Variant report

Variant	rs3735326
Chromosome Location	chr7:149536776-149536777
allele	C/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:0)
CpG islands
(count:0)
Chromatin interactive
region (count:13)
LncRNA
region (count:0)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

No data

(count:13 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr7:149466134..149470595-chr7:149532425..149537706,5	MCF-7	breast:
2	chr7:149470096..149472502-chr7:149535858..149537957,2	K562	blood:
3	chr7:149536256..149537911-chr7:149545323..149547402,2	K562	blood:
4	chr7:149520950..149523634-chr7:149534004..149537065,3	K562	blood:
5	chr7:149535432..149538355-chr7:150102358..150106003,3	MCF-7	breast:
6	chr7:149516696..149519376-chr7:149534960..149537116,2	MCF-7	breast:
7	chr7:149535857..149538432-chr7:149551451..149554289,3	MCF-7	breast:
8	chr7:149534427..149538606-chr7:149567610..149571411,8	MCF-7	breast:
9	chr7:149417465..149419893-chr7:149536657..149538216,2	K562	blood:
10	chr7:149520043..149524365-chr7:149535249..149538309,4	MCF-7	breast:
11	chr7:149534468..149539239-chr7:149549126..149555518,7	MCF-7	breast:
12	chr7:149536138..149537939-chr7:149539704..149541464,2	MCF-7	breast:
13	chr7:149534869..149537140-chr7:149569608..149571872,2	MCF-7	breast:

No data

Variant related genes	Relation type
ENSG00000197558	Chromatin interaction
ENSG00000196456	Chromatin interaction
ENSG00000181444	Chromatin interaction
ENSG00000106479	Chromatin interaction
ENSG00000133619	Chromatin interaction
ENSG00000171130	Chromatin interaction
ENSG00000204934	Chromatin interaction

Extended variants
information (count: 43 )
Associated
traits (count: 4 )

rSNPs within LD-proxies of this variant (count:25)

rs_ID	r²[population]
rs10239759	0.83[TSI][hapmap]
rs12530607	0.82[CEU][hapmap];0.85[JPT][hapmap];0.82[AMR][1000 genomes];0.89[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12534509	0.85[TSI][hapmap]
rs12535700	0.87[AFR][1000 genomes];1.00[AMR][1000 genomes];0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12536873	0.82[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1544444	1.00[CEU][hapmap];0.87[GIH][hapmap];0.93[JPT][hapmap];0.80[MEX][hapmap];0.85[TSI][hapmap];0.81[AMR][1000 genomes];0.85[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1544445	0.81[AMR][1000 genomes];0.85[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2074694	1.00[CEU][hapmap];0.93[JPT][hapmap];0.81[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs2240362	1.00[CEU][hapmap];0.93[JPT][hapmap];0.86[AMR][1000 genomes];0.83[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs55649542	0.80[EUR][1000 genomes]
rs59605875	0.84[AMR][1000 genomes];0.86[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs59644006	0.84[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs60475811	0.81[AMR][1000 genomes];0.82[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs60683676	0.81[AMR][1000 genomes];0.83[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs62492760	0.83[ASN][1000 genomes]
rs62492761	0.84[ASN][1000 genomes]
rs62492762	0.85[ASN][1000 genomes]
rs62492763	0.81[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs62492765	0.81[AMR][1000 genomes];0.82[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs62492769	0.81[AMR][1000 genomes];0.81[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs62492839	0.81[AMR][1000 genomes];0.80[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs62492841	0.87[AFR][1000 genomes];1.00[AMR][1000 genomes];0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs62492843	0.87[AFR][1000 genomes];1.00[AMR][1000 genomes];0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs73168071	0.84[EUR][1000 genomes]
rs740112	0.93[JPT][hapmap];0.91[MEX][hapmap];0.81[TSI][hapmap]

