Variant report

Variant	rs10736657
Chromosome Location	chr11:67081589-67081590
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:0)
CpG islands
(count:0)
Chromatin interactive
region (count:11)
LncRNA
region (count:0)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

No data

(count:11 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr11:67075683..67087551-chr11:67114391..67125856,27	MCF-7	breast:
2	chr11:67053008..67062318-chr11:67075341..67086484,24	K562	blood:
3	chr11:66844181..66847775-chr11:67079244..67082122,3	MCF-7	breast:
4	chr11:67081476..67083003-chr11:67154834..67157081,2	K562	blood:
5	chr11:67063910..67066181-chr11:67080598..67083311,2	K562	blood:
6	chr11:67079164..67081623-chr11:67380659..67383359,2	MCF-7	breast:
7	chr11:66820321..66823025-chr11:67079850..67082744,2	MCF-7	breast:
8	chr11:67080724..67082915-chr11:67083631..67085541,2	K562	blood:
9	chr11:67078342..67081725-chr11:67139517..67143464,5	MCF-7	breast:
10	chr11:67080526..67082690-chr11:67144959..67147019,2	MCF-7	breast:
11	chr11:67077940..67083214-chr11:67140082..67142904,6	MCF-7	breast:

No data

Variant related genes	Relation type
ENSG00000256514	Chromatin interaction
ENSG00000172932	Chromatin interaction
ENSG00000231793	Chromatin interaction
ENSG00000175505	Chromatin interaction
ENSG00000175482	Chromatin interaction

Extended variants
information (count: 49 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:37)

rs_ID	r²[population]
rs10896166	0.85[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs12791853	0.80[AMR][1000 genomes]
rs12805811	0.81[ASN][1000 genomes]
rs1419861	0.85[ASN][1000 genomes]
rs1638569	0.82[ASN][1000 genomes]
rs17878756	0.82[ASN][1000 genomes]
rs17883741	0.82[ASN][1000 genomes]
rs1790731	0.85[ASN][1000 genomes]
rs1790735	0.85[ASN][1000 genomes]
rs1790737	0.82[ASN][1000 genomes]
rs1790738	0.82[ASN][1000 genomes]
rs1790739	0.82[ASN][1000 genomes]
rs1790762	0.85[ASN][1000 genomes]
rs1894112	0.85[ASN][1000 genomes]
rs1944096	0.85[ASN][1000 genomes]
rs2286619	0.82[ASN][1000 genomes]
rs2298815	0.80[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs2429459	0.85[ASN][1000 genomes]
rs2429463	0.85[ASN][1000 genomes]
rs2511057	0.85[ASN][1000 genomes]
rs2514257	0.85[ASN][1000 genomes]
rs2532605	0.85[ASN][1000 genomes]
rs2852875	0.84[ASN][1000 genomes]
rs34087937	0.81[ASN][1000 genomes]
rs35821109	0.82[ASN][1000 genomes]
rs35876769	0.82[ASN][1000 genomes]
rs3737460	0.85[AMR][1000 genomes];0.86[ASN][1000 genomes]
rs4244822	0.90[AMR][1000 genomes];0.81[ASN][1000 genomes]
rs61734600	0.82[ASN][1000 genomes]
rs6591241	0.85[AMR][1000 genomes]
rs66466718	0.85[AMR][1000 genomes]
rs71457775	0.82[ASN][1000 genomes]
rs7394531	0.82[ASN][1000 genomes]
rs7934433	0.90[AMR][1000 genomes];0.86[ASN][1000 genomes]
rs867193	0.82[ASN][1000 genomes]
rs9326373	0.81[ASN][1000 genomes]
rs9734588	0.85[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:12 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv531397	chr11:66653381-67465721	Active TSS Enhancers Strong transcription Flanking Active TSS Weak transcription Transcr. at gene 5' and 3' Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	271 gene(s)	inside rSNPs	diseases
2	nsv933183	chr11:67008447-67160993	Flanking Active TSS Weak transcription Enhancers Transcr. at gene 5' and 3' Strong transcription Genic enhancers Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	88 gene(s)	inside rSNPs	diseases
3	nsv897796	chr11:67021518-67186000	Weak transcription Strong transcription Active TSS Flanking Active TSS Enhancers ZNF genes & repeats Transcr. at gene 5' and 3' Genic enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	103 gene(s)	inside rSNPs	diseases
4	nsv897797	chr11:67023040-67293234	Flanking Active TSS Strong transcription Enhancers Active TSS Weak transcription Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	206 gene(s)	inside rSNPs	diseases
5	nsv897800	chr11:67024534-67086298	Enhancers Weak transcription Flanking Active TSS Genic enhancers Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Strong transcription Bivalent Enhancer ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	50 gene(s)	inside rSNPs	diseases
6	nsv1043037	chr11:67027193-67357425	Enhancers Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Flanking Active TSS Strong transcription Genic enhancers Active TSS ZNF genes & repeats Weak transcription Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	213 gene(s)	inside rSNPs	diseases
7	nsv468603	chr11:67033076-67164495	Enhancers Weak transcription Genic enhancers Strong transcription Flanking Active TSS Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	85 gene(s)	inside rSNPs	diseases
8	nsv555253	chr11:67033076-67164495	Weak transcription Strong transcription Flanking Active TSS Genic enhancers Enhancers Active TSS Bivalent/Poised TSS Bivalent Enhancer Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	85 gene(s)	inside rSNPs	diseases
9	nsv897801	chr11:67033076-67432479	Bivalent Enhancer Enhancers Weak transcription Strong transcription Flanking Active TSS Genic enhancers Active TSS ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	236 gene(s)	inside rSNPs	diseases
10	nsv1047890	chr11:67058231-67184436	Flanking Active TSS Enhancers Strong transcription Genic enhancers Weak transcription Bivalent Enhancer Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS Active TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	88 gene(s)	inside rSNPs	diseases
11	nsv1048230	chr11:67058231-67252397	Active TSS Enhancers Weak transcription Flanking Active TSS Genic enhancers Strong transcription Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent Enhancer ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	146 gene(s)	inside rSNPs	diseases
12	nsv897803	chr11:67067075-67084761	Active TSS Strong transcription Weak transcription Enhancers Flanking Active TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	32 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10736657	RPS6KB2	cis	brain	BrainEAC

