Variant report

Variant	nsv897572
Chromosome Location	chr11:50730482-51456554
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:1559)
CpG islands
(count:122)
Chromatin interactive
region (count:1)
LncRNA
region (count:1)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

(count:1559 , 50 per page) page: 1 2 3 4 5 6 7 ... 32

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	ARID3A	chr11:51250147-51250516	HepG2	liver:	n/a	n/a
2	ATF1	chr11:50767721-50767932	K562	blood:	n/a	n/a
3	ATF1	chr11:51250147-51250516	K562	blood:	n/a	n/a
4	ATF1	chr11:50741510-50741536	K562	blood:	n/a	n/a
5	ATF1	chr11:50771363-50771551	K562	blood:	n/a	n/a
6	ATF1	chr11:50757990-50758182	K562	blood:	n/a	n/a
7	ATF1	chr11:50755176-50755720	K562	blood:	n/a	n/a
8	BACH1	chr11:51219237-51219611	K562	blood:	n/a	n/a
9	BACH1	chr11:50765324-50765524	K562	blood:	n/a	n/a
10	BACH1	chr11:50739007-50739300	K562	blood:	n/a	n/a
11	BACH1	chr11:51234203-51234576	H1-hESC	embryonic stem cell:	n/a	n/a
12	BACH1	chr11:50744265-50744293	K562	blood:	n/a	n/a
13	BACH1	chr11:51292058-51292433	K562	blood:	n/a	n/a
14	BACH1	chr11:50767401-50767428	K562	blood:	n/a	n/a
15	BACH1	chr11:50780465-50780837	K562	blood:	n/a	n/a
16	BACH1	chr11:50762679-50763056	K562	blood:	n/a	n/a
17	BACH1	chr11:50769674-50770049	K562	blood:	n/a	n/a
18	BACH1	chr11:50741715-50742187	K562	blood:	n/a	n/a
19	BACH1	chr11:50759699-50760188	K562	blood:	n/a	n/a
20	BATF	chr11:50770838-50771135	GM12878	blood:	n/a	n/a
21	BATF	chr11:50782290-50782554	GM12878	blood:	n/a	n/a
22	BATF	chr11:50756360-50756521	GM12878	blood:	n/a	n/a
23	BATF	chr11:50761809-50762209	GM12878	blood:	n/a	n/a
24	BATF	chr11:50779460-50779823	GM12878	blood:	n/a	n/a
25	BATF	chr11:50768336-50768651	GM12878	blood:	n/a	n/a
26	BATF	chr11:50764082-50764319	GM12878	blood:	n/a	n/a
27	BATF	chr11:51199100-51199269	GM12878	blood:	n/a	n/a
28	BATF	chr11:50764084-50764312	GM12878	blood:	n/a	n/a
29	BATF	chr11:50772285-50772433	GM12878	blood:	n/a	n/a
30	BATF	chr11:50756315-50756627	GM12878	blood:	n/a	n/a
31	BATF	chr11:50749839-50750367	GM12878	blood:	n/a	n/a
32	BATF	chr11:50742992-50743342	GM12878	blood:	n/a	n/a
33	BATF	chr11:51250243-51250386	GM12878	blood:	n/a	n/a
34	BATF	chr11:50779519-50779853	GM12878	blood:	n/a	n/a
35	BATF	chr11:50755495-50755763	GM12878	blood:	n/a	n/a
36	BATF	chr11:50767583-50768188	GM12878	blood:	n/a	n/a
37	BATF	chr11:50772283-50772434	GM12878	blood:	n/a	n/a
38	BATF	chr11:51199068-51199248	GM12878	blood:	n/a	n/a
39	BATF	chr11:50757466-50757719	GM12878	blood:	n/a	n/a
40	BCL11A	chr11:50750931-50751324	GM12878	blood:	n/a	n/a
41	BCL11A	chr11:50772281-50772426	GM12878	blood:	n/a	n/a
42	BCL11A	chr11:50749864-50750376	GM12878	blood:	n/a	n/a
43	BCL11A	chr11:50779445-50779875	GM12878	blood:	n/a	n/a
44	BCL11A	chr11:50743014-50743152	GM12878	blood:	n/a	n/a
45	BCL11A	chr11:50764003-50764304	GM12878	blood:	n/a	n/a
46	BCL11A	chr11:50756231-50756543	GM12878	blood:	n/a	n/a
47	BCL11A	chr11:50761565-50762209	GM12878	blood:	n/a	n/a
48	BCL11A	chr11:51199021-51199258	GM12878	blood:	n/a	n/a
49	BCL11A	chr11:50770619-50771168	GM12878	blood:	n/a	n/a
50	BCL11A	chr11:51199061-51199240	GM12878	blood:	n/a	n/a

