Variant report

Variant	rs74146234
Chromosome Location	chr10:89682209-89682210
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	REST	chr10:89682025-89682528	MCF-7	breast:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
2	REST	chr10:89681822-89682619	HL-60	blood:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
3	REST	chr10:89682097-89682351	HepG2	liver:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
4	REST	chr10:89682092-89682366	A549	lung:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
5	REST	chr10:89681987-89682468	PFSK-1	brain:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
6	REST	chr10:89682147-89682312	HepG2	liver:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
7	REST	chr10:89681975-89682445	Hela-S3	cervix:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
8	REST	chr10:89682094-89682369	PFSK-1	brain:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
9	REST	chr10:89681989-89682517	PANC-1	pancreas:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
10	ZNF143	chr10:89682206-89682408	H1-hESC	embryonic stem cell:	n/a	n/a
11	REST	chr10:89682017-89682460	HL-60	blood:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
12	REST	chr10:89681932-89682547	PANC-1	pancreas:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
13	POLR2A	chr10:89682167-89682485	GM12892	blood:	n/a	n/a
14	REST	chr10:89682038-89682369	HepG2	liver:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
15	TEAD4	chr10:89682095-89682480	A549	lung:	n/a	n/a
16	REST	chr10:89682021-89682426	GM12878	blood:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
17	REST	chr10:89682160-89682275	PANC-1	pancreas:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
18	REST	chr10:89681768-89682553	A549	lung:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
19	REST	chr10:89682160-89682282	K562	blood:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
20	REST	chr10:89682080-89682511	HCT-116	colon:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
21	POLR2A	chr10:89680977-89682540	GM12892	blood:	n/a	n/a
22	REST	chr10:89681763-89682425	PFSK-1	brain:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
23	REST	chr10:89682191-89682313	GM12878	blood:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
24	REST	chr10:89682107-89682379	K562	blood:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
25	REST	chr10:89681832-89682406	SK-N-SH	brain:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
26	REST	chr10:89682068-89682420	HCT-116	colon:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
27	REST	chr10:89682026-89682489	MCF-7	breast:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
28	REST	chr10:89682121-89682383	Hela-S3	cervix:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
29	REST	chr10:89682144-89682349	SK-N-SH	brain:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
30	REST	chr10:89681683-89682711	ECC-1	luminal epithelium:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
31	REST	chr10:89681839-89682420	H1-hESC	embryonic stem cell:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
32	REST	chr10:89681585-89682476	PFSK-1	brain:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
33	REST	chr10:89681768-89682408	H1-hESC	embryonic stem cell:	n/a	chr10:89682228-89682237 chr10:89682228-89682248
34	REST	chr10:89681806-89682654	ECC-1	luminal epithelium:	n/a	chr10:89682228-89682237 chr10:89682228-89682248

No.	Distal block	Cell Line	Cell type
1	chr10:89679106..89681199-chr10:89681260..89684202,3	K562	blood:
2	chr10:89673644..89678140-chr10:89679296..89683460,5	K562	blood:
3	chr10:89620410..89622010-chr10:89680788..89683163,3	MCF-7	breast:

Variant related genes	Relation type
PTEN	TF binding region

Extended variants
information (count: 8 )
Associated
traits (count: 0)

rSNPs within LD-proxies of this variant (count:5)

rs_ID	r²[population]
rs34262484	0.95[AFR][1000 genomes]
rs61417477	0.95[AFR][1000 genomes]
rs74146231	0.85[AFR][1000 genomes]
rs74146236	0.90[AFR][1000 genomes]
rs74146237	0.80[AFR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:3 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv1793518	chr10:89625582-89733420	Weak transcription Strong transcription Enhancers Active TSS Genic enhancers Flanking Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	10 gene(s)	inside rSNPs	diseases
2	esv1798260	chr10:89625582-89733420	Weak transcription Genic enhancers Strong transcription Enhancers ZNF genes & repeats Active TSS Flanking Active TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	10 gene(s)	inside rSNPs	diseases
3	nsv1044043	chr10:89678935-89701069	Enhancers Weak transcription Genic enhancers Flanking Active TSS Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	4 gene(s)	inside rSNPs	diseases

