Variant report

Variant	nsv948019
Chromosome Location	chr10:57369503-57388877
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	CEBPB	chr10:57387967-57388151	H1-hESC	embryonic stem cell:	n/a	n/a
2	CHD1	chr10:57388207-57388403	H1-hESC	embryonic stem cell:	n/a	chr10:57388308-57388318
3	CTCF	chr10:57388362-57388436	ProgFib	skin:	n/a	n/a
4	CTCF	chr10:57388370-57388442	GM12891	blood:	n/a	n/a
5	CTCF	chr10:57383597-57383746	A549	lung:	n/a	n/a
6	CTCF	chr10:57388020-57388170	HAc	cerebellar:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
7	CTCF	chr10:57388080-57388230	HA-sp	spinal cord:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
8	CTCF	chr10:57388040-57388190	BE2_C	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
9	CTCF	chr10:57388340-57388490	HRPEpiC	eye:	n/a	n/a
10	CTCF	chr10:57388022-57388154	Medullo	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
11	CTCF	chr10:57387998-57388168	SK-N-SH_RA	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
12	CTCF	chr10:57377009-57377064	GM10248	blood:	n/a	n/a
13	CTCF	chr10:57388040-57388190	HPF	lung:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
14	CTCF	chr10:57388327-57388440	H1-hESC	embryonic stem cell:	n/a	n/a
15	CTCF	chr10:57388010-57388123	HUVEC	blood vessel:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
16	CTCF	chr10:57383649-57383745	Hela-S3	cervix:	n/a	n/a
17	CTCF	chr10:57387955-57388208	SK-N-SH_RA	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
18	CTCF	chr10:57383574-57383853	A549	lung:	n/a	n/a
19	CTCF	chr10:57388040-57388190	SK-N-SH_RA	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
20	CTCF	chr10:57388278-57388500	Gliobla	brain:	n/a	n/a
21	CTCF	chr10:57381999-57382118	GM13976	blood:	n/a	n/a
22	CTCF	chr10:57388220-57388370	WERI-Rb-1	eye:	n/a	n/a
23	CTCF	chr10:57387969-57388253	Gliobla	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
24	CTCF	chr10:57375308-57375398	GM13977	blood:	n/a	n/a
25	CTCF	chr10:57388264-57388490	MCF-7	breast:	n/a	n/a
26	CTCF	chr10:57388312-57388489	A549	lung:	n/a	n/a
27	CTCF	chr10:57388274-57388459	MCF-7	breast:	n/a	n/a
28	CTCF	chr10:57388020-57388170	A549	lung:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
29	CTCF	chr10:57377306-57377393	GM13976	blood:	n/a	n/a
30	CTCF	chr10:57388020-57388170	WERI-Rb-1	eye:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
31	CTCF	chr10:57387860-57388010	HEK293	kidney:	n/a	n/a
32	CTCF	chr10:57388100-57388250	HUVEC	blood vessel:	n/a	n/a
33	CTCF	chr10:57388000-57388150	HBMEC	blood vessel:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
34	CTCF	chr10:57383570-57383743	A549	lung:	n/a	n/a
35	CTCF	chr10:57388072-57388157	MCF-7	breast:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
36	CTCF	chr10:57383642-57383730	MCF-7	breast:	n/a	n/a
37	CTCF	chr10:57388040-57388190	HRPEpiC	eye:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
38	CTCF	chr10:57388060-57388210	BE2_C	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
39	CTCF	chr10:57383653-57383698	MCF-7	breast:	n/a	n/a
40	CTCF	chr10:57388066-57388142	NHEK	skin:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
41	CTCF	chr10:57388000-57388150	HRE	kidney:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
42	CTCF	chr10:57388000-57388150	SK-N-SH_RA	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
43	CTCF	chr10:57388015-57388201	A549	lung:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
44	CTCF	chr10:57388011-57388146	ProgFib	skin:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
45	CTCF	chr10:57383523-57383765	A549	lung:	n/a	n/a
46	CTCF	chr10:57387755-57388826	SK-N-SH	brain:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
47	CTCF	chr10:57388320-57388424	MCF-7	breast:	n/a	n/a
48	CTCF	chr10:57388259-57388262	MCF-7	breast:	n/a	n/a
49	CTCF	chr10:57388013-57388193	MCF-7	breast:	n/a	chr10:57388081-57388094 chr10:57388081-57388094
50	CTCF	chr10:57388398-57388443	NHEK	skin:	n/a	n/a