(count:122 , 50 per page) page: 1 2 3

No.	Chromosome Location	Cell Line	Cell type	Cell Stage
1	chr11:51413644-51413694	SK-N-SH	brain:	n/a
2	chr11:51411541-51411591	PANC-1	pancreas:	n/a
3	chr11:51413644-51413694	Hela-S3	cervix:	n/a
4	chr11:51411541-51411591	HUVEC	blood vessel:	n/a
5	chr11:51413644-51413694	BE2_C	brain:	n/a
6	chr11:51413644-51413694	U87	brain:	n/a
7	chr11:51413644-51413694	HCT-116	colon:	n/a
8	chr11:51413644-51413694	AG09309	skin:	n/a
9	chr11:51413644-51413694	MCF10A-Er-Src	breast:	n/a
10	chr11:51413644-51413694	MCF-7	breast:	n/a
11	chr11:51411541-51411591	HL-60	blood:	n/a
12	chr11:51413644-51413694	SK-N-MC	brain:	n/a
13	chr11:51411541-51411591	CMK	blood:	n/a
14	chr11:51411541-51411591	HCF	heart:	n/a
15	chr11:51413644-51413694	NH-A	brain:	n/a
16	chr11:51411541-51411591	MCF10A-Er-Src	breast:	n/a
17	chr11:51411541-51411591	IMR90	lung:	fetal
18	chr11:51411541-51411591	AG10803	skin:	n/a
19	chr11:51413644-51413694	RPTEC	kidney:	n/a
20	chr11:51411541-51411591	AG09319	gingival:	n/a
21	chr11:51413644-51413694	HCF	heart:	n/a
22	chr11:51411541-51411591	SAEC	small airway:	n/a
23	chr11:51413644-51413694	GM06990	blood:	n/a
24	chr11:51411541-51411591	HCM	heart:	n/a
25	chr11:51411541-51411591	Hela-S3	cervix:	n/a
26	chr11:51411541-51411591	HRCEpiC	kidney:	n/a
27	chr11:51413644-51413694	NB4	blood:	n/a
28	chr11:51413644-51413694	NHBE	bronchial:	n/a
29	chr11:51413644-51413694	Hepatocyte	liver:	n/a
30	chr11:51411541-51411591	BE2_C	brain:	n/a
31	chr11:51411541-51411591	SK-N-MC	brain:	n/a
32	chr11:51411541-51411591	H1-hESC	embryonic stem cell:	embryo
33	chr11:51413644-51413694	PANC-1	pancreas:	n/a
34	chr11:51411541-51411591	RPTEC	kidney:	n/a
35	chr11:51413644-51413694	GM12891	blood:	n/a
36	chr11:51413644-51413694	A549	lung:	n/a
37	chr11:51411541-51411591	U87	brain:	n/a
38	chr11:51411541-51411591	NH-A	brain:	n/a
39	chr11:51413644-51413694	HRE	kidney:	n/a
40	chr11:51413644-51413694	Jurkat	blood:	n/a
41	chr11:51411541-51411591	LNCaP	prostate:	n/a
42	chr11:51411541-51411591	Jurkat	blood:	n/a
43	chr11:51411541-51411591	ovcar-3	ovarian:	n/a
44	chr11:51413644-51413694	ProgFib	skin:	n/a
45	chr11:51411541-51411591	GM12878	blood:	n/a
46	chr11:51411541-51411591	AG04450	lung:	fetal
47	chr11:51411541-51411591	HepG2	liver:	n/a
48	chr11:51411541-51411591	GM06990	blood:	n/a
49	chr11:51413644-51413694	AG10803	skin:	n/a
50	chr11:51413644-51413694	HNPCEpiC	eye:	n/a