Chromatin state (count:108 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:67070200-67084400	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
2	chr11:67070400-67083800	Weak transcription	Dnd41	blood
3	chr11:67071800-67084400	Weak transcription	Fetal Kidney	kidney
4	chr11:67072000-67084000	Weak transcription	HUVEC	blood vessel
5	chr11:67072200-67084000	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
6	chr11:67072200-67084000	Weak transcription	Brain Germinal Matrix	brain
7	chr11:67072200-67084400	Weak transcription	Fetal Brain Female	brain
8	chr11:67072400-67084400	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
9	chr11:67072400-67084400	Weak transcription	HSMMtube	muscle
10	chr11:67072400-67084400	Weak transcription	NHDF-Ad	bronchial
11	chr11:67072400-67084600	Weak transcription	Small Intestine	intestine
12	chr11:67073400-67084400	Weak transcription	H1 Cell Line	embryonic stem cell
13	chr11:67075800-67084400	Weak transcription	Rectal Smooth Muscle	rectum
14	chr11:67076400-67084400	Weak transcription	Duodenum Smooth Muscle	Duodenum
15	chr11:67077000-67082000	Enhancers	HMEC	breast
16	chr11:67077000-67084400	Weak transcription	Thymus	Thymus
17	chr11:67077200-67082000	Enhancers	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
18	chr11:67077400-67084200	Weak transcription	H9 Cell Line	embryonic stem cell
19	chr11:67077400-67084400	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
20	chr11:67077400-67084400	Weak transcription	Brain Angular Gyrus	brain
21	chr11:67077600-67084000	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
22	chr11:67077600-67084000	Weak transcription	Osteobl	bone
23	chr11:67077800-67083200	Enhancers	Breast Myoepithelial Primary Cells	Breast
24	chr11:67077800-67084200	Weak transcription	Cortex derived primary cultured neurospheres	brain
25	chr11:67078000-67084000	Weak transcription	A549	lung
26	chr11:67078200-67082200	Enhancers	Stomach Mucosa	stomach
27	chr11:67078200-67084400	Weak transcription	Left Ventricle	heart
28	chr11:67078400-67081600	Enhancers	Placenta Amnion	Placenta Amnion
29	chr11:67078400-67082000	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
30	chr11:67078400-67082000	Enhancers	Primary T helper naive cells from peripheral blood	blood
31	chr11:67078400-67082000	Enhancers	Primary T helper cells fromperipheralblood	blood
32	chr11:67078400-67082400	Enhancers	Primary T cells fromperipheralblood	blood
33	chr11:67078400-67084400	Weak transcription	Brain Substantia Nigra	brain
34	chr11:67078600-67084400	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
35	chr11:67078600-67084400	Weak transcription	Fetal Lung	lung
36	chr11:67078600-67084400	Weak transcription	NHLF	lung
37	chr11:67078800-67084000	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
38	chr11:67078800-67084400	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
39	chr11:67078800-67084400	Weak transcription	Brain Cingulate Gyrus	brain
40	chr11:67078800-67084400	Weak transcription	Colon Smooth Muscle	Colon
41	chr11:67078800-67084400	Weak transcription	Ovary	ovary
42	chr11:67079000-67082000	Enhancers	Primary T helper naive cells fromperipheralblood	blood
43	chr11:67079000-67084400	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
44	chr11:67079200-67084200	Weak transcription	Foreskin Melanocyte Primary Cells skin03	Skin
45	chr11:67079200-67084400	Weak transcription	Muscle Satellite Cultured Cells	--
46	chr11:67079200-67084400	Weak transcription	Brain Inferior Temporal Lobe	brain
47	chr11:67079200-67084400	Weak transcription	Skeletal Muscle Male	skeletal muscle
48	chr11:67079200-67084400	Weak transcription	Skeletal Muscle Female	skeletal muscle
49	chr11:67079400-67081800	Enhancers	Rectal Mucosa Donor 29	rectum
50	chr11:67079400-67084000	Weak transcription	Fetal Muscle Leg	muscle

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