Variant report

Variant	rs73135361
Chromosome Location	chr3:97907669-97907670
allele	C/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr3:97907135..97908080-chr3:98062563..98063391,2	MCF-7	breast:
2	chr3:97907135..97908282-chr3:98048120..98049025,6	MCF-7	breast:

Extended variants
information (count: 237 )
Associated
traits (count: 0)

rSNPs within LD-proxies of this variant (count:184)

rs_ID	r²[population]
rs1024053	0.81[ASN][1000 genomes]
rs1024056	0.81[ASN][1000 genomes]
rs11706357	0.82[ASN][1000 genomes]
rs11706390	0.83[ASN][1000 genomes]
rs11711844	0.82[ASN][1000 genomes]
rs11715218	0.81[ASN][1000 genomes]
rs11716683	0.82[ASN][1000 genomes]
rs11716786	0.83[ASN][1000 genomes]
rs11717559	0.82[ASN][1000 genomes]
rs11719433	0.80[ASN][1000 genomes]
rs11720006	0.80[ASN][1000 genomes]
rs12330386	0.81[ASN][1000 genomes]
rs12489167	0.81[ASN][1000 genomes]
rs12489398	0.81[ASN][1000 genomes]
rs12490755	0.82[ASN][1000 genomes]
rs12498051	0.82[ASN][1000 genomes]
rs12695682	0.82[ASN][1000 genomes]
rs12695683	0.81[ASN][1000 genomes]
rs12695684	0.81[ASN][1000 genomes]
rs13059290	0.82[ASN][1000 genomes]
rs13060486	0.83[AMR][1000 genomes];0.81[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs13060569	0.82[ASN][1000 genomes]
rs13060763	0.82[ASN][1000 genomes]
rs13061180	0.82[ASN][1000 genomes]
rs13061364	0.84[ASN][1000 genomes]
rs13064891	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13065259	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13067607	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13071373	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs13071754	0.84[ASN][1000 genomes]
rs13071952	0.82[ASN][1000 genomes]
rs13080640	0.82[ASN][1000 genomes]
rs13083770	0.83[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13084823	0.82[ASN][1000 genomes]
rs13084986	0.82[ASN][1000 genomes]
rs13088324	0.82[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs13088529	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13089594	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13090994	0.80[ASN][1000 genomes]
rs13091352	0.81[ASN][1000 genomes]
rs13093005	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13093180	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs13094850	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs13095222	0.84[ASN][1000 genomes]
rs13099950	0.82[ASN][1000 genomes]
rs13099965	0.83[ASN][1000 genomes]
rs13433842	0.81[ASN][1000 genomes]
rs13433847	0.81[ASN][1000 genomes]
rs1532463	0.83[ASN][1000 genomes]
rs1532464	0.80[ASN][1000 genomes]
rs1587280	0.81[ASN][1000 genomes]
rs1908993	0.82[ASN][1000 genomes]
rs1908994	0.82[ASN][1000 genomes]
rs1908995	0.82[ASN][1000 genomes]
rs2047391	0.82[ASN][1000 genomes]
rs2047392	0.82[ASN][1000 genomes]
rs2047393	0.81[ASN][1000 genomes]
rs2291810	0.82[ASN][1000 genomes]
rs34043420	0.82[ASN][1000 genomes]
rs34051821	0.86[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs34072146	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs34137690	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs34225419	0.82[ASN][1000 genomes]
rs34236895	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34250420	0.81[ASN][1000 genomes]
rs34263554	0.81[ASN][1000 genomes]
rs34290035	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34305303	0.84[ASN][1000 genomes]
rs34332524	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs34424109	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34428635	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34448974	0.82[ASN][1000 genomes]
rs34554465	0.84[ASN][1000 genomes]
rs34637074	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34672191	0.81[ASN][1000 genomes]
rs34775658	0.82[ASN][1000 genomes]
rs34776005	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34800460	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34818739	0.82[ASN][1000 genomes]
rs34826958	0.80[ASN][1000 genomes]
rs34859603	0.82[ASN][1000 genomes]
rs34924704	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs34931487	0.83[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs35042029	0.83[ASN][1000 genomes]
rs35100128	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs35127256	0.82[ASN][1000 genomes]
rs35220065	0.82[ASN][1000 genomes]
rs35221063	0.82[ASN][1000 genomes]
