Variant report

Variant	nsv4398
Chromosome Location	chr1:211034582-211079117
allele	n/a
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	BHLHE40	chr1:211057362-211057637	HepG2	liver:	n/a	chr1:211057470-211057479
2	CEBPB	chr1:211061130-211061221	A549	lung:	n/a	n/a
3	CEBPB	chr1:211057140-211057369	A549	lung:	n/a	n/a
4	CEBPB	chr1:211040496-211040590	A549	lung:	n/a	n/a
5	CEBPB	chr1:211057115-211057426	IMR90	lung:	n/a	n/a
6	CEBPB	chr1:211056816-211056932	A549	lung:	n/a	n/a
7	CEBPB	chr1:211069470-211069605	H1-hESC	embryonic stem cell:	n/a	n/a
8	CTCF	chr1:211055840-211055990	HRPEpiC	eye:	n/a	n/a
9	CTCF	chr1:211071320-211071470	HMF	breast:	n/a	chr1:211071340-211071353
10	CTCF	chr1:211055840-211055990	HRE	kidney:	n/a	n/a
11	CTCF	chr1:211050680-211050830	HA-sp	spinal cord:	n/a	n/a
12	CTCF	chr1:211055800-211055950	HAc	cerebellar:	n/a	n/a
13	CTCF	chr1:211059640-211059790	HRE	kidney:	n/a	n/a
14	CTCF	chr1:211038860-211039010	HFF-Myc	foreskin:	n/a	n/a
15	CTCF	chr1:211074808-211074855	GM13976	blood:	n/a	n/a
16	E2F4	chr1:211067566-211067681	MCF10A-Er-Src	breast:	n/a	n/a
17	E2F4	chr1:211056170-211056468	MCF10A-Er-Src	breast:	n/a	n/a
18	E2F4	chr1:211069358-211069366	MCF10A-Er-Src	breast:	n/a	n/a
19	E2F6	chr1:211075410-211075728	H1-hESC	embryonic stem cell:	n/a	n/a
20	E2F6	chr1:211075386-211075983	H1-hESC	embryonic stem cell:	n/a	n/a
21	FOS	chr1:211057033-211057554	MCF10A-Er-Src	breast:	n/a	n/a
22	FOS	chr1:211055818-211056541	MCF10A-Er-Src	breast:	n/a	chr1:211056069-211056078 chr1:211056078-211056090 chr1:211055978-211055986 chr1:211055976-211055988
23	FOS	chr1:211066388-211066409	MCF10A-Er-Src	breast:	n/a	n/a
24	FOS	chr1:211055646-211056587	MCF10A-Er-Src	breast:	n/a	chr1:211056069-211056078 chr1:211056078-211056090 chr1:211055978-211055986 chr1:211055976-211055988
25	FOS	chr1:211057115-211057467	MCF10A-Er-Src	breast:	n/a	n/a
26	FOS	chr1:211057120-211057505	MCF10A-Er-Src	breast:	n/a	n/a
27	FOS	chr1:211055590-211056783	MCF10A-Er-Src	breast:	n/a	chr1:211056069-211056078 chr1:211056078-211056090 chr1:211055978-211055986 chr1:211055976-211055988
28	FOS	chr1:211057011-211057499	MCF10A-Er-Src	breast:	n/a	n/a
29	FOS	chr1:211058225-211058410	MCF10A-Er-Src	breast:	n/a	chr1:211058244-211058255
30	FOS	chr1:211055616-211056747	MCF10A-Er-Src	breast:	n/a	chr1:211056069-211056078 chr1:211056078-211056090 chr1:211055978-211055986 chr1:211055976-211055988
31	FOS	chr1:211040000-211040183	MCF10A-Er-Src	breast:	n/a	n/a
32	FOSL1	chr1:211056037-211056600	HCT-116	colon:	n/a	chr1:211056069-211056078 chr1:211056078-211056090
33	FOSL2	chr1:211055759-211056573	A549	lung:	n/a	chr1:211056069-211056078 chr1:211056078-211056090 chr1:211055978-211055986 chr1:211055976-211055988
34	GATA2	chr1:211057181-211057353	SH-SY5Y	brain:	n/a	chr1:211057285-211057293
35	GATA2	chr1:211069096-211069365	SH-SY5Y	brain:	n/a	chr1:211069346-211069362 chr1:211069265-211069275
36	GATA2	chr1:211074189-211074515	SH-SY5Y	brain:	n/a	n/a
37	GATA3	chr1:211073903-211074535	SH-SY5Y	brain:	n/a	n/a
38	GATA3	chr1:211076456-211076607	SH-SY5Y	brain:	n/a	n/a
39	GATA3	chr1:211036672-211036811	SH-SY5Y	brain:	n/a	n/a
40	GATA3	chr1:211043393-211043489	SH-SY5Y	brain:	n/a	n/a
41	GATA3	chr1:211069149-211069601	SH-SY5Y	brain:	n/a	chr1:211069346-211069362 chr1:211069265-211069275
42	GATA3	chr1:211078647-211078713	SH-SY5Y	brain:	n/a	n/a
43	HEY1	chr1:211035460-211035672	K562	blood:	n/a	n/a
44	JUND	chr1:211056048-211056569	HCT-116	colon:	n/a	chr1:211056069-211056078 chr1:211056078-211056090
45	MAFF	chr1:211039957-211040237	HepG2	liver:	n/a	chr1:211040066-211040084
46	MAFF	chr1:211039892-211040247	K562	blood:	n/a	chr1:211040066-211040084
47	MAFF	chr1:211051920-211052249	HepG2	liver:	n/a	chr1:211052091-211052109
48	MAFF	chr1:211051949-211052220	K562	blood:	n/a	chr1:211052091-211052109
49	MAFK	chr1:211051969-211052253	Hela-S3	cervix:	n/a	chr1:211052092-211052107
50	MAFK	chr1:211039895-211040247	IMR90	lung:	n/a	chr1:211040067-211040082

