Variant report

Variant	rs607146
Chromosome Location	chr11:94238274-94238275
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr11:94058573..94059789-chr11:94237428..94238328,4	K562	blood:
2	chr11:94058769..94059489-chr11:94237596..94238568,2	MCF-7	breast:
3	chr11:93904956..93905513-chr11:94237606..94238533,2	K562	blood:
4	chr11:93628315..93628898-chr11:94237624..94238351,2	MCF-7	breast:

Extended variants
information (count: 21 )
Associated
traits (count: 19 )

rSNPs within LD-proxies of this variant (count:21)

rs_ID	r²[population]
rs11020767	0.83[AMR][1000 genomes]
rs12292294	0.84[AMR][1000 genomes]
rs1257774	0.86[AMR][1000 genomes]
rs13447646	0.99[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs512150	0.94[CEU][hapmap];0.81[JPT][hapmap];0.94[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs516381	0.81[AMR][1000 genomes]
rs521669	0.85[AMR][1000 genomes]
rs522596	0.83[JPT][hapmap];0.92[AMR][1000 genomes]
rs529126	0.84[JPT][hapmap];0.83[AMR][1000 genomes]
rs540514	0.82[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs552126	0.90[CEU][hapmap];0.90[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs581002	0.82[AMR][1000 genomes]
rs584707	0.86[CEU][hapmap];0.85[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs592068	0.83[JPT][hapmap];0.85[AMR][1000 genomes]
rs598599	0.91[CEU][hapmap];0.88[GIH][hapmap];0.88[MEX][hapmap];0.92[TSI][hapmap];0.90[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs603937	0.92[AMR][1000 genomes]
rs607974	0.82[MEX][hapmap];0.83[TSI][hapmap];0.89[AMR][1000 genomes]
rs640627	0.87[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs663530	0.87[JPT][hapmap];0.85[AMR][1000 genomes]
rs687109	0.94[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs7110046	0.81[AMR][1000 genomes]

mRNA abundance (count:19)

SNP	Gene	Cis/trans	Tissue	Source
rs607146	MRE11A	cis	Esophagus Muscularis	GTEx
rs607146	MRE11A	cis	cerebellum	SCAN
rs607146	RP11-685N10.1	cis	Esophagus Mucosa	GTEx
rs607146	MRE11A	cis	multi-tissue	Pritchard
rs607146	RP11-685N10.1	cis	Heart Left Ventricle	GTEx
rs607146	RP11-685N10.1	cis	Adipose Subcutaneous	GTEx
rs607146	MRE11A	cis	Artery Tibial	GTEx
rs607146	MRE11A	cis	Skin Sun Exposed Lower leg	GTEx
rs607146	MRE11A	cis	parietal	SCAN
rs607146	SLC36A4	cis	parietal	SCAN
rs607146	MRE11A	Cis_1M	lymphoblastoid	RTeQTL
rs607146	MRE11A	cis	lung	GTEx
rs607146	RP11-685N10.1	cis	Skin Sun Exposed Lower leg	GTEx
rs607146	MRE11A	cis	Nerve Tibial	GTEx
rs607146	MRE11A	cis	Adipose Subcutaneous	GTEx
rs607146	RP11-685N10.1	cis	Nerve Tibial	GTEx
rs607146	RP11-685N10.1	cis	lung	GTEx
rs607146	RP11-685N10.1	cis	Artery Tibial	GTEx
rs607146	RP11-685N10.1	cis	Esophagus Muscularis	GTEx

Chromatin state (count:73 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:94227800-94238400	Weak transcription	Small Intestine	intestine
2	chr11:94227800-94238800	Weak transcription	H9 Cell Line	embryonic stem cell
3	chr11:94227800-94245200	Weak transcription	Gastric	stomach
4	chr11:94228000-94245000	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
5	chr11:94228000-94245200	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
6	chr11:94228000-94245800	Weak transcription	Stomach Mucosa	stomach
7	chr11:94228400-94245200	Weak transcription	Fetal Stomach	stomach
8	chr11:94231600-94245200	Weak transcription	Esophagus	oesophagus
9	chr11:94232400-94245000	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
10	chr11:94232600-94245200	Weak transcription	NHLF	lung
11	chr11:94232800-94245200	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
12	chr11:94233000-94238800	Weak transcription	HepG2	liver
13	chr11:94233000-94245200	Weak transcription	Psoas Muscle	Psoas
14	chr11:94233400-94240600	Weak transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
15	chr11:94233400-94245200	Weak transcription	Fetal Intestine Large	intestine
16	chr11:94233600-94238400	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
17	chr11:94233600-94240800	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
18	chr11:94233600-94245000	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
19	chr11:94233600-94245000	Weak transcription	Brain Hippocampus Middle	brain
20	chr11:94233600-94245000	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
21	chr11:94233600-94245200	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
22	chr11:94233600-94245200	Weak transcription	Muscle Satellite Cultured Cells	--
23	chr11:94233600-94245200	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
24	chr11:94233600-94245200	Weak transcription	Brain Inferior Temporal Lobe	brain
25	chr11:94233600-94245200	Weak transcription	Colon Smooth Muscle	Colon
26	chr11:94233600-94245200	Weak transcription	Ovary	ovary
27	chr11:94233600-94245200	Weak transcription	Spleen	Spleen
28	chr11:94233600-94245200	Weak transcription	NHDF-Ad	bronchial
29	chr11:94233600-94245400	Weak transcription	Skeletal Muscle Male	skeletal muscle
30	chr11:94233800-94245200	Weak transcription	Duodenum Smooth Muscle	Duodenum
31	chr11:94233800-94245200	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
32	chr11:94234000-94240200	Weak transcription	Colonic Mucosa	Colon
33	chr11:94234000-94240600	Weak transcription	Rectal Smooth Muscle	rectum
34	chr11:94234000-94240600	Weak transcription	HMEC	breast
35	chr11:94234000-94245000	Weak transcription	Fetal Kidney	kidney
36	chr11:94234000-94245000	Weak transcription	NHEK	skin
37	chr11:94234000-94245200	Weak transcription	Primary hematopoietic stem cells short term culture	blood
38	chr11:94234000-94245200	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
39	chr11:94234200-94239400	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
40	chr11:94234200-94240200	Weak transcription	Rectal Mucosa Donor 31	rectum
41	chr11:94234200-94245000	Weak transcription	Primary T killer memory cells from peripheral blood	blood
42	chr11:94234200-94245200	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
43	chr11:94234200-94245200	Weak transcription	Brain Substantia Nigra	brain
44	chr11:94234200-94245200	Weak transcription	Duodenum Mucosa	Duodenum
45	chr11:94234200-94245200	Weak transcription	Placenta Amnion	Placenta Amnion
46	chr11:94234200-94245200	Weak transcription	Stomach Smooth Muscle	stomach
47	chr11:94234400-94240600	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
48	chr11:94234400-94245000	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
49	chr11:94234400-94245200	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
50	chr11:94234600-94239000	Weak transcription	Primary B cells from peripheral blood	blood

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