Variant report

Variant	rs10915837
Chromosome Location	chr1:225664596-225664597
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr1:225664099..225665880-chr1:226167899..226170601,2	K562	blood:
2	chr1:225661061..225665257-chr1:226163112..226166318,3	K562	blood:
3	chr1:225662746..225665144-chr1:225672666..225674544,2	MCF-7	breast:
4	chr1:225664480..225667161-chr1:225903900..225905865,2	K562	blood:

Extended variants
information (count: 52 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:45)

rs_ID	r²[population]
rs10753406	0.81[ASN][1000 genomes]
rs10799313	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10799314	0.84[AFR][1000 genomes];0.86[ASN][1000 genomes]
rs10799315	0.87[AFR][1000 genomes];0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs10799316	0.86[AFR][1000 genomes];0.94[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10799317	0.92[AFR][1000 genomes];0.82[AMR][1000 genomes];0.91[ASN][1000 genomes]
rs10799318	0.91[AFR][1000 genomes];0.90[ASN][1000 genomes]
rs10799319	0.85[ASN][1000 genomes]
rs10915833	0.89[AFR][1000 genomes];0.82[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs10915835	0.99[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10915838	0.92[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs10915839	0.89[AFR][1000 genomes];0.92[ASN][1000 genomes]
rs10915847	0.81[ASN][1000 genomes]
rs11584675	0.91[AFR][1000 genomes];0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs12028305	0.84[ASN][1000 genomes]
rs1222440	0.99[AMR][1000 genomes];0.94[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs12729655	0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs3820226	0.85[ASN][1000 genomes]
rs4653643	0.87[ASN][1000 genomes]
rs487591	0.80[ASN][1000 genomes]
rs498350	0.81[ASN][1000 genomes]
rs510293	0.81[ASN][1000 genomes]
rs511649	0.81[ASN][1000 genomes]
rs516249	0.81[ASN][1000 genomes]
rs551996	0.81[ASN][1000 genomes]
rs554744	0.81[ASN][1000 genomes]
rs554992	0.81[ASN][1000 genomes]
rs561656	0.81[ASN][1000 genomes]
rs6426076	0.91[AFR][1000 genomes];0.82[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs6426077	0.92[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs6426078	0.95[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs6668770	0.97[AFR][1000 genomes];0.82[AMR][1000 genomes];0.91[ASN][1000 genomes]
rs6676201	0.99[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6678806	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs6702555	0.92[AFR][1000 genomes];0.89[ASN][1000 genomes]
rs6751	0.87[ASN][1000 genomes]
rs712062	0.81[ASN][1000 genomes]
rs7515907	0.91[AFR][1000 genomes];0.82[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs7515963	0.99[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7524766	0.84[AFR][1000 genomes];0.80[AMR][1000 genomes];0.91[ASN][1000 genomes]
rs7540181	0.81[ASN][1000 genomes]
rs7541598	0.91[AFR][1000 genomes];0.82[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs7555139	0.84[ASN][1000 genomes]
rs7555553	0.90[AFR][1000 genomes];0.82[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs9804142	0.92[AFR][1000 genomes];0.86[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:7 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv832714	chr1:225592333-225805396	Enhancers Flanking Active TSS Weak transcription ZNF genes & repeats Strong transcription Genic enhancers Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	20 gene(s)	inside rSNPs	diseases
2	nsv1004851	chr1:225614140-225684184	Enhancers Weak transcription Bivalent Enhancer Flanking Active TSS Active TSS Strong transcription ZNF genes & repeats Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
3	esv34905	chr1:225631404-225676582	Flanking Active TSS Enhancers Weak transcription Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats Strong transcription Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	17 gene(s)	inside rSNPs	diseases
4	nsv873227	chr1:225656388-225687981	Enhancers Weak transcription Strong transcription Bivalent Enhancer Flanking Active TSS Genic enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	10 gene(s)	inside rSNPs	diseases
5	nsv8880	chr1:225656408-225687710	Enhancers Strong transcription Weak transcription Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Active TSS Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	10 gene(s)	inside rSNPs	diseases
6	nsv826842	chr1:225658062-225686586	Enhancers Weak transcription Flanking Active TSS Strong transcription Active TSS Bivalent/Poised TSS Bivalent Enhancer Genic enhancers Flanking Bivalent TSS/Enh	Chromatin interactive region lncRNA miRNA target site	9 gene(s)	inside rSNPs	diseases
7	nsv441740	chr1:225659217-225684196	Flanking Active TSS Enhancers Strong transcription Bivalent Enhancer Weak transcription Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers	Chromatin interactive region lncRNA miRNA target site	9 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10915837	LBR	cis	Artery Tibial	GTEx

