Variant report

Variant	rs3733086
Chromosome Location	chr3:48699519-48699520
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:103)
CpG islands
(count:0)
Chromatin interactive
region (count:19)
LncRNA
region (count:0)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

(count:103 , 50 per page) page: 1 2 3

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	REST	chr3:48698992-48699711	PFSK-1	brain:	n/a	n/a
2	SIN3AK20	chr3:48698909-48699720	MCF-7	breast:	n/a	n/a
3	MAX	chr3:48699044-48699520	MCF-7	breast:	n/a	n/a
4	SIN3A	chr3:48698800-48699957	H1-hESC	embryonic stem cell:	n/a	n/a
5	POLR2A	chr3:48699227-48699929	HepG2	liver:	n/a	n/a
6	POLR2A	chr3:48698961-48699783	H1-hESC	embryonic stem cell:	n/a	n/a
7	REST	chr3:48698829-48700050	MCF-7	breast:	n/a	n/a
8	HEY1	chr3:48699322-48699727	HepG2	liver:	n/a	n/a
9	ELF1	chr3:48698877-48699851	GM12878	blood:	n/a	n/a
10	POLR2A	chr3:48698903-48702611	H1-hESC	embryonic stem cell:	n/a	n/a
11	REST	chr3:48698726-48700055	PFSK-1	brain:	n/a	n/a
12	SREBP1	chr3:48698687-48699855	GM12878	blood:	n/a	n/a
13	REST	chr3:48698585-48700084	GM12878	blood:	n/a	n/a
14	SIN3AK20	chr3:48698971-48699691	MCF-7	breast:	n/a	n/a
15	TAF7	chr3:48699015-48699538	H1-hESC	embryonic stem cell:	n/a	n/a
16	MYBL2	chr3:48698930-48699549	HepG2	liver:	n/a	n/a
17	RCOR1	chr3:48699089-48699629	GM12878	blood:	n/a	n/a
18	REST	chr3:48698881-48699818	PANC-1	pancreas:	n/a	n/a
19	REST	chr3:48698779-48699894	H1-hESC	embryonic stem cell:	n/a	n/a
20	SIN3AK20	chr3:48698880-48699604	H1-hESC	embryonic stem cell:	n/a	n/a
21	REST	chr3:48697968-48700052	U87	brain:	n/a	n/a
22	PML	chr3:48698894-48699562	GM12878	blood:	n/a	n/a
23	HEY1	chr3:48699089-48699818	HepG2	liver:	n/a	n/a
24	REST	chr3:48698714-48699936	GM12878	blood:	n/a	n/a
25	MAX	chr3:48698988-48699532	A549	lung:	n/a	n/a
26	REST	chr3:48698816-48702243	H1-neurons	neurons:	n/a	chr3:48700747-48700767 chr3:48700550-48700563 chr3:48700448-48700466 chr3:48700747-48700761 chr3:48700547-48700560 chr3:48700447-48700467 chr3:48700453-48700467 chr3:48700547-48700556
27	REST	chr3:48698818-48699992	MCF-7	breast:	n/a	n/a
28	REST	chr3:48698929-48699652	SK-N-SH	brain:	n/a	n/a
29	REST	chr3:48698786-48700095	H1-hESC	embryonic stem cell:	n/a	n/a
30	HNF4A	chr3:48699139-48699584	HepG2	liver:	n/a	chr3:48699419-48699434
31	ZNF263	chr3:48699024-48699529	HEK293-T-REx	kidney:	n/a	n/a
32	POLR2A	chr3:48699136-48701888	H1-neurons	neurons:	n/a	n/a
33	REST	chr3:48698967-48699689	GM12878	blood:	n/a	n/a
34	REST	chr3:48698806-48700068	PFSK-1	brain:	n/a	n/a
35	REST	chr3:48698971-48699671	Hela-S3	cervix:	n/a	n/a
36	TEAD4	chr3:48698982-48699737	A549	lung:	n/a	n/a
37	MAX	chr3:48698761-48699591	ECC-1	luminal epithelium:	n/a	n/a
38	REST	chr3:48698724-48700110	PFSK-1	brain:	n/a	n/a
39	NFATC1	chr3:48699023-48699542	GM12878	blood:	n/a	n/a
40	REST	chr3:48698516-48700039	A549	lung:	n/a	n/a
41	POLR2A	chr3:48698839-48700010	HepG2	liver:	n/a	n/a
42	REST	chr3:48698808-48699747	GM12878	blood:	n/a	n/a
43	TCF12	chr3:48698892-48699556	ECC-1	luminal epithelium:	n/a	n/a
44	POLR2A	chr3:48699506-48701960	H1-neurons	neurons:	n/a	n/a
45	ZBTB7A	chr3:48698836-48699644	ECC-1	luminal epithelium:	n/a	n/a
46	PAX5	chr3:48698791-48699545	GM12892	blood:	n/a	n/a
47	ZNF143	chr3:48699060-48699524	H1-hESC	embryonic stem cell:	n/a	n/a
48	REST	chr3:48698944-48699615	PANC-1	pancreas:	n/a	n/a
49	REST	chr3:48697975-48701977	HL-60	blood:	n/a	chr3:48700747-48700767 chr3:48700550-48700563 chr3:48700448-48700466 chr3:48700747-48700761 chr3:48700547-48700560 chr3:48700447-48700467 chr3:48700453-48700467 chr3:48700547-48700556
50	HNF4G	chr3:48699140-48699565	HepG2	liver:	n/a	n/a