Variant overlapped rSNPs/rCNVs (count:18 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1034350	chr7:149264094-149666356	Weak transcription ZNF genes & repeats Enhancers Flanking Bivalent TSS/Enh Strong transcription Active TSS Flanking Active TSS Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	39 gene(s)	inside rSNPs	diseases
2	nsv539190	chr7:149264094-149666356	Flanking Active TSS Genic enhancers Weak transcription Active TSS Enhancers Bivalent Enhancer ZNF genes & repeats Strong transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	39 gene(s)	inside rSNPs	diseases
3	nsv1023901	chr7:149364044-149747442	Enhancers Weak transcription Active TSS Bivalent Enhancer Strong transcription Flanking Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	40 gene(s)	inside rSNPs	diseases
4	nsv539191	chr7:149364044-149747442	Active TSS Enhancers Strong transcription Weak transcription Genic enhancers Bivalent Enhancer Flanking Active TSS ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	40 gene(s)	inside rSNPs	diseases
5	nsv469576	chr7:149379626-149563233	Weak transcription Enhancers Flanking Active TSS Bivalent Enhancer Strong transcription Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	21 gene(s)	inside rSNPs	diseases
6	nsv1031581	chr7:149386249-149570178	Weak transcription Flanking Active TSS Active TSS Enhancers Bivalent Enhancer ZNF genes & repeats Genic enhancers Strong transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	31 gene(s)	inside rSNPs	diseases
7	nsv539192	chr7:149386249-149570178	Genic enhancers Weak transcription Enhancers Flanking Bivalent TSS/Enh Flanking Active TSS Active TSS Bivalent Enhancer Bivalent/Poised TSS Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	31 gene(s)	inside rSNPs	diseases
8	nsv831184	chr7:149424835-149600093	Weak transcription Flanking Active TSS Active TSS Enhancers Flanking Bivalent TSS/Enh Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	33 gene(s)	inside rSNPs	diseases
9	esv2758139	chr7:149441590-149956415	Strong transcription Active TSS Bivalent Enhancer Weak transcription Enhancers ZNF genes & repeats Flanking Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	40 gene(s)	inside rSNPs	diseases
10	esv2759571	chr7:149441590-149956415	Strong transcription Weak transcription Enhancers Active TSS Bivalent Enhancer Flanking Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	40 gene(s)	inside rSNPs	diseases
11	nsv889408	chr7:149458623-149539138	Enhancers Active TSS Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Weak transcription ZNF genes & repeats Strong transcription Genic enhancers Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	13 gene(s)	inside rSNPs	diseases
12	nsv521861	chr7:149458623-149582906	Weak transcription Bivalent/Poised TSS Enhancers Flanking Active TSS Genic enhancers Bivalent Enhancer Active TSS Strong transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	32 gene(s)	inside rSNPs	diseases
13	nsv889409	chr7:149458623-149585379	Flanking Active TSS Flanking Bivalent TSS/Enh Enhancers Active TSS Weak transcription Bivalent Enhancer Genic enhancers Strong transcription Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	32 gene(s)	inside rSNPs	diseases
14	nsv889411	chr7:149465674-149539138	Flanking Bivalent TSS/Enh ZNF genes & repeats Active TSS Bivalent/Poised TSS Flanking Active TSS Enhancers Bivalent Enhancer Weak transcription Genic enhancers Strong transcription Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	13 gene(s)	inside rSNPs	diseases
15	nsv1029471	chr7:149496177-149810381	Strong transcription Enhancers Weak transcription Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Flanking Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
16	nsv539193	chr7:149496177-149810381	Flanking Active TSS Weak transcription Transcr. at gene 5' and 3' Bivalent Enhancer Active TSS Enhancers Strong transcription Genic enhancers Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
17	nsv1033095	chr7:149508083-149781872	Flanking Active TSS Bivalent/Poised TSS Active TSS Weak transcription Enhancers Strong transcription Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
18	nsv608987	chr7:149509981-149547703	Weak transcription Bivalent/Poised TSS Enhancers Flanking Active TSS Active TSS Strong transcription Genic enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	12 gene(s)	inside rSNPs	diseases

mRNA abundance (count:4)

SNP	Gene	Cis/trans	Tissue	Source
rs3735326	TMEM176B	cis	parietal	SCAN
rs3735326	RARRES2	cis	lymphoblastoid	seeQTL
rs3735326	ACTR3C	cis	cerebellum	SCAN
rs3735326	C7orf33	cis	cerebellum	SCAN