No.	Distal block	Cell Line	Cell type
1	chr1:211068269..211070405-chr1:211089672..211092278,2	K562	blood:
2	chr1:211045386..211048022-chr1:211050863..211053308,2	K562	blood:
3	chr1:211045386..211048022-chr1:211050863..211053308,2	K562	blood:
4	chr1:211066382..211068905-chr1:211069492..211072195,2	K562	blood:
5	chr1:211034614..211036383-chr1:211038052..211040181,2	K562	blood:
6	chr1:211066382..211068905-chr1:211069492..211072195,2	K562	blood:
7	chr1:211034100..211037099-chr11:9405144..9407454,2	MCF-7	breast:
8	chr1:211069010..211070968-chr1:211071970..211074084,2	K562	blood:
9	chr1:211053499..211055688-chr1:211056595..211058715,2	K562	blood:
10	chr1:210628672..210630917-chr1:211075753..211078223,2	K562	blood:
11	chr1:211053499..211055688-chr1:211056595..211058715,2	K562	blood:
12	chr1:211035595..211037101-chr11:9405067..9407537,2	K562	blood:
13	chr1:211035584..211036100-chr11:9405909..9406698,6	HCT-116	colon:
14	chr1:211034097..211035602-chr11:9405126..9407786,2	MCF-7	breast:
15	chr1:211070734..211072894-chr1:211089401..211091123,2	K562	blood:
16	chr1:211069010..211070968-chr1:211071970..211074084,2	K562	blood:

Variant related genes	Relation type
IPO8P1	TF binding region
ENSG00000224668	chromatin interactions
ENSG00000205339	chromatin interactions

Extended variants
information (count: 1683 )
Associated
traits (count: 93 )

Variant overlapped rSNPs/rCNVs (count:1683 , 50 per page) page: 1 2 3 4 5 6 7 ... 34