(count:1 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr11:50731452..50731974-chr8:46856234..46856754,2	MCF-7	breast:

(count:1 , 50 per page) page: 1

No.	lncRNA name	Chromosome Location	lncRNA alias
1	lnc-OR4A5-2	chr11:51455830-51456700	NONHSAT021348

No data

Variant related genes	Relation type
OR4A8P	TF binding region
OR4A5	TF binding region
OR4A6P	TF binding region
OR4A2P	TF binding region
OR4A7P	TF binding region
ENSG00000264637	TF binding region
OR4A8P	CpG island
OR4A5	CpG island
OR4A6P	CpG island
OR4A2P	CpG island
OR4A7P	CpG island
ENSG00000264637	CpG island

Extended variants
information (count: 16698 )
Associated
traits (count: 57 )

Variant overlapped rSNPs/rCNVs (count:16698 , 50 per page) page: 1 2 3 4 5 6 7 ... 334

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs4980491	chr11:50730483-50730484	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
2	rs537345057	chr11:50730487-50730488	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
3	rs61918645	chr11:50730498-50730499	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
4	rs200037388	chr11:50730499-50730500	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
5	rs201147220	chr11:50730511-50730512	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
6	rs61918646	chr11:50730521-50730522	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
7	rs542775883	chr11:50730526-50730527	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
8	rs559454436	chr11:50730529-50730530	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
9	rs113269062	chr11:50730530-50730531	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
10	rs201946395	chr11:50730533-50730534	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
11	rs181835379	chr11:50730539-50730540	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
12	rs200178635	chr11:50730541-50730542	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
13	rs370981150	chr11:50730551-50730552	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
14	rs61918647	chr11:50730552-50730553	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
15	rs202126347	chr11:50730553-50730554	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
16	rs544629514	chr11:50730556-50730557	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
17	rs200310817	chr11:50730559-50730560	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
18	rs147298737	chr11:50730560-50730561	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
19	rs541677088	chr11:50730570-50730571	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
20	rs564810075	chr11:50730573-50730574	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
21	rs533495162	chr11:50730578-50730579	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
22	rs550057744	chr11:50730580-50730581	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
23	rs371573027	chr11:50730581-50730582	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
24	rs202135993	chr11:50730592-50730593	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
25	rs549087497	chr11:50730602-50730603	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
26	rs565790756	chr11:50730610-50730611	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
27	rs535028630	chr11:50730630-50730631	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
28	rs551527257	chr11:50730677-50730678	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
29	rs571613988	chr11:50730679-50730680	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
30	rs536977432	chr11:50730689-50730690	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
31	rs374579242	chr11:50730695-50730696	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
32	rs113790752	chr11:50730709-50730710	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
33	rs186155612	chr11:50730723-50730724	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
34	rs557279899	chr11:50730730-50730731	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
35	rs573893027	chr11:50730733-50730734	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
36	rs536420825	chr11:50730743-50730744	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
37	rs112223439	chr11:50730745-50730746	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
38	rs553105715	chr11:50730749-50730750	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
39	rs201539426	chr11:50730760-50730761	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
40	rs199535231	chr11:50730768-50730769	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
41	rs572809044	chr11:50730773-50730774	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
42	rs200660942	chr11:50730798-50730799	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
43	rs545077801	chr11:50730823-50730824	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
44	rs143149044	chr11:50730834-50730835	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
45	rs564774510	chr11:50730849-50730850	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
46	rs143273437	chr11:50730853-50730854	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
47	rs144086448	chr11:50730866-50730867	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
48	rs149409966	chr11:50730868-50730869	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
49	rs113792383	chr11:50730872-50730873	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a
50	rs200294650	chr11:50730886-50730887	ZNF genes & repeats Weak transcription	n/a	n/a	Overlapped CNVs	n/a

