Variant report

Variant	rs964285
Chromosome Location	chr15:59170964-59170965
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr15:59168045..59172125-chr15:59189388..59193241,4	K562	blood:
2	chr15:59167194..59169096-chr15:59170311..59172735,2	K562	blood:
3	chr15:59169081..59172963-chr15:59222560..59227013,5	K562	blood:
4	chr15:59169557..59171872-chr15:59175822..59177559,2	K562	blood:
5	chr15:59167284..59169096-chr15:59170311..59173301,2	K562	blood:
6	chr15:59166234..59168603-chr15:59169493..59172522,3	MCF-7	breast:
7	chr15:59169108..59171726-chr15:59174874..59180386,5	K562	blood:

Variant related genes	Relation type
ENSG00000137776	Chromatin interaction

Extended variants
information (count: 13 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:6)

rs_ID	r²[population]
rs11630265	0.94[AMR][1000 genomes];0.94[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11856185	0.80[EUR][1000 genomes]
rs12901551	1.00[CEU][hapmap];1.00[CHB][hapmap];0.93[JPT][hapmap];0.94[AMR][1000 genomes];0.94[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs632811	0.81[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs7179399	0.91[AFR][1000 genomes];0.94[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7179456	0.82[ASW][hapmap];0.92[CEU][hapmap];0.90[CHB][hapmap];0.90[CHD][hapmap];0.96[GIH][hapmap];0.95[MEX][hapmap];0.90[TSI][hapmap];0.92[AMR][1000 genomes];0.89[EUR][1000 genomes];0.85[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:7 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv34110	chr15:58949991-59381634	Weak transcription Bivalent Enhancer Strong transcription Enhancers Active TSS Flanking Active TSS ZNF genes & repeats Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	87 gene(s)	inside rSNPs	diseases
2	esv1826703	chr15:59005922-59213678	Flanking Active TSS Enhancers Strong transcription Weak transcription Active TSS Genic enhancers Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	44 gene(s)	inside rSNPs	diseases
3	esv1798487	chr15:59027139-59213678	Strong transcription Weak transcription Enhancers Active TSS Bivalent/Poised TSS Flanking Active TSS Genic enhancers Bivalent Enhancer ZNF genes & repeats Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	42 gene(s)	inside rSNPs	diseases
4	nsv527307	chr15:59103328-60018487	Enhancers Genic enhancers Weak transcription Flanking Bivalent TSS/Enh Strong transcription Flanking Active TSS Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	145 gene(s)	inside rSNPs	diseases
5	nsv1035640	chr15:59105360-59190930	Enhancers Strong transcription Weak transcription Active TSS Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS Genic enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	11 gene(s)	inside rSNPs	diseases
6	nsv904270	chr15:59140329-59238415	Genic enhancers Weak transcription Flanking Active TSS Active TSS Strong transcription Enhancers ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	48 gene(s)	inside rSNPs	diseases
7	nsv94675	chr15:59164881-59174380	Strong transcription Weak transcription Genic enhancers Enhancers	Chromatin interactive region miRNA target site	4 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs964285	ADAM10	cis	parietal	SCAN

Chromatin state (count:125 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr15:59147600-59174600	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
2	chr15:59157800-59172600	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
3	chr15:59158000-59171800	Weak transcription	Right Ventricle	heart
4	chr15:59158200-59174600	Weak transcription	Pancreatic Islets	Pancreatic Islet
5	chr15:59166800-59179400	Weak transcription	Fetal Heart	heart
6	chr15:59167000-59193200	Strong transcription	Foreskin Melanocyte Primary Cells skin03	Skin
7	chr15:59167400-59173600	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
8	chr15:59167600-59172000	Strong transcription	GM12878-XiMat	blood
9	chr15:59167600-59176000	Strong transcription	HSMM	muscle
10	chr15:59167800-59187600	Strong transcription	Foreskin Fibroblast Primary Cells skin01	Skin
11	chr15:59167800-59194000	Strong transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
12	chr15:59168000-59175400	Weak transcription	Small Intestine	intestine
13	chr15:59168000-59182000	Strong transcription	Thymus	Thymus
14	chr15:59168000-59188800	Strong transcription	Fetal Muscle Leg	muscle
15	chr15:59168200-59171000	Strong transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
16	chr15:59168200-59189000	Strong transcription	Fetal Muscle Trunk	muscle
17	chr15:59168200-59202200	Strong transcription	Fetal Thymus	thymus
18	chr15:59168400-59171000	Strong transcription	Gastric	stomach
19	chr15:59168400-59181800	Strong transcription	Breast Myoepithelial Primary Cells	Breast
20	chr15:59168400-59182600	Strong transcription	NHLF	lung
21	chr15:59168400-59188400	Strong transcription	Stomach Smooth Muscle	stomach
22	chr15:59168400-59188800	Strong transcription	IMR90 fetal lung fibroblasts Cell Line	lung
23	chr15:59168400-59193200	Strong transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
24	chr15:59168400-59193200	Strong transcription	Duodenum Smooth Muscle	Duodenum
25	chr15:59168400-59206600	Strong transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
26	chr15:59168400-59209600	Strong transcription	Monocytes-CD14+_RO01746	blood
27	chr15:59168600-59171800	Strong transcription	Fetal Kidney	kidney
28	chr15:59168600-59176200	Strong transcription	Primary neutrophils fromperipheralblood	blood
29	chr15:59168600-59178000	Strong transcription	Foreskin Melanocyte Primary Cells skin01	Skin
30	chr15:59168600-59188600	Strong transcription	Skeletal Muscle Male	skeletal muscle
31	chr15:59168600-59189400	Strong transcription	Ganglion Eminence derived primary cultured neurospheres	brain
32	chr15:59168600-59193000	Strong transcription	A549	lung
33	chr15:59168600-59195800	Strong transcription	Dnd41	blood
34	chr15:59168600-59202400	Strong transcription	H9 Derived Neuron Cultured Cells	ES cell derived
35	chr15:59168600-59209800	Strong transcription	HUES6 Cell Line	embryonic stem cell
36	chr15:59168600-59220000	Strong transcription	iPS-20b Cell Line	embryonic stem cell
37	chr15:59168800-59176000	Strong transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
38	chr15:59168800-59177400	Strong transcription	HSMMtube	muscle
39	chr15:59168800-59180400	Weak transcription	Stomach Mucosa	stomach
40	chr15:59168800-59190200	Strong transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
41	chr15:59168800-59193200	Strong transcription	Muscle Satellite Cultured Cells	--
42	chr15:59168800-59193200	Strong transcription	Adipose Nuclei	Adipose
43	chr15:59169000-59179800	Strong transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
44	chr15:59169000-59190400	Strong transcription	Cortex derived primary cultured neurospheres	brain
45	chr15:59169000-59193000	Strong transcription	Primary T helper 17 cells PMA-I stimulated	--
46	chr15:59169000-59193200	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
47	chr15:59169000-59193400	Strong transcription	K562	blood
48	chr15:59169000-59209800	Strong transcription	HUES64 Cell Line	embryonic stem cell
49	chr15:59169000-59210600	Strong transcription	HUES48 Cell Line	embryonic stem cell
50	chr15:59169200-59171000	Strong transcription	Foreskin Fibroblast Primary Cells skin02	Skin

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