Variant report

Variant	rs7456834
Chromosome Location	chr7:6416588-6416589
allele	C/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr7:6413015..6417903-chr7:6435938..6439469,5	MCF-7	breast:
2	chr7:6415178..6416975-chr7:6426266..6428182,2	MCF-7	breast:
3	chr7:6412517..6417079-chr7:6439604..6446019,8	MCF-7	breast:
4	chr7:6414882..6417650-chr7:6542443..6546000,3	MCF-7	breast:
5	chr7:6387187..6388731-chr7:6415190..6416736,2	K562	blood:

Variant related genes	Relation type
ENSG00000136238	Chromatin interaction
ENSG00000178397	Chromatin interaction

Extended variants
information (count: 70 )
Associated
traits (count: 7 )

rSNPs within LD-proxies of this variant (count:58)

rs_ID	r²[population]
rs10261256	0.95[CHB][hapmap];0.84[ASN][1000 genomes]
rs10266716	0.83[ASN][1000 genomes]
rs1055428	0.85[AMR][1000 genomes]
rs10951982	0.94[CEU][hapmap];1.00[CHB][hapmap];0.90[JPT][hapmap];0.84[AFR][1000 genomes];0.93[AMR][1000 genomes];0.87[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs10951983	0.89[CEU][hapmap];0.86[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs1123675	0.83[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs11514801	0.84[AFR][1000 genomes];0.93[AMR][1000 genomes];0.87[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs11514802	0.91[AMR][1000 genomes];0.87[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs11514804	0.84[AFR][1000 genomes];0.91[AMR][1000 genomes];0.84[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11760556	0.83[ASN][1000 genomes]
rs11760562	0.83[ASN][1000 genomes]
rs11763354	0.80[AFR][1000 genomes];0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs11767078	0.83[ASN][1000 genomes]
rs11772942	0.81[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs12532493	0.83[ASN][1000 genomes]
rs12535659	0.82[ASN][1000 genomes]
rs12536544	0.84[CEU][hapmap]
rs12537483	0.83[ASN][1000 genomes]
rs12537894	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap];0.82[ASN][1000 genomes]
rs12538142	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap];0.83[ASN][1000 genomes]
rs12539027	0.83[ASN][1000 genomes]
rs13221129	0.81[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs17196595	0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1880118	1.00[CEU][hapmap];0.95[CHB][hapmap];0.90[JPT][hapmap];1.00[YRI][hapmap];0.88[AMR][1000 genomes];0.92[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs2272157	0.83[ASN][1000 genomes]
rs2303361	0.94[CEU][hapmap];0.95[CHB][hapmap];1.00[JPT][hapmap];0.85[AMR][1000 genomes];0.81[EUR][1000 genomes]
rs2347339	0.93[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.84[AFR][1000 genomes];0.90[AMR][1000 genomes];0.84[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs33986000	0.88[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs33986648	0.88[AMR][1000 genomes];0.84[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs33999234	0.96[AMR][1000 genomes];0.85[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs34106847	0.95[AMR][1000 genomes];0.85[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs34414425	0.87[AFR][1000 genomes];0.91[AMR][1000 genomes];0.93[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs34884077	0.87[AFR][1000 genomes];0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs35277609	0.88[AMR][1000 genomes];0.81[ASN][1000 genomes]
rs35444732	0.81[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs35733871	0.84[AFR][1000 genomes];0.91[AMR][1000 genomes];0.84[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs35745599	0.86[AMR][1000 genomes];0.80[EUR][1000 genomes]
rs3729790	1.00[CEU][hapmap];0.95[CHB][hapmap];0.90[JPT][hapmap];0.85[YRI][hapmap];0.87[AFR][1000 genomes];0.91[AMR][1000 genomes];0.93[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs3750038	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap];0.83[ASN][1000 genomes]
rs3828944	0.89[CEU][hapmap];0.81[CHB][hapmap];0.83[JPT][hapmap];0.85[YRI][hapmap];0.85[AMR][1000 genomes]
rs4720672	0.81[JPT][hapmap];1.00[YRI][hapmap]
rs4724800	0.95[CHB][hapmap];0.84[ASN][1000 genomes]
rs4724801	0.95[AMR][1000 genomes];0.83[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs4724802	0.88[AMR][1000 genomes];0.80[EUR][1000 genomes]
