Variant report

Variant	rs10104895
Chromosome Location	chr8:61876044-61876045
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr8:61865655..61871190-chr8:61872116..61876156,6	K562	blood:
2	chr8:61873753..61875664-chr8:61875994..61878043,2	MCF-7	breast:

Extended variants
information (count: 19 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:13)

rs_ID	r²[population]
rs10086776	0.87[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs10109249	0.80[ASN][1000 genomes]
rs10110018	0.84[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs11985124	0.85[ASN][1000 genomes]
rs11988513	0.85[ASN][1000 genomes]
rs12335258	0.84[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs28583647	0.98[AMR][1000 genomes];0.88[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs28688155	0.98[AMR][1000 genomes];0.88[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs6987075	0.85[ASN][1000 genomes]
rs6990915	0.85[ASN][1000 genomes]
rs7001966	0.82[ASN][1000 genomes]
rs72652592	0.84[AMR][1000 genomes];0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9692725	0.83[CHD][hapmap]

Variant overlapped rSNPs/rCNVs (count:6 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv526196	chr8:61593569-61877623	Weak transcription Enhancers Strong transcription Flanking Active TSS Genic enhancers Bivalent/Poised TSS ZNF genes & repeats Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	11 gene(s)	inside rSNPs	diseases
2	nsv429919	chr8:61771472-61979873	Enhancers Flanking Active TSS Bivalent Enhancer Weak transcription Active TSS Genic enhancers Strong transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	11 gene(s)	inside rSNPs	diseases
3	nsv890947	chr8:61815886-61882751	Active TSS Weak transcription Bivalent Enhancer Enhancers Bivalent/Poised TSS Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	diseases
4	nsv948922	chr8:61818964-62475097	Enhancers Weak transcription Flanking Bivalent TSS/Enh Active TSS Bivalent Enhancer Strong transcription Flanking Active TSS ZNF genes & repeats Bivalent/Poised TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	17 gene(s)	inside rSNPs	diseases
5	nsv890948	chr8:61844766-61954970	Flanking Active TSS Weak transcription Enhancers Bivalent Enhancer Active TSS ZNF genes & repeats Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
6	esv2764117	chr8:61858213-61879683	Enhancers Flanking Active TSS Weak transcription ZNF genes & repeats Active TSS Genic enhancers Bivalent Enhancer Strong transcription	Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	diseases

Variant related diseases (count:1)

Disease	PMID	Source
Pulmonary function decline	22424883	GWAS catalog

Chromatin state (count:38 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr8:61862800-61879200	Weak transcription	Primary T helper naive cells from peripheral blood	blood
2	chr8:61862800-61879600	Weak transcription	Rectal Mucosa Donor 29	rectum
3	chr8:61864000-61884400	Weak transcription	Primary T cells from cord blood	blood
4	chr8:61868200-61877600	Weak transcription	Primary B cells from peripheral blood	blood
5	chr8:61868200-61878200	Weak transcription	Primary B cells from cord blood	blood
6	chr8:61869200-61879800	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
7	chr8:61869400-61877800	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
8	chr8:61871600-61878800	Weak transcription	GM12878-XiMat	blood
9	chr8:61873600-61878400	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
10	chr8:61873600-61879000	Enhancers	Fetal Muscle Leg	muscle
11	chr8:61873800-61878400	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
12	chr8:61874000-61876600	Enhancers	HUES6 Cell Line	embryonic stem cell
13	chr8:61874200-61876200	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
14	chr8:61874400-61876200	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
15	chr8:61874400-61876600	Weak transcription	Muscle Satellite Cultured Cells	--
16	chr8:61874400-61876800	Weak transcription	Fetal Lung	lung
17	chr8:61874400-61877600	Weak transcription	Brain Hippocampus Middle	brain
18	chr8:61874600-61877800	Weak transcription	Fetal Kidney	kidney
19	chr8:61874600-61883800	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
20	chr8:61875000-61877800	Weak transcription	Ganglion Eminence derived primary cultured neurospheres	brain
21	chr8:61875400-61876400	Enhancers	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
22	chr8:61875600-61876800	Enhancers	HUES64 Cell Line	embryonic stem cell
23	chr8:61875600-61876800	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
24	chr8:61875600-61878000	Enhancers	iPS-18 Cell Line	embryonic stem cell
25	chr8:61875800-61876200	Enhancers	Pancreatic Islets	Pancreatic Islet
26	chr8:61875800-61876600	Enhancers	iPS-20b Cell Line	embryonic stem cell
27	chr8:61875800-61876800	Enhancers	H1 Cell Line	embryonic stem cell
28	chr8:61875800-61876800	Enhancers	HSMM	muscle
29	chr8:61875800-61878200	Enhancers	iPS-15b Cell Line	embryonic stem cell
30	chr8:61875800-61878800	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
31	chr8:61875800-61879800	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
32	chr8:61876000-61876200	Enhancers	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
33	chr8:61876000-61876600	Enhancers	H9 Cell Line	embryonic stem cell
34	chr8:61876000-61876600	Enhancers	HUES48 Cell Line	embryonic stem cell
35	chr8:61876000-61876800	Enhancers	Brain Germinal Matrix	brain
36	chr8:61876000-61876800	Enhancers	Fetal Brain Male	brain
37	chr8:61876000-61877000	Enhancers	ES-I3 Cell Line	embryonic stem cell
38	chr8:61876000-61879000	Enhancers	Fetal Muscle Trunk	muscle

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