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	rs77085882	chr1:211034608-211034609	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
2	rs550679199	chr1:211034620-211034621	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
3	rs56336842	chr1:211034705-211034706	Weak transcription	Chromatin interactive region	1 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
4	rs181920241	chr1:211034724-211034725	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
5	rs554565095	chr1:211034830-211034831	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
6	rs573485044	chr1:211034849-211034850	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
7	rs112014129	chr1:211034860-211034861	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
8	rs559147035	chr1:211034866-211034867	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
9	rs577353136	chr1:211034867-211034868	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
10	rs544722043	chr1:211034913-211034914	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
11	rs550551930	chr1:211034916-211034917	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
12	rs116192614	chr1:211034980-211034981	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
13	rs574560366	chr1:211034982-211034983	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
14	rs541828453	chr1:211035011-211035012	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
15	rs149112617	chr1:211035040-211035041	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
16	rs532029175	chr1:211035041-211035042	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
17	rs546567092	chr1:211035046-211035047	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
18	rs565121808	chr1:211035054-211035055	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
19	rs532184687	chr1:211035057-211035058	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
20	rs550766548	chr1:211035156-211035157	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
21	rs568983567	chr1:211035165-211035166	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
22	rs536307101	chr1:211035213-211035214	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
23	rs372120248	chr1:211035240-211035241	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
24	rs548885294	chr1:211035247-211035248	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
25	rs536857698	chr1:211035267-211035268	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
26	rs144840950	chr1:211035270-211035271	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
27	rs376322133	chr1:211035289-211035290	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
28	rs568884857	chr1:211035296-211035297	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
29	rs534544829	chr1:211035297-211035298	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
30	rs138534910	chr1:211035334-211035335	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
31	rs555166383	chr1:211035359-211035360	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
32	rs80085912	chr1:211035376-211035377	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
33	rs556295426	chr1:211035378-211035379	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
34	rs574592912	chr1:211035394-211035395	Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
35	rs571575973	chr1:211035409-211035410	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
36	rs541914640	chr1:211035411-211035412	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
37	rs61848965	chr1:211035446-211035447	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
38	rs386639038	chr1:211035450-211035451	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
39	rs4951679	chr1:211035452-211035453	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	LD-proxies of rSNP Overlapped rCNV	n/a
40	rs565053671	chr1:211035491-211035492	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
41	rs532402024	chr1:211035503-211035504	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
42	rs544422594	chr1:211035518-211035519	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
43	rs536379289	chr1:211035546-211035547	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
44	rs529857280	chr1:211035555-211035556	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
45	rs548291926	chr1:211035568-211035569	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
46	rs373111352	chr1:211035569-211035570	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
47	rs145226048	chr1:211035581-211035582	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
48	rs377562711	chr1:211035586-211035587	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
49	rs552119173	chr1:211035595-211035596	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a
50	rs571071000	chr1:211035596-211035597	Active TSS ZNF genes & repeats Weak transcription	Chromatin interactive region	1 gene(s)	Overlapped CNVs	n/a

Variant related diseases (count:93)