rs4724803	0.85[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs4724804	0.85[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs4724806	0.84[JPT][hapmap];1.00[YRI][hapmap];0.83[AMR][1000 genomes]
rs58072643	0.83[ASN][1000 genomes]
rs71524068	0.85[AMR][1000 genomes];0.84[ASN][1000 genomes]
rs71531381	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs71531384	0.85[AMR][1000 genomes];0.82[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs71531392	0.82[ASN][1000 genomes]
rs7455288	0.93[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7797644	0.85[AMR][1000 genomes]
rs836472	0.83[CEU][hapmap]
rs836545	0.81[AMR][1000 genomes]
rs836548	0.85[CEU][hapmap]
rs9374	0.94[CEU][hapmap];0.95[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap];0.88[AMR][1000 genomes];0.84[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:12 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv948912	chr7:5803903-6623553	Active TSS Flanking Active TSS Weak transcription Strong transcription Enhancers Transcr. at gene 5' and 3' Bivalent/Poised TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	123 gene(s)	inside rSNPs	diseases
2	nsv1034060	chr7:5814823-6745710	Bivalent Enhancer Active TSS Weak transcription Flanking Active TSS Enhancers Genic enhancers Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	138 gene(s)	inside rSNPs	diseases
3	nsv538711	chr7:5814823-6745710	Weak transcription ZNF genes & repeats Flanking Active TSS Enhancers Active TSS Genic enhancers Strong transcription Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	138 gene(s)	inside rSNPs	diseases
4	nsv1028242	chr7:5819084-6645024	Flanking Active TSS Weak transcription Enhancers Bivalent/Poised TSS Strong transcription Bivalent Enhancer Active TSS Genic enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	127 gene(s)	inside rSNPs	diseases
5	nsv538712	chr7:5819084-6645024	Weak transcription Active TSS Genic enhancers Enhancers Bivalent Enhancer Flanking Active TSS Strong transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	127 gene(s)	inside rSNPs	diseases
6	nsv949531	chr7:5949371-6753694	Strong transcription Bivalent Enhancer Bivalent/Poised TSS Enhancers Weak transcription Genic enhancers Flanking Active TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh ZNF genes & repeats Active TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	129 gene(s)	inside rSNPs	diseases
7	nsv1021037	chr7:6070792-6426966	Strong transcription Enhancers Flanking Active TSS Active TSS Weak transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	64 gene(s)	inside rSNPs	diseases
8	nsv538713	chr7:6070792-6426966	Weak transcription Flanking Active TSS Enhancers Genic enhancers Active TSS Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	64 gene(s)	inside rSNPs	diseases
9	nsv530989	chr7:6176729-6438197	Strong transcription Enhancers Weak transcription Genic enhancers Active TSS Transcr. at gene 5' and 3' Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
10	nsv1020236	chr7:6248930-6690377	Weak transcription Enhancers Flanking Active TSS Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Strong transcription Genic enhancers Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	52 gene(s)	inside rSNPs	diseases
11	nsv497874	chr7:6296768-6614902	Transcr. at gene 5' and 3' Enhancers Weak transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Active TSS Strong transcription Genic enhancers Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	30 gene(s)	inside rSNPs	diseases
12	nsv605999	chr7:6396719-6472881	Weak transcription Strong transcription Genic enhancers Flanking Active TSS Active TSS ZNF genes & repeats Enhancers Transcr. at gene 5' and 3' Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	11 gene(s)	inside rSNPs	diseases

mRNA abundance (count:7)

SNP	Gene	Cis/trans	Tissue	Source
rs7456834	DAGLB	cis	Whole Blood	GTEx
rs7456834	DAGLB	cis	Skin Sun Exposed Lower leg	GTEx
rs7456834	DAGLB	cis	Artery Tibial	GTEx
rs7456834	DAGLB	cis	Nerve Tibial	GTEx
rs7456834	DAGLB	cis	Thyroid	GTEx
rs7456834	RAC1	Cis_1M	lymphoblastoid	RTeQTL
rs7456834	DAGLB	cis	Adipose Subcutaneous	GTEx

