Variant report

Variant	rs1416901
Chromosome Location	chr10:21820453-21820454
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	CEBPB	chr10:21819869-21820526	K562	blood:	n/a	chr10:21820338-21820351
2	CEBPB	chr10:21820128-21820495	K562	blood:	n/a	chr10:21820338-21820351
3	MYC	chr10:21820231-21820537	MCF10A-Er-Src	breast:	n/a	n/a
4	RUNX3	chr10:21820042-21820494	GM12878	blood:	n/a	chr10:21820272-21820281 chr10:21820264-21820281 chr10:21820272-21820281
5	FOS	chr10:21820136-21820456	MCF10A-Er-Src	breast:	n/a	n/a
6	CEBPB	chr10:21820146-21820501	IMR90	lung:	n/a	chr10:21820338-21820351

No.	Distal block	Cell Line	Cell type
1	chr10:21763967..21765915-chr10:21820410..21823036,2	MCF-7	breast:
2	chr10:21784105..21788419-chr10:21820020..21825934,15	K562	blood:
3	chr10:21819505..21821864-chr10:21895840..21898768,2	K562	blood:
4	chr10:21779286..21780842-chr10:21820192..21822090,2	K562	blood:
5	chr10:21819973..21822184-chr10:22292181..22294416,2	K562	blood:
6	chr10:21783009..21787738-chr10:21813105..21820576,17	MCF-7	breast:

Variant related genes	Relation type
MLLT10	TF binding region
ENSG00000204682	Chromatin interaction
ENSG00000136770	Chromatin interaction
ENSG00000222071	Chromatin interaction

Extended variants
information (count: 36 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:13)

