Variant report

Variant	rs10741118
Chromosome Location	chr10:27074012-27074013
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	FOS	chr10:27073564-27074402	MCF10A-Er-Src	breast:	n/a	n/a
2	STAT3	chr10:27073527-27074383	MCF10A-Er-Src	breast:	n/a	chr10:27074124-27074135
3	MYC	chr10:27073931-27074287	MCF10A-Er-Src	breast:	n/a	n/a
4	TCF7L2	chr10:27073899-27074386	MCF-7	breast:	n/a	n/a
5	FOS	chr10:27073547-27074397	MCF10A-Er-Src	breast:	n/a	n/a
6	CEBPB	chr10:27073928-27074275	K562	blood:	n/a	chr10:27074099-27074110
7	CEBPB	chr10:27073967-27074172	H1-hESC	embryonic stem cell:	n/a	chr10:27074099-27074110
8	CEBPB	chr10:27073943-27074197	HepG2	liver:	n/a	chr10:27074099-27074110
9	CEBPB	chr10:27073919-27074276	IMR90	lung:	n/a	chr10:27074099-27074110
10	TCF7L2	chr10:27073918-27074307	Hela-S3	cervix:	n/a	n/a
11	CEBPB	chr10:27073915-27074274	Hela-S3	cervix:	n/a	chr10:27074099-27074110
12	CEBPB	chr10:27073858-27074371	MCF-7	breast:	n/a	chr10:27074099-27074110
13	FOS	chr10:27073559-27074383	MCF10A-Er-Src	breast:	n/a	n/a
14	STAT3	chr10:27073520-27074365	MCF10A-Er-Src	breast:	n/a	chr10:27074124-27074135
15	CEBPB	chr10:27073920-27074259	A549	lung:	n/a	chr10:27074099-27074110
16	STAT3	chr10:27073536-27074321	MCF10A-Er-Src	breast:	n/a	chr10:27074124-27074135
17	MYC	chr10:27073926-27074383	MCF10A-Er-Src	breast:	n/a	n/a
18	FOS	chr10:27073828-27074386	MCF10A-Er-Src	breast:	n/a	n/a
19	STAT3	chr10:27073928-27074266	MCF10A-Er-Src	breast:	n/a	chr10:27074124-27074135

No.	Distal block	Cell Line	Cell type
1	chr10:27073078..27074935-chr10:27148333..27150643,2	K562	blood:
2	chr10:27067079..27070597-chr10:27072640..27074844,4	K562	blood:
3	chr10:27071993..27074236-chr10:27148436..27150093,2	MCF-7	breast:

Variant related genes	Relation type
ENSG00000223027	TF binding region
ENSG00000136754	Chromatin interaction

Extended variants
information (count: 11 )
Associated
traits (count: 0)

rSNPs within LD-proxies of this variant (count:6)

rs_ID	r²[population]
rs10829104	0.86[AMR][1000 genomes];0.91[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs1409128	1.00[CEU][hapmap];0.95[CHB][hapmap];0.94[JPT][hapmap];0.91[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs16927348	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap]
rs4581345	0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7922118	1.00[CEU][hapmap];0.95[CHB][hapmap];1.00[JPT][hapmap];0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9804398	0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:5 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv3415799	chr10:26929831-27233591	Strong transcription Weak transcription Enhancers Active TSS Flanking Active TSS Genic enhancers ZNF genes & repeats Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	23 gene(s)	inside rSNPs	diseases
2	nsv933544	chr10:27005220-27111998	Weak transcription ZNF genes & repeats Enhancers Strong transcription Active TSS Genic enhancers Flanking Active TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	8 gene(s)	inside rSNPs	diseases
3	nsv831812	chr10:27061506-27234267	Enhancers Weak transcription Strong transcription ZNF genes & repeats Flanking Active TSS Active TSS Genic enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	12 gene(s)	inside rSNPs	diseases
4	nsv971858	chr10:27066006-27157708	Enhancers Weak transcription Active TSS Flanking Active TSS ZNF genes & repeats Strong transcription Genic enhancers Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	9 gene(s)	inside rSNPs	diseases
5	nsv6132	chr10:27066081-27075522	Enhancers Weak transcription Active TSS Genic enhancers Flanking Active TSS Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region	2 gene(s)	inside rSNPs	diseases

