Variant report

Variant	rs10945749
Chromosome Location	chr6:161828535-161828536
allele	C/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr6:161827499..161830369-chr6:161855859..161857703,2	MCF-7	breast:
2	chr6:161826891..161829319-chr6:161893488..161895593,2	K562	blood:
3	chr6:161827498..161831035-chr6:161833776..161838096,4	K562	blood:

Extended variants
information (count: 34 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:10)

rs_ID	r²[population]
rs10945748	0.90[CEU][hapmap]
rs10945750	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs12196495	0.82[ASN][1000 genomes]
rs12197865	0.93[ASN][1000 genomes]
rs12215039	0.87[ASN][1000 genomes]
rs17560782	0.80[AMR][1000 genomes]
rs35757923	0.80[ASN][1000 genomes]
rs4533970	1.00[CHB][hapmap]
rs62435931	0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs62435937	0.87[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:24 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv886817	chr6:161371621-161846654	Strong transcription Enhancers Weak transcription Genic enhancers Active TSS ZNF genes & repeats Bivalent/Poised TSS Flanking Active TSS Bivalent Enhancer Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	7 gene(s)	inside rSNPs	diseases
2	esv3381361	chr6:161373617-161864101	Weak transcription Enhancers Genic enhancers Strong transcription Flanking Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Active TSS Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	8 gene(s)	inside rSNPs	diseases
3	esv2752091	chr6:161592100-161855785	Weak transcription Enhancers ZNF genes & repeats Flanking Active TSS Strong transcription Bivalent Enhancer Bivalent/Poised TSS Active TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region	5 gene(s)	inside rSNPs	diseases
4	nsv481931	chr6:161647026-161961906	Weak transcription Enhancers Genic enhancers Active TSS Flanking Active TSS ZNF genes & repeats Strong transcription Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region	5 gene(s)	inside rSNPs	diseases
5	nsv1031234	chr6:161676768-162250726	Enhancers ZNF genes & repeats Weak transcription Active TSS Bivalent Enhancer Strong transcription Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
6	nsv1025168	chr6:161702621-161831885	Weak transcription Enhancers Flanking Active TSS Active TSS ZNF genes & repeats Bivalent Enhancer Genic enhancers Strong transcription	Chromatin interactive region	2 gene(s)	inside rSNPs	diseases
7	nsv886819	chr6:161712035-162520133	Enhancers Flanking Active TSS Active TSS Weak transcription Bivalent Enhancer ZNF genes & repeats Strong transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	4 gene(s)	inside rSNPs	diseases
8	nsv886820	chr6:161712880-162184932	Flanking Active TSS Enhancers ZNF genes & repeats Weak transcription Active TSS Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	4 gene(s)	inside rSNPs	diseases
9	nsv830854	chr6:161739926-161927515	Weak transcription Enhancers Flanking Active TSS Bivalent Enhancer Active TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Strong transcription Genic enhancers Bivalent/Poised TSS	Chromatin interactive region	3 gene(s)	inside rSNPs	diseases
10	nsv518931	chr6:161793319-162406335	Enhancers Weak transcription Genic enhancers Flanking Active TSS Bivalent Enhancer Active TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent/Poised TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	diseases
11	nsv481861	chr6:161802883-162160197	Enhancers Weak transcription Flanking Active TSS Active TSS Bivalent Enhancer ZNF genes & repeats Strong transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	diseases
12	nsv1033192	chr6:161812419-161860010	Flanking Active TSS Enhancers Weak transcription Active TSS Bivalent Enhancer ZNF genes & repeats Flanking Bivalent TSS/Enh	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
13	nsv886821	chr6:161812626-161859628	Enhancers Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent Enhancer ZNF genes & repeats	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
14	nsv1024921	chr6:161814295-161860636	Enhancers Weak transcription Flanking Active TSS Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
15	esv2761040	chr6:161814307-161860636	Weak transcription Enhancers Active TSS Flanking Active TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent Enhancer	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
16	nsv520078	chr6:161814907-161860010	Enhancers Flanking Active TSS Weak transcription Active TSS Bivalent Enhancer ZNF genes & repeats Flanking Bivalent TSS/Enh	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
17	nsv605066	chr6:161814907-161860010	Weak transcription Enhancers Active TSS Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer ZNF genes & repeats	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
18	nsv481930	chr6:161815297-161860058	Weak transcription Enhancers Active TSS Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
19	nsv605067	chr6:161816660-161860010	Weak transcription Flanking Active TSS Enhancers Active TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent Enhancer	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
20	nsv1022345	chr6:161816661-161860010	Weak transcription Enhancers Active TSS Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
21	nsv1018065	chr6:161816661-161860169	Enhancers ZNF genes & repeats Flanking Active TSS Weak transcription Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
22	nsv1018466	chr6:161816661-161860636	Weak transcription Flanking Active TSS Active TSS Enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
23	nsv605068	chr6:161817168-161860010	Enhancers ZNF genes & repeats Weak transcription Active TSS Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases
24	nsv1023319	chr6:161817703-161860636	Weak transcription ZNF genes & repeats Active TSS Bivalent Enhancer Enhancers Flanking Bivalent TSS/Enh Flanking Active TSS	Chromatin interactive region	1 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10945749	PXN	trans	lymphoblastoid	RTeQTL

