Variant report

Variant	rs2421552
Chromosome Location	chr2:73758803-73758804
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

Extended variants
information (count: 189 )
Associated
traits (count: 5 )

rSNPs within LD-proxies of this variant (count:185)

rs_ID	r²[population]
rs10168931	1.00[ASN][1000 genomes]
rs10169213	0.86[AFR][1000 genomes];0.95[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10169714	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10170786	0.84[EUR][1000 genomes]
rs10170849	0.93[EUR][1000 genomes]
rs10173534	0.86[AFR][1000 genomes];0.92[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10178678	0.87[AFR][1000 genomes];0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10179134	0.83[AMR][1000 genomes];0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10181563	0.94[AMR][1000 genomes];0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10183818	0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10184268	0.83[EUR][1000 genomes]
rs10185080	0.85[AFR][1000 genomes];0.94[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10186501	0.90[EUR][1000 genomes]
rs10187192	0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10187416	0.91[EUR][1000 genomes]
rs10189574	0.90[EUR][1000 genomes]
rs10190219	0.90[AFR][1000 genomes];0.86[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10193972	0.91[EUR][1000 genomes]
rs10195357	0.86[EUR][1000 genomes]
rs10195358	0.86[EUR][1000 genomes]
rs10197409	0.86[EUR][1000 genomes]
rs10197755	0.87[AFR][1000 genomes];0.94[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10198549	0.89[AFR][1000 genomes];0.95[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10199224	0.87[AFR][1000 genomes];0.97[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10206899	0.81[AMR][1000 genomes]
rs10207220	0.88[AFR][1000 genomes];0.94[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10207264	0.91[EUR][1000 genomes]
rs10209517	0.82[EUR][1000 genomes]
rs10469966	0.85[AMR][1000 genomes];0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10496191	0.89[EUR][1000 genomes]
rs10496192	1.00[ASN][1000 genomes]
rs10496193	0.89[EUR][1000 genomes]
rs1052162	0.82[EUR][1000 genomes]
rs11126404	0.81[EUR][1000 genomes]
rs1114380	0.92[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11674602	0.88[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11675958	1.00[ASN][1000 genomes]
rs11676385	0.92[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11679594	1.00[ASN][1000 genomes]
rs11679809	0.91[AFR][1000 genomes];0.86[AMR][1000 genomes];0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11680965	1.00[ASN][1000 genomes]
rs11686019	0.81[EUR][1000 genomes]
rs11686541	1.00[ASN][1000 genomes]
rs11689164	1.00[ASN][1000 genomes]
rs11689392	0.84[EUR][1000 genomes]
rs11689588	0.87[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11693586	0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11693588	0.82[AFR][1000 genomes];0.92[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11884776	0.99[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11893881	0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11899740	0.83[AMR][1000 genomes];0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11899902	0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11901272	0.85[EUR][1000 genomes]
rs11903916	0.84[EUR][1000 genomes]
rs13383871	0.90[AFR][1000 genomes];0.86[AMR][1000 genomes];0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13384756	1.00[ASN][1000 genomes]
rs13384952	0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13385564	0.93[AFR][1000 genomes];0.92[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13391552	0.94[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13392691	0.92[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13392872	0.91[AMR][1000 genomes];0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13398956	0.85[AFR][1000 genomes];0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13400985	0.87[AFR][1000 genomes];0.88[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13409366	0.82[AMR][1000 genomes];0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13409668	0.94[EUR][1000 genomes]
rs13410232	1.00[ASN][1000 genomes]
rs13411311	0.94[AFR][1000 genomes];0.92[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs13421462	0.95[AFR][1000 genomes];0.92[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13427832	0.82[EUR][1000 genomes]
rs13428235	0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13431267	0.82[AFR][1000 genomes];0.94[AMR][1000 genomes];0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13431529	1.00[ASN][1000 genomes]
rs13432605	0.89[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13538	1.00[ASN][1000 genomes]
rs1403284	0.84[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1534471	0.89[EUR][1000 genomes]
rs1589576	1.00[ASN][1000 genomes]
rs17009149	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs17009159	0.84[AFR][1000 genomes];0.92[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs17349321	1.00[ASN][1000 genomes]
rs1881245	0.89[EUR][1000 genomes]
rs1918863	0.88[EUR][1000 genomes]
rs2056486	0.91[EUR][1000 genomes]
rs2140195	0.91[EUR][1000 genomes]
rs2421550	0.88[EUR][1000 genomes]
rs2421555	0.84[EUR][1000 genomes]
rs2421577	0.82[EUR][1000 genomes]
rs28879089	0.91[AMR][1000 genomes];0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2901438	0.89[EUR][1000 genomes]
rs3738848	0.94[EUR][1000 genomes]
rs3813227	0.89[EUR][1000 genomes]
rs4547554	1.00[ASN][1000 genomes]
rs56014217	0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs56145559	0.83[EUR][1000 genomes]
rs56154726	0.82[AFR][1000 genomes];0.92[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs56672945	0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs58603761	0.91[EUR][1000 genomes]
rs60844734	0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs62149774	1.00[ASN][1000 genomes]
