Variant report

Variant	rs11227699
Chromosome Location	chr11:66898492-66898493
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr11:66888331..66890567-chr11:66897930..66899479,2	MCF-7	breast:
2	chr11:66896524..66901223-chr11:66901384..66904536,5	K562	blood:
3	chr11:66884732..66891772-chr11:66894798..66900811,8	K562	blood:

Variant related genes	Relation type
ENSG00000173120	Chromatin interaction

Extended variants
information (count: 18 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:16)

rs_ID	r²[population]
rs10732253	1.00[GIH][hapmap]
rs12420556	0.90[MEX][hapmap]
rs12421536	0.90[MEX][hapmap]
rs1253784	1.00[GIH][hapmap]
rs1574103	0.89[MEX][hapmap]
rs28589383	0.90[EUR][1000 genomes]
rs3741189	1.00[GIH][hapmap]
rs3825022	1.00[GIH][hapmap]
rs4457752	1.00[GIH][hapmap]
rs4930415	0.90[MEX][hapmap]
rs645387	1.00[GIH][hapmap]
rs682509	1.00[GIH][hapmap]
rs7396248	0.84[MEX][hapmap]
rs7937611	1.00[GIH][hapmap]
rs7941655	0.85[CEU][hapmap];0.90[JPT][hapmap]
rs887315	0.90[MEX][hapmap]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv531397	chr11:66653381-67465721	Active TSS Enhancers Strong transcription Flanking Active TSS Weak transcription Transcr. at gene 5' and 3' Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	271 gene(s)	inside rSNPs	diseases
2	nsv532287	chr11:66784014-67023899	Weak transcription Strong transcription Bivalent Enhancer Enhancers Flanking Active TSS Active TSS Transcr. at gene 5' and 3' Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	48 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs11227699	RPS6KB2	cis	lymphoblastoid	seeQTL

Chromatin state (count:125 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:66887800-66899600	Weak transcription	Spleen	Spleen
2	chr11:66888600-66922600	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
3	chr11:66888800-66898600	Weak transcription	Gastric	stomach
4	chr11:66888800-66902200	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
5	chr11:66888800-66907400	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
6	chr11:66889000-66899400	Weak transcription	H9 Cell Line	embryonic stem cell
7	chr11:66889000-66900000	Weak transcription	Placenta Amnion	Placenta Amnion
8	chr11:66889000-66901800	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
9	chr11:66889000-66920400	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
10	chr11:66889200-66899200	Weak transcription	iPS-18 Cell Line	embryonic stem cell
11	chr11:66889200-66901600	Weak transcription	ES-I3 Cell Line	embryonic stem cell
12	chr11:66889600-66899200	Weak transcription	NHDF-Ad	bronchial
13	chr11:66889600-66899400	Weak transcription	H1 Cell Line	embryonic stem cell
14	chr11:66889600-66899800	Weak transcription	Colonic Mucosa	Colon
15	chr11:66889800-66899200	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
16	chr11:66889800-66899200	Weak transcription	Brain Hippocampus Middle	brain
17	chr11:66889800-66900000	Weak transcription	Rectal Smooth Muscle	rectum
18	chr11:66889800-66901400	Weak transcription	A549	lung
19	chr11:66889800-66902000	Weak transcription	HUVEC	blood vessel
20	chr11:66889800-66902200	Weak transcription	Aorta	Aorta
21	chr11:66889800-66902400	Weak transcription	iPS-15b Cell Line	embryonic stem cell
22	chr11:66889800-66903800	Weak transcription	Pancreatic Islets	Pancreatic Islet
23	chr11:66889800-66923400	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
24	chr11:66890000-66898800	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
25	chr11:66890000-66901400	Weak transcription	Brain Cingulate Gyrus	brain
26	chr11:66890000-66901600	Weak transcription	HSMMtube	muscle
27	chr11:66890000-66908400	Strong transcription	Fetal Stomach	stomach
28	chr11:66890000-66912800	Weak transcription	Psoas Muscle	Psoas
29	chr11:66890200-66899600	Weak transcription	Ovary	ovary
30	chr11:66890200-66920000	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
31	chr11:66890400-66909400	Strong transcription	Fetal Muscle Trunk	muscle
32	chr11:66890800-66900200	Weak transcription	Fetal Brain Male	brain
33	chr11:66890800-66912600	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
34	chr11:66890800-66923000	Strong transcription	Fetal Thymus	thymus
35	chr11:66891200-66900200	Weak transcription	Brain Angular Gyrus	brain
36	chr11:66891200-66901400	Weak transcription	Skeletal Muscle Male	skeletal muscle
37	chr11:66891400-66899000	Weak transcription	Left Ventricle	heart
38	chr11:66891400-66899400	Weak transcription	Brain Anterior Caudate	brain
39	chr11:66891400-66899400	Weak transcription	Stomach Smooth Muscle	stomach
40	chr11:66891400-66899800	Weak transcription	Esophagus	oesophagus
41	chr11:66891400-66900000	Strong transcription	Primary B cells from peripheral blood	blood
42	chr11:66891400-66901200	Weak transcription	Pancreas	Pancrea
43	chr11:66891400-66903200	Weak transcription	Fetal Heart	heart
44	chr11:66891400-66908800	Strong transcription	Fetal Muscle Leg	muscle
45	chr11:66892200-66908600	Strong transcription	HUES6 Cell Line	embryonic stem cell
46	chr11:66892400-66904400	Strong transcription	Thymus	Thymus
47	chr11:66892600-66914000	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
48	chr11:66892800-66911800	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
49	chr11:66892800-66912600	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
50	chr11:66892800-66913000	Strong transcription	Primary hematopoietic stem cells short term culture	blood

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