No data

Chromatin state (count:121 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:89647000-89711200	Weak transcription	Stomach Smooth Muscle	stomach
2	chr10:89648000-89683000	Weak transcription	Rectal Smooth Muscle	rectum
3	chr10:89663600-89686400	Weak transcription	H9 Cell Line	embryonic stem cell
4	chr10:89663600-89687400	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
5	chr10:89663800-89725400	Weak transcription	Colonic Mucosa	Colon
6	chr10:89666000-89712400	Weak transcription	Fetal Brain Male	brain
7	chr10:89666600-89682800	Weak transcription	Placenta	Placenta
8	chr10:89671600-89682800	Weak transcription	Spleen	Spleen
9	chr10:89673600-89726000	Weak transcription	Brain Substantia Nigra	brain
10	chr10:89674000-89685600	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
11	chr10:89674200-89695200	Weak transcription	Brain Cingulate Gyrus	brain
12	chr10:89674200-89711000	Weak transcription	HepG2	liver
13	chr10:89674600-89682600	Weak transcription	Cortex derived primary cultured neurospheres	brain
14	chr10:89674600-89684400	Weak transcription	Fetal Kidney	kidney
15	chr10:89674600-89686400	Weak transcription	HSMMtube	muscle
16	chr10:89674600-89687000	Weak transcription	Rectal Mucosa Donor 29	rectum
17	chr10:89674600-89689800	Weak transcription	Fetal Lung	lung
18	chr10:89674600-89695600	Weak transcription	Fetal Muscle Trunk	muscle
19	chr10:89674800-89724400	Weak transcription	Fetal Brain Female	brain
20	chr10:89675400-89686400	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
21	chr10:89675400-89726000	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
22	chr10:89675600-89682800	Weak transcription	Pancreas	Pancrea
23	chr10:89675600-89682800	Weak transcription	Sigmoid Colon	Sigmoid Colon
24	chr10:89675600-89683800	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
25	chr10:89675600-89685400	Weak transcription	Duodenum Mucosa	Duodenum
26	chr10:89675600-89686200	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
27	chr10:89675600-89687200	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
28	chr10:89675600-89705000	Weak transcription	Fetal Stomach	stomach
29	chr10:89675600-89705200	Weak transcription	Esophagus	oesophagus
30	chr10:89676000-89682400	Weak transcription	iPS-18 Cell Line	embryonic stem cell
31	chr10:89676200-89683000	Weak transcription	Fetal Intestine Large	intestine
32	chr10:89676200-89686400	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
33	chr10:89676400-89682400	Weak transcription	Fetal Muscle Leg	muscle
34	chr10:89676600-89682800	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
35	chr10:89676600-89682800	Weak transcription	Gastric	stomach
36	chr10:89676600-89682800	Weak transcription	Psoas Muscle	Psoas
37	chr10:89676600-89683800	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
38	chr10:89676600-89683800	Weak transcription	NHDF-Ad	bronchial
39	chr10:89676600-89685400	Weak transcription	NH-A	brain
40	chr10:89676600-89685400	Weak transcription	Osteobl	bone
41	chr10:89676600-89685600	Weak transcription	ES-I3 Cell Line	embryonic stem cell
42	chr10:89676600-89686200	Weak transcription	Rectal Mucosa Donor 31	rectum
43	chr10:89676600-89686400	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
44	chr10:89676600-89686400	Weak transcription	Muscle Satellite Cultured Cells	--
45	chr10:89676600-89686400	Weak transcription	HMEC	breast
46	chr10:89676600-89686600	Weak transcription	Small Intestine	intestine
47	chr10:89676600-89695400	Weak transcription	Brain Anterior Caudate	brain
48	chr10:89676800-89685400	Weak transcription	K562	blood
49	chr10:89676800-89686400	Weak transcription	NHEK	skin
50	chr10:89676800-89691000	Weak transcription	Placenta Amnion	Placenta Amnion

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