rs_ID	r²[population]
rs10828247	0.91[CEU][hapmap];1.00[CHB][hapmap];0.85[LWK][hapmap];0.95[MKK][hapmap];0.89[TSI][hapmap];1.00[YRI][hapmap];0.80[AFR][1000 genomes];0.96[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10828248	0.82[CEU][hapmap];1.00[CHB][hapmap];0.82[LWK][hapmap];0.95[MKK][hapmap];0.91[TSI][hapmap];1.00[YRI][hapmap];0.93[AFR][1000 genomes];0.97[AMR][1000 genomes];0.95[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs10828249	0.83[CEU][hapmap];1.00[CHB][hapmap];0.82[LWK][hapmap];0.95[MKK][hapmap];0.91[TSI][hapmap];1.00[YRI][hapmap];0.91[AFR][1000 genomes];0.97[AMR][1000 genomes];0.94[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10828250	0.81[EUR][1000 genomes]
rs11012732	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs12251016	0.92[AFR][1000 genomes];0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs12253527	0.98[AFR][1000 genomes];0.96[AMR][1000 genomes];0.94[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs12256551	0.82[CEU][hapmap]
rs12779865	0.83[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs1802669	0.92[AFR][1000 genomes];0.94[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs6482189	0.81[CEU][hapmap];1.00[CHB][hapmap]
rs7084454	0.82[CEU][hapmap];0.93[YRI][hapmap];0.84[AFR][1000 genomes];0.91[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs7098100	0.91[CEU][hapmap];1.00[CHB][hapmap];0.91[TSI][hapmap];0.84[AMR][1000 genomes];0.93[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:23 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv825284	chr10:21739527-21847437	Active TSS Weak transcription Flanking Active TSS Flanking Bivalent TSS/Enh Strong transcription Bivalent/Poised TSS Enhancers Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
2	nsv825285	chr10:21742026-21874334	Strong transcription Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
3	nsv825286	chr10:21757784-21838890	Flanking Active TSS Bivalent/Poised TSS Weak transcription Active TSS Enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Genic enhancers Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
4	nsv825288	chr10:21759085-21831354	Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Active TSS Enhancers Strong transcription Weak transcription Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
5	nsv825289	chr10:21762506-21845875	Strong transcription Enhancers Active TSS Bivalent/Poised TSS Flanking Active TSS Weak transcription Bivalent Enhancer Genic enhancers Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
6	nsv527055	chr10:21764019-21822856	Bivalent/Poised TSS Weak transcription Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Active TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
7	nsv825290	chr10:21777857-21830878	Active TSS Flanking Active TSS Weak transcription Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription Bivalent/Poised TSS Enhancers Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
8	nsv894936	chr10:21781589-21827796	Active TSS Bivalent/Poised TSS Weak transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Enhancers Genic enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
9	nsv550200	chr10:21782842-21824727	Active TSS Bivalent/Poised TSS Enhancers Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Weak transcription Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3' Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
10	nsv894937	chr10:21782842-21827796	Enhancers Transcr. at gene 5' and 3' Flanking Active TSS Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Weak transcription Bivalent Enhancer Strong transcription Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
11	nsv517469	chr10:21783634-21822856	Active TSS Bivalent Enhancer Flanking Active TSS Weak transcription Enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
12	nsv894938	chr10:21784899-21827796	Enhancers Flanking Active TSS Active TSS Weak transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
13	nsv894939	chr10:21789406-21830104	Bivalent Enhancer Enhancers Active TSS Flanking Active TSS Bivalent/Poised TSS Weak transcription Flanking Bivalent TSS/Enh Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
14	nsv825291	chr10:21792100-21830946	Active TSS Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Weak transcription Strong transcription Bivalent Enhancer Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
15	nsv894940	chr10:21796081-21823525	Active TSS Flanking Active TSS Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
16	nsv550201	chr10:21796081-21824727	Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
17	nsv894941	chr10:21796081-21827796	Weak transcription Enhancers Active TSS Strong transcription Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
18	nsv894942	chr10:21798241-21823525	Flanking Active TSS Active TSS Enhancers Weak transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
19	nsv894943	chr10:21798241-21824619	Active TSS Flanking Bivalent TSS/Enh Enhancers Flanking Active TSS Weak transcription Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
20	nsv894944	chr10:21798241-21827796	Flanking Active TSS Active TSS Weak transcription Bivalent Enhancer Enhancers Strong transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Genic enhancers Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
21	nsv894945	chr10:21798241-21830104	Active TSS Bivalent Enhancer Enhancers Weak transcription Flanking Active TSS Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
22	nsv894946	chr10:21798241-21831215	Enhancers Bivalent/Poised TSS Weak transcription Flanking Active TSS Strong transcription Genic enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
23	nsv1052477	chr10:21810270-21889726	Active TSS Genic enhancers Enhancers Weak transcription Strong transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Flanking Active TSS ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs1416901	MLLT10	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:93 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:21816600-21821800	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
2	chr10:21816600-21821800	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
3	chr10:21816600-21822400	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
4	chr10:21816600-21822400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
5	chr10:21817000-21821600	Weak transcription	Primary T helper cells fromperipheralblood	blood
6	chr10:21817000-21821800	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
7	chr10:21817000-21821800	Weak transcription	Primary T cells fromperipheralblood	blood
8	chr10:21817000-21821800	Weak transcription	Placenta Amnion	Placenta Amnion
9	chr10:21817000-21822200	Weak transcription	Placenta	Placenta
10	chr10:21817200-21821200	Weak transcription	Primary T cells from cord blood	blood
11	chr10:21817200-21821200	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
12	chr10:21817200-21821200	Weak transcription	Fetal Intestine Large	intestine
13	chr10:21817200-21821600	Weak transcription	Primary neutrophils fromperipheralblood	blood
14	chr10:21817200-21821600	Weak transcription	Primary T helper naive cells fromperipheralblood	blood
15	chr10:21817200-21821800	Weak transcription	Fetal Stomach	stomach
16	chr10:21817400-21821200	Weak transcription	Fetal Intestine Small	intestine
17	chr10:21817400-21821600	Weak transcription	Primary T helper naive cells from peripheral blood	blood
18	chr10:21817400-21821600	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
19	chr10:21817600-21821600	Weak transcription	Primary T helper cells PMA-I stimulated	--
20	chr10:21817600-21821600	Weak transcription	Stomach Smooth Muscle	stomach
21	chr10:21817600-21821600	Weak transcription	Monocytes-CD14+_RO01746	blood
22	chr10:21817600-21821800	Weak transcription	Primary monocytes fromperipheralblood	blood
23	chr10:21817600-21821800	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
24	chr10:21817600-21821800	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
25	chr10:21817600-21821800	Weak transcription	Hela-S3	cervix
26	chr10:21817800-21821000	Weak transcription	Pancreatic Islets	Pancreatic Islet
27	chr10:21817800-21821200	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
28	chr10:21817800-21821600	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
29	chr10:21817800-21821600	Weak transcription	Duodenum Smooth Muscle	Duodenum
30	chr10:21817800-21821800	Weak transcription	NHLF	lung
31	chr10:21818000-21821200	Weak transcription	Foreskin Melanocyte Primary Cells skin03	Skin
32	chr10:21818000-21821200	Weak transcription	Adipose Nuclei	Adipose
33	chr10:21818000-21821200	Weak transcription	Brain Angular Gyrus	brain
34	chr10:21818000-21821600	Weak transcription	Brain Inferior Temporal Lobe	brain
35	chr10:21818000-21821600	Weak transcription	Colon Smooth Muscle	Colon
36	chr10:21818000-21822000	Weak transcription	Osteobl	bone
37	chr10:21818000-21822200	Weak transcription	Small Intestine	intestine
38	chr10:21818200-21821000	Weak transcription	HUVEC	blood vessel
39	chr10:21818200-21821200	Weak transcription	H9 Cell Line	embryonic stem cell
40	chr10:21818200-21821200	Weak transcription	NHDF-Ad	bronchial
41	chr10:21818200-21821600	Weak transcription	Brain Anterior Caudate	brain
42	chr10:21818200-21821600	Weak transcription	Brain Cingulate Gyrus	brain
43	chr10:21818200-21821600	Weak transcription	HMEC	breast
44	chr10:21818200-21821800	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
45	chr10:21818200-21821800	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
46	chr10:21818200-21821800	Weak transcription	Brain Germinal Matrix	brain
47	chr10:21818200-21821800	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
48	chr10:21818200-21821800	Weak transcription	HSMMtube	muscle
49	chr10:21818200-21822000	Weak transcription	Fetal Muscle Leg	muscle
50	chr10:21818200-21822200	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung

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