rs35239283	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs35292867	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs35309919	0.84[ASN][1000 genomes]
rs35399810	0.82[ASN][1000 genomes]
rs35515951	0.84[ASN][1000 genomes]
rs35594072	0.84[ASN][1000 genomes]
rs35594582	0.81[AMR][1000 genomes];0.81[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs35694938	0.81[AMR][1000 genomes];0.81[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs35734642	0.81[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs35814153	0.85[ASN][1000 genomes]
rs35838671	0.85[AMR][1000 genomes];0.87[ASN][1000 genomes]
rs35847759	0.84[ASN][1000 genomes]
rs35852963	0.82[ASN][1000 genomes]
rs35915850	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs36023249	0.82[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs36037993	0.82[ASN][1000 genomes]
rs3828452	0.82[ASN][1000 genomes]
rs3828453	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs3828454	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs3828456	0.81[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs3828457	0.83[ASN][1000 genomes]
rs3828458	0.83[ASN][1000 genomes]
rs3828459	0.83[ASN][1000 genomes]
rs3828460	0.82[ASN][1000 genomes]
rs3828461	0.82[ASN][1000 genomes]
rs4365665	0.81[ASN][1000 genomes]
rs4405956	0.83[AMR][1000 genomes];0.85[ASN][1000 genomes]
rs4532173	0.81[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs4532174	0.83[ASN][1000 genomes]
rs4546179	0.81[ASN][1000 genomes]
rs4621367	0.81[ASN][1000 genomes]
rs4857080	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs4857081	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs4857082	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs4857342	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs55802233	0.84[ASN][1000 genomes]
rs56001215	0.84[ASN][1000 genomes]
rs56206401	0.83[ASN][1000 genomes]
rs58188940	0.82[ASN][1000 genomes]
rs58605422	0.84[ASN][1000 genomes]
rs59598356	0.84[ASN][1000 genomes]
rs61264422	0.85[ASN][1000 genomes]
rs62267772	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs62267798	0.84[ASN][1000 genomes]
rs62267799	0.84[ASN][1000 genomes]
rs62267800	0.84[ASN][1000 genomes]
rs62267801	0.84[ASN][1000 genomes]
rs62267804	0.87[AMR][1000 genomes]
rs62267806	0.82[ASN][1000 genomes]
rs6414338	0.81[ASN][1000 genomes]
rs6439682	0.81[ASN][1000 genomes]
rs6439684	0.81[ASN][1000 genomes]
rs67191025	0.84[ASN][1000 genomes]
rs67472895	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs6765411	0.82[ASN][1000 genomes]
rs6765598	0.82[ASN][1000 genomes]
rs6765605	0.81[ASN][1000 genomes]
rs6765940	0.81[ASN][1000 genomes]
rs6766605	0.82[ASN][1000 genomes]
rs6768197	0.82[ASN][1000 genomes]
rs6770869	0.81[ASN][1000 genomes]
rs6771099	0.81[ASN][1000 genomes]
rs67743720	0.84[ASN][1000 genomes]
rs6776813	0.82[ASN][1000 genomes]
rs67838020	0.82[AMR][1000 genomes];0.80[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs6791813	0.82[ASN][1000 genomes]
rs6802178	0.82[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs68030363	0.81[AMR][1000 genomes];0.81[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs68064286	0.84[ASN][1000 genomes]
rs6806465	0.82[AMR][1000 genomes]
rs6806695	0.83[ASN][1000 genomes]
rs68091373	0.82[ASN][1000 genomes]
rs6809326	0.82[ASN][1000 genomes]
rs6809633	0.82[ASN][1000 genomes]
rs68151968	0.84[ASN][1000 genomes]
rs72922871	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs72927015	0.84[ASN][1000 genomes]
rs72927019	0.84[ASN][1000 genomes]
rs72927022	0.84[ASN][1000 genomes]
rs72927032	0.84[AMR][1000 genomes];0.86[ASN][1000 genomes]
rs72927033	0.81[ASN][1000 genomes]
rs73135346	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs73135348	0.84[ASN][1000 genomes]
rs73135351	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs73853270	0.81[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs7430016	0.80[ASN][1000 genomes]
rs7634043	0.80[ASN][1000 genomes]
rs7634735	0.81[ASN][1000 genomes]
rs9824733	0.81[ASN][1000 genomes]
rs9840421	0.82[ASN][1000 genomes]
rs9848264	0.81[ASN][1000 genomes]
rs9859733	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs9879287	0.82[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs9879316	0.82[ASN][1000 genomes]
rs9883025	0.81[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs995557	0.81[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:53 , 50 per page) page: 1 2