Chromatin state (count:64 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr1:225655600-225677000	Weak transcription	Right Atrium	heart
2	chr1:225660600-225666200	Enhancers	Primary T helper 17 cells PMA-I stimulated	--
3	chr1:225660800-225666200	Enhancers	Primary T cells fromperipheralblood	blood
4	chr1:225660800-225666200	Enhancers	Primary T killer naive cells fromperipheralblood	blood
5	chr1:225660800-225666800	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
6	chr1:225661000-225666200	Enhancers	Primary T helper cells PMA-I stimulated	--
7	chr1:225661000-225666200	Enhancers	Fetal Thymus	thymus
8	chr1:225662000-225667000	Enhancers	Primary T killer memory cells from peripheral blood	blood
9	chr1:225662200-225671800	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
10	chr1:225662400-225665000	Enhancers	Colon Smooth Muscle	Colon
11	chr1:225662600-225671800	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
12	chr1:225663000-225665400	Weak transcription	Primary hematopoietic stem cells short term culture	blood
13	chr1:225663200-225665000	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
14	chr1:225663200-225665200	Weak transcription	Primary T regulatory cells fromperipheralblood	blood
15	chr1:225663200-225665400	Weak transcription	Fetal Muscle Leg	muscle
16	chr1:225663200-225665400	Weak transcription	NHEK	skin
17	chr1:225663200-225665600	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
18	chr1:225663200-225665600	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
19	chr1:225663200-225665600	Weak transcription	Primary monocytes fromperipheralblood	blood
20	chr1:225663200-225665600	Weak transcription	Primary hematopoietic stem cells	blood
21	chr1:225663200-225665600	Weak transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
22	chr1:225663200-225665600	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
23	chr1:225663200-225665600	Weak transcription	Fetal Stomach	stomach
24	chr1:225663200-225665600	Weak transcription	Spleen	Spleen
25	chr1:225663200-225665600	Weak transcription	Monocytes-CD14+_RO01746	blood
26	chr1:225663200-225665800	Weak transcription	HSMMtube	muscle
27	chr1:225663200-225666200	Enhancers	Primary T helper naive cells fromperipheralblood	blood
28	chr1:225663200-225668600	Weak transcription	Fetal Intestine Large	intestine
29	chr1:225663200-225668600	Weak transcription	Pancreas	Pancrea
30	chr1:225663200-225668600	Weak transcription	Stomach Mucosa	stomach
31	chr1:225663200-225668800	Weak transcription	Rectal Mucosa Donor 29	rectum
32	chr1:225663200-225668800	Weak transcription	Rectal Mucosa Donor 31	rectum
33	chr1:225663200-225669800	Weak transcription	Ovary	ovary
34	chr1:225663200-225670200	Weak transcription	Osteobl	bone
35	chr1:225663200-225683800	Weak transcription	HUES6 Cell Line	embryonic stem cell
36	chr1:225663200-225686400	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
37	chr1:225663200-225696400	Weak transcription	Duodenum Smooth Muscle	Duodenum
38	chr1:225663400-225665200	Weak transcription	Primary B cells from cord blood	blood
39	chr1:225663400-225665200	Weak transcription	HMEC	breast
40	chr1:225663400-225665400	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
41	chr1:225663400-225665400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
42	chr1:225663400-225665400	Weak transcription	Esophagus	oesophagus
43	chr1:225663400-225665400	Weak transcription	Fetal Muscle Trunk	muscle
44	chr1:225663400-225665400	Weak transcription	Placenta	Placenta
45	chr1:225663400-225665600	Weak transcription	Breast Myoepithelial Primary Cells	Breast
46	chr1:225663400-225665600	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
47	chr1:225663400-225667400	Weak transcription	Fetal Brain Male	brain
48	chr1:225663400-225668400	Weak transcription	Duodenum Mucosa	Duodenum
49	chr1:225663400-225668800	Weak transcription	Brain Germinal Matrix	brain
50	chr1:225663400-225668800	Weak transcription	Fetal Brain Female	brain

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