Variant report

Variant	rs7087381
Chromosome Location	chr10:1126293-1126294
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:1121902..1123802-chr10:1124909..1126467,2	MCF-7	breast:
2	chr10:1123452..1126459-chr10:1129377..1132325,3	K562	blood:

Extended variants
information (count: 64 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:43)

rs_ID	r²[population]
rs10159718	0.94[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];0.86[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.91[MEX][hapmap];0.97[TSI][hapmap];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs10736941	0.96[EUR][1000 genomes]
rs1079388	0.94[EUR][1000 genomes]
rs10794715	0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10794718	0.95[JPT][hapmap]
rs10903361	0.95[AMR][1000 genomes];1.00[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10903362	0.92[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.97[AMR][1000 genomes];0.95[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs10903364	0.80[EUR][1000 genomes]
rs10903365	0.99[AMR][1000 genomes];0.94[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs10903366	1.00[CEU][hapmap];0.95[CHB][hapmap];1.00[JPT][hapmap];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs10903370	1.00[CEU][hapmap];0.95[GIH][hapmap];0.86[JPT][hapmap];0.97[TSI][hapmap];0.96[EUR][1000 genomes]
rs10903371	0.81[CEU][hapmap];0.81[JPT][hapmap];0.81[EUR][1000 genomes]
rs11250245	0.89[ASN][1000 genomes]
rs11250256	1.00[CHB][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs11250258	0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs11250260	0.81[GIH][hapmap];1.00[JPT][hapmap]
rs12569814	0.85[ASN][1000 genomes]
rs12768746	0.95[CHB][hapmap];0.86[CHD][hapmap];1.00[JPT][hapmap]
rs12784270	1.00[JPT][hapmap]
rs1871625	0.81[YRI][hapmap]
rs1871626	0.95[GIH][hapmap];0.81[JPT][hapmap];0.85[TSI][hapmap]
rs2101050	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap];0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs2127605	0.99[ASN][1000 genomes]
rs34766854	0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs3750729	0.95[CHB][hapmap]
rs3793774	1.00[JPT][hapmap]
rs3793777	0.95[CHB][hapmap]
rs3816735	0.81[GIH][hapmap];0.85[JPT][hapmap]
rs4519019	1.00[CEU][hapmap];1.00[CHB][hapmap];0.98[CHD][hapmap];1.00[GIH][hapmap];0.95[JPT][hapmap];0.96[MEX][hapmap];1.00[TSI][hapmap];0.94[AMR][1000 genomes];0.95[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs4880757	0.81[CEU][hapmap];0.91[CHB][hapmap]
rs4880765	1.00[CEU][hapmap];0.95[GIH][hapmap];0.86[JPT][hapmap];0.97[TSI][hapmap];0.96[EUR][1000 genomes]
rs4880766	1.00[CEU][hapmap];0.90[JPT][hapmap];0.96[EUR][1000 genomes]
rs5014941	0.95[GIH][hapmap];0.81[JPT][hapmap];0.85[TSI][hapmap]
rs55701841	0.99[ASN][1000 genomes]
rs67388830	0.97[AMR][1000 genomes];0.94[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs7074721	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.96[MEX][hapmap];1.00[TSI][hapmap];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7075662	0.82[AFR][1000 genomes];0.97[AMR][1000 genomes];0.91[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs7076083	0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs7079726	0.91[CHB][hapmap]
rs7082272	0.95[CHB][hapmap]
rs7084283	0.96[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7088740	0.87[TSI][hapmap]
rs7099607	0.81[CHB][hapmap]

