Variant report

Variant	rs586355
Chromosome Location	chr10:6558188-6558189
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:6556912..6559699-chr10:6561579..6563335,2	K562	blood:
2	chr10:6536042..6540361-chr10:6554431..6558363,4	K562	blood:

Extended variants
information (count: 14 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:11)

rs_ID	r²[population]
rs2387407	0.83[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.86[AMR][1000 genomes];0.91[ASN][1000 genomes]
rs500766	0.85[JPT][hapmap]
rs510745	1.00[ASW][hapmap];1.00[LWK][hapmap];1.00[MKK][hapmap];1.00[AFR][1000 genomes]
rs563798	1.00[ASW][hapmap];0.93[CEU][hapmap];1.00[CHB][hapmap];0.85[CHD][hapmap];0.92[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];0.95[TSI][hapmap];1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs606289	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs619125	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs627715	0.93[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.86[AFR][1000 genomes];0.95[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs657701	0.97[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs667254	0.85[JPT][hapmap]
rs676674	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs7083579	1.00[ASW][hapmap]

Variant overlapped rSNPs/rCNVs (count:3 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1042286	chr10:5795129-6578445	Enhancers Weak transcription Genic enhancers Active TSS Flanking Active TSS Strong transcription Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	76 gene(s)	inside rSNPs	diseases
2	nsv1053440	chr10:6354798-6669469	Enhancers Flanking Active TSS Strong transcription Weak transcription Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	32 gene(s)	inside rSNPs	diseases
3	nsv1047309	chr10:6495583-6714060	Weak transcription Strong transcription Enhancers Bivalent/Poised TSS Flanking Active TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Bivalent Enhancer Active TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	23 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs586355	FBXO18	cis	parietal	SCAN

Chromatin state (count:51 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:6499200-6562000	Weak transcription	Brain Anterior Caudate	brain
2	chr10:6510000-6572000	Weak transcription	iPS-15b Cell Line	embryonic stem cell
3	chr10:6544600-6558200	Weak transcription	Breast Myoepithelial Primary Cells	Breast
4	chr10:6546800-6561200	Weak transcription	HMEC	breast
5	chr10:6549800-6562400	Weak transcription	Brain Cingulate Gyrus	brain
6	chr10:6550400-6562600	Weak transcription	Brain Substantia Nigra	brain
7	chr10:6550600-6562400	Weak transcription	Brain Hippocampus Middle	brain
8	chr10:6553200-6559000	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
9	chr10:6553200-6561200	Weak transcription	NHEK	skin
10	chr10:6553200-6571400	Weak transcription	Pancreas	Pancrea
11	chr10:6553600-6558200	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
12	chr10:6553600-6558200	Weak transcription	H9 Cell Line	embryonic stem cell
13	chr10:6553600-6558400	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
14	chr10:6553600-6558800	Weak transcription	H1 Cell Line	embryonic stem cell
15	chr10:6553600-6559800	Weak transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
16	chr10:6553800-6558800	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
17	chr10:6553800-6559600	Weak transcription	Fetal Intestine Small	intestine
18	chr10:6556400-6563400	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
19	chr10:6556600-6558400	Weak transcription	Primary T killer memory cells from peripheral blood	blood
20	chr10:6556800-6558400	Weak transcription	Primary T helper naive cells from peripheral blood	blood
21	chr10:6556800-6560200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
22	chr10:6556800-6561200	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
23	chr10:6556800-6561200	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
24	chr10:6557000-6558400	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
25	chr10:6557000-6558400	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
26	chr10:6557000-6559400	Enhancers	K562	blood
27	chr10:6557000-6560800	Weak transcription	HUES64 Cell Line	embryonic stem cell
28	chr10:6557200-6558200	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
29	chr10:6557200-6558200	Enhancers	Monocytes-CD14+_RO01746	blood
30	chr10:6557200-6558400	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
31	chr10:6557200-6558400	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
32	chr10:6557200-6558800	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
33	chr10:6557200-6561800	Weak transcription	HUES6 Cell Line	embryonic stem cell
34	chr10:6557200-6562200	Weak transcription	Fetal Muscle Trunk	muscle
35	chr10:6557400-6558200	Weak transcription	Primary T cells from cord blood	blood
36	chr10:6557400-6558200	Weak transcription	Primary T cells fromperipheralblood	blood
37	chr10:6557400-6558200	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
38	chr10:6557400-6558400	Weak transcription	Fetal Muscle Leg	muscle
39	chr10:6557400-6558400	Weak transcription	Psoas Muscle	Psoas
40	chr10:6557400-6558600	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
41	chr10:6557400-6558600	Weak transcription	Thymus	Thymus
42	chr10:6557400-6558800	Enhancers	Primary hematopoietic stem cells	blood
43	chr10:6557400-6582400	Weak transcription	Dnd41	blood
44	chr10:6557600-6558200	Weak transcription	Fetal Thymus	thymus
45	chr10:6557600-6558400	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
46	chr10:6557800-6558200	Weak transcription	Primary T regulatory cells fromperipheralblood	blood
47	chr10:6557800-6561800	Weak transcription	Primary hematopoietic stem cells short term culture	blood
48	chr10:6557800-6563400	Enhancers	Primary T helper cells fromperipheralblood	blood
49	chr10:6558000-6558600	Enhancers	Skeletal Muscle Female	skeletal muscle
50	chr10:6558000-6560200	Enhancers	Skeletal Muscle Male	skeletal muscle

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