Variant related diseases (count:57)

Disease	PMID	Source
Chordoma	21602918	CNVD
Breast cancer	21949216	CNVD
Cancer	21637783	CNVD
Non-syndromic sensorineural hearing loss	19222835	CNVD
T-cell acute lymphoblastic leukemia	20065082	CNVD
Ewing''s sarcoma	21437220	CNVD
Glioblastoma multiforme	21080181	CNVD
Endometrial cancer	22040021	CNVD
Astrocytoma	17387387	CNVD
Breast cancer	21264507	CNVD
Beckwith-Wiedemann syndrome	21518781	CNVD
Wilms tumour	21518781	CNVD
Hepatoblastoma	21518781	CNVD
Acute lymphoblastic leukemia	20067559	CNVD
Gastrointestinal stromal cancer	17535989	CNVD
Paraganglioma	17535989	CNVD
Pulmonary chondroma	17535989	CNVD
Wilms tumour	21544195	CNVD
Medulloblastoma	21979893	CNVD
Gastric cancer	17908304	CNVD
Multiple myeloma	20724749	CNVD
Acute lymphoblastic leukemia	20435627	CNVD
Autism	22495311	CNVD
Chronic lymphocytic leukemia	21546498	CNVD
Non-small cell lung cancer	21385341	CNVD
Intellectual disability	22102821	CNVD
Renal cell carcinoma	18194544	CNVD
Potocki-Shaffer syndrome	19222835	CNVD
WAGR syndrome	19222835	CNVD
Lung cancer	18438408	CNVD
Breast cancer	16608533	CNVD
Hirschsprung''s Disease	21712996	CNVD
Follicular lymphoma	20505157	CNVD
Colorectal cancer	21128281	CNVD
Glioblastoma multiforme	21138945	CNVD
Breast cancer	21364760	CNVD
Prostate cancer	18632612	CNVD
Breast cancer	21990379	CNVD
Myelofibrosis	22110671	CNVD
Intellectual disability	22045946	CNVD
small cell lung cancer	20016488	CNVD
Mortal	21835882	CNVD
Breast cancer	21785460	CNVD
Esophageal cancer	21851588	CNVD
Acute myeloid leukemia	20729466	CNVD
Breast cancer	17142309	CNVD
Bipolar disorder	19214233	CNVD
Medulloblastoma	21163964	CNVD
early-passage human iPS cells	21368824	CNVD
Non-syndromic sensorineural hearing loss	21293372	CNVD
Cancer	20164919	CNVD
Williams Syndrome	20824207	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Schizophrenia	21346763	CNVD
Non-syndromic sensorineural hearing loss	18451855	CNVD
Ovarian clear cell carcinoma	21343371	CNVD
Breast cancer	22522925	CNVD

