Variant report

Variant	rs7436306
Chromosome Location	chr4:2923294-2923295
allele	C/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

Extended variants
information (count: 25 )
Associated
traits (count: 5 )

rSNPs within LD-proxies of this variant (count:21)

rs_ID	r²[population]
rs1014947	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1014948	0.92[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12623	0.91[AMR][1000 genomes];0.98[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs12643323	0.95[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12647647	0.95[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12647713	0.94[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12649553	0.87[AMR][1000 genomes];0.98[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs16843589	0.95[AMR][1000 genomes];0.98[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs16843603	0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs17833981	0.87[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs17834203	0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2032470	0.82[AFR][1000 genomes];0.87[AMR][1000 genomes];0.80[EUR][1000 genomes]
rs3021131	0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs55754437	0.94[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs55927173	0.80[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs59150074	0.86[AFR][1000 genomes];0.84[AMR][1000 genomes];0.86[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs624833	0.83[ASN][1000 genomes]
rs6600769	0.86[AFR][1000 genomes];0.87[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs6819310	0.80[EUR][1000 genomes]
rs6824567	0.85[AFR][1000 genomes];0.84[AMR][1000 genomes];0.85[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs7678161	0.82[EUR][1000 genomes];0.91[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:4 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv3418626	chr4:2741174-3461492	Genic enhancers Weak transcription Active TSS Strong transcription Enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	63 gene(s)	inside rSNPs	diseases
2	esv3397632	chr4:2741239-3460583	Enhancers Flanking Active TSS Weak transcription Genic enhancers Active TSS Strong transcription Bivalent Enhancer ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	63 gene(s)	inside rSNPs	diseases
3	nsv461163	chr4:2906285-3234980	Enhancers Strong transcription Flanking Active TSS Genic enhancers Weak transcription Bivalent/Poised TSS Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	52 gene(s)	inside rSNPs	diseases
4	nsv593437	chr4:2906285-3234980	Genic enhancers Active TSS Strong transcription Enhancers Flanking Active TSS Weak transcription Transcr. at gene 5' and 3' ZNF genes & repeats Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	52 gene(s)	inside rSNPs	diseases

mRNA abundance (count:5)

SNP	Gene	Cis/trans	Tissue	Source
rs7436306	GRK4	Cis_1M	lymphoblastoid	RTeQTL
rs7436306	GRK4	cis	Artery Aorta	GTEx
rs7436306	GRK4	cis	Thyroid	GTEx
rs7436306	GRK4	cis	Skin Sun Exposed Lower leg	GTEx
rs7436306	GRK4	cis	Artery Tibial	GTEx

Chromatin state (count:124 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr4:2893200-2932600	Strong transcription	Fetal Thymus	thymus
2	chr4:2901200-2934600	Weak transcription	Hela-S3	cervix
3	chr4:2903000-2925400	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
4	chr4:2907400-2935400	Weak transcription	Pancreatic Islets	Pancreatic Islet
5	chr4:2909400-2923400	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
6	chr4:2910600-2927800	Weak transcription	Small Intestine	intestine
7	chr4:2911200-2924000	Weak transcription	iPS-15b Cell Line	embryonic stem cell
8	chr4:2911200-2935000	Weak transcription	Psoas Muscle	Psoas
9	chr4:2912600-2934800	Weak transcription	A549	lung
10	chr4:2913000-2923800	Weak transcription	ES-I3 Cell Line	embryonic stem cell
11	chr4:2913000-2935000	Weak transcription	K562	blood
12	chr4:2913800-2924000	Weak transcription	Stomach Mucosa	stomach
13	chr4:2914000-2925800	Weak transcription	NHDF-Ad	bronchial
14	chr4:2914200-2925200	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
15	chr4:2915600-2923400	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
16	chr4:2915600-2924800	Weak transcription	Brain Substantia Nigra	brain
17	chr4:2915600-2933000	Weak transcription	Right Atrium	heart
18	chr4:2916400-2923400	Weak transcription	Primary T killer memory cells from peripheral blood	blood
19	chr4:2916400-2929800	Weak transcription	Fetal Heart	heart
20	chr4:2916800-2924200	Weak transcription	NH-A	brain
21	chr4:2916800-2924800	Weak transcription	Pancreas	Pancrea
22	chr4:2917000-2924000	Weak transcription	HSMM	muscle
23	chr4:2917000-2932000	Strong transcription	Breast Myoepithelial Primary Cells	Breast
24	chr4:2917200-2924200	Weak transcription	Primary hematopoietic stem cells	blood
25	chr4:2917200-2924800	Weak transcription	HepG2	liver
26	chr4:2917400-2924200	Weak transcription	HUVEC	blood vessel
27	chr4:2917400-2925000	Weak transcription	Primary B cells from cord blood	blood
28	chr4:2917400-2925000	Weak transcription	Colon Smooth Muscle	Colon
29	chr4:2917600-2925200	Weak transcription	Placenta Amnion	Placenta Amnion
30	chr4:2917800-2924000	Weak transcription	Primary hematopoietic stem cells short term culture	blood
31	chr4:2917800-2924200	Weak transcription	Rectal Mucosa Donor 31	rectum
32	chr4:2917800-2924600	Weak transcription	NHEK	skin
33	chr4:2917800-2924800	Weak transcription	Colonic Mucosa	Colon
34	chr4:2917800-2924800	Weak transcription	HMEC	breast
35	chr4:2917800-2925000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
36	chr4:2917800-2925000	Weak transcription	Gastric	stomach
37	chr4:2917800-2925000	Weak transcription	Dnd41	blood
38	chr4:2917800-2925200	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
39	chr4:2917800-2925400	Weak transcription	NHLF	lung
40	chr4:2917800-2926000	Weak transcription	Aorta	Aorta
41	chr4:2918000-2924200	Weak transcription	Spleen	Spleen
42	chr4:2918000-2925200	Weak transcription	HSMMtube	muscle
43	chr4:2918400-2925000	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
44	chr4:2918600-2923600	Weak transcription	Fetal Intestine Large	intestine
45	chr4:2918600-2923800	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
46	chr4:2918600-2923800	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
47	chr4:2918600-2923800	Weak transcription	Thymus	Thymus
48	chr4:2918600-2924000	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
49	chr4:2918600-2924000	Weak transcription	Esophagus	oesophagus
50	chr4:2918600-2924000	Weak transcription	Lung	lung

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