Variant report

Variant	rs4376189
Chromosome Location	chr4:186612675-186612676
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

Extended variants
information (count: 25 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:18)

rs_ID	r²[population]
rs10003750	0.93[ASN][1000 genomes]
rs10011292	0.82[JPT][hapmap]
rs11132338	0.82[JPT][hapmap];0.94[TSI][hapmap];0.81[EUR][1000 genomes]
rs11132339	0.82[CEU][hapmap]
rs1124024	0.83[ASN][1000 genomes]
rs1542847	0.92[AMR][1000 genomes];0.87[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2030144	0.82[JPT][hapmap];0.94[TSI][hapmap]
rs4407549	0.86[CHB][hapmap];1.00[JPT][hapmap];0.87[AMR][1000 genomes];0.88[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs4640708	0.82[CEU][hapmap];0.86[CHB][hapmap];0.90[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.94[TSI][hapmap];0.88[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs4862561	0.86[CHB][hapmap];1.00[JPT][hapmap];0.84[AFR][1000 genomes];0.87[AMR][1000 genomes];0.94[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs4862566	0.82[JPT][hapmap]
rs6825669	0.83[TSI][hapmap]
rs6826210	0.83[TSI][hapmap]
rs6851734	0.84[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs7340885	0.86[CHB][hapmap];0.82[JPT][hapmap];0.94[TSI][hapmap];0.85[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs7688359	1.00[CHB][hapmap];0.82[JPT][hapmap];0.82[YRI][hapmap];0.85[AFR][1000 genomes];0.92[AMR][1000 genomes];0.87[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs7696530	0.87[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs950590	0.82[JPT][hapmap]

Variant overlapped rSNPs/rCNVs (count:7 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv432684	chr4:186412851-186742851	Enhancers Flanking Active TSS Weak transcription Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription ZNF genes & repeats Genic enhancers Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	13 gene(s)	inside rSNPs	diseases
2	nsv830169	chr4:186455064-186638163	Weak transcription Strong transcription Enhancers Bivalent/Poised TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Flanking Active TSS Active TSS Transcr. at gene 5' and 3' Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	10 gene(s)	inside rSNPs	diseases
3	nsv1028146	chr4:186503899-187338335	Strong transcription Enhancers Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS Weak transcription Flanking Bivalent TSS/Enh Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	31 gene(s)	inside rSNPs	diseases
4	nsv1020731	chr4:186512433-186724031	Enhancers Weak transcription Strong transcription Active TSS ZNF genes & repeats Genic enhancers Bivalent Enhancer Flanking Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
5	nsv1023917	chr4:186533075-186997806	Enhancers Weak transcription Flanking Active TSS Strong transcription Active TSS Genic enhancers Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
6	nsv537420	chr4:186533075-186997806	Weak transcription Enhancers Flanking Bivalent TSS/Enh Active TSS Flanking Active TSS Strong transcription Genic enhancers ZNF genes & repeats Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
7	nsv830171	chr4:186610113-186789271	Weak transcription Enhancers ZNF genes & repeats Active TSS Flanking Active TSS Strong transcription Genic enhancers Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	2 gene(s)	inside rSNPs	diseases

Variant related diseases (count:1)

Disease	PMID	Source
Visceral adipose tissue/subcutaneous adipose tissue ratio	22589738	GWAS catalog

Chromatin state (count:24 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr4:186597200-186626000	Weak transcription	HepG2	liver
2	chr4:186598400-186613200	Weak transcription	Fetal Stomach	stomach
3	chr4:186598600-186615800	Weak transcription	Fetal Intestine Small	intestine
4	chr4:186599600-186621200	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
5	chr4:186601000-186615400	Weak transcription	Pancreatic Islets	Pancreatic Islet
6	chr4:186602400-186614800	Weak transcription	HUES48 Cell Line	embryonic stem cell
7	chr4:186603800-186614800	Weak transcription	NH-A	brain
8	chr4:186604000-186613400	Weak transcription	HUVEC	blood vessel
9	chr4:186604200-186614400	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
10	chr4:186606200-186618400	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
11	chr4:186606200-186621000	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
12	chr4:186607000-186616400	Weak transcription	Colon Smooth Muscle	Colon
13	chr4:186607800-186621200	Weak transcription	Osteobl	bone
14	chr4:186607800-186621800	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
15	chr4:186608000-186626000	Weak transcription	HSMM	muscle
16	chr4:186608600-186616800	Weak transcription	HSMMtube	muscle
17	chr4:186609000-186615400	Weak transcription	Rectal Smooth Muscle	rectum
18	chr4:186611000-186613200	Weak transcription	Right Atrium	heart
19	chr4:186611000-186614200	Weak transcription	Left Ventricle	heart
20	chr4:186611000-186617600	Weak transcription	Aorta	Aorta
21	chr4:186611000-186625600	Weak transcription	Pancreas	Pancrea
22	chr4:186611000-186626000	Weak transcription	Gastric	stomach
23	chr4:186611200-186617000	Weak transcription	Liver	Liver
24	chr4:186611800-186614000	Weak transcription	Fetal Heart	heart

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