No data

(count:19 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr3:48697809..48699544-chr3:49049957..49052349,2	MCF-7	breast:
2	chr3:48670997..48674874-chr3:48698947..48702118,7	MCF-7	breast:
3	chr3:48699299..48703873-chr3:48715927..48726939,20	MCF-7	breast:
4	chr3:48698129..48704726-chr3:48706101..48715056,13	MCF-7	breast:
5	chr3:48695950..48699824-chr3:48710158..48713070,3	K562	blood:
6	chr3:48698351..48700757-chr3:49057854..49060697,2	K562	blood:
7	chr3:48699257..48701574-chr3:49057854..49059590,2	K562	blood:
8	chr3:48699225..48701604-chr3:48731929..48734312,2	MCF-7	breast:
9	chr3:48670764..48674544-chr3:48699167..48702803,6	K562	blood:
10	chr3:48698197..48700148-chr3:48700175..48701734,2	MCF-7	breast:
11	chr3:48675163..48677992-chr3:48697938..48699928,2	K562	blood:
12	chr3:48670764..48674544-chr3:48698929..48702803,9	K562	blood:
13	chr3:48647141..48648853-chr3:48697785..48700969,3	MCF-7	breast:
14	chr3:48698738..48703197-chr3:48713751..48717809,8	K562	blood:
15	chr3:48667529..48675453-chr3:48697968..48703139,10	MCF-7	breast:
16	chr3:48678686..48683466-chr3:48696483..48700259,5	K562	blood:
17	chr3:48686566..48688475-chr3:48697453..48700260,2	MCF-7	breast:
18	chr3:48593030..48597118-chr3:48698507..48702121,6	MCF-7	breast:
19	chr3:48678987..48680520-chr3:48698680..48701564,2	K562	blood:

No data

Variant related genes	Relation type
ENSG00000228350	TF binding region
ENSG00000178149	Chromatin interaction
ENSG00000271973	Chromatin interaction
ENSG00000263898	Chromatin interaction
ENSG00000010256	Chromatin interaction
ENSG00000207605	Chromatin interaction
ENSG00000213672	Chromatin interaction
ENSG00000178252	Chromatin interaction
ENSG00000228350	Chromatin interaction
ENSG00000114268	Chromatin interaction
ENSG00000225697	Chromatin interaction
ENSG00000068745	Chromatin interaction
ENSG00000008300	Chromatin interaction
ENSG00000178057	Chromatin interaction

Extended variants
information (count: 79 )
Associated
traits (count: 6 )

rSNPs within LD-proxies of this variant (count:69)