Variant overlapped rSNPs/rCNVs (count:21 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv540386	chr10:224406-1197416	Active TSS Weak transcription Enhancers Strong transcription Flanking Active TSS ZNF genes & repeats Genic enhancers Transcr. at gene 5' and 3' Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	51 gene(s)	inside rSNPs	diseases
2	nsv1054659	chr10:611444-1133578	Weak transcription Enhancers Flanking Active TSS Bivalent Enhancer Strong transcription Genic enhancers Active TSS ZNF genes & repeats Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA	43 gene(s)	inside rSNPs	diseases
3	nsv466697	chr10:734229-1129527	ZNF genes & repeats Weak transcription Flanking Active TSS Strong transcription Active TSS Bivalent Enhancer Enhancers Genic enhancers Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	39 gene(s)	inside rSNPs	diseases
4	nsv549765	chr10:734229-1129527	Genic enhancers Enhancers Active TSS Flanking Active TSS ZNF genes & repeats Weak transcription Strong transcription Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	39 gene(s)	inside rSNPs	diseases
5	nsv530116	chr10:776548-1401075	Weak transcription Enhancers Strong transcription Genic enhancers Flanking Active TSS Active TSS ZNF genes & repeats Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	41 gene(s)	inside rSNPs	diseases
6	nsv1052540	chr10:887562-1300134	Strong transcription Weak transcription Enhancers Active TSS Genic enhancers ZNF genes & repeats Flanking Active TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
7	nsv540407	chr10:887562-1300134	Weak transcription Enhancers Active TSS Strong transcription Flanking Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
8	nsv533861	chr10:945438-1382068	Enhancers Weak transcription Strong transcription Active TSS Flanking Active TSS Genic enhancers Bivalent Enhancer ZNF genes & repeats Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
9	nsv530117	chr10:945438-1729634	Enhancers Weak transcription Flanking Active TSS ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3' Active TSS Strong transcription Genic enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	38 gene(s)	inside rSNPs	diseases
10	nsv540408	chr10:955835-1260680	Enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats Genic enhancers Active TSS Weak transcription Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	34 gene(s)	inside rSNPs	diseases
11	nsv817532	chr10:964660-1885945	Bivalent/Poised TSS Enhancers Strong transcription Flanking Active TSS Active TSS Weak transcription Bivalent Enhancer Genic enhancers Flanking Bivalent TSS/Enh ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	39 gene(s)	inside rSNPs	diseases
12	nsv1050577	chr10:986723-1277854	Weak transcription Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats Flanking Active TSS Enhancers Genic enhancers Bivalent/Poised TSS Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	30 gene(s)	inside rSNPs	diseases
13	nsv540409	chr10:986723-1277854	Weak transcription Strong transcription Enhancers ZNF genes & repeats Flanking Active TSS Genic enhancers Bivalent Enhancer Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	30 gene(s)	inside rSNPs	diseases
14	nsv949405	chr10:1010464-1376105	Weak transcription Active TSS Bivalent/Poised TSS Strong transcription Flanking Active TSS Enhancers Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	30 gene(s)	inside rSNPs	diseases
15	nsv1048254	chr10:1016006-1146595	Weak transcription Enhancers Strong transcription Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Active TSS ZNF genes & repeats Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	26 gene(s)	inside rSNPs	diseases
16	nsv894722	chr10:1058837-1274538	Strong transcription Enhancers Weak transcription Active TSS Genic enhancers Flanking Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	25 gene(s)	inside rSNPs	diseases
17	nsv1046220	chr10:1064024-1188998	Active TSS Enhancers Weak transcription Strong transcription Genic enhancers Flanking Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	22 gene(s)	inside rSNPs	diseases
18	nsv894723	chr10:1073684-1259485	Enhancers Weak transcription Genic enhancers Active TSS Strong transcription Flanking Active TSS Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	24 gene(s)	inside rSNPs	diseases
19	nsv894725	chr10:1110464-1421516	Strong transcription Weak transcription Genic enhancers Bivalent Enhancer ZNF genes & repeats Enhancers Active TSS Flanking Active TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	8 gene(s)	inside rSNPs	diseases
20	nsv1054432	chr10:1115626-1230431	Strong transcription Weak transcription Enhancers Flanking Active TSS Genic enhancers Bivalent/Poised TSS ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3' Active TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	7 gene(s)	inside rSNPs	diseases
21	nsv1041498	chr10:1117200-1760190	Genic enhancers Strong transcription Weak transcription Enhancers Active TSS Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Flanking Active TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	12 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs7087381	ADARB2	cis	parietal	SCAN
rs7087381	C10orf110	cis	cerebellum	SCAN

