Variant report

Variant	rs7089122
Chromosome Location	chr10:93647412-93647413
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:93645639..93650363-chr10:93664527..93668609,7	MCF-7	breast:

Variant related genes	Relation type
ENSG00000272817	Chromatin interaction

Extended variants
information (count: 22 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:20)

rs_ID	r²[population]
rs10881986	0.86[ASN][1000 genomes]
rs11186728	0.85[ASN][1000 genomes]
rs12359353	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs1538831	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs1630388	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs1770469	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs1770474	0.91[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs1772187	0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs2259094	0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs2259287	0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2259659	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs2260773	0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs2261029	0.91[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs2261035	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs4565819	0.91[AFR][1000 genomes];0.90[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs6583789	0.91[AFR][1000 genomes];0.94[AMR][1000 genomes];0.95[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs6583790	0.81[EUR][1000 genomes]
rs7083959	0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs7919191	0.90[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9420573	0.82[AMR][1000 genomes];0.91[EUR][1000 genomes];0.87[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv7491	chr10:93626192-93671694	Enhancers Weak transcription Active TSS Flanking Active TSS Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
2	esv1842657	chr10:93634155-93668663	Flanking Active TSS Enhancers Weak transcription Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs7089122	TNKS2	cis	Thyroid	GTEx
rs7089122	TNKS2-AS1	cis	Thyroid	GTEx

Chromatin state (count:122 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:93644200-93648600	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
2	chr10:93645800-93649400	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
3	chr10:93646600-93647600	Active TSS	Fetal Brain Female	brain
4	chr10:93646600-93648000	Active TSS	ES-I3 Cell Line	embryonic stem cell
5	chr10:93646600-93648400	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
6	chr10:93646800-93647600	Active TSS	H9 Cell Line	embryonic stem cell
7	chr10:93646800-93647600	Active TSS	Primary T helper cells PMA-I stimulated	--
8	chr10:93646800-93647600	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
9	chr10:93646800-93647600	Flanking Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
10	chr10:93646800-93647600	Flanking Active TSS	Foreskin Melanocyte Primary Cells skin01	Skin
11	chr10:93646800-93647600	Active TSS	Brain Angular Gyrus	brain
12	chr10:93646800-93647600	Active TSS	Colon Smooth Muscle	Colon
13	chr10:93646800-93647600	Active TSS	Fetal Kidney	kidney
14	chr10:93646800-93647600	Active TSS	A549	lung
15	chr10:93646800-93647800	Flanking Active TSS	IMR90 fetal lung fibroblasts Cell Line	lung
16	chr10:93646800-93647800	Flanking Active TSS	iPS-18 Cell Line	embryonic stem cell
17	chr10:93646800-93647800	Active TSS	Primary T killer naive cells fromperipheralblood	blood
18	chr10:93646800-93647800	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin02	Skin
19	chr10:93646800-93647800	Flanking Active TSS	Foreskin Melanocyte Primary Cells skin03	Skin
20	chr10:93646800-93647800	Active TSS	Brain Anterior Caudate	brain
21	chr10:93646800-93647800	Active TSS	Brain Cingulate Gyrus	brain
22	chr10:93646800-93647800	Active TSS	Brain Hippocampus Middle	brain
23	chr10:93646800-93647800	Active TSS	Brain Dorsolateral Prefrontal Cortex	brain
24	chr10:93646800-93647800	Active TSS	Brain Substantia Nigra	brain
25	chr10:93646800-93647800	Flanking Active TSS	Fetal Muscle Leg	muscle
26	chr10:93646800-93647800	Active TSS	Right Atrium	heart
27	chr10:93646800-93648000	Active TSS	Breast Myoepithelial Primary Cells	Breast
28	chr10:93646800-93648000	Flanking Active TSS	Primary hematopoietic stem cells short term culture	blood
29	chr10:93646800-93648000	Flanking Active TSS	Primary T helper cells fromperipheralblood	blood
30	chr10:93646800-93648000	Flanking Bivalent TSS/Enh	Primary T regulatory cells fromperipheralblood	blood
31	chr10:93646800-93648000	Flanking Bivalent TSS/Enh	Primary hematopoietic stem cells G-CSF-mobilized Male	--
32	chr10:93646800-93648000	Flanking Active TSS	Foreskin Keratinocyte Primary Cells skin03	Skin
33	chr10:93646800-93648000	Flanking Active TSS	Adipose Nuclei	Adipose
34	chr10:93646800-93648000	Active TSS	Aorta	Aorta
35	chr10:93646800-93648000	Active TSS	Brain Inferior Temporal Lobe	brain
36	chr10:93646800-93648000	Flanking Active TSS	Fetal Adrenal Gland	Adrenal Gland
37	chr10:93646800-93648000	Flanking Active TSS	Fetal Brain Male	brain
38	chr10:93646800-93648000	Active TSS	Stomach Smooth Muscle	stomach
39	chr10:93646800-93648000	Flanking Active TSS	HUVEC	blood vessel
40	chr10:93646800-93648000	Flanking Bivalent TSS/Enh	Monocytes-CD14+_RO01746	blood
41	chr10:93646800-93648000	Flanking Active TSS	NH-A	brain
42	chr10:93646800-93648000	Flanking Active TSS	NHEK	skin
43	chr10:93647000-93647600	Active TSS	iPS-15b Cell Line	embryonic stem cell
44	chr10:93647000-93647600	Flanking Bivalent TSS/Enh	Primary T cells fromperipheralblood	blood
45	chr10:93647000-93647600	Active TSS	Primary T helper memory cells from peripheral blood 2	blood
46	chr10:93647000-93647600	Flanking Bivalent TSS/Enh	Colonic Mucosa	Colon
47	chr10:93647000-93647600	Active TSS	Fetal Heart	heart
48	chr10:93647000-93647600	Bivalent/Poised TSS	Fetal Stomach	stomach
49	chr10:93647000-93647600	Active TSS	HSMM	muscle
50	chr10:93647000-93647800	Flanking Active TSS	H1 Cell Line	embryonic stem cell

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