rs_ID	r²[population]
rs11557629	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs11706203	0.87[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs11706983	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs11708786	0.80[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs11715177	0.80[AMR][1000 genomes]
rs11719291	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs12107252	0.87[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs12107418	0.88[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs12715429	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs13063223	0.80[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs13063312	0.86[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs13070798	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs13076269	0.81[EUR][1000 genomes];0.80[ASN][1000 genomes]
rs13086240	0.82[AMR][1000 genomes]
rs13090013	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs13096357	0.85[EUR][1000 genomes];0.80[ASN][1000 genomes]
rs13316551	0.87[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs13324119	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs13324142	0.80[AFR][1000 genomes];0.86[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs13324950	0.80[AMR][1000 genomes]
rs13434258	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs17080319	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs2276850	0.80[AFR][1000 genomes];0.86[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs2276852	0.82[ASN][1000 genomes]
rs2286651	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.94[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs2286652	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.94[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs2302295	0.93[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs2310996	0.84[ASN][1000 genomes]
rs2310997	0.84[AFR][1000 genomes];0.88[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs28452701	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs28567949	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs28657585	0.87[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs28793701	0.80[AMR][1000 genomes]
rs34096717	0.86[AMR][1000 genomes];0.98[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs34153629	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs34368826	0.82[AFR][1000 genomes];0.86[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs34577723	0.90[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs34638686	0.82[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs35064573	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs3806694	0.81[AFR][1000 genomes];0.86[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs3821875	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs3821876	0.80[AFR][1000 genomes];0.86[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs4077495	0.80[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs56735597	0.80[AMR][1000 genomes]
rs57334642	0.86[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs6768448	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs6773261	0.85[EUR][1000 genomes];0.80[ASN][1000 genomes]
rs68042649	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs73078349	0.85[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs73078362	0.85[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs740787	0.84[ASN][1000 genomes]
rs7620853	0.86[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs7631574	0.82[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs9809222	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9811027	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs9811318	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9812200	0.90[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs9812977	0.90[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs9821797	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9834996	0.80[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs9836462	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9841602	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9854034	0.81[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs9868809	0.85[AFR][1000 genomes];0.85[EUR][1000 genomes]
rs9873726	0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9877542	0.80[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs9877685	0.80[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs9878063	0.81[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs9882549	0.80[AMR][1000 genomes];0.83[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:10 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1008232	chr3:48517121-48702416	Transcr. at gene 5' and 3' Active TSS Genic enhancers Enhancers Strong transcription Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Weak transcription ZNF genes & repeats Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	50 gene(s)	inside rSNPs	diseases
2	nsv523981	chr3:48520289-48721040	Weak transcription Enhancers Strong transcription Flanking Active TSS ZNF genes & repeats Active TSS Bivalent Enhancer Genic enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	52 gene(s)	inside rSNPs	diseases
3	nsv834685	chr3:48565009-48745774	Strong transcription Active TSS Genic enhancers Weak transcription Enhancers Flanking Active TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	55 gene(s)	inside rSNPs	diseases
4	nsv876762	chr3:48591481-48731487	Strong transcription Enhancers Flanking Bivalent TSS/Enh Weak transcription Genic enhancers Flanking Active TSS Active TSS Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	53 gene(s)	inside rSNPs	diseases
5	nsv818138	chr3:48610925-48731487	Strong transcription Weak transcription Enhancers Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	49 gene(s)	inside rSNPs	diseases
6	nsv590246	chr3:48628014-48721040	Flanking Active TSS Weak transcription Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Enhancers Strong transcription Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	47 gene(s)	inside rSNPs	diseases
7	nsv590247	chr3:48661985-48801929	Transcr. at gene 5' and 3' Strong transcription Active TSS Genic enhancers Enhancers Flanking Active TSS Weak transcription Bivalent/Poised TSS ZNF genes & repeats Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	53 gene(s)	inside rSNPs	diseases
8	nsv876763	chr3:48669648-48710310	Weak transcription Active TSS Enhancers Flanking Bivalent TSS/Enh Flanking Active TSS Strong transcription Bivalent Enhancer Genic enhancers Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	35 gene(s)	inside rSNPs	diseases
9	esv3409347	chr3:48697698-48701896	Flanking Bivalent TSS/Enh Enhancers Bivalent Enhancer Bivalent/Poised TSS Flanking Active TSS Active TSS Weak transcription ZNF genes & repeats Transcr. at gene 5' and 3' Genic enhancers Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	27 gene(s)	inside rSNPs	diseases
10	nsv822075	chr3:48698492-48699585	Weak transcription Flanking Bivalent TSS/Enh Active TSS Enhancers Flanking Active TSS Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3' Strong transcription Bivalent/Poised TSS Genic enhancers	TF binding region CpG island Chromatin interactive region	16 gene(s)	inside rSNPs	diseases

mRNA abundance (count:6)

SNP	Gene	Cis/trans	Tissue	Source
rs3733086	WDR6	cis	Esophagus Mucosa	GTEx
rs3733086	WDR6	cis	Adipose Subcutaneous	GTEx
rs3733086	ENSG00000008300	cis	multi-tissue	Pritchard
rs3733086	SLC26A6	cis	lung	GTEx
rs3733086	WDR6	cis	Whole Blood	GTEx
rs3733086	WDR6	cis	Skin Sun Exposed Lower leg	GTEx