rs62149777	1.00[ASN][1000 genomes]
rs62149781	0.91[AMR][1000 genomes];0.85[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs62149782	1.00[ASN][1000 genomes]
rs62149804	1.00[ASN][1000 genomes]
rs62151564	1.00[ASN][1000 genomes]
rs62151646	0.81[AFR][1000 genomes];0.88[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs62151652	0.83[AFR][1000 genomes];0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs62153182	1.00[ASN][1000 genomes]
rs62153183	1.00[ASN][1000 genomes]
rs6546835	0.89[EUR][1000 genomes]
rs6546836	0.89[EUR][1000 genomes]
rs6546837	0.89[EUR][1000 genomes]
rs6546838	0.89[EUR][1000 genomes]
rs6546839	0.89[EUR][1000 genomes]
rs6546845	0.90[EUR][1000 genomes]
rs6546847	0.86[EUR][1000 genomes]
rs6546849	0.82[EUR][1000 genomes]
rs6546850	0.82[EUR][1000 genomes]
rs6546851	0.82[EUR][1000 genomes]
rs6546852	0.82[EUR][1000 genomes]
rs6546853	0.82[EUR][1000 genomes]
rs6546854	0.86[AMR][1000 genomes];0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6546857	0.81[AMR][1000 genomes];0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6546858	0.82[EUR][1000 genomes]
rs6546859	0.82[EUR][1000 genomes]
rs6546860	0.82[EUR][1000 genomes]
rs6704782	0.89[AFR][1000 genomes];0.91[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6705489	0.84[AFR][1000 genomes];0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6707722	0.89[EUR][1000 genomes]
rs6708766	0.94[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6710438	0.92[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6711033	0.91[EUR][1000 genomes]
rs6719753	0.92[EUR][1000 genomes]
rs6723247	0.82[EUR][1000 genomes]
rs6724782	0.89[EUR][1000 genomes]
rs6726694	0.82[EUR][1000 genomes]
rs6735946	0.84[AFR][1000 genomes];0.95[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6736866	0.86[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6740223	0.89[EUR][1000 genomes]
rs6740766	0.87[AFR][1000 genomes];0.94[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6741067	0.82[EUR][1000 genomes]
rs6744398	0.81[AMR][1000 genomes];1.00[ASN][1000 genomes]
rs6745368	0.86[AFR][1000 genomes];0.91[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6745480	0.82[EUR][1000 genomes]
rs6753344	0.82[AFR][1000 genomes];0.86[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6755217	0.83[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6755241	0.91[AFR][1000 genomes];0.86[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6756885	0.91[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6756987	0.90[EUR][1000 genomes]
rs6759452	1.00[ASN][1000 genomes]
rs73947808	0.81[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7424690	0.94[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7558944	0.89[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7564890	0.83[AFR][1000 genomes];0.85[AMR][1000 genomes];0.92[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7566364	0.82[EUR][1000 genomes]
rs7566385	0.93[EUR][1000 genomes]
rs7567585	0.91[EUR][1000 genomes]
rs7572722	0.85[AFR][1000 genomes];0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7576245	0.82[EUR][1000 genomes]
rs7580750	0.86[EUR][1000 genomes]
rs7580825	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7582051	1.00[ASN][1000 genomes]
rs7582606	0.94[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7583255	0.87[AFR][1000 genomes];0.89[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7584575	0.89[EUR][1000 genomes]
rs7585004	0.89[EUR][1000 genomes]
rs7585124	0.89[EUR][1000 genomes]
rs7586463	0.87[AFR][1000 genomes];0.91[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7587577	0.87[AMR][1000 genomes];0.87[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7588169	0.90[EUR][1000 genomes]
rs7594511	0.83[AFR][1000 genomes];0.88[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7596773	0.84[AMR][1000 genomes];0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7598396	0.82[AFR][1000 genomes];0.86[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7598419	0.84[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs7598946	0.89[EUR][1000 genomes]
rs7602980	0.80[AFR][1000 genomes];0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7603647	0.91[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7604682	0.86[EUR][1000 genomes]
rs7607014	0.91[EUR][1000 genomes]
rs7607892	0.88[AFR][1000 genomes];0.94[AMR][1000 genomes];0.90[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9309473	0.90[AFR][1000 genomes];0.95[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs9653557	0.87[AFR][1000 genomes];0.97[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9749859	0.84[EUR][1000 genomes]
rs9750915	0.91[AMR][1000 genomes];0.89[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9753079	0.80[EUR][1000 genomes]
rs9807961	0.90[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:4 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv428051	chr2:73717032-74030067	ZNF genes & repeats Strong transcription Weak transcription Active TSS Enhancers Flanking Active TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	22 gene(s)	inside rSNPs	diseases
2	esv2757806	chr2:73717032-74078592	Active TSS Weak transcription ZNF genes & repeats Enhancers Genic enhancers Flanking Active TSS Strong transcription Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	36 gene(s)	inside rSNPs	diseases
3	esv2759060	chr2:73717032-74078592	Enhancers Weak transcription ZNF genes & repeats Flanking Active TSS Strong transcription Genic enhancers Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	36 gene(s)	inside rSNPs	diseases
4	nsv874267	chr2:73717656-73857002	Weak transcription Strong transcription ZNF genes & repeats Enhancers Flanking Active TSS Genic enhancers Active TSS Transcr. at gene 5' and 3'	TF binding region Chromatin interactive region lncRNA miRNA target site	5 gene(s)	inside rSNPs	diseases

mRNA abundance (count:5)