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv869347	chr3:97742604-98051633	ZNF genes & repeats Enhancers Weak transcription Flanking Active TSS Active TSS Genic enhancers Bivalent/Poised TSS Strong transcription Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	27 gene(s)	inside rSNPs	diseases
2	nsv877209	chr3:97806616-98049409	Weak transcription Enhancers Active TSS Bivalent Enhancer Flanking Active TSS ZNF genes & repeats Strong transcription Genic enhancers Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	18 gene(s)	inside rSNPs	diseases
3	nsv963576	chr3:97825434-98041343	Weak transcription Enhancers Active TSS ZNF genes & repeats Strong transcription Flanking Active TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	17 gene(s)	inside rSNPs	diseases
4	nsv1004820	chr3:97852875-98169488	Enhancers Weak transcription Flanking Active TSS Active TSS ZNF genes & repeats Strong transcription Bivalent Enhancer Bivalent/Poised TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	19 gene(s)	inside rSNPs	diseases
5	nsv834773	chr3:97855362-98043888	Flanking Active TSS Enhancers Weak transcription Active TSS Strong transcription Genic enhancers ZNF genes & repeats Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	15 gene(s)	inside rSNPs	diseases
6	nsv1000834	chr3:97859880-98095473	Enhancers Weak transcription Flanking Active TSS Bivalent Enhancer Active TSS ZNF genes & repeats Bivalent/Poised TSS Strong transcription Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	17 gene(s)	inside rSNPs	diseases
7	nsv877210	chr3:97866177-97992964	ZNF genes & repeats Enhancers Weak transcription Active TSS Flanking Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	13 gene(s)	inside rSNPs	diseases
8	esv2566065	chr3:97873442-97931531	Active TSS Enhancers ZNF genes & repeats Weak transcription Flanking Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
9	esv5601	chr3:97874279-97931369	Enhancers Weak transcription Active TSS Flanking Active TSS ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
10	esv3428925	chr3:97874391-97931104	Weak transcription ZNF genes & repeats Enhancers Flanking Active TSS Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
11	esv3326206	chr3:97874447-97931276	Weak transcription Enhancers Active TSS ZNF genes & repeats Flanking Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
12	nsv513059	chr3:97875075-97932953	Weak transcription ZNF genes & repeats Enhancers Active TSS Flanking Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
13	esv3430659	chr3:97878961-97933659	Flanking Active TSS Enhancers Active TSS Weak transcription ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
14	esv3504753	chr3:97881256-97920688	Enhancers Weak transcription ZNF genes & repeats Active TSS Flanking Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
15	esv3504754	chr3:97881256-97920688	Enhancers Weak transcription Flanking Active TSS Active TSS ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
16	esv3520819	chr3:97882130-97921660	Weak transcription ZNF genes & repeats Enhancers Active TSS Strong transcription Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	n/a
17	esv3520820	chr3:97882130-97921660	Weak transcription ZNF genes & repeats Enhancers Flanking Active TSS Strong transcription Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	n/a
18	esv1792159	chr3:97887491-97919363	Enhancers Weak transcription ZNF genes & repeats Flanking Active TSS Active TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
19	esv1810766	chr3:97887491-97919363	Enhancers Weak transcription Active TSS ZNF genes & repeats Strong transcription Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
20	esv1823394	chr3:97887491-97919363	ZNF genes & repeats Enhancers Weak transcription Flanking Active TSS Strong transcription Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
21	esv1824074	chr3:97887491-97919363	Enhancers Weak transcription ZNF genes & repeats Active TSS Strong transcription Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
22	esv1836052	chr3:97887491-97919363	Weak transcription Flanking Active TSS Enhancers Active TSS ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
23	esv1836766	chr3:97887491-97919363	ZNF genes & repeats Enhancers Active TSS Weak transcription Strong transcription Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