Chromatin state (count:45 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr6:161780600-161835800	Weak transcription	Right Atrium	heart
2	chr6:161818000-161828600	Weak transcription	Pancreas	Pancrea
3	chr6:161821800-161834000	Weak transcription	Fetal Muscle Trunk	muscle
4	chr6:161823600-161829000	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
5	chr6:161826800-161829200	Enhancers	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
6	chr6:161826800-161829200	Enhancers	HMEC	breast
7	chr6:161826800-161829400	Enhancers	NHDF-Ad	bronchial
8	chr6:161826800-161829400	Enhancers	NHLF	lung
9	chr6:161826800-161831000	Enhancers	Muscle Satellite Cultured Cells	--
10	chr6:161827000-161828800	Enhancers	Foreskin Keratinocyte Primary Cells skin03	Skin
11	chr6:161827000-161829800	Enhancers	HSMMtube	muscle
12	chr6:161827200-161828800	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
13	chr6:161827200-161829000	Enhancers	NHEK	skin
14	chr6:161827400-161829200	Enhancers	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
15	chr6:161827400-161829200	Enhancers	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
16	chr6:161827400-161829200	Enhancers	Foreskin Melanocyte Primary Cells skin03	Skin
17	chr6:161827400-161829400	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
18	chr6:161827400-161829400	Enhancers	NH-A	brain
19	chr6:161827400-161829400	Enhancers	Osteobl	bone
20	chr6:161827600-161828800	Enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
21	chr6:161827600-161828800	Enhancers	Foreskin Melanocyte Primary Cells skin01	Skin
22	chr6:161827600-161828800	Enhancers	Adipose Nuclei	Adipose
23	chr6:161827600-161828800	Enhancers	Brain Hippocampus Middle	brain
24	chr6:161827600-161829000	Enhancers	Brain Inferior Temporal Lobe	brain
25	chr6:161827600-161829200	Enhancers	GM12878-XiMat	blood
26	chr6:161827600-161829800	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
27	chr6:161827600-161829800	Enhancers	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
28	chr6:161827600-161829800	Enhancers	Foreskin Fibroblast Primary Cells skin01	Skin
29	chr6:161827600-161831400	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
30	chr6:161827600-161831400	Enhancers	Fetal Muscle Leg	muscle
31	chr6:161827800-161828800	Enhancers	H1 Derived Mesenchymal Stem Cells	ES cell derived
32	chr6:161827800-161828800	Enhancers	Ganglion Eminence derived primary cultured neurospheres	brain
33	chr6:161827800-161828800	Enhancers	Brain Cingulate Gyrus	brain
34	chr6:161827800-161829200	Enhancers	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
35	chr6:161827800-161829200	Enhancers	Skeletal Muscle Male	skeletal muscle
36	chr6:161827800-161829600	Weak transcription	A549	lung
37	chr6:161828000-161828600	Weak transcription	Psoas Muscle	Psoas
38	chr6:161828200-161828600	Enhancers	Cortex derived primary cultured neurospheres	brain
39	chr6:161828200-161828600	Weak transcription	Skeletal Muscle Female	skeletal muscle
40	chr6:161828200-161828800	Enhancers	Foreskin Keratinocyte Primary Cells skin02	Skin
41	chr6:161828400-161828600	Enhancers	Fetal Brain Male	brain
42	chr6:161828400-161828600	Flanking Active TSS	HSMM	muscle
43	chr6:161828400-161828800	Enhancers	Brain Substantia Nigra	brain
44	chr6:161828400-161828800	Flanking Active TSS	K562	blood
45	chr6:161828400-161829400	Enhancers	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived

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