Variant report

Variant	esv3428108
Chromosome Location	chr15:40744855-40746413
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:34)
CpG islands
(count:61)
Chromatin interactive
region (count:9)
LncRNA
region (count:2)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

(count:34 , 50 per page) page: 1

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	CEBPB	chr15:40746103-40746128	Hela-S3	cervix:	n/a	n/a
2	CEBPB	chr15:40745991-40746276	IMR90	lung:	n/a	chr15:40746122-40746133
3	CEBPB	chr15:40746017-40746286	K562	blood:	n/a	chr15:40746122-40746133
4	CEBPB	chr15:40746089-40746253	HepG2	liver:	n/a	chr15:40746122-40746133
5	CEBPB	chr15:40745989-40746209	K562	blood:	n/a	chr15:40746122-40746133
6	CTCF	chr15:40746336-40746383	Spleen_OC	spleen:	n/a	n/a
7	CTCF	chr15:40746390-40746435	Spleen_OC	spleen:	n/a	n/a
8	EBF1	chr15:40744364-40744992	GM12878	blood:	n/a	n/a
9	EBF1	chr15:40744640-40744920	GM12878	blood:	n/a	n/a
10	EBF1	chr15:40746155-40746542	GM12878	blood:	n/a	n/a
11	EBF1	chr15:40746163-40746473	GM12878	blood:	n/a	n/a
12	ELF1	chr15:40746159-40746392	K562	blood:	n/a	n/a
13	ELF1	chr15:40744509-40745028	GM12878	blood:	n/a	chr15:40744765-40744778
14	MYC	chr15:40746297-40746324	NB4	blood:	n/a	n/a
15	PAX5	chr15:40746219-40746481	GM12878	blood:	n/a	chr15:40746320-40746329
16	PAX5	chr15:40744399-40744894	GM12878	blood:	n/a	chr15:40744538-40744556 chr15:40744766-40744775 chr15:40744536-40744555
17	POLR2A	chr15:40746189-40746636	GM12878	blood:	n/a	n/a
18	POLR2A	chr15:40746268-40746527	GM12878	blood:	n/a	n/a
19	POLR2A	chr15:40744868-40744931	K562	blood:	n/a	n/a
20	POLR2A	chr15:40744859-40744863	K562	blood:	n/a	n/a
21	POLR2A	chr15:40744726-40744994	GM12878	blood:	n/a	n/a
22	POLR2A	chr15:40746249-40746551	H1-hESC	embryonic stem cell:	n/a	n/a
23	POLR2A	chr15:40744779-40744994	H1-hESC	embryonic stem cell:	n/a	n/a
24	POLR2A	chr15:40746374-40746549	GM12878	blood:	n/a	n/a
25	POLR2A	chr15:40744699-40745018	GM12878	blood:	n/a	n/a
26	RUNX3	chr15:40744535-40744885	GM12878	blood:	n/a	n/a
27	RUNX3	chr15:40746086-40746439	GM12878	blood:	n/a	n/a
28	RUNX3	chr15:40746150-40746409	GM12878	blood:	n/a	n/a
29	SIN3A	chr15:40745206-40745284	H1-hESC	embryonic stem cell:	n/a	chr15:40745259-40745272
30	SPI1	chr15:40746239-40746371	GM12878	blood:	n/a	n/a
31	SPI1	chr15:40744564-40744930	GM12878	blood:	n/a	n/a
32	SPI1	chr15:40746142-40746513	GM12891	blood:	n/a	n/a
33	SPI1	chr15:40744594-40744959	GM12891	blood:	n/a	n/a
34	SPI1	chr15:40746163-40746416	GM12878	blood:	n/a	n/a