Chromatin state (count:126 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr7:6412800-6416600	Active TSS	Rectal Mucosa Donor 29	rectum
2	chr7:6413000-6416600	Active TSS	GM12878-XiMat	blood
3	chr7:6413000-6416800	Active TSS	iPS-15b Cell Line	embryonic stem cell
4	chr7:6413200-6416600	Active TSS	HepG2	liver
5	chr7:6413400-6416600	Active TSS	HUES6 Cell Line	embryonic stem cell
6	chr7:6413400-6416600	Active TSS	Foreskin Fibroblast Primary Cells skin02	Skin
7	chr7:6413600-6416600	Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
8	chr7:6413600-6416600	Active TSS	Foreskin Melanocyte Primary Cells skin01	Skin
9	chr7:6413600-6416600	Active TSS	Left Ventricle	heart
10	chr7:6413600-6416600	Active TSS	Right Atrium	heart
11	chr7:6413600-6416600	Active TSS	HSMM	muscle
12	chr7:6413600-6416600	Active TSS	NHLF	lung
13	chr7:6413600-6417000	Active TSS	Esophagus	oesophagus
14	chr7:6413600-6417200	Active TSS	HUES48 Cell Line	embryonic stem cell
15	chr7:6413800-6416600	Active TSS	Right Ventricle	heart
16	chr7:6414400-6417200	Active TSS	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
17	chr7:6415200-6416600	Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
18	chr7:6415200-6416600	Active TSS	Foreskin Keratinocyte Primary Cells skin03	Skin
19	chr7:6415400-6417000	Weak transcription	Spleen	Spleen
20	chr7:6415400-6417200	Enhancers	Primary B cells from peripheral blood	blood
21	chr7:6415600-6416600	Enhancers	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
22	chr7:6415600-6416600	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
23	chr7:6415600-6416600	Weak transcription	Gastric	stomach
24	chr7:6415600-6416600	Weak transcription	Pancreas	Pancrea
25	chr7:6415600-6416800	Enhancers	Primary T helper memory cells from peripheral blood 1	blood
26	chr7:6415600-6417800	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
27	chr7:6415600-6418000	Enhancers	Primary T helper naive cells fromperipheralblood	blood
28	chr7:6415600-6418200	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
29	chr7:6415600-6423800	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
30	chr7:6415800-6416600	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
31	chr7:6415800-6416600	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
32	chr7:6415800-6416600	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
33	chr7:6415800-6416600	Weak transcription	Brain Anterior Caudate	brain
34	chr7:6415800-6416600	Enhancers	Brain Dorsolateral Prefrontal Cortex	brain
35	chr7:6415800-6416600	Enhancers	Brain Substantia Nigra	brain
36	chr7:6415800-6416600	Enhancers	Colon Smooth Muscle	Colon
37	chr7:6415800-6416600	Enhancers	Fetal Brain Male	brain
38	chr7:6415800-6416600	Enhancers	Fetal Muscle Trunk	muscle
39	chr7:6415800-6416600	Enhancers	Fetal Stomach	stomach
40	chr7:6415800-6416600	Weak transcription	Ovary	ovary
41	chr7:6415800-6416600	Weak transcription	Sigmoid Colon	Sigmoid Colon
42	chr7:6415800-6416600	Enhancers	Skeletal Muscle Female	skeletal muscle
43	chr7:6415800-6416600	Enhancers	Osteobl	bone
44	chr7:6415800-6416800	Enhancers	Primary T helper cells fromperipheralblood	blood
45	chr7:6415800-6416800	Active TSS	Ganglion Eminence derived primary cultured neurospheres	brain
46	chr7:6415800-6417000	Enhancers	Fetal Lung	lung
47	chr7:6415800-6417200	Enhancers	Primary T killer memory cells from peripheral blood	blood
48	chr7:6415800-6417400	Enhancers	Primary T cells fromperipheralblood	blood
49	chr7:6415800-6417600	Enhancers	Brain Angular Gyrus	brain
50	chr7:6415800-6417600	Enhancers	Fetal Kidney	kidney

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