Chromatin state (count:117 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr7:149535000-149536800	Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
2	chr7:149535200-149536800	Active TSS	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
3	chr7:149535200-149536800	Active TSS	Brain Germinal Matrix	brain
4	chr7:149535400-149537000	Active TSS	NHLF	lung
5	chr7:149535800-149537000	Flanking Active TSS	Primary T helper cells fromperipheralblood	blood
6	chr7:149536000-149536800	Flanking Active TSS	Primary T helper 17 cells PMA-I stimulated	--
7	chr7:149536000-149536800	Flanking Active TSS	Primary T regulatory cells fromperipheralblood	blood
8	chr7:149536000-149536800	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Female	--
9	chr7:149536000-149536800	Flanking Active TSS	NHEK	skin
10	chr7:149536000-149537000	Flanking Active TSS	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
11	chr7:149536000-149537000	Flanking Active TSS	Brain Anterior Caudate	brain
12	chr7:149536000-149537000	Flanking Active TSS	Skeletal Muscle Male	skeletal muscle
13	chr7:149536000-149537000	Flanking Active TSS	Dnd41	blood
14	chr7:149536000-149537200	Flanking Active TSS	Primary T cells from cord blood	blood
15	chr7:149536000-149537200	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
16	chr7:149536200-149536800	Flanking Active TSS	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
17	chr7:149536200-149536800	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
18	chr7:149536200-149536800	Flanking Active TSS	Brain Angular Gyrus	brain
19	chr7:149536200-149536800	Flanking Active TSS	Brain Inferior Temporal Lobe	brain
20	chr7:149536200-149536800	Flanking Active TSS	Hela-S3	cervix
21	chr7:149536200-149537000	Bivalent/Poised TSS	HUES64 Cell Line	embryonic stem cell
22	chr7:149536200-149537000	Flanking Active TSS	Colon Smooth Muscle	Colon
23	chr7:149536200-149537000	Flanking Active TSS	Duodenum Smooth Muscle	Duodenum
24	chr7:149536200-149537000	Flanking Active TSS	A549	lung
25	chr7:149536200-149537000	Flanking Active TSS	GM12878-XiMat	blood
26	chr7:149536200-149537200	Flanking Active TSS	Primary T helper cells PMA-I stimulated	--
27	chr7:149536400-149536800	Flanking Bivalent TSS/Enh	iPS-15b Cell Line	embryonic stem cell
28	chr7:149536400-149536800	Flanking Active TSS	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
29	chr7:149536400-149536800	Enhancers	Primary T cells effector/memory enriched fromperipheralblood	blood
30	chr7:149536400-149536800	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
31	chr7:149536400-149536800	Flanking Active TSS	Muscle Satellite Cultured Cells	--
32	chr7:149536400-149536800	Enhancers	Foreskin Melanocyte Primary Cells skin01	Skin
33	chr7:149536400-149536800	Enhancers	Primary mononuclear cells fromperipheralblood	Blood
34	chr7:149536400-149536800	Enhancers	Fetal Adrenal Gland	Adrenal Gland
35	chr7:149536400-149536800	Flanking Active TSS	Pancreatic Islets	Pancreatic Islet
36	chr7:149536400-149536800	Enhancers	Psoas Muscle	Psoas
37	chr7:149536400-149536800	Active TSS	Rectal Mucosa Donor 29	rectum
38	chr7:149536400-149536800	Flanking Active TSS	Rectal Smooth Muscle	rectum
39	chr7:149536400-149536800	Enhancers	Stomach Mucosa	stomach
40	chr7:149536400-149536800	Flanking Active TSS	NHDF-Ad	bronchial
41	chr7:149536400-149537000	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
42	chr7:149536400-149537000	Flanking Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
43	chr7:149536400-149537000	Flanking Active TSS	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
44	chr7:149536400-149537000	Enhancers	Primary neutrophils fromperipheralblood	blood
45	chr7:149536400-149537000	Enhancers	Primary B cells from peripheral blood	blood
46	chr7:149536400-149537000	Enhancers	Primary T helper memory cells from peripheral blood 1	blood
47	chr7:149536400-149537000	Enhancers	Adipose Nuclei	Adipose
48	chr7:149536400-149537000	Enhancers	Liver	Liver
49	chr7:149536400-149537000	Enhancers	Fetal Intestine Large	intestine
50	chr7:149536400-149537000	Enhancers	Gastric	stomach

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