(count:61 , 50 per page) page: 1 2

No.	Chromosome Location	Cell Line	Cell type	Cell Stage
1	chr15:40745035-40745085	U87	brain:	n/a
2	chr15:40745035-40745085	Jurkat	blood:	n/a
3	chr15:40745035-40745085	NH-A	brain:	n/a
4	chr15:40745035-40745085	RPTEC	kidney:	n/a
5	chr15:40745035-40745085	AG04449	skin:	fetal
6	chr15:40745035-40745085	HRCEpiC	kidney:	n/a
7	chr15:40745035-40745085	HCT-116	colon:	n/a
8	chr15:40745035-40745085	Hepatocyte	liver:	n/a
9	chr15:40745035-40745085	HIPEpiC	eye:	n/a
10	chr15:40745035-40745085	HEEpiC	esophagus:	n/a
11	chr15:40745035-40745085	HNPCEpiC	eye:	n/a
12	chr15:40745035-40745085	PANC-1	pancreas:	n/a
13	chr15:40745035-40745085	AG09309	skin:	n/a
14	chr15:40745035-40745085	SK-N-MC	brain:	n/a
15	chr15:40745035-40745085	NB4	blood:	n/a
16	chr15:40745035-40745085	HEK293	kidney:	embryo
17	chr15:40745035-40745085	AoSMC	blood vessel:	n/a
18	chr15:40745035-40745085	Hela-S3	cervix:	n/a
19	chr15:40745035-40745085	BE2_C	brain:	n/a
20	chr15:40745035-40745085	GM19239	blood:	n/a
21	chr15:40745035-40745085	SK-N-SH_RA	brain:	n/a
22	chr15:40745035-40745085	MCF10A-Er-Src	breast:	n/a
23	chr15:40745035-40745085	HepG2	liver:	n/a
24	chr15:40745035-40745085	Caco-2	colon:	n/a
25	chr15:40745035-40745085	HMEC	breast:	n/a
26	chr15:40745035-40745085	SAEC	small airway:	n/a
27	chr15:40745035-40745085	SK-N-SH	brain:	n/a
28	chr15:40745035-40745085	K562	blood:	n/a
29	chr15:40745035-40745085	IMR90	lung:	fetal
30	chr15:40745035-40745085	AG04450	lung:	fetal
31	chr15:40745035-40745085	H1-hESC	embryonic stem cell:	embryo
32	chr15:40745035-40745085	NHDF-neo	bronchial:	n/a
33	chr15:40745035-40745085	LNCaP	prostate:	n/a
34	chr15:40745035-40745085	T-47D	breast:	n/a
35	chr15:40745035-40745085	HL-60	blood:	n/a
36	chr15:40745035-40745085	PrEC	prostate:	n/a
37	chr15:40745035-40745085	ProgFib	skin:	n/a
38	chr15:40745035-40745085	GM12892	blood:	n/a
39	chr15:40745035-40745085	ECC-1	luminal epithelium:	n/a
40	chr15:40745035-40745085	A549	lung:	n/a
41	chr15:40745035-40745085	HRE	kidney:	n/a
42	chr15:40745035-40745085	GM06990	blood:	n/a
43	chr15:40745035-40745085	NHBE	bronchial:	n/a
44	chr15:40745035-40745085	HPAEpiC	pulmonary alveolar:	n/a
45	chr15:40745035-40745085	HAEpiC	amniotic membrane:	n/a
46	chr15:40745035-40745085	HUVEC	blood vessel:	n/a
47	chr15:40745035-40745085	SKMC	muscle:	n/a
48	chr15:40745035-40745085	GM12891	blood:	n/a
49	chr15:40745035-40745085	BJ	skin:	n/a
50	chr15:40745035-40745085	HCF	heart:	n/a

(count:9 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr15:40744227..40745769-chr15:40750283..40752518,2	K562	blood:
2	chr15:40743916..40746207-chr15:40767844..40769362,2	K562	blood:
3	chr15:40744169..40746104-chr15:40756811..40759374,2	MCF-7	breast:
4	chr15:40732284..40734448-chr15:40743962..40746615,2	MCF-7	breast:
5	chr15:40729975..40738939-chr15:40745780..40750666,13	K562	blood:
6	chr15:40743208..40745711-chr15:40766264..40768804,2	MCF-7	breast:
7	chr15:40738374..40740268-chr15:40744165..40746234,2	MCF-7	breast:
8	chr15:40674267..40676664-chr15:40743987..40746424,2	MCF-7	breast:
9	chr15:40746042..40747567-chr15:40761663..40764195,2	MCF-7	breast:

(count:2 , 50 per page) page: 1

No.	lncRNA name	Chromosome Location	lncRNA alias
1	lnc-C15orf57-2	chr15:40746027-40746144	ENSG00000259364.1
2	lnc-C15orf57-2	chr15:40745643-40745745	ENSG00000259364.1

No data

Variant related genes	Relation type
BAHD1	TF binding region
BAHD1	CpG island
ENSG00000259211	chromatin interactions
ENSG00000128944	chromatin interactions
ENSG00000140320	chromatin interactions
ENSG00000169105	chromatin interactions

Extended variants
information (count: 41 )
Associated
traits (count: 67 )

