Variant report

Variant	rs35889496
Chromosome Location	chr8:89334910-89334911
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr8:89332241..89335176-chr8:89338649..89342279,4	MCF-7	breast:

Variant related genes	Relation type
ENSG00000156103	Chromatin interaction
ENSG00000253553	Chromatin interaction

Extended variants
information (count: 10 )
Associated
traits (count: 3 )

rSNPs within LD-proxies of this variant (count:6)

rs_ID	r²[population]
rs4246112	0.81[EUR][1000 genomes]
rs4246113	0.81[EUR][1000 genomes]
rs4515601	0.80[EUR][1000 genomes]
rs4548227	0.80[EUR][1000 genomes]
rs4961086	0.81[EUR][1000 genomes]
rs4961087	0.81[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:4 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1029898	chr8:88837956-89606641	Weak transcription Enhancers Flanking Active TSS Bivalent Enhancer Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Strong transcription ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	14 gene(s)	inside rSNPs	diseases
2	nsv1030028	chr8:89060085-89733470	Weak transcription Enhancers ZNF genes & repeats Flanking Active TSS Active TSS Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Strong transcription Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	9 gene(s)	inside rSNPs	diseases
3	nsv1019111	chr8:89186908-89475460	Weak transcription Active TSS Enhancers Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Bivalent Enhancer Strong transcription ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
4	nsv831386	chr8:89209788-89403546	Enhancers Genic enhancers Active TSS Bivalent Enhancer Weak transcription Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	diseases

mRNA abundance (count:3)

SNP	Gene	Cis/trans	Tissue	Source
rs35889496	MMP16	cis	Adipose Subcutaneous	GTEx
rs35889496	MMP16	cis	Skin Sun Exposed Lower leg	GTEx
rs35889496	MMP16	cis	Thyroid	GTEx

Chromatin state (count:37 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr8:89320800-89337600	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
2	chr8:89324400-89336200	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
3	chr8:89326600-89338200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
4	chr8:89327200-89336200	Weak transcription	Foreskin Melanocyte Primary Cells skin03	Skin
5	chr8:89327400-89336000	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
6	chr8:89327400-89336000	Weak transcription	Cortex derived primary cultured neurospheres	brain
7	chr8:89332000-89335000	Weak transcription	Aorta	Aorta
8	chr8:89332400-89336000	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
9	chr8:89332800-89336200	Weak transcription	H1 Cell Line	embryonic stem cell
10	chr8:89333000-89335200	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
11	chr8:89333000-89336000	Weak transcription	Brain Angular Gyrus	brain
12	chr8:89333200-89335000	Weak transcription	H9 Cell Line	embryonic stem cell
13	chr8:89333200-89335000	Enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
14	chr8:89333200-89335000	Weak transcription	Brain Germinal Matrix	brain
15	chr8:89333200-89335000	Weak transcription	Osteobl	bone
16	chr8:89333200-89335200	Weak transcription	Fetal Lung	lung
17	chr8:89333200-89335800	Weak transcription	HUES48 Cell Line	embryonic stem cell
18	chr8:89333200-89336000	Weak transcription	ES-I3 Cell Line	embryonic stem cell
19	chr8:89333200-89336000	Weak transcription	HUES64 Cell Line	embryonic stem cell
20	chr8:89333200-89336000	Weak transcription	NH-A	brain
21	chr8:89333200-89336000	Weak transcription	NHDF-Ad	bronchial
22	chr8:89333200-89336200	Weak transcription	HUES6 Cell Line	embryonic stem cell
23	chr8:89333200-89336200	Weak transcription	Brain Anterior Caudate	brain
24	chr8:89333200-89336200	Weak transcription	HUVEC	blood vessel
25	chr8:89333200-89336400	Weak transcription	Breast Myoepithelial Primary Cells	Breast
26	chr8:89333200-89336400	Weak transcription	Fetal Heart	heart
27	chr8:89333200-89336400	Weak transcription	Fetal Kidney	kidney
28	chr8:89333200-89336600	Weak transcription	Colon Smooth Muscle	Colon
29	chr8:89333200-89337600	Weak transcription	Rectal Smooth Muscle	rectum
30	chr8:89333200-89341600	Active TSS	Fetal Brain Female	brain
31	chr8:89333400-89335800	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
32	chr8:89333400-89336000	Weak transcription	iPS-18 Cell Line	embryonic stem cell
33	chr8:89333400-89336200	Weak transcription	iPS-15b Cell Line	embryonic stem cell
34	chr8:89333600-89335800	Weak transcription	iPS-20b Cell Line	embryonic stem cell
35	chr8:89334200-89335600	Weak transcription	Pancreatic Islets	Pancreatic Islet
36	chr8:89334600-89341600	Active TSS	Ganglion Eminence derived primary cultured neurospheres	brain
37	chr8:89334800-89335000	Enhancers	Fetal Brain Male	brain

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