Variant report

Variant	rs10741071
Chromosome Location	chr10:25237193-25237194
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	IKZF1	chr10:25236220-25237214	GM12878	blood:	n/a	n/a
2	GATA3	chr10:25236780-25237584	SK-N-SH	brain:	n/a	chr10:25237043-25237053 chr10:25237039-25237060 chr10:25237019-25237029
3	GATA2	chr10:25237144-25237415	SH-SY5Y	brain:	n/a	n/a

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:25235302..25239090-chr10:25240000..25243649,4	MCF-7	breast:
2	chr10:25228270..25233826-chr10:25234068..25237911,6	K562	blood:

Variant related genes	Relation type
ENSG00000273107	TF binding region
ENSG00000273107	Chromatin interaction
ENSG00000099256	Chromatin interaction

Extended variants
information (count: 19 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:18)

rs_ID	r²[population]
rs10741072	0.91[CHD][hapmap];0.83[JPT][hapmap];0.86[ASN][1000 genomes]
rs10764513	0.96[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10828731	0.81[ASN][1000 genomes]
rs11014318	0.87[JPT][hapmap];0.86[ASN][1000 genomes]
rs11014320	0.87[ASN][1000 genomes]
rs185669	0.82[CHD][hapmap];0.80[ASN][1000 genomes]
rs2035888	0.91[CHD][hapmap];0.87[JPT][hapmap];0.88[ASN][1000 genomes]
rs2478091	0.85[ASN][1000 genomes]
rs274295	0.96[ASN][1000 genomes]
rs274296	0.95[CHB][hapmap];0.93[CHD][hapmap];0.83[GIH][hapmap];0.91[JPT][hapmap];0.96[ASN][1000 genomes]
rs274297	0.95[ASN][1000 genomes]
rs274299	0.83[ASN][1000 genomes]
rs274300	0.90[ASN][1000 genomes]
rs274305	0.81[JPT][hapmap]
rs274311	0.82[JPT][hapmap]
rs274313	0.82[JPT][hapmap]
rs274316	0.86[JPT][hapmap];0.83[ASN][1000 genomes]
rs3748223	0.89[CHD][hapmap];0.83[JPT][hapmap];0.84[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:1 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1053278	chr10:25140776-25269093	Flanking Active TSS Enhancers Weak transcription Active TSS ZNF genes & repeats Strong transcription Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10741071	DHRS2	trans	cerebellum	SCAN

Chromatin state (count:67 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:25191600-25240600	Weak transcription	Stomach Smooth Muscle	stomach
2	chr10:25211400-25239800	Weak transcription	Fetal Kidney	kidney
3	chr10:25215800-25240000	Weak transcription	Fetal Muscle Trunk	muscle
4	chr10:25219200-25240000	Weak transcription	Dnd41	blood
5	chr10:25225400-25240000	Weak transcription	Duodenum Mucosa	Duodenum
6	chr10:25225400-25240000	Weak transcription	Fetal Brain Female	brain
7	chr10:25226200-25239800	Weak transcription	Fetal Lung	lung
8	chr10:25226400-25239200	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
9	chr10:25228200-25239800	Weak transcription	Fetal Stomach	stomach
10	chr10:25232600-25239800	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
11	chr10:25232800-25240000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
12	chr10:25233600-25237800	Enhancers	Brain Anterior Caudate	brain
13	chr10:25234200-25237200	Weak transcription	Hela-S3	cervix
14	chr10:25234200-25240400	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
15	chr10:25234200-25240400	Weak transcription	Colon Smooth Muscle	Colon
16	chr10:25234200-25240600	Weak transcription	Rectal Mucosa Donor 31	rectum
17	chr10:25234200-25240600	Weak transcription	Right Atrium	heart
18	chr10:25234400-25239800	Weak transcription	A549	lung
19	chr10:25234400-25239800	Weak transcription	HepG2	liver
20	chr10:25234400-25239800	Weak transcription	K562	blood
21	chr10:25234400-25240600	Weak transcription	Adipose Nuclei	Adipose
22	chr10:25234600-25239800	Weak transcription	Fetal Intestine Small	intestine
23	chr10:25234800-25238000	Enhancers	Brain Inferior Temporal Lobe	brain
24	chr10:25235400-25237600	Enhancers	Foreskin Melanocyte Primary Cells skin03	Skin
25	chr10:25235400-25240400	Enhancers	Brain Substantia Nigra	brain
26	chr10:25235600-25237200	Enhancers	Breast Myoepithelial Primary Cells	Breast
27	chr10:25235800-25237200	Enhancers	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
28	chr10:25235800-25237200	Enhancers	HMEC	breast
29	chr10:25235800-25237400	Enhancers	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
30	chr10:25235800-25237400	Enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
31	chr10:25235800-25237600	Enhancers	Cortex derived primary cultured neurospheres	brain
32	chr10:25235800-25237600	Enhancers	Ganglion Eminence derived primary cultured neurospheres	brain
33	chr10:25235800-25238000	Enhancers	Brain Angular Gyrus	brain
34	chr10:25236000-25237200	Enhancers	GM12878-XiMat	blood
35	chr10:25236000-25237200	Enhancers	HUVEC	blood vessel
36	chr10:25236000-25237200	Enhancers	NHDF-Ad	bronchial
37	chr10:25236000-25237400	Enhancers	NHEK	skin
38	chr10:25236000-25237800	Enhancers	Foreskin Melanocyte Primary Cells skin01	Skin
39	chr10:25236200-25237200	Enhancers	Foreskin Keratinocyte Primary Cells skin02	Skin
40	chr10:25236200-25237400	Enhancers	Primary T regulatory cells fromperipheralblood	blood
41	chr10:25236200-25241000	Weak transcription	Thymus	Thymus
42	chr10:25236600-25237400	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
43	chr10:25236600-25237400	Enhancers	Brain Dorsolateral Prefrontal Cortex	brain
44	chr10:25236600-25240200	Weak transcription	NHLF	lung
45	chr10:25236800-25237800	Enhancers	Brain Cingulate Gyrus	brain
46	chr10:25236800-25239400	Enhancers	Brain Hippocampus Middle	brain
47	chr10:25236800-25239800	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
48	chr10:25236800-25240000	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
49	chr10:25236800-25240600	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
50	chr10:25236800-25240600	Weak transcription	Left Ventricle	heart

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