Variant overlapped rSNPs/rCNVs (count:41 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs375811875	chr15:40744867-40744868	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
2	rs563225585	chr15:40744933-40744934	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
3	rs116211993	chr15:40744936-40744937	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
4	rs115066667	chr15:40744940-40744941	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
5	rs144412461	chr15:40744977-40744978	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
6	rs530356880	chr15:40745018-40745019	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
7	rs372978759	chr15:40745032-40745033	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
8	rs34616761	chr15:40745046-40745047	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
9	rs73309	chr15:40745064-40745065	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
10	rs181181547	chr15:40745068-40745069	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
11	rs551271673	chr15:40745070-40745071	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
12	rs367736993	chr15:40745108-40745109	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
13	rs543149659	chr15:40745139-40745140	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
14	rs74595335	chr15:40745226-40745227	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
15	rs375544629	chr15:40745241-40745242	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
16	rs556947852	chr15:40745281-40745282	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
17	rs149388991	chr15:40745284-40745285	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
18	rs536245266	chr15:40745286-40745287	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
19	rs553280818	chr15:40745299-40745300	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
20	rs547259784	chr15:40745334-40745335	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
21	rs186821106	chr15:40745370-40745371	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
22	rs545601873	chr15:40745432-40745433	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
23	rs565306410	chr15:40745435-40745436	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
24	rs143649609	chr15:40745453-40745454	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
25	rs543108584	chr15:40745529-40745530	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
26	rs563361878	chr15:40745540-40745541	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
27	rs71472441	chr15:40745559-40745560	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
28	rs528943075	chr15:40745581-40745582	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
29	rs2304644	chr15:40745594-40745595	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
30	rs559717393	chr15:40745596-40745597	Enhancers Weak transcription Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
31	rs528340145	chr15:40745883-40745884	Weak transcription Enhancers Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
32	rs551556624	chr15:40745908-40745909	Weak transcription Enhancers Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
33	rs71426377	chr15:40745963-40745964	Weak transcription Enhancers Flanking Active TSS	Chromatin interactive region	3 gene(s)	Overlapped CNVs	n/a
34	rs115102490	chr15:40745994-40745995	Weak transcription Enhancers Flanking Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a
35	rs148095586	chr15:40746137-40746138	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region lncRNA	4 gene(s)	Overlapped CNVs	n/a
36	rs549899474	chr15:40746192-40746193	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a
37	rs550710141	chr15:40746227-40746228	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a
38	rs575758883	chr15:40746232-40746233	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a
39	rs567402486	chr15:40746270-40746271	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a
40	rs536283116	chr15:40746329-40746330	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a
41	rs552916987	chr15:40746384-40746385	Weak transcription Enhancers Flanking Active TSS Active TSS	TF binding region Chromatin interactive region	4 gene(s)	Overlapped CNVs	n/a

Variant related diseases (count:67)

Disease	PMID	Source
HDAC8	0	CNVD
NIPBL	0	CNVD
RAD21	0	CNVD
SMC1A	0	CNVD
SMC3	0	CNVD
Ewing''s sarcoma	21437220	CNVD
Schizophrenia	19415332	CNVD
Breast cancer	22522925	CNVD
Autism	22495311	CNVD
Wilms tumour	21544195	CNVD
Angelman syndrome	16183798	CNVD
Acute lymphoblastic leukemia	20067559	CNVD
Testicular germ cell tumor	18059402	CNVD
cataract	16735990	CNVD
Cancer	21637783	CNVD
Colorectal cancer	20709793	CNVD
Medulloblastoma	21979893	CNVD
spastic paraplegia with thinning of corpus callosum	19105190	CNVD
Schizophrenia	21324950	CNVD
Astrocytoma	17387387	CNVD
Esophageal squamous carcinoma	21637470	CNVD
Endometrial cancer	22040021	CNVD
Breast cancer	21264507	CNVD
Disease	21824424	CNVD
Melanoma	18172304	CNVD
Colorectal cancer	16774939	CNVD
Gastric cancer	17167181	CNVD
Neuroblastoma	19435921	CNVD
Colorectal cancer	19359472	CNVD
Monoclonal gammopathy of undetermined significance	17077331	CNVD
Multiple myeloma	17077331	CNVD
Colorectal cancer	16272173	CNVD
Gastrointestinal stromal cancer	20470368	CNVD
Multiple myeloma	17550852	CNVD
Intellectual disability	22102821	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Acute myeloid leukemia	20729466	CNVD
Prostate cancer	16573809	CNVD
Basal cell lymphoma	16317097	CNVD
Diffuse large b-cell lymphoma	16317097	CNVD
Multiple myeloma	20724749	CNVD
Lung cancer	18438408	CNVD
Chronic lymphocytic leukemia	21546498	CNVD
Breast cancer	21785460	CNVD
Gastrointestinal stromal cancer	16982739	CNVD
Ovarian cancer	22174824	CNVD
Prostate cancer	18632612	CNVD
small cell lung cancer	20016488	CNVD
Acute lymphoblastic leukemia	22237106	CNVD
Oral squamous cell carcinoma	17134496	CNVD
Basal cell lymphoma	17053054	CNVD
Acute lymphoblastic leukemia	18458336	CNVD
lymphocytic leukemia	21291569	CNVD
Cancer	20164920	CNVD
Hodgkin''s lymphoma	18641027	CNVD
Cancer	21129771	CNVD
Papillary thyroid carcinoma	22161024	CNVD
Splenic marginal zone lymphoma	21957467	CNVD
Breast cancer	21045282	CNVD
Breast cancer	22032731	CNVD
low-grade B-cell lymphoma tumor	18367492	CNVD
Gastrointestinal stromal cancer	20877625	CNVD
Multiple myeloma	16616336	CNVD
Renal cell carcinoma	18765545	CNVD
Basal cell lymphoma	17170743	CNVD
Follicular lymphoma	17170743	CNVD
Chronic lymphocytic leukemia	20421269	CNVD

