Variant report

Variant	rs35935345
Chromosome Location	chr18:43651549-43651550
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr18:43578214..43579999-chr18:43649262..43651951,2	K562	blood:

Extended variants
information (count: 32 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:28)

rs_ID	r²[population]
rs11876373	0.82[ASN][1000 genomes]
rs12709735	0.87[AMR][1000 genomes];0.88[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs12966247	0.90[AFR][1000 genomes];0.87[AMR][1000 genomes];0.97[ASN][1000 genomes]
rs1866321	0.80[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs1964984	0.91[AMR][1000 genomes];0.88[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs2578183	0.93[AMR][1000 genomes];0.89[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs2578192	0.88[AFR][1000 genomes];0.99[AMR][1000 genomes];0.90[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs2850646	0.85[AFR][1000 genomes];0.96[AMR][1000 genomes];0.92[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs28524126	0.82[ASN][1000 genomes]
rs35657986	0.82[ASN][1000 genomes]
rs3745002	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs3753069	0.95[AMR][1000 genomes];0.89[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs4257298	0.87[AMR][1000 genomes];0.88[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs4275936	0.81[AMR][1000 genomes]
rs4890312	0.86[ASN][1000 genomes]
rs60986007	0.82[ASN][1000 genomes]
rs6507663	0.86[ASN][1000 genomes]
rs6507664	0.80[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs7238347	0.80[AFR][1000 genomes];0.83[AMR][1000 genomes];0.93[ASN][1000 genomes]
rs7239525	1.00[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs8085233	0.82[ASN][1000 genomes]
rs8096719	0.86[AFR][1000 genomes];0.86[AMR][1000 genomes];0.93[ASN][1000 genomes]
rs9946831	0.81[ASN][1000 genomes]
rs9950234	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9954534	0.82[ASN][1000 genomes]
rs9955008	0.98[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9962297	0.89[AFR][1000 genomes];0.85[AMR][1000 genomes];0.97[ASN][1000 genomes]
rs9965812	0.81[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:4 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1064882	chr18:43558343-43687674	Bivalent Enhancer Flanking Active TSS Enhancers Strong transcription Weak transcription Bivalent/Poised TSS Active TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
2	nsv543693	chr18:43558343-43687674	Flanking Active TSS Enhancers Weak transcription Strong transcription Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
3	nsv1062024	chr18:43589516-43749410	Active TSS Strong transcription Enhancers Flanking Active TSS Weak transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	15 gene(s)	inside rSNPs	diseases
4	nsv543694	chr18:43589516-43749410	Strong transcription Weak transcription Active TSS Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Active TSS ZNF genes & repeats Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	15 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs35935345	C18orf25	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:124 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr18:43648000-43651600	Weak transcription	Hela-S3	cervix
2	chr18:43650200-43651600	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
3	chr18:43650200-43651800	Flanking Active TSS	Primary hematopoietic stem cells short term culture	blood
4	chr18:43650200-43652800	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
5	chr18:43650400-43651600	Flanking Active TSS	Primary monocytes fromperipheralblood	blood
6	chr18:43650600-43651600	Flanking Active TSS	IMR90 fetal lung fibroblasts Cell Line	lung
7	chr18:43650600-43651600	Flanking Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
8	chr18:43650600-43651600	Flanking Active TSS	HMEC	breast
9	chr18:43650600-43651800	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Female	--
10	chr18:43650800-43651600	Flanking Active TSS	Primary T helper memory cells from peripheral blood 2	blood
11	chr18:43650800-43651600	Flanking Active TSS	Primary T helper naive cells fromperipheralblood	blood
12	chr18:43650800-43651600	Flanking Active TSS	Primary T killer memory cells from peripheral blood	blood
13	chr18:43650800-43651600	Flanking Active TSS	Foreskin Keratinocyte Primary Cells skin03	Skin
14	chr18:43650800-43651600	Flanking Active TSS	Osteobl	bone
15	chr18:43650800-43651800	Flanking Active TSS	Primary T helper cells PMA-I stimulated	--
16	chr18:43650800-43651800	Flanking Active TSS	Primary T helper cells fromperipheralblood	blood
17	chr18:43650800-43651800	Flanking Active TSS	Primary T killer naive cells fromperipheralblood	blood
18	chr18:43650800-43651800	Flanking Active TSS	NHEK	skin
19	chr18:43650800-43652000	Flanking Active TSS	Primary Natural Killer cells fromperipheralblood	blood
20	chr18:43650800-43652000	Flanking Active TSS	Fetal Thymus	thymus
21	chr18:43650800-43652400	Active TSS	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
22	chr18:43650800-43652400	Active TSS	Rectal Mucosa Donor 31	rectum
23	chr18:43650800-43652600	Bivalent/Poised TSS	ES-I3 Cell Line	embryonic stem cell
24	chr18:43650800-43652600	Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
25	chr18:43650800-43652600	Flanking Active TSS	Primary hematopoietic stem cells	blood
26	chr18:43650800-43652600	Flanking Active TSS	Primary mononuclear cells fromperipheralblood	Blood
27	chr18:43650800-43652800	Bivalent/Poised TSS	HUES6 Cell Line	embryonic stem cell
28	chr18:43650800-43652800	Active TSS	Duodenum Smooth Muscle	Duodenum
29	chr18:43650800-43652800	Flanking Active TSS	Skeletal Muscle Female	skeletal muscle
30	chr18:43650800-43653000	Bivalent/Poised TSS	iPS-15b Cell Line	embryonic stem cell
31	chr18:43650800-43653000	Flanking Active TSS	Stomach Smooth Muscle	stomach
32	chr18:43651000-43651600	Flanking Active TSS	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
33	chr18:43651000-43651600	Flanking Active TSS	Primary T helper naive cells from peripheral blood	blood
34	chr18:43651000-43651600	Flanking Active TSS	Primary T cells effector/memory enriched fromperipheralblood	blood
35	chr18:43651000-43651600	Bivalent/Poised TSS	Foreskin Melanocyte Primary Cells skin01	Skin
36	chr18:43651000-43651600	Flanking Active TSS	Liver	Liver
37	chr18:43651000-43651600	Flanking Active TSS	Fetal Intestine Large	intestine
38	chr18:43651000-43651600	Flanking Active TSS	Fetal Intestine Small	intestine
39	chr18:43651000-43651600	Flanking Active TSS	GM12878-XiMat	blood
40	chr18:43651000-43651800	Flanking Active TSS	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
41	chr18:43651000-43651800	Flanking Active TSS	Duodenum Mucosa	Duodenum
42	chr18:43651000-43651800	Flanking Active TSS	Placenta	Placenta
43	chr18:43651000-43651800	Flanking Active TSS	Monocytes-CD14+_RO01746	blood
44	chr18:43651000-43652000	Flanking Active TSS	H1 Derived Mesenchymal Stem Cells	ES cell derived
45	chr18:43651000-43652000	Flanking Bivalent TSS/Enh	Fetal Adrenal Gland	Adrenal Gland
46	chr18:43651000-43652000	Flanking Active TSS	Skeletal Muscle Male	skeletal muscle
47	chr18:43651000-43652400	Active TSS	Brain Anterior Caudate	brain
48	chr18:43651000-43652400	Bivalent/Poised TSS	Brain Dorsolateral Prefrontal Cortex	brain
49	chr18:43651000-43652400	Active TSS	HSMM	muscle
50	chr18:43651000-43652600	Bivalent/Poised TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived

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