No.	Chromosome Location	Cell Line	Cell type	Cell Stage
1	chr10:57387702-57387752	PANC-1	pancreas:	n/a
2	chr10:57387978-57388028	MCF-7	breast:	n/a
3	chr10:57387978-57388028	AoSMC	blood vessel:	n/a
4	chr10:57387636-57387686	PANC-1	pancreas:	n/a
5	chr10:57387702-57387752	SAEC	small airway:	n/a
6	chr10:57388069-57388119	LNCaP	prostate:	n/a
7	chr10:57388283-57388333	HCPEpiC	choroid plexus:	n/a
8	chr10:57387636-57387686	HCM	heart:	n/a
9	chr10:57387511-57387561	Caco-2	colon:	n/a
10	chr10:57388069-57388119	HRE	kidney:	n/a
11	chr10:57387636-57387686	AoSMC	blood vessel:	n/a
12	chr10:57387978-57388028	SAEC	small airway:	n/a
13	chr10:57388283-57388333	NHDF-neo	bronchial:	n/a
14	chr10:57387636-57387686	NH-A	brain:	n/a
15	chr10:57388283-57388333	LNCaP	prostate:	n/a
16	chr10:57388069-57388119	HNPCEpiC	eye:	n/a
17	chr10:57387715-57387765	GM12878	blood:	n/a
18	chr10:57388283-57388333	HepG2	liver:	n/a
19	chr10:57387715-57387765	GM12891	blood:	n/a
20	chr10:57388402-57388452	AoSMC	blood vessel:	n/a
21	chr10:57387715-57387765	HMEC	breast:	n/a
22	chr10:57388341-57388391	NH-A	brain:	n/a
23	chr10:57388069-57388119	NHBE	bronchial:	n/a
24	chr10:57387636-57387686	T-47D	breast:	n/a
25	chr10:57388069-57388119	HUVEC	blood vessel:	n/a
26	chr10:57387702-57387752	U87	brain:	n/a
27	chr10:57388341-57388391	HepG2	liver:	n/a
28	chr10:57387636-57387686	PFSK-1	brain:	n/a
29	chr10:57388069-57388119	PrEC	prostate:	n/a
30	chr10:57387978-57388028	RPTEC	kidney:	n/a
31	chr10:57387978-57388028	BJ	skin:	n/a
32	chr10:57387702-57387752	K562	blood:	n/a
33	chr10:57388402-57388452	A549	lung:	n/a
34	chr10:57387636-57387686	U87	brain:	n/a
35	chr10:57388402-57388452	MCF10A-Er-Src	breast:	n/a
36	chr10:57387636-57387686	HAEpiC	amniotic membrane:	n/a
37	chr10:57388069-57388119	SK-N-SH_RA	brain:	n/a
38	chr10:57387715-57387765	SK-N-SH_RA	brain:	n/a
39	chr10:57387702-57387752	HEK293	kidney:	embryo
40	chr10:57387978-57388028	ProgFib	skin:	n/a
41	chr10:57387715-57387765	GM19239	blood:	n/a
42	chr10:57387715-57387765	AoSMC	blood vessel:	n/a
43	chr10:57387702-57387752	PrEC	prostate:	n/a
44	chr10:57387978-57388028	SKMC	muscle:	n/a
45	chr10:57387715-57387765	NHBE	bronchial:	n/a
46	chr10:57387636-57387686	NHBE	bronchial:	n/a
47	chr10:57387715-57387765	SK-N-MC	brain:	n/a
48	chr10:57388069-57388119	U87	brain:	n/a
49	chr10:57387636-57387686	HPAEpiC	pulmonary alveolar:	n/a
50	chr10:57387636-57387686	GM06990	blood:	n/a

Variant related genes	Relation type
PCDH15	TF binding region
PCDH15	CpG island

Extended variants
information (count: 544 )
Associated
traits (count: 62 )

Variant overlapped rSNPs/rCNVs (count:544 , 50 per page) page: 1 2 3 4 5 6 7 ... 11