Chromatin state (count:213 , 50 per page) page: 1 2 3 4 5

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr15:40734800-40746400	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
2	chr15:40734800-40747000	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
3	chr15:40734800-40751000	Weak transcription	Aorta	Aorta
4	chr15:40735000-40746600	Weak transcription	HSMM	muscle
5	chr15:40735200-40747800	Weak transcription	Brain Cingulate Gyrus	brain
6	chr15:40736800-40748600	Weak transcription	Brain Inferior Temporal Lobe	brain
7	chr15:40738000-40750400	Weak transcription	Brain Germinal Matrix	brain
8	chr15:40738200-40746600	Weak transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
9	chr15:40738200-40746800	Weak transcription	Adipose Nuclei	Adipose
10	chr15:40738200-40747000	Weak transcription	Fetal Muscle Leg	muscle
11	chr15:40738200-40751000	Weak transcription	Rectal Smooth Muscle	rectum
12	chr15:40738400-40746800	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
13	chr15:40738400-40747000	Weak transcription	Colon Smooth Muscle	Colon
14	chr15:40738400-40747200	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
15	chr15:40738600-40746000	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
16	chr15:40738600-40746200	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
17	chr15:40738600-40746400	Weak transcription	NHEK	skin
18	chr15:40738600-40746800	Weak transcription	NHLF	lung
19	chr15:40738800-40746800	Weak transcription	Breast Myoepithelial Primary Cells	Breast
20	chr15:40740400-40745000	Enhancers	Primary T helper cells PMA-I stimulated	--
21	chr15:40740600-40745600	Enhancers	Primary T cells fromperipheralblood	blood
22	chr15:40740600-40749600	Enhancers	Rectal Mucosa Donor 31	rectum
23	chr15:40741000-40745200	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
24	chr15:40741200-40747800	Enhancers	K562	blood
25	chr15:40741400-40745200	Enhancers	Primary T killer memory cells from peripheral blood	blood
26	chr15:40741400-40746400	Enhancers	Primary T helper memory cells from peripheral blood 1	blood
27	chr15:40741600-40746600	Weak transcription	A549	lung
28	chr15:40741800-40745600	Weak transcription	HMEC	breast
29	chr15:40741800-40746000	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
30	chr15:40741800-40746200	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
31	chr15:40741800-40746200	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
32	chr15:40741800-40746600	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
33	chr15:40741800-40746600	Weak transcription	NH-A	brain
34	chr15:40741800-40746600	Weak transcription	NHDF-Ad	bronchial
35	chr15:40741800-40746600	Weak transcription	Osteobl	bone
36	chr15:40742000-40745000	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
37	chr15:40742000-40745400	Enhancers	Primary T cells effector/memory enriched fromperipheralblood	blood
38	chr15:40742000-40745800	Enhancers	HUES64 Cell Line	embryonic stem cell
39	chr15:40742200-40745400	Enhancers	Primary T helper naive cells from peripheral blood	blood
40	chr15:40742200-40745600	Enhancers	iPS DF 19.11 Cell Line	embryonic stem cell
41	chr15:40742200-40745600	Enhancers	Left Ventricle	heart
42	chr15:40742200-40746000	Enhancers	Primary T killer naive cells fromperipheralblood	blood
43	chr15:40742200-40747800	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
44	chr15:40742200-40749200	Enhancers	Sigmoid Colon	Sigmoid Colon
45	chr15:40742200-40749600	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
46	chr15:40742400-40745200	Enhancers	Liver	Liver
47	chr15:40742400-40746000	Enhancers	iPS-15b Cell Line	embryonic stem cell
48	chr15:40742400-40762200	Weak transcription	Pancreatic Islets	Pancreatic Islet
49	chr15:40742600-40745000	Weak transcription	Ganglion Eminence derived primary cultured neurospheres	brain
50	chr15:40742600-40745400	Enhancers	Pancreas	Pancrea

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