Variant report

Variant	rs12256551
Chromosome Location	chr10:21799726-21799727
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr10:21794668..21800963-chr10:21813670..21817700,8	MCF-7	breast:
2	chr10:21799042..21801453-chr10:21803205..21806030,4	MCF-7	breast:
3	chr10:21798837..21800885-chr10:21814411..21817123,2	MCF-7	breast:
4	chr10:21798661..21801415-chr10:22093331..22096294,2	K562	blood:

Variant related genes	Relation type
ENSG00000180592	Chromatin interaction

Extended variants
information (count: 35 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:13)

rs_ID	r²[population]
rs10159545	0.81[EUR][1000 genomes]
rs10828246	0.82[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs10828247	0.91[CEU][hapmap]
rs10828248	0.82[CEU][hapmap]
rs10828249	0.83[CEU][hapmap]
rs11012725	0.92[AMR][1000 genomes];0.91[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs11012730	0.95[CEU][hapmap];1.00[CHB][hapmap];0.96[YRI][hapmap];0.88[AMR][1000 genomes];0.89[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs1416901	0.82[CEU][hapmap]
rs2183271	0.81[YRI][hapmap]
rs35336290	0.83[EUR][1000 genomes]
rs5011832	1.00[CHB][hapmap];0.83[EUR][1000 genomes]
rs874149	1.00[CHB][hapmap];0.81[EUR][1000 genomes]
rs9732777	0.81[AMR][1000 genomes];0.83[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:22 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv825284	chr10:21739527-21847437	Active TSS Weak transcription Flanking Active TSS Flanking Bivalent TSS/Enh Strong transcription Bivalent/Poised TSS Enhancers Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
2	nsv825285	chr10:21742026-21874334	Strong transcription Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
3	nsv825286	chr10:21757784-21838890	Flanking Active TSS Bivalent/Poised TSS Weak transcription Active TSS Enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Genic enhancers Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
4	nsv825288	chr10:21759085-21831354	Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Active TSS Enhancers Strong transcription Weak transcription Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
5	nsv825289	chr10:21762506-21845875	Strong transcription Enhancers Active TSS Bivalent/Poised TSS Flanking Active TSS Weak transcription Bivalent Enhancer Genic enhancers Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
6	nsv527055	chr10:21764019-21822856	Bivalent/Poised TSS Weak transcription Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Active TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
7	nsv825290	chr10:21777857-21830878	Active TSS Flanking Active TSS Weak transcription Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription Bivalent/Poised TSS Enhancers Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
8	nsv894936	chr10:21781589-21827796	Active TSS Bivalent/Poised TSS Weak transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Enhancers Genic enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
9	nsv550200	chr10:21782842-21824727	Active TSS Bivalent/Poised TSS Enhancers Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Weak transcription Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3' Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
10	nsv894937	chr10:21782842-21827796	Enhancers Transcr. at gene 5' and 3' Flanking Active TSS Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Weak transcription Bivalent Enhancer Strong transcription Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
11	nsv517469	chr10:21783634-21822856	Active TSS Bivalent Enhancer Flanking Active TSS Weak transcription Enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
12	nsv894938	chr10:21784899-21827796	Enhancers Flanking Active TSS Active TSS Weak transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
13	nsv894939	chr10:21789406-21830104	Bivalent Enhancer Enhancers Active TSS Flanking Active TSS Bivalent/Poised TSS Weak transcription Flanking Bivalent TSS/Enh Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
14	nsv825291	chr10:21792100-21830946	Active TSS Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Weak transcription Strong transcription Bivalent Enhancer Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
15	nsv894940	chr10:21796081-21823525	Active TSS Flanking Active TSS Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
16	nsv550201	chr10:21796081-21824727	Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
17	nsv894941	chr10:21796081-21827796	Weak transcription Enhancers Active TSS Strong transcription Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
18	nsv894942	chr10:21798241-21823525	Flanking Active TSS Active TSS Enhancers Weak transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