Disease	PMID	Source
Breast cancer	17603634	CNVD
Esophageal squamous carcinoma	21637470	CNVD
HIV/AIDS	22032296	CNVD
Schizophrenia	19415332	CNVD
Autism	22495311	CNVD
Liposarcoma	21253554	CNVD
Burkitt''s lymphoma	18698080	CNVD
Melanoma	18172304	CNVD
Rett syndrome	21593744	CNVD
Medulloblastoma	21979893	CNVD
Cancer	20164919	CNVD
Acute lymphoblastic leukemia	17443227	CNVD
Wilms tumour	21544195	CNVD
Breast cancer	17133270	CNVD
Non-small cell lung cancer	21044232	CNVD
Cervical cancer	21063398	CNVD
Acute lymphoblastic leukemia	20435627	CNVD
Astrocytoma	17387387	CNVD
Breast cancer	20632083	CNVD
Endometrial cancer	22040021	CNVD
Ewing''s sarcoma	21437220	CNVD
Gastrointestinal stromal cancer	20470368	CNVD
Glioblastoma multiforme	19960244	CNVD
Glioblastoma multiforme	21080181	CNVD
Hepatocellular carcinoma	22174799	CNVD
Medulloblastoma	21292688	CNVD
Phyllodes tumor	17334353	CNVD
Breast cancer	21264507	CNVD
Multiple myeloma	21628407	CNVD
Cancer	16751803	CNVD
Prostate cancer	16705090	CNVD
Neuroblastoma	19435921	CNVD
Breast cancer	17850661	CNVD
Breast cancer	16461572	CNVD
Intracranial tumor	16823260	CNVD
Medulloblastoma	18056178	CNVD
Monoclonal gammopathy of undetermined significance	17077331	CNVD
Primary mediastinal b-cell lymphoma	17728785	CNVD
Colorectal cancer	16272173	CNVD
Acute lymphoblastic leukemia	21098271	CNVD
Neuroblastoma	21899760	CNVD
Glioblastoma multiforme	17002787	CNVD
Breast cancer	21858162	CNVD
Non-small cell lung cancer	21385341	CNVD
Acute lymphoblastic leukemia	21980252	CNVD
Breast cancer	16608533	CNVD
Ewing''s sarcoma	22429812	CNVD
Acute promyelocytic leukemia	19109227	CNVD
Basal cell lymphoma	16317097	CNVD
Diffuse large b-cell lymphoma	16317097	CNVD
Breast cancer	17001317	CNVD
Acute myeloid leukemia	21251322	CNVD
Multiple myeloma	17550852	CNVD
Prostate cancer	18632612	CNVD
Acute myeloid leukemia	20729466	CNVD
Hodgkin''s lymphoma	17606441	CNVD
Testicular germ cell tumor	18059402	CNVD
Ependymoma	18628472	CNVD
Leukemia	18628472	CNVD
Neuroblastoma	18923191	CNVD
Acute lymphoblastic leukemia	19100363	CNVD
Breast cancer	21509527	CNVD
Endometrioid adenocarcinoma	16974079	CNVD
Breast cancer	17393978	CNVD
Hepatocellular carcinoma	16750200	CNVD
Acute lymphoblastic leukemia	22237106	CNVD
Basal cell lymphoma	17170743	CNVD
Follicular lymphoma	17170743	CNVD
Trisomy 5 syndrome	21098271	CNVD
Urothelial carcinoma	21177765	CNVD
Acute lymphoblastic leukemia	20067559	CNVD
Chordoma	18071362	CNVD
Macular degeneration	22558131	CNVD
Alzheimer''s disease	21403675	CNVD
Multiple myeloma	16461302	CNVD
van der Woude syndrome	22470819	CNVD
van der Woude syndrome	20818247	CNVD
T-cell lymphomas	19863542	CNVD
T-cell prolymphocytic leukemia	19278963	CNVD
Cancer	17060936	CNVD
Atypical hemolytic uremic syndrome	19861685	CNVD
Hepatocellular carcinoma	18803288	CNVD
Urothelial tumor	18831757	CNVD
Lung cancer	18438408	CNVD
Ovarian cancer	21720365	CNVD
Breast cancer	21364760	CNVD
small cell lung cancer	20016488	CNVD
Ovarian clear cell carcinoma	19293255	CNVD
Pancreatic ductal adenocarcinoma	19077451	CNVD
Pancreatic cancer	17952125	CNVD
early-passage human iPS cells	21368824	CNVD
Breast cancer	22522925	CNVD
Non-syndromic sensorineural hearing loss	21293372	CNVD