Chromatin state (count:127 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:1108600-1142400	Weak transcription	Stomach Mucosa	stomach
2	chr10:1108600-1144600	Weak transcription	Fetal Heart	heart
3	chr10:1114200-1132200	Weak transcription	Pancreatic Islets	Pancreatic Islet
4	chr10:1117200-1130800	Weak transcription	Right Atrium	heart
5	chr10:1117200-1138600	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
6	chr10:1117400-1129800	Weak transcription	iPS-15b Cell Line	embryonic stem cell
7	chr10:1117400-1141400	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
8	chr10:1117800-1168600	Strong transcription	Monocytes-CD14+_RO01746	blood
9	chr10:1118000-1126600	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
10	chr10:1118000-1127000	Strong transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
11	chr10:1118000-1127200	Strong transcription	Fetal Muscle Trunk	muscle
12	chr10:1118000-1156400	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
13	chr10:1118000-1168400	Strong transcription	Primary hematopoietic stem cells short term culture	blood
14	chr10:1118000-1173800	Strong transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
15	chr10:1118200-1129000	Strong transcription	Primary neutrophils fromperipheralblood	blood
16	chr10:1118400-1128000	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
17	chr10:1119200-1132200	Weak transcription	Fetal Kidney	kidney
18	chr10:1119600-1131400	Weak transcription	Placenta Amnion	Placenta Amnion
19	chr10:1120600-1130400	Weak transcription	Colonic Mucosa	Colon
20	chr10:1120600-1130400	Weak transcription	Psoas Muscle	Psoas
21	chr10:1121000-1130000	Weak transcription	H9 Cell Line	embryonic stem cell
22	chr10:1121000-1130000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
23	chr10:1121400-1154400	Strong transcription	Primary T cells fromperipheralblood	blood
24	chr10:1122000-1126800	Strong transcription	Fetal Intestine Large	intestine
25	chr10:1122000-1135200	Strong transcription	Fetal Adrenal Gland	Adrenal Gland
26	chr10:1122200-1168400	Strong transcription	Primary monocytes fromperipheralblood	blood
27	chr10:1122400-1126600	Strong transcription	Primary T helper 17 cells PMA-I stimulated	--
28	chr10:1122600-1168800	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
29	chr10:1123000-1128400	Strong transcription	HUES48 Cell Line	embryonic stem cell
30	chr10:1123000-1138000	Strong transcription	Primary T helper naive cells fromperipheralblood	blood
31	chr10:1123000-1168600	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
32	chr10:1123200-1126400	Strong transcription	NHDF-Ad	bronchial
33	chr10:1123200-1126600	Strong transcription	Left Ventricle	heart
34	chr10:1123200-1127000	Strong transcription	Fetal Muscle Leg	muscle
35	chr10:1123200-1127200	Strong transcription	Rectal Mucosa Donor 29	rectum
36	chr10:1123200-1137800	Strong transcription	Skeletal Muscle Female	skeletal muscle
37	chr10:1123200-1145200	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
38	chr10:1123200-1145800	Strong transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
39	chr10:1123200-1155200	Strong transcription	Primary T regulatory cells fromperipheralblood	blood
40	chr10:1123200-1155800	Strong transcription	Dnd41	blood
41	chr10:1123200-1178400	Strong transcription	Liver	Liver
42	chr10:1123400-1127000	Strong transcription	ES-UCSF4 Cell Line	embryonic stem cell
43	chr10:1123400-1127000	Strong transcription	Fetal Brain Female	brain
44	chr10:1123400-1128000	Strong transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
45	chr10:1123400-1128200	Strong transcription	iPS-20b Cell Line	embryonic stem cell
46	chr10:1123400-1132600	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
47	chr10:1123400-1133000	Strong transcription	Foreskin Melanocyte Primary Cells skin03	Skin
48	chr10:1123400-1134000	Strong transcription	iPS-18 Cell Line	embryonic stem cell
49	chr10:1123400-1138000	Strong transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
50	chr10:1123400-1138200	Strong transcription	Adipose Nuclei	Adipose

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