Chromatin state (count:387 , 50 per page) page: 1 2 3 4 5 6 7 8

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:50709600-50752200	ZNF genes & repeats	HUES64 Cell Line	embryonic stem cell
2	chr11:50724800-50738400	Weak transcription	Aorta	Aorta
3	chr11:50730800-50737000	ZNF genes & repeats	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
4	chr11:50730800-50770200	ZNF genes & repeats	HUES48 Cell Line	embryonic stem cell
5	chr11:50731000-50731200	ZNF genes & repeats	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
6	chr11:50731000-50731400	Active TSS	Primary T helper cells PMA-I stimulated	--
7	chr11:50731000-50731400	ZNF genes & repeats	Duodenum Smooth Muscle	Duodenum
8	chr11:50731000-50731600	ZNF genes & repeats	ES-I3 Cell Line	embryonic stem cell
9	chr11:50731000-50732000	ZNF genes & repeats	iPS-20b Cell Line	embryonic stem cell
10	chr11:50732200-50732600	ZNF genes & repeats	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
11	chr11:50733600-50738400	Weak transcription	NH-A	brain
12	chr11:50734200-50734400	Weak transcription	Pancreatic Islets	Pancreatic Islet
13	chr11:50734400-50734600	ZNF genes & repeats	Pancreatic Islets	Pancreatic Islet
14	chr11:50734600-50738400	Weak transcription	Pancreatic Islets	Pancreatic Islet
15	chr11:50735800-50741600	Weak transcription	NHDF-Ad	bronchial
16	chr11:50736200-50737000	ZNF genes & repeats	ES-I3 Cell Line	embryonic stem cell
17	chr11:50736600-50737000	ZNF genes & repeats	GM12878-XiMat	blood
18	chr11:50737000-50738400	Weak transcription	GM12878-XiMat	blood
19	chr11:50738000-50747600	ZNF genes & repeats	iPS-20b Cell Line	embryonic stem cell
20	chr11:50738200-50738800	ZNF genes & repeats	ES-I3 Cell Line	embryonic stem cell
21	chr11:50738200-50739000	ZNF genes & repeats	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
22	chr11:50738400-50738600	ZNF genes & repeats	Primary T helper naive cells fromperipheralblood	blood
23	chr11:50738400-50738600	Flanking Active TSS	Aorta	Aorta
24	chr11:50738400-50738600	ZNF genes & repeats	Pancreatic Islets	Pancreatic Islet
25	chr11:50738400-50738800	ZNF genes & repeats	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
26	chr11:50738400-50738800	Active TSS	Psoas Muscle	Psoas
27	chr11:50738400-50738800	Active TSS	Stomach Mucosa	stomach
28	chr11:50738400-50738800	ZNF genes & repeats	GM12878-XiMat	blood
29	chr11:50738400-50738800	ZNF genes & repeats	HUVEC	blood vessel
30	chr11:50738400-50738800	ZNF genes & repeats	NH-A	brain
31	chr11:50738400-50739000	ZNF genes & repeats	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
32	chr11:50738600-50738800	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
33	chr11:50738600-50738800	Active TSS	Aorta	Aorta
34	chr11:50738600-50738800	ZNF genes & repeats	NHEK	skin
35	chr11:50738600-50743000	ZNF genes & repeats	iPS-18 Cell Line	embryonic stem cell
36	chr11:50741000-50741200	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
37	chr11:50741200-50741400	Enhancers	Primary T helper naive cells from peripheral blood	blood
38	chr11:50741200-50772800	ZNF genes & repeats	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
39	chr11:50741400-50741800	Flanking Active TSS	Primary T helper naive cells from peripheral blood	blood
40	chr11:50741400-50741800	ZNF genes & repeats	Primary T cells effector/memory enriched fromperipheralblood	blood
41	chr11:50741600-50741800	ZNF genes & repeats	Primary T helper memory cells from peripheral blood 1	blood
42	chr11:50741600-50741800	Active TSS	NHDF-Ad	bronchial
43	chr11:50741600-50742000	ZNF genes & repeats	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
44	chr11:50745000-50745200	ZNF genes & repeats	ES-I3 Cell Line	embryonic stem cell
45	chr11:50746000-50769600	ZNF genes & repeats	iPS-18 Cell Line	embryonic stem cell
46	chr11:50746600-50747400	ZNF genes & repeats	HUVEC	blood vessel
47	chr11:50746800-50747200	Active TSS	Psoas Muscle	Psoas
48	chr11:50747000-50747200	Enhancers	Primary T helper naive cells fromperipheralblood	blood
49	chr11:50747000-50747200	Enhancers	Primary T killer memory cells from peripheral blood	blood
50	chr11:50748400-50748800	ZNF genes & repeats	ES-UCSF4 Cell Line	embryonic stem cell

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