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs560290969	chr10:57374031-57374032	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
2	rs139857956	chr10:57374038-57374039	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
3	rs559399062	chr10:57374043-57374044	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
4	rs552271245	chr10:57374118-57374119	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
5	rs570950483	chr10:57374169-57374170	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
6	rs544802555	chr10:57374244-57374245	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
7	rs564780332	chr10:57374252-57374253	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
8	rs557120987	chr10:57374267-57374268	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
9	rs550432860	chr10:57374280-57374281	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
10	rs567225460	chr10:57374293-57374294	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
11	rs56383341	chr10:57374294-57374295	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
12	rs529673011	chr10:57374307-57374308	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
13	rs191961645	chr10:57374319-57374320	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
14	rs183541235	chr10:57374386-57374387	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
15	rs535379358	chr10:57374419-57374420	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
16	rs186900933	chr10:57374463-57374464	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
17	rs571895746	chr10:57374480-57374481	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
18	rs537522871	chr10:57374513-57374514	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
19	rs192095692	chr10:57374541-57374542	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
20	rs149829334	chr10:57374604-57374605	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
21	rs2463942	chr10:57374612-57374613	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
22	rs183350423	chr10:57374679-57374680	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
23	rs115466594	chr10:57374680-57374681	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
24	rs186796173	chr10:57374699-57374700	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
25	rs111930041	chr10:57374726-57374727	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
26	rs2204247	chr10:57374839-57374840	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
27	rs530642115	chr10:57374870-57374871	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
28	rs139983344	chr10:57374939-57374940	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
29	rs560829738	chr10:57374956-57374957	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
30	rs566362028	chr10:57374969-57374970	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
31	rs35754015	chr10:57374992-57374993	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
32	rs145499665	chr10:57375020-57375021	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
33	rs147665506	chr10:57375074-57375075	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
34	rs566506461	chr10:57375086-57375087	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
35	rs528773344	chr10:57375122-57375123	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
36	rs191258568	chr10:57375141-57375142	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
37	rs571833187	chr10:57375168-57375169	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
38	rs529520190	chr10:57375241-57375242	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
39	rs549556613	chr10:57375250-57375251	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
40	rs557382186	chr10:57375264-57375265	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
41	rs182724044	chr10:57375371-57375372	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
42	rs375877358	chr10:57375375-57375376	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
43	rs117512386	chr10:57375381-57375382	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
44	rs552937008	chr10:57375435-57375436	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
45	rs572930575	chr10:57375449-57375450	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
46	rs188100963	chr10:57375523-57375524	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
47	rs569348063	chr10:57375580-57375581	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
48	rs192886157	chr10:57375588-57375589	Weak transcription	n/a	n/a	Overlapped CNVs	n/a
49	rs1916524	chr10:57375598-57375599	Weak transcription	n/a	n/a	LD-proxies of rSNP Overlapped rCNV	n/a
50	rs575356782	chr10:57375610-57375611	Weak transcription	n/a	n/a	Overlapped CNVs	n/a

Variant related diseases (count:62)

Disease	PMID	Source
Pancreatic endocrine tumor	17639061	CNVD
Gastric cancer	17908304	CNVD
Chordoma	21602918	CNVD
Ewing''s sarcoma	21437220	CNVD
Glioblastoma multiforme	21080181	CNVD
Medulloblastoma	21979893	CNVD
Melanoma	18172304	CNVD
Pleomorphic xanthoastrocytoma	20730472	CNVD
Thoracic aortic aneurysm	21092924	CNVD
Ewing''s sarcoma	17952124	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Hodgkin''s lymphoma	17606441	CNVD
Acute lymphoblastic leukemia	20435627	CNVD
Acute lymphoblastic leukemia	20724749	CNVD
Autism	22495311	CNVD
Esophageal cancer	21851588	CNVD
Prostate cancer	18632612	CNVD
Autism	18414403	CNVD
Cockayne syndrome	18421352	CNVD
Glioblastoma	16823260	CNVD
Medulloblastoma	16968546	CNVD
Neuroblastoma	17533364	CNVD
T-cell lymphomas	19863542	CNVD
Testicular germ cell tumor	18059402	CNVD
Squamous cell cancer	21044232	CNVD
Glioma	21971842	CNVD
Cancer	21637783	CNVD
Non-small cell lung cancer	21044232	CNVD
Non-syndromic sensorineural hearing loss	18471307	CNVD
Colorectal cancer	20709793	CNVD
Endometrial cancer	22040021	CNVD
Breast cancer	21264507	CNVD
Esophageal squamous carcinoma	21637470	CNVD
Liposarcoma	21253554	CNVD
Oligodendroglial tumors	17285580	CNVD
Obesity	21956041	CNVD
Basal cell lymphoma	16317097	CNVD
Diffuse large b-cell lymphoma	16317097	CNVD
Lung cancer	18438408	CNVD
Breast cancer	21364760	CNVD
small cell lung cancer	20016488	CNVD
Colorectal cancer	16272173	CNVD
Metanephric adenoma	20802469	CNVD
Autism	20841430	CNVD
Mental retardation	17124404	CNVD
Epilepsy	20923578	CNVD
Prostate cancer	16573809	CNVD
Schizophrenia	19329560	CNVD
Heart failure	18772530	CNVD
Heart failure	18854381	CNVD
Hyperglycemia	19060297	CNVD
Endometrioid adenocarcinoma	16974079	CNVD
Myelofibrosis	22110671	CNVD
Acute lymphoblastic leukemia	21390130	CNVD
Glioblastoma multiforme	22286061	CNVD
Myeloproliferative neoplasm	20015882	CNVD
Usher syndrome	20538994	CNVD
Glioblastoma multiforme	17002787	CNVD
Autism	20858243	CNVD
Cancer	20164919	CNVD
Pancreatic ductal adenocarcinoma	19077451	CNVD
Non-syndromic sensorineural hearing loss	21293372	CNVD

