Variant report

Variant	rs4394298
Chromosome Location	chr7:21981091-21981092
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr7:21980188..21982336-chr7:21983683..21985760,3	MCF-7	breast:

Variant related genes	Relation type
ENSG00000164649	Chromatin interaction

Extended variants
information (count: 11 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:8)

rs_ID	r²[population]
rs10262937	0.80[CEU][hapmap];0.90[CHB][hapmap];0.93[CHD][hapmap];0.97[GIH][hapmap];1.00[JPT][hapmap];0.88[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs12669549	0.88[EUR][1000 genomes]
rs12700337	0.90[CEU][hapmap];0.95[CHB][hapmap];0.88[CHD][hapmap];0.97[GIH][hapmap];0.95[JPT][hapmap];0.80[MKK][hapmap];0.91[TSI][hapmap];0.89[AMR][1000 genomes];0.96[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs55681513	0.89[EUR][1000 genomes]
rs6461623	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs6946675	1.00[GIH][hapmap];1.00[MEX][hapmap];1.00[TSI][hapmap];0.91[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs6978094	0.81[TSI][hapmap]
rs9638794	0.82[AMR][1000 genomes];0.95[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:3 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1018133	chr7:21740118-22055283	Active TSS Enhancers Strong transcription Weak transcription Flanking Active TSS Genic enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	22 gene(s)	inside rSNPs	diseases
2	nsv1027453	chr7:21918474-21982448	Enhancers Flanking Active TSS Genic enhancers Strong transcription Weak transcription Active TSS ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region miRNA target site	2 gene(s)	inside rSNPs	diseases
3	nsv870325	chr7:21979039-22120493	Bivalent Enhancer Enhancers Flanking Active TSS Active TSS Weak transcription Bivalent/Poised TSS Genic enhancers Flanking Bivalent TSS/Enh Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	20 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs4394298	IL6	cis	cerebellum	SCAN

Chromatin state (count:95 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr7:21938600-21984000	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
2	chr7:21951600-21982600	Weak transcription	HSMM	muscle
3	chr7:21956600-21983600	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
4	chr7:21963600-21983600	Weak transcription	Ovary	ovary
5	chr7:21965200-21982400	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
6	chr7:21967800-21982000	Weak transcription	Fetal Stomach	stomach
7	chr7:21973200-21981200	Enhancers	Primary neutrophils fromperipheralblood	blood
8	chr7:21973200-21984200	Weak transcription	Esophagus	oesophagus
9	chr7:21975800-21982600	Weak transcription	Primary T cells fromperipheralblood	blood
10	chr7:21976200-21982400	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
11	chr7:21976400-21982400	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
12	chr7:21976800-21984000	Weak transcription	Adipose Nuclei	Adipose
13	chr7:21977200-21982400	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
14	chr7:21977600-21983400	Weak transcription	Fetal Intestine Small	intestine
15	chr7:21978400-21982400	Enhancers	Primary B cells from peripheral blood	blood
16	chr7:21978400-21984000	Enhancers	Primary T helper cells PMA-I stimulated	--
17	chr7:21978600-21981800	Enhancers	iPS-15b Cell Line	embryonic stem cell
18	chr7:21978600-21983400	Enhancers	Colon Smooth Muscle	Colon
19	chr7:21978600-21983400	Enhancers	HUVEC	blood vessel
20	chr7:21978800-21981200	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
21	chr7:21978800-21981200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
22	chr7:21978800-21982800	Enhancers	ES-I3 Cell Line	embryonic stem cell
23	chr7:21979200-21981400	Enhancers	Primary T cells from cord blood	blood
24	chr7:21979200-21981800	Enhancers	Gastric	stomach
25	chr7:21979200-21983200	Enhancers	H1 Cell Line	embryonic stem cell
26	chr7:21979200-21984000	Enhancers	Breast Myoepithelial Primary Cells	Breast
27	chr7:21979400-21982800	Weak transcription	HSMMtube	muscle
28	chr7:21979400-21983000	Weak transcription	NHLF	lung
29	chr7:21979400-21984200	Weak transcription	Skeletal Muscle Male	skeletal muscle
30	chr7:21979600-21981800	Enhancers	H9 Cell Line	embryonic stem cell
31	chr7:21979600-21982600	Weak transcription	NH-A	brain
32	chr7:21979800-21981200	Weak transcription	Fetal Lung	lung
33	chr7:21979800-21981800	Enhancers	Fetal Heart	heart
34	chr7:21979800-21982600	Enhancers	Foreskin Keratinocyte Primary Cells skin03	Skin
35	chr7:21979800-21983600	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
36	chr7:21979800-21984000	Weak transcription	Fetal Kidney	kidney
37	chr7:21980000-21981600	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
38	chr7:21980200-21981600	Enhancers	Foreskin Fibroblast Primary Cells skin01	Skin
39	chr7:21980200-21984000	Weak transcription	Skeletal Muscle Female	skeletal muscle
40	chr7:21980400-21981200	Enhancers	Primary hematopoietic stem cells	blood
41	chr7:21980400-21981200	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
42	chr7:21980400-21981200	Weak transcription	Left Ventricle	heart
43	chr7:21980400-21981200	Weak transcription	Pancreas	Pancrea
44	chr7:21980400-21981200	Enhancers	Placenta Amnion	Placenta Amnion
45	chr7:21980400-21981200	Weak transcription	Right Ventricle	heart
46	chr7:21980400-21981200	Enhancers	Thymus	Thymus
47	chr7:21980400-21981800	Weak transcription	Primary T regulatory cells fromperipheralblood	blood
48	chr7:21980400-21982400	Enhancers	Brain Anterior Caudate	brain
49	chr7:21980400-21982400	Enhancers	Stomach Smooth Muscle	stomach
50	chr7:21980400-21982600	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived

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