SNP	Gene	Cis/trans	Tissue	Source
rs2421552	ALMS1P	cis	Whole Blood	GTEx
rs2421552	ALMS1P	cis	Thyroid	GTEx
rs2421552	ALMS1P	cis	Skin Sun Exposed Lower leg	GTEx
rs2421552	ALMS1P	cis	Nerve Tibial	GTEx
rs2421552	ALMS1	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:106 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr2:73731600-73759000	Weak transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
2	chr2:73731800-73807600	Weak transcription	Hela-S3	cervix
3	chr2:73736400-73761600	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
4	chr2:73741000-73759400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
5	chr2:73741000-73767400	Weak transcription	Rectal Smooth Muscle	rectum
6	chr2:73744200-73759000	Weak transcription	HSMMtube	muscle
7	chr2:73744200-73799800	Weak transcription	NH-A	brain
8	chr2:73744600-73764400	Weak transcription	HSMM	muscle
9	chr2:73746000-73765200	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
10	chr2:73747800-73786800	Weak transcription	Skeletal Muscle Female	skeletal muscle
11	chr2:73748000-73762000	Weak transcription	Rectal Mucosa Donor 29	rectum
12	chr2:73751800-73759400	ZNF genes & repeats	Primary hematopoietic stem cells G-CSF-mobilized Male	--
13	chr2:73752600-73759800	Weak transcription	Skeletal Muscle Male	skeletal muscle
14	chr2:73752600-73762600	Weak transcription	Fetal Kidney	kidney
15	chr2:73754400-73760000	Weak transcription	Colon Smooth Muscle	Colon
16	chr2:73754600-73762000	Weak transcription	Rectal Mucosa Donor 31	rectum
17	chr2:73754800-73759000	Weak transcription	Brain Anterior Caudate	brain
18	chr2:73754800-73759200	ZNF genes & repeats	iPS-20b Cell Line	embryonic stem cell
19	chr2:73755200-73760000	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
20	chr2:73756000-73766800	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
21	chr2:73756200-73759400	ZNF genes & repeats	HUES64 Cell Line	embryonic stem cell
22	chr2:73756400-73759000	ZNF genes & repeats	Primary hematopoietic stem cells G-CSF-mobilized Female	--
23	chr2:73756400-73765000	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
24	chr2:73756600-73759200	ZNF genes & repeats	HUES6 Cell Line	embryonic stem cell
25	chr2:73756600-73759400	Strong transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
26	chr2:73756800-73764000	Weak transcription	Fetal Brain Male	brain
27	chr2:73757000-73760800	Strong transcription	Primary T cells from cord blood	blood
28	chr2:73757000-73764200	Weak transcription	K562	blood
29	chr2:73757000-73764600	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
30	chr2:73757400-73759000	ZNF genes & repeats	Fetal Stomach	stomach
31	chr2:73757400-73759000	Weak transcription	Monocytes-CD14+_RO01746	blood
32	chr2:73757400-73759400	Strong transcription	Placenta Amnion	Placenta Amnion
33	chr2:73757600-73759000	Weak transcription	Duodenum Smooth Muscle	Duodenum
34	chr2:73757600-73759800	Strong transcription	Primary T helper naive cells fromperipheralblood	blood
35	chr2:73757600-73759800	Strong transcription	Fetal Lung	lung
36	chr2:73757600-73760400	ZNF genes & repeats	Lung	lung
37	chr2:73757600-73760600	Strong transcription	Stomach Smooth Muscle	stomach
38	chr2:73757600-73760800	Strong transcription	Ovary	ovary
39	chr2:73757800-73759000	ZNF genes & repeats	iPS-15b Cell Line	embryonic stem cell
40	chr2:73757800-73760000	Weak transcription	Primary T cells fromperipheralblood	blood
41	chr2:73757800-73760600	Strong transcription	Right Ventricle	heart
42	chr2:73757800-73760800	Strong transcription	Left Ventricle	heart
43	chr2:73757800-73764400	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
44	chr2:73757800-73764600	Strong transcription	Primary T helper cells fromperipheralblood	blood
45	chr2:73758000-73759200	Weak transcription	Gastric	stomach
46	chr2:73758000-73759200	Weak transcription	Pancreas	Pancrea
47	chr2:73758000-73760600	Strong transcription	Aorta	Aorta
48	chr2:73758000-73765000	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
49	chr2:73758000-73799800	Weak transcription	Brain Cingulate Gyrus	brain
50	chr2:73758200-73759000	Weak transcription	Foreskin Melanocyte Primary Cells skin03	Skin

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