Chromatin state (count:107 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr3:48697800-48699800	Weak transcription	A549	lung
2	chr3:48698400-48700000	Flanking Active TSS	Ganglion Eminence derived primary cultured neurospheres	brain
3	chr3:48698400-48700400	Bivalent Enhancer	Primary Natural Killer cells fromperipheralblood	blood
4	chr3:48698400-48700400	Enhancers	Fetal Heart	heart
5	chr3:48698400-48700600	Bivalent Enhancer	Primary B cells from peripheral blood	blood
6	chr3:48698400-48700800	Enhancers	Lung	lung
7	chr3:48698400-48701800	Active TSS	iPS-15b Cell Line	embryonic stem cell
8	chr3:48698600-48699600	Bivalent Enhancer	Breast Myoepithelial Primary Cells	Breast
9	chr3:48698600-48699600	Flanking Active TSS	Primary hematopoietic stem cells short term culture	blood
10	chr3:48698600-48699600	Bivalent Enhancer	Primary mononuclear cells fromperipheralblood	Blood
11	chr3:48698600-48699600	Bivalent Enhancer	Rectal Mucosa Donor 29	rectum
12	chr3:48698600-48699800	Flanking Bivalent TSS/Enh	Primary hematopoietic stem cells G-CSF-mobilized Male	--
13	chr3:48698600-48700000	Bivalent Enhancer	Primary T killer naive cells fromperipheralblood	blood
14	chr3:48698600-48700000	Flanking Active TSS	Cortex derived primary cultured neurospheres	brain
15	chr3:48698600-48700000	Flanking Active TSS	Foreskin Melanocyte Primary Cells skin01	Skin
16	chr3:48698600-48700200	Enhancers	Gastric	stomach
17	chr3:48698600-48700200	Enhancers	HMEC	breast
18	chr3:48698600-48700400	Active TSS	Brain Cingulate Gyrus	brain
19	chr3:48698600-48701800	Active TSS	HUES48 Cell Line	embryonic stem cell
20	chr3:48698600-48702400	Active TSS	HUES64 Cell Line	embryonic stem cell
21	chr3:48698800-48699600	Enhancers	Primary T helper memory cells from peripheral blood 1	blood
22	chr3:48698800-48699600	Flanking Bivalent TSS/Enh	Primary T regulatory cells fromperipheralblood	blood
23	chr3:48698800-48699600	Enhancers	Primary T killer memory cells from peripheral blood	blood
24	chr3:48698800-48699600	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
25	chr3:48698800-48699800	Bivalent/Poised TSS	Primary T cells from cord blood	blood
26	chr3:48698800-48699800	Enhancers	Primary T helper naive cells from peripheral blood	blood
27	chr3:48698800-48700000	Flanking Bivalent TSS/Enh	Foreskin Keratinocyte Primary Cells skin03	Skin
28	chr3:48698800-48700000	Flanking Bivalent TSS/Enh	Fetal Adrenal Gland	Adrenal Gland
29	chr3:48698800-48700400	Bivalent Enhancer	Primary monocytes fromperipheralblood	blood
30	chr3:48698800-48700400	Enhancers	Right Atrium	heart
31	chr3:48698800-48701600	Active TSS	Pancreatic Islets	Pancreatic Islet
32	chr3:48698800-48701800	Active TSS	H1 Cell Line	embryonic stem cell
33	chr3:48698800-48701800	Active TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
34	chr3:48698800-48701800	Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
35	chr3:48698800-48701800	Active TSS	iPS-18 Cell Line	embryonic stem cell
36	chr3:48698800-48702000	Active TSS	H9 Cell Line	embryonic stem cell
37	chr3:48699000-48699600	Flanking Active TSS	Primary T helper 17 cells PMA-I stimulated	--
38	chr3:48699000-48699600	Bivalent/Poised TSS	NHEK	skin
39	chr3:48699000-48699800	Flanking Active TSS	Spleen	Spleen
40	chr3:48699000-48700200	Bivalent Enhancer	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
41	chr3:48699000-48700400	Active TSS	HepG2	liver
42	chr3:48699000-48700400	Enhancers	K562	blood
43	chr3:48699000-48701600	Active TSS	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
44	chr3:48699000-48701800	Active TSS	iPS-20b Cell Line	embryonic stem cell
45	chr3:48699000-48701800	Active TSS	Brain Hippocampus Middle	brain
46	chr3:48699000-48701800	Active TSS	Brain Substantia Nigra	brain
47	chr3:48699000-48702000	Active TSS	Brain Angular Gyrus	brain
48	chr3:48699000-48702000	Active TSS	Brain Anterior Caudate	brain
49	chr3:48699000-48702000	Active TSS	Brain Inferior Temporal Lobe	brain
50	chr3:48699000-48702200	Active TSS	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived

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