19	nsv894943	chr10:21798241-21824619	Active TSS Flanking Bivalent TSS/Enh Enhancers Flanking Active TSS Weak transcription Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
20	nsv894944	chr10:21798241-21827796	Flanking Active TSS Active TSS Weak transcription Bivalent Enhancer Enhancers Strong transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Genic enhancers Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
21	nsv894945	chr10:21798241-21830104	Active TSS Bivalent Enhancer Enhancers Weak transcription Flanking Active TSS Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
22	nsv894946	chr10:21798241-21831215	Enhancers Bivalent/Poised TSS Weak transcription Flanking Active TSS Strong transcription Genic enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs12256551	MLLT10	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:93 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:21789800-21799800	Weak transcription	Lung	lung
2	chr10:21795800-21799800	Enhancers	Fetal Heart	heart
3	chr10:21795800-21799800	Weak transcription	A549	lung
4	chr10:21796400-21801000	Weak transcription	K562	blood
5	chr10:21796800-21800000	Active TSS	ES-WA7 Cell Line	embryonic stem cell
6	chr10:21796800-21801000	Active TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
7	chr10:21797000-21800000	Active TSS	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
8	chr10:21797200-21799800	Active TSS	H9 Cell Line	embryonic stem cell
9	chr10:21797200-21800200	Active TSS	ES-I3 Cell Line	embryonic stem cell
10	chr10:21797400-21800200	Active TSS	HUES48 Cell Line	embryonic stem cell
11	chr10:21797400-21806600	Active TSS	Fetal Brain Female	brain
12	chr10:21797600-21799800	Active TSS	iPS-15b Cell Line	embryonic stem cell
13	chr10:21798200-21799800	Active TSS	Brain Inferior Temporal Lobe	brain
14	chr10:21798400-21799800	Active TSS	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
15	chr10:21798400-21799800	Active TSS	Brain Dorsolateral Prefrontal Cortex	brain
16	chr10:21798400-21800200	Enhancers	Fetal Brain Male	brain
17	chr10:21798600-21799800	Active TSS	Breast Myoepithelial Primary Cells	Breast
18	chr10:21798600-21799800	Active TSS	Colon Smooth Muscle	Colon
19	chr10:21798600-21799800	Flanking Active TSS	Fetal Muscle Trunk	muscle
20	chr10:21798600-21800200	Active TSS	HUES6 Cell Line	embryonic stem cell
21	chr10:21798800-21799800	Active TSS	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
22	chr10:21798800-21799800	Active TSS	H9 Derived Neuron Cultured Cells	ES cell derived
23	chr10:21798800-21799800	Active TSS	iPS-20b Cell Line	embryonic stem cell
24	chr10:21798800-21799800	Active TSS	Liver	Liver
25	chr10:21798800-21799800	Active TSS	Brain Cingulate Gyrus	brain
26	chr10:21798800-21799800	Active TSS	Brain Hippocampus Middle	brain
27	chr10:21798800-21799800	Active TSS	Brain Substantia Nigra	brain
28	chr10:21798800-21799800	Active TSS	Right Ventricle	heart
29	chr10:21798800-21799800	Active TSS	NHLF	lung
30	chr10:21798800-21799800	Active TSS	Osteobl	bone
31	chr10:21798800-21800000	Active TSS	iPS DF 6.9 Cell Line	embryonic stem cell
32	chr10:21798800-21800000	Flanking Active TSS	Primary hematopoietic stem cells	blood
33	chr10:21798800-21800000	Flanking Active TSS	Cortex derived primary cultured neurospheres	brain
34	chr10:21798800-21800200	Active TSS	ES-UCSF4 Cell Line	embryonic stem cell
35	chr10:21798800-21802200	Flanking Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
36	chr10:21799000-21799800	Active TSS	H1 Cell Line	embryonic stem cell
37	chr10:21799000-21799800	Active TSS	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
38	chr10:21799000-21799800	Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
39	chr10:21799000-21799800	Active TSS	Foreskin Keratinocyte Primary Cells skin03	Skin
40	chr10:21799000-21799800	Active TSS	Left Ventricle	heart
41	chr10:21799000-21799800	Flanking Bivalent TSS/Enh	Monocytes-CD14+_RO01746	blood
42	chr10:21799000-21799800	Active TSS	NHDF-Ad	bronchial
43	chr10:21799000-21800000	Bivalent Enhancer	Primary monocytes fromperipheralblood	blood
44	chr10:21799000-21800000	Bivalent Enhancer	Primary B cells from peripheral blood	blood
45	chr10:21799000-21800000	Enhancers	Primary hematopoietic stem cells short term culture	blood
46	chr10:21799000-21800000	Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
47	chr10:21799000-21800000	Flanking Bivalent TSS/Enh	Fetal Thymus	thymus
48	chr10:21799000-21800600	Active TSS	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
49	chr10:21799200-21799800	Active TSS	iPS DF 19.11 Cell Line	embryonic stem cell
50	chr10:21799200-21799800	Bivalent Enhancer	Primary T cells fromperipheralblood	blood

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