rs569118891	chr18:65718762-65718763	Flanking Active TSS Enhancers	n/a	n/a	Overlapped CNVs	n/a
49	rs371737419	chr18:65718836-65718837	Enhancers	n/a	n/a	Overlapped CNVs	n/a
50	rs141227717	chr18:65718852-65718853	Enhancers	n/a	n/a	Overlapped CNVs	n/a

Variant related diseases (count:84)

Disease	PMID	Source
Chordoma	21602918	CNVD
Ewing''s sarcoma	21437220	CNVD
Neuroblastoma	18923191	CNVD
Esophageal squamous carcinoma	21637470	CNVD
Glioblastoma multiforme	21080181	CNVD
Chronic lymphocytic leukemia	21546498	CNVD
Cancer	21637783	CNVD
Medulloblastoma	21979893	CNVD
Splenic marginal zone lymphoma	21957467	CNVD
Trisomy 18 syndrome	17576883	CNVD
Barrett''s syndrome	19417022	CNVD
Ewing''s sarcoma	17952124	CNVD
Multiple myeloma	17550852	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Thoracic aortic aneurysm	21092924	CNVD
Melanoma	18172304	CNVD
Basal cell lymphoma	16317097	CNVD
Diffuse large b-cell lymphoma	16317097	CNVD
Hodgkin''s lymphoma	17606441	CNVD
Acute lymphoblastic leukemia	17690704	CNVD
18q deletion syndrome	19533772	CNVD
Acute myeloid leukemia	16864856	CNVD
Colorectal cancer	21102417	CNVD
Colorectal cancer	20709793	CNVD
Pancreatic cancer	21811562	CNVD
Basal cell lymphoma	21115979	CNVD
Mucosa-associated lymphoid tissue lymphomas	21459788	CNVD
Endometrial cancer	22040021	CNVD
Breast cancer	21264507	CNVD
Oligodendroglial tumors	17285580	CNVD
colon cancer	17210682	CNVD
Prostate cancer	16573809	CNVD
Autism	16446308	CNVD
Colorectal cancer	19359472	CNVD
Colorectal cancer	16272173	CNVD
Human rectal carcinomas	16397240	CNVD
Medulloblastoma	18056178	CNVD
Gastrointestinal stromal cancer	16982739	CNVD
Cancer	16751803	CNVD
Metanephric adenoma	20802469	CNVD
small cell lung cancer	20016488	CNVD
Invasive pancreatic ductal carcinoma	16982739	CNVD
Colorectal cancer	21297112	CNVD
Breast cancer	17603634	CNVD
Thyroid cancer	19087340	CNVD
Urothelial carcinoma	21177765	CNVD
Oral cancer	21386901	CNVD
Colorectal cancer	19150955	CNVD
Acute myeloid leukemia	21251322	CNVD
Seminomas	18059402	CNVD
Breast cancer	16272173	CNVD
Breast cancer	17133270	CNVD
prenatal diagnosis	22389664	CNVD
Medulloblastoma	16783165	CNVD
Burkitt''s lymphoma	18698080	CNVD
Colorectal cancer	16774939	CNVD
Endometrioid adenocarcinoma	16974079	CNVD
Testicular germ cell tumor	18059402	CNVD
Glioblastoma	21080181	CNVD
High-grade prostatic intraepithelial neoplasia	16573809	CNVD
Burkitt''s lymphoma	20823134	CNVD
Lung cancer	18438408	CNVD
Anaplastic large cell lymphoma	18179710	CNVD
Hodgkin''s lymphoma	18179710	CNVD
Colorectal cancer	16912164	CNVD
Intracranial aneurysm	16715129	CNVD
Hodgkin''s lymphoma	18641027	CNVD
Gastric cancer	22539939	CNVD
Ovarian cancer	20844748	CNVD
Squamous cell cancer	20885788	CNVD
Malignant fibrous histiocytomas	21085701	CNVD
Breast cancer	21364760	CNVD
Oral squamous cell carcinoma	17134496	CNVD
Bladder cancer	21909424	CNVD
Pancreatic cancer	21811587	CNVD
Lung squamous cell carcinoma	22363434	CNVD
Myelofibrosis	22110671	CNVD
Glioblastoma multiforme	22286061	CNVD
Melanoma	20877625	CNVD
Pancreatic cancer	17952125	CNVD
Breast cancer	22522925	CNVD
Non-syndromic sensorineural hearing loss	18451855	CNVD
Bipolar disorder	19114987	CNVD
Non-syndromic sensorineural hearing loss	22037309	CNVD