24	esv1850194	chr3:97887491-97919363	Enhancers Weak transcription Strong transcription Active TSS ZNF genes & repeats Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
25	esv1850328	chr3:97887491-97919363	Enhancers ZNF genes & repeats Weak transcription Active TSS Strong transcription Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
26	nsv442868	chr3:97887491-97919363	Enhancers Strong transcription Weak transcription Active TSS ZNF genes & repeats Flanking Active TSS	TF binding region CpG island Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
27	esv19096	chr3:97891026-97913396	Enhancers ZNF genes & repeats Active TSS Weak transcription Flanking Active TSS	TF binding region Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	n/a
28	esv2762341	chr3:97899320-97926120	Enhancers Weak transcription ZNF genes & repeats Flanking Active TSS Active TSS Strong transcription	TF binding region Chromatin interactive region lncRNA	5 gene(s)	inside rSNPs	n/a
29	esv13637	chr3:97899419-97913491	Active TSS Enhancers Weak transcription Flanking Active TSS ZNF genes & repeats	TF binding region Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	n/a
30	esv13127	chr3:97899419-97939393	Weak transcription Enhancers Flanking Active TSS ZNF genes & repeats Active TSS Strong transcription	TF binding region Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
31	nsv870074	chr3:97903273-97948850	Enhancers Weak transcription ZNF genes & repeats Flanking Active TSS Active TSS Strong transcription	TF binding region Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
32	nsv591044	chr3:97903999-97908449	Weak transcription Enhancers	Chromatin interactive region lncRNA	n/a	inside rSNPs	n/a
33	esv18642	chr3:97904245-97909194	Enhancers Weak transcription	Chromatin interactive region lncRNA	n/a	inside rSNPs	n/a
34	esv19824	chr3:97904245-97914149	Active TSS Enhancers Weak transcription ZNF genes & repeats	TF binding region Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	n/a
35	nsv591045	chr3:97906319-97908449	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
36	nsv591046	chr3:97906585-97908143	Weak transcription Enhancers	Chromatin interactive region	n/a	inside rSNPs	n/a
37	nsv591047	chr3:97906585-97908304	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
38	nsv591048	chr3:97906585-97908381	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
39	nsv591049	chr3:97906585-97908449	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
40	nsv591050	chr3:97906992-97908143	Weak transcription Enhancers	Chromatin interactive region	n/a	inside rSNPs	n/a
41	nsv591051	chr3:97906992-97908449	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
42	nsv591052	chr3:97907062-97908304	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
43	nsv591053	chr3:97907062-97908381	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
44	nsv591054	chr3:97907062-97908449	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
45	nsv591055	chr3:97907062-97908664	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
46	nsv591056	chr3:97907062-97914008	Enhancers Weak transcription ZNF genes & repeats Active TSS	TF binding region Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	n/a
47	nsv591057	chr3:97907201-97908381	Weak transcription Enhancers	Chromatin interactive region	n/a	inside rSNPs	n/a
48	nsv591058	chr3:97907201-97908449	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
49	nsv591059	chr3:97907201-97908720	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a
50	esv20358	chr3:97907291-97909658	Enhancers Weak transcription	Chromatin interactive region	n/a	inside rSNPs	n/a

No data

Chromatin state (count:8 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr3:97906800-97908000	Enhancers	Primary hematopoietic stem cells	blood
2	chr3:97906800-97908400	Enhancers	Primary monocytes fromperipheralblood	blood
3	chr3:97907000-97908000	Enhancers	HUES64 Cell Line	embryonic stem cell
4	chr3:97907000-97908000	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
5	chr3:97907000-97908200	Enhancers	ES-I3 Cell Line	embryonic stem cell
6	chr3:97907000-97910200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
7	chr3:97907200-97907800	Enhancers	HUES48 Cell Line	embryonic stem cell
8	chr3:97907400-97908400	Enhancers	HUES6 Cell Line	embryonic stem cell

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