Chromatin state (count:205 , 50 per page) page: 1 2 3 4 5

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:57374000-57386000	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
2	chr10:57380000-57387000	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
3	chr10:57381200-57381400	ZNF genes & repeats	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
4	chr10:57381200-57381400	Enhancers	H1 Derived Mesenchymal Stem Cells	ES cell derived
5	chr10:57381200-57381400	Bivalent Enhancer	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
6	chr10:57381400-57385400	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
7	chr10:57381400-57387200	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
8	chr10:57382800-57383000	Enhancers	H9 Cell Line	embryonic stem cell
9	chr10:57384200-57387000	Weak transcription	H9 Cell Line	embryonic stem cell
10	chr10:57385200-57385400	Bivalent Enhancer	HUES48 Cell Line	embryonic stem cell
11	chr10:57385200-57385600	Bivalent Enhancer	iPS-15b Cell Line	embryonic stem cell
12	chr10:57385200-57385800	Enhancers	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
13	chr10:57385600-57385800	Bivalent Enhancer	ES-I3 Cell Line	embryonic stem cell
14	chr10:57385600-57385800	Bivalent Enhancer	iPS-20b Cell Line	embryonic stem cell
15	chr10:57385800-57386800	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
16	chr10:57386000-57386200	Enhancers	Fetal Adrenal Gland	Adrenal Gland
17	chr10:57386200-57386600	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
18	chr10:57386600-57386800	Enhancers	Fetal Adrenal Gland	Adrenal Gland
19	chr10:57386800-57387000	Enhancers	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
20	chr10:57386800-57387000	Bivalent Enhancer	iPS-18 Cell Line	embryonic stem cell
21	chr10:57386800-57387000	Flanking Active TSS	Fetal Adrenal Gland	Adrenal Gland
22	chr10:57386800-57387200	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
23	chr10:57386800-57388600	Bivalent/Poised TSS	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
24	chr10:57386800-57388800	Bivalent/Poised TSS	HUES64 Cell Line	embryonic stem cell
25	chr10:57386800-57388800	Bivalent/Poised TSS	iPS-15b Cell Line	embryonic stem cell
26	chr10:57387000-57387200	Flanking Active TSS	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
27	chr10:57387000-57387200	Bivalent Enhancer	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
28	chr10:57387000-57387200	Flanking Bivalent TSS/Enh	iPS-18 Cell Line	embryonic stem cell
29	chr10:57387000-57387200	Flanking Bivalent TSS/Enh	iPS-20b Cell Line	embryonic stem cell
30	chr10:57387000-57387200	Active TSS	Fetal Adrenal Gland	Adrenal Gland
31	chr10:57387000-57387200	Active TSS	Fetal Kidney	kidney
32	chr10:57387000-57387600	Active TSS	H9 Cell Line	embryonic stem cell
33	chr10:57387000-57388600	Bivalent/Poised TSS	ES-I3 Cell Line	embryonic stem cell
34	chr10:57387000-57388600	Bivalent/Poised TSS	H1 Cell Line	embryonic stem cell
35	chr10:57387000-57388600	Bivalent/Poised TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
36	chr10:57387000-57388600	Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
37	chr10:57387000-57388800	Bivalent/Poised TSS	HUES48 Cell Line	embryonic stem cell
38	chr10:57387000-57388800	Bivalent/Poised TSS	HUES6 Cell Line	embryonic stem cell
39	chr10:57387200-57387400	Bivalent Enhancer	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
40	chr10:57387200-57387400	Flanking Active TSS	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
41	chr10:57387200-57387400	Flanking Bivalent TSS/Enh	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
42	chr10:57387200-57387400	Active TSS	iPS DF 19.11 Cell Line	embryonic stem cell
43	chr10:57387200-57387400	Flanking Active TSS	ES-UCSF4 Cell Line	embryonic stem cell
44	chr10:57387200-57387400	Bivalent Enhancer	Primary hematopoietic stem cells G-CSF-mobilized Female	--
45	chr10:57387200-57387400	Bivalent Enhancer	Primary hematopoietic stem cells G-CSF-mobilized Male	--
46	chr10:57387200-57387400	Bivalent/Poised TSS	Cortex derived primary cultured neurospheres	brain
47	chr10:57387200-57387400	Flanking Bivalent TSS/Enh	Brain Germinal Matrix	brain
48	chr10:57387200-57387400	Active TSS	Brain Hippocampus Middle	brain
49	chr10:57387200-57387400	Bivalent Enhancer	Fetal Brain Male	brain
50	chr10:57387200-57387400	Bivalent Enhancer	Fetal Muscle Trunk	muscle

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