Variant report

Variant	rs10459527
Chromosome Location	chr14:24795862-24795863
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr14:24794139..24796164-chr14:24797754..24799865,2	K562	blood:
2	chr14:24789439..24822082-chr14:24898039..24913135,99	MCF-7	breast:
3	chr14:24791358..24808812-chr14:24895309..24913599,55	K562	blood:
4	chr14:24791657..24793644-chr14:24793834..24797111,3	MCF-7	breast:
5	chr14:24781460..24810019-chr14:24892340..24914262,110	MCF-7	breast:

Variant related genes	Relation type
ENSG00000100441	Chromatin interaction
ENSG00000129467	Chromatin interaction
ENSG00000100445	Chromatin interaction
ENSG00000139899	Chromatin interaction

Extended variants
information (count: 17 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:12)

rs_ID	r²[population]
rs1109152	0.81[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs12436194	0.80[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs17184689	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs2295300	0.84[EUR][1000 genomes]
rs2877642	0.83[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs3181251	0.80[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs3212242	0.90[EUR][1000 genomes]
rs3212243	0.90[EUR][1000 genomes]
rs3212260	0.81[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs55970272	0.82[AFR][1000 genomes]
rs8008406	0.86[EUR][1000 genomes]
rs882726	0.81[AMR][1000 genomes];0.95[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:5 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1041336	chr14:24726564-25527319	Weak transcription Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Enhancers Active TSS Strong transcription Flanking Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	107 gene(s)	inside rSNPs	diseases
2	nsv542000	chr14:24726564-25527319	Genic enhancers Enhancers Flanking Bivalent TSS/Enh Weak transcription Active TSS Strong transcription Transcr. at gene 5' and 3' Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	107 gene(s)	inside rSNPs	diseases
3	nsv564059	chr14:24776401-24796813	Strong transcription Genic enhancers Weak transcription Enhancers Flanking Active TSS Bivalent/Poised TSS Bivalent Enhancer Active TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
4	nsv564060	chr14:24776401-24809795	Bivalent Enhancer Flanking Bivalent TSS/Enh Weak transcription Genic enhancers Enhancers Strong transcription Flanking Active TSS Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	30 gene(s)	inside rSNPs	diseases
5	nsv516237	chr14:24793762-24799358	Weak transcription Enhancers Bivalent Enhancer Flanking Active TSS Flanking Bivalent TSS/Enh Genic enhancers Strong transcription Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region	14 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10459527	LTB4R	cis	Thyroid	GTEx

Chromatin state (count:31 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr14:24784600-24796400	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
2	chr14:24784800-24796600	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
3	chr14:24786200-24801600	Weak transcription	Left Ventricle	heart
4	chr14:24787000-24801200	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
5	chr14:24787200-24796400	Weak transcription	Osteobl	bone
6	chr14:24788400-24801000	Weak transcription	Gastric	stomach
7	chr14:24790400-24796400	Weak transcription	Colonic Mucosa	Colon
8	chr14:24791600-24796600	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
9	chr14:24792200-24798200	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
10	chr14:24793400-24796400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
11	chr14:24793400-24796600	Weak transcription	Skeletal Muscle Female	skeletal muscle
12	chr14:24793400-24797400	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
13	chr14:24793600-24796600	Weak transcription	Lung	lung
14	chr14:24793800-24796400	Weak transcription	Spleen	Spleen
15	chr14:24793800-24797200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
16	chr14:24793800-24801000	Weak transcription	Right Ventricle	heart
17	chr14:24794200-24796400	Enhancers	Primary neutrophils fromperipheralblood	blood
18	chr14:24794200-24797200	Weak transcription	Fetal Stomach	stomach
19	chr14:24794400-24796400	Enhancers	Primary hematopoietic stem cells short term culture	blood
20	chr14:24794800-24796400	Weak transcription	Primary hematopoietic stem cells	blood
21	chr14:24794800-24796400	Weak transcription	Skeletal Muscle Male	skeletal muscle
22	chr14:24794800-24801200	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
23	chr14:24794800-24801200	Weak transcription	K562	blood
24	chr14:24795000-24796400	Weak transcription	Fetal Thymus	thymus
25	chr14:24795000-24796400	Enhancers	Monocytes-CD14+_RO01746	blood
26	chr14:24795000-24801200	Enhancers	Primary monocytes fromperipheralblood	blood
27	chr14:24795200-24796400	Weak transcription	Adipose Nuclei	Adipose
28	chr14:24795400-24796600	Weak transcription	Pancreas	Pancrea
29	chr14:24795600-24801600	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
30	chr14:24795800-24797000	Enhancers	Primary B cells from cord blood	blood
31	chr14:24795800-24797000	Enhancers	Fetal Adrenal Gland	Adrenal Gland

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