Variant report

Variant	rs10887945
Chromosome Location	chr10:91087256-91087257
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	MAX	chr10:91087227-91088327	A549	lung:	n/a	n/a
2	FOS	chr10:91087223-91088456	HUVEC	blood vessel:	n/a	n/a
3	FOXM1	chr10:91087238-91088474	ECC-1	luminal epithelium:	n/a	n/a
4	TEAD4	chr10:91087206-91088314	SK-N-SH	brain:	n/a	chr10:91087910-91087919
5	MTA3	chr10:91087202-91087907	GM12878	blood:	n/a	n/a
6	MAX	chr10:91087237-91088401	ECC-1	luminal epithelium:	n/a	n/a

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:91086403..91089519-chr10:91091273..91094339,4	K562	blood:

Variant related genes	Relation type
IFIT3	TF binding region
ENSG00000119917	Chromatin interaction

Extended variants
information (count: 29 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:24)

rs_ID	r²[population]
rs10788641	0.92[EUR][1000 genomes]
rs10887942	0.82[AFR][1000 genomes];1.00[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10887946	0.98[AMR][1000 genomes];0.99[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs10887947	0.98[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs10887948	0.80[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs11203064	0.90[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11203065	0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11203078	0.83[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs1141862	0.80[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs12220939	0.94[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs191027	0.84[EUR][1000 genomes]
rs304492	0.81[AMR][1000 genomes]
rs304501	0.84[EUR][1000 genomes]
rs304502	0.84[AMR][1000 genomes]
rs304503	0.84[AMR][1000 genomes]
rs304505	0.83[AMR][1000 genomes]
rs304506	0.83[AMR][1000 genomes]
rs304508	0.84[EUR][1000 genomes]
rs305374	0.81[EUR][1000 genomes]
rs4934472	1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs627127	0.82[EUR][1000 genomes]
rs627496	0.87[EUR][1000 genomes]
rs781501	0.92[AMR][1000 genomes]
rs812451	0.83[AMR][1000 genomes];0.87[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:5 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1042848	chr10:90466032-91318474	Weak transcription Enhancers Flanking Active TSS Active TSS Bivalent/Poised TSS Bivalent Enhancer Strong transcription Genic enhancers Flanking Bivalent TSS/Enh ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	66 gene(s)	inside rSNPs	diseases
2	nsv540741	chr10:90466032-91318474	Enhancers Flanking Active TSS Weak transcription Genic enhancers Bivalent Enhancer ZNF genes & repeats Strong transcription Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	66 gene(s)	inside rSNPs	diseases
3	nsv1041964	chr10:90861380-91378356	Flanking Active TSS Enhancers Weak transcription Genic enhancers Bivalent/Poised TSS Active TSS Flanking Bivalent TSS/Enh Strong transcription Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	82 gene(s)	inside rSNPs	diseases
4	nsv1040375	chr10:91022218-91153074	Enhancers Active TSS Weak transcription Flanking Active TSS Transcr. at gene 5' and 3' Strong transcription Genic enhancers ZNF genes & repeats Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	16 gene(s)	inside rSNPs	diseases
5	esv34085	chr10:91065949-91174175	Enhancers Weak transcription Active TSS Strong transcription Genic enhancers Flanking Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	14 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10887945	IFIT5	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:97 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:91085600-91087400	Enhancers	Brain Hippocampus Middle	brain
2	chr10:91085800-91087400	Weak transcription	Fetal Heart	heart
3	chr10:91086200-91087400	Enhancers	ES-I3 Cell Line	embryonic stem cell
4	chr10:91086200-91087400	Weak transcription	HUES48 Cell Line	embryonic stem cell
5	chr10:91086200-91087600	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
6	chr10:91086400-91087400	Enhancers	Foreskin Melanocyte Primary Cells skin03	Skin
7	chr10:91086600-91087400	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
8	chr10:91086600-91087400	Enhancers	HUES6 Cell Line	embryonic stem cell
9	chr10:91086600-91087400	Enhancers	iPS-20b Cell Line	embryonic stem cell
10	chr10:91086600-91087400	Enhancers	Ganglion Eminence derived primary cultured neurospheres	brain
11	chr10:91086600-91087400	Enhancers	Hela-S3	cervix
12	chr10:91086600-91087400	Enhancers	NH-A	brain
13	chr10:91086600-91087800	Flanking Active TSS	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
14	chr10:91086600-91088200	Enhancers	H1 Cell Line	embryonic stem cell
15	chr10:91086600-91088200	Enhancers	H9 Cell Line	embryonic stem cell
16	chr10:91086600-91089200	Enhancers	iPS-18 Cell Line	embryonic stem cell
17	chr10:91086800-91087400	Flanking Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
18	chr10:91086800-91087400	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
19	chr10:91086800-91087400	Enhancers	Primary T killer naive cells fromperipheralblood	blood
20	chr10:91086800-91087400	Enhancers	Primary T killer memory cells from peripheral blood	blood
21	chr10:91086800-91087400	Weak transcription	Brain Angular Gyrus	brain
22	chr10:91086800-91087600	Flanking Active TSS	Muscle Satellite Cultured Cells	--
23	chr10:91086800-91087800	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
24	chr10:91087000-91087400	Enhancers	Primary T helper 17 cells PMA-I stimulated	--
25	chr10:91087000-91087400	Active TSS	Adipose Nuclei	Adipose
26	chr10:91087000-91087400	Flanking Active TSS	Fetal Adrenal Gland	Adrenal Gland
27	chr10:91087000-91087400	Enhancers	Fetal Lung	lung
28	chr10:91087000-91087400	Enhancers	Skeletal Muscle Male	skeletal muscle
29	chr10:91087000-91088000	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
30	chr10:91087000-91088200	Active TSS	Foreskin Fibroblast Primary Cells skin02	Skin
31	chr10:91087000-91088200	Active TSS	HSMM	muscle
32	chr10:91087000-91088400	Active TSS	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
33	chr10:91087000-91088400	Active TSS	Brain Dorsolateral Prefrontal Cortex	brain
34	chr10:91087000-91088400	Flanking Active TSS	HUVEC	blood vessel
35	chr10:91087000-91088600	Flanking Active TSS	Primary T helper cells PMA-I stimulated	--
36	chr10:91087000-91088800	Enhancers	iPS-15b Cell Line	embryonic stem cell
37	chr10:91087000-91088800	Flanking Active TSS	Primary B cells from cord blood	blood
38	chr10:91087000-91089000	Active TSS	Rectal Mucosa Donor 29	rectum
39	chr10:91087000-91089400	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
40	chr10:91087000-91089600	Flanking Active TSS	Primary neutrophils fromperipheralblood	blood
41	chr10:91087200-91087400	Flanking Active TSS	Primary monocytes fromperipheralblood	blood
42	chr10:91087200-91087400	Enhancers	Primary T helper cells fromperipheralblood	blood
43	chr10:91087200-91087400	Active TSS	Primary T regulatory cells fromperipheralblood	blood
44	chr10:91087200-91087400	Active TSS	Cortex derived primary cultured neurospheres	brain
45	chr10:91087200-91087400	Flanking Active TSS	Liver	Liver
46	chr10:91087200-91087400	Enhancers	Brain Substantia Nigra	brain
47	chr10:91087200-91087400	Flanking Active TSS	Skeletal Muscle Female	skeletal muscle
48	chr10:91087200-91087400	Enhancers	GM12878-XiMat	blood
49	chr10:91087200-91087400	Flanking Active TSS	HepG2	liver
50	chr10:91087200-91087400	Enhancers	K562	blood

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