Variant report

Variant	rs1921845
Chromosome Location	chr7:16468934-16468935
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr7:16459387..16461845-chr7:16467572..16471113,4	MCF-7	breast:
2	chr7:16468224..16469938-chr7:16474022..16476641,2	K562	blood:
3	chr7:16467203..16469517-chr7:16495684..16498438,2	K562	blood:

Variant related genes	Relation type
ENSG00000214960	Chromatin interaction

Extended variants
information (count: 25 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:21)

rs_ID	r²[population]
rs10464288	0.96[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs17617508	0.94[CEU][hapmap];0.85[CHB][hapmap];0.86[CHD][hapmap];0.83[GIH][hapmap];0.86[JPT][hapmap];0.91[MKK][hapmap];0.91[TSI][hapmap];0.84[AMR][1000 genomes];0.88[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs17674339	0.84[AMR][1000 genomes];0.89[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs1921840	0.94[CEU][hapmap]
rs1921843	0.83[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs2389632	0.87[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs2389633	0.92[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2389638	0.98[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs55746209	0.96[AMR][1000 genomes];0.93[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs55790136	0.91[ASN][1000 genomes]
rs55944246	0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs56061198	0.96[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs56176134	0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs56199980	0.96[AMR][1000 genomes];0.93[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs59379368	0.92[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs60255112	0.84[AMR][1000 genomes];0.87[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs6461247	1.00[AFR][1000 genomes];0.84[AMR][1000 genomes];0.89[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs67088819	1.00[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs67609961	0.84[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs73071078	0.84[AMR][1000 genomes];0.89[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs7791775	0.93[CEU][hapmap];0.92[CHB][hapmap];1.00[JPT][hapmap];0.98[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:4 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1016642	chr7:15884061-16799788	Genic enhancers Weak transcription Flanking Active TSS Active TSS Enhancers Strong transcription ZNF genes & repeats Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	56 gene(s)	inside rSNPs	diseases
2	esv2759514	chr7:16236162-16527390	Flanking Active TSS Enhancers Active TSS Strong transcription Weak transcription ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	21 gene(s)	inside rSNPs	diseases
3	esv2758105	chr7:16272822-16527390	Enhancers Weak transcription ZNF genes & repeats Active TSS Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Strong transcription Transcr. at gene 5' and 3' Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	18 gene(s)	inside rSNPs	diseases
4	nsv1034151	chr7:16415497-16578081	ZNF genes & repeats Enhancers Flanking Active TSS Weak transcription Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Active TSS Strong transcription Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	11 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs1921845	SOSTDC1	cis	parietal	SCAN

Chromatin state (count:20 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr7:16461400-16469000	Weak transcription	Aorta	Aorta
2	chr7:16461600-16469600	Weak transcription	Gastric	stomach
3	chr7:16461600-16478600	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
4	chr7:16462200-16473200	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
5	chr7:16462600-16473400	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
6	chr7:16467800-16469400	Weak transcription	Esophagus	oesophagus
7	chr7:16468000-16469000	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
8	chr7:16468000-16469000	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
9	chr7:16468000-16469000	Enhancers	Foreskin Fibroblast Primary Cells skin01	Skin
10	chr7:16468000-16470200	Enhancers	K562	blood
11	chr7:16468000-16470200	Enhancers	NH-A	brain
12	chr7:16468000-16470400	Enhancers	Stomach Mucosa	stomach
13	chr7:16468000-16470400	Enhancers	Osteobl	bone
14	chr7:16468200-16469200	Enhancers	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
15	chr7:16468200-16469800	Enhancers	Muscle Satellite Cultured Cells	--
16	chr7:16468400-16469000	Enhancers	HSMM	muscle
17	chr7:16468600-16469600	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
18	chr7:16468600-16469600	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
19	chr7:16468800-16469200	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
20	chr7:16468800-16469600	Weak transcription	NHLF	lung

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