Chromatin state (count:337 , 50 per page) page: 1 2 3 4 5 6 7

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr18:65708000-65709400	Enhancers	HSMM	muscle
2	chr18:65718000-65719400	Enhancers	HUES64 Cell Line	embryonic stem cell
3	chr18:65718200-65718400	Enhancers	HUES48 Cell Line	embryonic stem cell
4	chr18:65718400-65718800	Flanking Active TSS	HUES48 Cell Line	embryonic stem cell
5	chr18:65718400-65719000	Enhancers	iPS-20b Cell Line	embryonic stem cell
6	chr18:65718400-65719200	Enhancers	HUES6 Cell Line	embryonic stem cell
7	chr18:65718400-65719200	Enhancers	iPS-15b Cell Line	embryonic stem cell
8	chr18:65718400-65719400	Enhancers	iPS-18 Cell Line	embryonic stem cell
9	chr18:65718800-65719200	Enhancers	HUES48 Cell Line	embryonic stem cell
10	chr18:65719000-65719400	Enhancers	ES-I3 Cell Line	embryonic stem cell
11	chr18:65724000-65724800	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
12	chr18:65733000-65733400	ZNF genes & repeats	NHDF-Ad	bronchial
13	chr18:65742800-65745000	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
14	chr18:65743400-65744800	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
15	chr18:65744800-65750200	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
16	chr18:65745000-65746000	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
17	chr18:65746000-65746400	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
18	chr18:65746400-65750200	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
19	chr18:65749000-65749200	Enhancers	iPS-15b Cell Line	embryonic stem cell
20	chr18:65749200-65752400	Weak transcription	iPS-15b Cell Line	embryonic stem cell
21	chr18:65750000-65750600	Enhancers	NH-A	brain
22	chr18:65750000-65751000	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
23	chr18:65750000-65751200	Enhancers	Muscle Satellite Cultured Cells	--
24	chr18:65750000-65752000	Enhancers	HUVEC	blood vessel
25	chr18:65750200-65750800	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
26	chr18:65750200-65750800	Enhancers	IMR90 fetal lung fibroblasts Cell Line	lung
27	chr18:65750200-65750800	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
28	chr18:65750200-65750800	Enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
29	chr18:65750200-65750800	Enhancers	NHDF-Ad	bronchial
30	chr18:65750200-65750800	Enhancers	NHLF	lung
31	chr18:65750200-65751000	Enhancers	HSMM	muscle
32	chr18:65750200-65751000	Enhancers	Osteobl	bone
33	chr18:65750200-65751400	Enhancers	Adipose Nuclei	Adipose
34	chr18:65750200-65751600	Enhancers	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
35	chr18:65750200-65751800	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
36	chr18:65750400-65750600	Enhancers	HUES64 Cell Line	embryonic stem cell
37	chr18:65750400-65750800	Enhancers	Fetal Adrenal Gland	Adrenal Gland
38	chr18:65750400-65751000	Enhancers	iPS-18 Cell Line	embryonic stem cell
39	chr18:65750600-65751000	Active TSS	NH-A	brain
40	chr18:65750600-65753400	Enhancers	HUES48 Cell Line	embryonic stem cell
41	chr18:65750800-65751800	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
42	chr18:65751000-65752000	Enhancers	NH-A	brain
43	chr18:65751400-65752600	Enhancers	Brain Germinal Matrix	brain
44	chr18:65751600-65751800	Enhancers	Fetal Brain Male	brain
45	chr18:65751600-65752000	Enhancers	Pancreatic Islets	Pancreatic Islet
46	chr18:65751600-65754200	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
47	chr18:65751800-65752000	Enhancers	Fetal Adrenal Gland	Adrenal Gland
48	chr18:65751800-65753200	Weak transcription	Fetal Brain Male	brain
49	chr18:65752000-65752200	Enhancers	ES-I3 Cell Line	embryonic stem cell
50	chr18:65752200-65752600	Active TSS	ES-WA7 Cell Line	embryonic stem cell

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