Variant report

Variant	rs7845008
Chromosome Location	chr8:125515791-125515792
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr8:125515035..125519543-chr8:125547357..125551225,5	MCF-7	breast:
2	chr8:125487371..125489055-chr8:125515121..125516817,2	MCF-7	breast:
3	chr8:125488240..125490491-chr8:125514107..125516385,2	MCF-7	breast:

Variant related genes	Relation type
ENSG00000147687	Chromatin interaction

Extended variants
information (count: 35 )
Associated
traits (count: 4 )

rSNPs within LD-proxies of this variant (count:34)

rs_ID	r²[population]
rs10956184	1.00[CEU][hapmap];1.00[CHB][hapmap];0.89[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.94[MEX][hapmap];0.95[AMR][1000 genomes];0.97[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs10956185	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];1.00[TSI][hapmap];1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs10956189	1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[LWK][hapmap];0.89[MEX][hapmap];0.89[MKK][hapmap];0.80[TSI][hapmap];0.95[AMR][1000 genomes];0.86[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs12542260	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];0.97[TSI][hapmap];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs12544211	0.96[AMR][1000 genomes];0.88[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs12544621	1.00[ASW][hapmap];1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];0.89[MKK][hapmap];0.81[TSI][hapmap];1.00[AMR][1000 genomes];0.88[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs12545267	1.00[CHB][hapmap];1.00[JPT][hapmap];0.95[AMR][1000 genomes];0.87[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs12546906	0.85[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs12548836	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];1.00[TSI][hapmap];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12550707	0.82[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs12550827	1.00[ASW][hapmap];1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];0.89[MEX][hapmap];0.89[MKK][hapmap];0.81[TSI][hapmap];0.96[AMR][1000 genomes];0.87[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs28576577	1.00[LWK][hapmap]
rs4128469	0.88[CEU][hapmap];0.97[TSI][hapmap];0.81[EUR][1000 genomes]
rs4512366	1.00[CEU][hapmap];1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.94[MEX][hapmap];0.94[TSI][hapmap];0.95[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs4551335	1.00[CEU][hapmap];0.85[CHB][hapmap];1.00[JPT][hapmap];1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs4602869	0.85[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs4870898	0.80[EUR][1000 genomes]
rs5004281	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];0.94[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];1.00[TSI][hapmap];1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs56942034	0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs57941917	0.97[AMR][1000 genomes];0.83[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs62527880	0.81[EUR][1000 genomes]
rs62527883	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs62527884	0.81[EUR][1000 genomes]
rs62527886	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs62527901	1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs62527908	1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs62527910	1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs6987213	1.00[CEU][hapmap];0.81[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs6987358	0.87[CEU][hapmap];0.83[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs7009847	0.81[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs72713049	0.81[EUR][1000 genomes]
rs7830325	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs7834203	0.81[EUR][1000 genomes]
rs7836802	0.82[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:1 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv531508	chr8:125390194-125587953	Flanking Active TSS Strong transcription Enhancers Weak transcription ZNF genes & repeats Genic enhancers Active TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	84 gene(s)	inside rSNPs	diseases

mRNA abundance (count:4)

SNP	Gene	Cis/trans	Tissue	Source
rs7845008	ZHX2	cis	parietal	SCAN
rs7845008	TRIB1	cis	parietal	SCAN
rs7845008	ZHX2	cis	cerebellum	SCAN
rs7845008	TRMT12	cis	Whole Blood	GTEx

Chromatin state (count:123 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr8:125488200-125515800	Weak transcription	Lung	lung
2	chr8:125488200-125550400	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
3	chr8:125489000-125519800	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
4	chr8:125489000-125531200	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
5	chr8:125489000-125541200	Weak transcription	Gastric	stomach
6	chr8:125489000-125543400	Weak transcription	Small Intestine	intestine
7	chr8:125493200-125539400	Weak transcription	Placenta Amnion	Placenta Amnion
8	chr8:125496600-125549600	Weak transcription	Rectal Smooth Muscle	rectum
9	chr8:125496800-125521200	Weak transcription	Fetal Heart	heart
10	chr8:125496800-125547400	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
11	chr8:125499000-125537200	Weak transcription	Esophagus	oesophagus
12	chr8:125499200-125515800	Weak transcription	Right Ventricle	heart
13	chr8:125499800-125515800	Weak transcription	Colon Smooth Muscle	Colon
14	chr8:125500000-125526200	Weak transcription	Colonic Mucosa	Colon
15	chr8:125500000-125538000	Weak transcription	ES-I3 Cell Line	embryonic stem cell
16	chr8:125500000-125538400	Weak transcription	Psoas Muscle	Psoas
17	chr8:125500000-125549600	Weak transcription	Fetal Brain Male	brain
18	chr8:125500200-125530800	Weak transcription	iPS-15b Cell Line	embryonic stem cell
19	chr8:125500400-125526400	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
20	chr8:125501600-125516000	Weak transcription	Primary T killer memory cells from peripheral blood	blood
21	chr8:125501600-125524600	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
22	chr8:125501600-125535000	Weak transcription	Brain Cingulate Gyrus	brain
23	chr8:125501600-125550000	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
24	chr8:125502000-125515800	Weak transcription	HSMMtube	muscle
25	chr8:125503800-125515800	Weak transcription	Thymus	Thymus
26	chr8:125503800-125518800	Weak transcription	Brain Hippocampus Middle	brain
27	chr8:125504000-125515800	Weak transcription	HMEC	breast
28	chr8:125504000-125518800	Weak transcription	H9 Cell Line	embryonic stem cell
29	chr8:125504000-125518800	Weak transcription	Brain Substantia Nigra	brain
30	chr8:125504000-125521200	Weak transcription	Brain Inferior Temporal Lobe	brain
31	chr8:125504000-125524800	Weak transcription	Pancreas	Pancrea
32	chr8:125504000-125525000	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
33	chr8:125504000-125525800	Weak transcription	NHLF	lung
34	chr8:125504000-125550800	Weak transcription	Spleen	Spleen
35	chr8:125504400-125518800	Weak transcription	Ovary	ovary
36	chr8:125505800-125538600	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
37	chr8:125506000-125538600	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
38	chr8:125507600-125522000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
39	chr8:125508400-125532200	Strong transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
40	chr8:125510200-125536800	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
41	chr8:125510400-125536200	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
42	chr8:125510800-125532200	Strong transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
43	chr8:125511600-125536400	Strong transcription	HUES48 Cell Line	embryonic stem cell
44	chr8:125512000-125536000	Strong transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
45	chr8:125512200-125516200	Strong transcription	A549	lung
46	chr8:125512200-125516800	Strong transcription	Adipose Nuclei	Adipose
47	chr8:125512200-125517800	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
48	chr8:125512200-125528000	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
49	chr8:125512200-125530400	Strong transcription	Fetal Adrenal Gland	Adrenal Gland
50	chr8:125512200-125531600	Strong transcription	iPS-20b Cell Line	embryonic stem cell

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