Chromatin state (count:164 , 50 per page) page: 1 2 3 4

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr1:211024800-211035400	Weak transcription	HSMM	muscle
2	chr1:211024800-211046800	Weak transcription	HSMMtube	muscle
3	chr1:211027000-211035400	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
4	chr1:211031400-211035400	Weak transcription	Brain Anterior Caudate	brain
5	chr1:211035400-211035600	Active TSS	Brain Anterior Caudate	brain
6	chr1:211035400-211035600	Active TSS	Esophagus	oesophagus
7	chr1:211035400-211035800	Active TSS	H1 Cell Line	embryonic stem cell
8	chr1:211035400-211035800	Active TSS	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
9	chr1:211035400-211035800	Active TSS	H1 Derived Mesenchymal Stem Cells	ES cell derived
10	chr1:211035400-211035800	Active TSS	H9 Cell Line	embryonic stem cell
11	chr1:211035400-211035800	Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
12	chr1:211035400-211035800	Active TSS	HUES6 Cell Line	embryonic stem cell
13	chr1:211035400-211035800	Active TSS	IMR90 fetal lung fibroblasts Cell Line	lung
14	chr1:211035400-211035800	Active TSS	iPS DF 19.11 Cell Line	embryonic stem cell
15	chr1:211035400-211035800	Active TSS	Primary hematopoietic stem cells short term culture	blood
16	chr1:211035400-211035800	Active TSS	Primary T regulatory cells fromperipheralblood	blood
17	chr1:211035400-211035800	Active TSS	Muscle Satellite Cultured Cells	--
18	chr1:211035400-211035800	Active TSS	Colonic Mucosa	Colon
19	chr1:211035400-211035800	Active TSS	Fetal Muscle Trunk	muscle
20	chr1:211035400-211035800	Active TSS	Fetal Muscle Leg	muscle
21	chr1:211035400-211035800	Active TSS	Fetal Stomach	stomach
22	chr1:211035400-211035800	Active TSS	Gastric	stomach
23	chr1:211035400-211035800	Active TSS	Left Ventricle	heart
24	chr1:211035400-211035800	Active TSS	Ovary	ovary
25	chr1:211035400-211035800	Active TSS	Psoas Muscle	Psoas
26	chr1:211035400-211035800	Active TSS	Skeletal Muscle Female	skeletal muscle
27	chr1:211035400-211035800	Active TSS	Dnd41	blood
28	chr1:211035400-211035800	Active TSS	HepG2	liver
29	chr1:211035400-211035800	Active TSS	HMEC	breast
30	chr1:211035400-211036000	ZNF genes & repeats	HSMM	muscle
31	chr1:211035600-211035800	Flanking Active TSS	Esophagus	oesophagus
32	chr1:211035800-211038200	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
33	chr1:211035800-211038800	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
34	chr1:211036000-211054800	Weak transcription	HSMM	muscle
35	chr1:211039800-211040200	Active TSS	Liver	Liver
36	chr1:211046800-211047600	Enhancers	HSMMtube	muscle
37	chr1:211047200-211047600	Enhancers	A549	lung
38	chr1:211047400-211048000	Enhancers	Muscle Satellite Cultured Cells	--
39	chr1:211047400-211048200	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
40	chr1:211050000-211050400	Active TSS	Pancreatic Islets	Pancreatic Islet
41	chr1:211050400-211050800	Enhancers	Pancreatic Islets	Pancreatic Islet
42	chr1:211054400-211056400	Enhancers	Foreskin Melanocyte Primary Cells skin03	Skin
43	chr1:211054600-211054800	Enhancers	Foreskin Melanocyte Primary Cells skin01	Skin
44	chr1:211054800-211055200	Genic enhancers	HSMM	muscle
45	chr1:211055000-211055600	Enhancers	HSMMtube	muscle
46	chr1:211055200-211055600	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
47	chr1:211055200-211055600	Enhancers	HSMM	muscle
48	chr1:211055200-211055600	Enhancers	Osteobl	bone
49	chr1:211055200-211055800	Enhancers	Muscle Satellite Cultured Cells	--
50	chr1:211055200-211056400	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin

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