No data

Chromatin state (count:80 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:27044800-27082000	Weak transcription	Fetal Lung	lung
2	chr10:27051400-27082000	Weak transcription	Fetal Stomach	stomach
3	chr10:27058000-27079200	Weak transcription	Dnd41	blood
4	chr10:27064600-27074200	Enhancers	Primary T helper naive cells fromperipheralblood	blood
5	chr10:27066200-27074600	Enhancers	Primary T killer naive cells fromperipheralblood	blood
6	chr10:27066400-27074600	Enhancers	Breast Myoepithelial Primary Cells	Breast
7	chr10:27066400-27075200	Enhancers	Primary T helper cells PMA-I stimulated	--
8	chr10:27068400-27079400	Weak transcription	Primary hematopoietic stem cells	blood
9	chr10:27068600-27074200	Weak transcription	Primary hematopoietic stem cells short term culture	blood
10	chr10:27069200-27078800	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
11	chr10:27069400-27079600	Weak transcription	K562	blood
12	chr10:27069800-27075000	Enhancers	Primary T killer memory cells from peripheral blood	blood
13	chr10:27069800-27084600	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
14	chr10:27070200-27076600	Weak transcription	Fetal Muscle Leg	muscle
15	chr10:27070600-27074400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
16	chr10:27070600-27082800	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
17	chr10:27070800-27091800	Weak transcription	Primary neutrophils fromperipheralblood	blood
18	chr10:27071000-27075000	Enhancers	Foreskin Keratinocyte Primary Cells skin02	Skin
19	chr10:27071000-27075000	Enhancers	Foreskin Keratinocyte Primary Cells skin03	Skin
20	chr10:27071000-27080600	Weak transcription	Fetal Intestine Large	intestine
21	chr10:27071000-27080800	Weak transcription	Duodenum Smooth Muscle	Duodenum
22	chr10:27071000-27082000	Weak transcription	Fetal Brain Male	brain
23	chr10:27071000-27083800	Weak transcription	Fetal Intestine Small	intestine
24	chr10:27071000-27084600	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
25	chr10:27071200-27074600	Weak transcription	Duodenum Mucosa	Duodenum
26	chr10:27071200-27074600	Weak transcription	Left Ventricle	heart
27	chr10:27071200-27075000	Enhancers	NHEK	skin
28	chr10:27071200-27075600	Weak transcription	HUES48 Cell Line	embryonic stem cell
29	chr10:27071200-27075600	Weak transcription	HUES64 Cell Line	embryonic stem cell
30	chr10:27071200-27078000	Weak transcription	Psoas Muscle	Psoas
31	chr10:27071200-27078200	Weak transcription	Primary T helper naive cells from peripheral blood	blood
32	chr10:27071200-27079400	Weak transcription	HSMM	muscle
33	chr10:27071200-27079400	Weak transcription	Osteobl	bone
34	chr10:27071200-27079800	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
35	chr10:27071200-27080800	Weak transcription	Brain Angular Gyrus	brain
36	chr10:27071200-27082000	Weak transcription	A549	lung
37	chr10:27071200-27089000	Weak transcription	Lung	lung
38	chr10:27071200-27089600	Weak transcription	Spleen	Spleen
39	chr10:27071400-27074600	Weak transcription	Primary monocytes fromperipheralblood	blood
40	chr10:27071400-27079200	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
41	chr10:27071400-27080800	Weak transcription	Liver	Liver
42	chr10:27071400-27088600	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
43	chr10:27072000-27074600	Weak transcription	GM12878-XiMat	blood
44	chr10:27072000-27081800	Weak transcription	NH-A	brain
45	chr10:27072200-27080200	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
46	chr10:27072400-27074200	Enhancers	Brain Anterior Caudate	brain
47	chr10:27072400-27076400	Strong transcription	Primary B cells from cord blood	blood
48	chr10:27072600-27074800	Enhancers	HMEC	breast
49	chr10:27072800-27074200	Enhancers	Fetal Adrenal Gland	Adrenal Gland
50	chr10:27073000-27074200	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived

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