Variant report

Variant	rs10840105
Chromosome Location	chr11:8699662-8699663
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	FOS	chr11:8699653-8699794	MCF10A-Er-Src	breast:	n/a	n/a
2	STAT3	chr11:8699638-8699759	MCF10A-Er-Src	breast:	n/a	chr11:8699700-8699711

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr11:8676736..8679603-chr11:8698205..8700155,2	K562	blood:
2	chr11:8699371..8704185-chr11:8984475..8986762,4	K562	blood:

Variant related genes	Relation type
RPL27A	TF binding region
ENSG00000254900	TF binding region
ENSG00000254860	Chromatin interaction
ENSG00000175348	Chromatin interaction

Extended variants
information (count: 8 )
Associated
traits (count: 17 )

rSNPs within LD-proxies of this variant (count:8)

rs_ID	r²[population]
rs10840106	0.89[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs10840112	0.94[AMR][1000 genomes];0.93[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs11042041	0.93[AMR][1000 genomes];0.92[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs2036422	0.96[AMR][1000 genomes];0.94[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs2073684	0.92[AFR][1000 genomes];0.99[AMR][1000 genomes];0.94[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs35104495	0.92[AFR][1000 genomes];0.93[AMR][1000 genomes];0.92[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs7123653	0.93[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs7940366	0.90[AMR][1000 genomes];0.86[EUR][1000 genomes];0.81[ASN][1000 genomes]

mRNA abundance (count:17)

SNP	Gene	Cis/trans	Tissue	Source
rs10840105	TRIM66	cis	Artery Aorta	GTEx
rs10840105	TRIM66	cis	Stomach	GTEx
rs10840105	TRIM66	cis	Thyroid	GTEx
rs10840105	TRIM66	cis	brain	BrainEAC
rs10840105	TRIM66	cis	Adipose Subcutaneous	GTEx
rs10840105	TRIM66	cis	Skin Sun Exposed Lower leg	GTEx
rs10840105	TRIM66	cis	Whole Blood	GTEx
rs10840105	TRIM66	cis	Esophagus Mucosa	GTEx
rs10840105	TRIM66	cis	Heart Left Ventricle	GTEx
rs10840105	TRIM66	cis	lung	GTEx
rs10840105	TRIM66	cis	Esophagus Muscularis	GTEx
rs10840105	LOC256273	Cis_1M	lymphoblastoid	RTeQTL
rs10840105	TRIM66	cis	Artery Tibial	GTEx
rs10840105	RPL27A	cis	brain	BrainEAC
rs10840105	TRIM66	cis	Nerve Tibial	GTEx
rs10840105	TRIM66	cis	Muscle Skeletal	GTEx
rs10840105	TRIM66	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:113 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:8637000-8703200	Weak transcription	Small Intestine	intestine
2	chr11:8664200-8700400	Weak transcription	Stomach Mucosa	stomach
3	chr11:8684000-8701600	Strong transcription	Primary monocytes fromperipheralblood	blood
4	chr11:8684400-8701400	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
5	chr11:8690000-8703000	Weak transcription	Placenta Amnion	Placenta Amnion
6	chr11:8690400-8701200	Strong transcription	Primary T cells fromperipheralblood	blood
7	chr11:8693600-8700200	Weak transcription	HepG2	liver
8	chr11:8693600-8703000	Weak transcription	Primary T helper naive cells from peripheral blood	blood
9	chr11:8693600-8703200	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
10	chr11:8693600-8703200	Weak transcription	Primary hematopoietic stem cells	blood
11	chr11:8693600-8703200	Weak transcription	Fetal Lung	lung
12	chr11:8693600-8703400	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
13	chr11:8693600-8703400	Weak transcription	Ovary	ovary
14	chr11:8693800-8700200	Weak transcription	Rectal Mucosa Donor 31	rectum
15	chr11:8693800-8700200	Weak transcription	Sigmoid Colon	Sigmoid Colon
16	chr11:8693800-8700400	Weak transcription	Breast Myoepithelial Primary Cells	Breast
17	chr11:8693800-8700400	Weak transcription	Aorta	Aorta
18	chr11:8693800-8700400	Weak transcription	Rectal Mucosa Donor 29	rectum
19	chr11:8693800-8700600	Weak transcription	Fetal Thymus	thymus
20	chr11:8693800-8701000	Weak transcription	Gastric	stomach
21	chr11:8693800-8703000	Weak transcription	Primary T killer memory cells from peripheral blood	blood
22	chr11:8693800-8703000	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
23	chr11:8693800-8703000	Weak transcription	Hela-S3	cervix
24	chr11:8693800-8703200	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
25	chr11:8693800-8703200	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
26	chr11:8693800-8703200	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
27	chr11:8693800-8703200	Weak transcription	Foreskin Melanocyte Primary Cells skin03	Skin
28	chr11:8693800-8703200	Weak transcription	Brain Substantia Nigra	brain
29	chr11:8693800-8703200	Weak transcription	Colonic Mucosa	Colon
30	chr11:8693800-8703200	Weak transcription	Fetal Brain Female	brain
31	chr11:8693800-8703400	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
32	chr11:8693800-8703400	Weak transcription	Brain Germinal Matrix	brain
33	chr11:8693800-8703600	Weak transcription	Spleen	Spleen
34	chr11:8694000-8700000	Weak transcription	Adipose Nuclei	Adipose
35	chr11:8694000-8700200	Weak transcription	Fetal Intestine Large	intestine
36	chr11:8694000-8700400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
37	chr11:8694000-8700400	Weak transcription	Duodenum Smooth Muscle	Duodenum
38	chr11:8694000-8700400	Weak transcription	Pancreas	Pancrea
39	chr11:8694000-8700400	Weak transcription	Skeletal Muscle Female	skeletal muscle
40	chr11:8694000-8700600	Weak transcription	Brain Anterior Caudate	brain
41	chr11:8694000-8700600	Weak transcription	Placenta	Placenta
42	chr11:8694000-8700800	Weak transcription	Stomach Smooth Muscle	stomach
43	chr11:8694000-8701000	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
44	chr11:8694000-8701400	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
45	chr11:8694000-8701800	Weak transcription	Primary B cells from cord blood	blood
46	chr11:8694000-8702200	Weak transcription	HSMM	muscle
47	chr11:8694000-8702200	Weak transcription	K562	blood
48	chr11:8694000-8703000	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
49	chr11:8694000-8703000	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
50	chr11:8694000-8703000	Weak transcription	Primary T helper naive cells fromperipheralblood	blood

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