Variant report

Variant	rs4565819
Chromosome Location	chr10:93646268-93646269
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:93645639..93650363-chr10:93664527..93668609,7	MCF-7	breast:

Variant related genes	Relation type
ENSG00000272817	Chromatin interaction

Extended variants
information (count: 24 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:22)

rs_ID	r²[population]
rs10881986	0.88[ASN][1000 genomes]
rs11186716	0.81[ASN][1000 genomes]
rs11186728	0.83[ASN][1000 genomes]
rs12359353	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1538831	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1630388	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1770469	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1770474	0.89[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs1772187	0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2259094	0.88[AMR][1000 genomes];0.90[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2259287	0.88[AMR][1000 genomes];0.90[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs2259659	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2260773	0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs2261029	0.89[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs2261035	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs6583789	0.98[AFR][1000 genomes];0.92[AMR][1000 genomes];0.93[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs7083959	0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs7089122	0.91[AFR][1000 genomes];0.90[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7919191	0.88[AMR][1000 genomes];0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9420573	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs9633672	0.81[ASN][1000 genomes]
rs9633689	0.81[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv7491	chr10:93626192-93671694	Enhancers Weak transcription Active TSS Flanking Active TSS Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
2	esv1842657	chr10:93634155-93668663	Flanking Active TSS Enhancers Weak transcription Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs4565819	TNKS2-AS1	cis	Thyroid	GTEx
rs4565819	TNKS2	cis	Thyroid	GTEx

Chromatin state (count:78 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:93643600-93646800	Weak transcription	Esophagus	oesophagus
2	chr10:93643800-93646800	Weak transcription	Aorta	Aorta
3	chr10:93643800-93646800	Weak transcription	Rectal Smooth Muscle	rectum
4	chr10:93643800-93647000	Enhancers	H1 Cell Line	embryonic stem cell
5	chr10:93643800-93647000	Weak transcription	Lung	lung
6	chr10:93643800-93647000	Weak transcription	Pancreas	Pancrea
7	chr10:93643800-93647000	Weak transcription	HSMM	muscle
8	chr10:93644000-93646800	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
9	chr10:93644000-93646800	Weak transcription	Fetal Kidney	kidney
10	chr10:93644000-93646800	Weak transcription	Right Atrium	heart
11	chr10:93644000-93647000	Enhancers	Cortex derived primary cultured neurospheres	brain
12	chr10:93644000-93647000	Weak transcription	HMEC	breast
13	chr10:93644000-93647000	Weak transcription	NHDF-Ad	bronchial
14	chr10:93644200-93646800	Enhancers	iPS-18 Cell Line	embryonic stem cell
15	chr10:93644200-93646800	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
16	chr10:93644200-93646800	Weak transcription	Muscle Satellite Cultured Cells	--
17	chr10:93644200-93646800	Weak transcription	Brain Anterior Caudate	brain
18	chr10:93644200-93646800	Weak transcription	Duodenum Smooth Muscle	Duodenum
19	chr10:93644200-93646800	Weak transcription	NH-A	brain
20	chr10:93644200-93647000	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
21	chr10:93644200-93647000	Weak transcription	Placenta Amnion	Placenta Amnion
22	chr10:93644200-93647200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
23	chr10:93644200-93647200	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
24	chr10:93644200-93648600	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
25	chr10:93644400-93646800	Enhancers	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
26	chr10:93644400-93646800	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
27	chr10:93644400-93646800	Enhancers	Ganglion Eminence derived primary cultured neurospheres	brain
28	chr10:93644400-93646800	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
29	chr10:93644400-93646800	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
30	chr10:93644400-93646800	Weak transcription	Adipose Nuclei	Adipose
31	chr10:93644400-93646800	Weak transcription	Brain Angular Gyrus	brain
32	chr10:93644400-93646800	Weak transcription	Brain Hippocampus Middle	brain
33	chr10:93644400-93646800	Weak transcription	Colon Smooth Muscle	Colon
34	chr10:93644400-93646800	Weak transcription	Fetal Muscle Leg	muscle
35	chr10:93644400-93646800	Weak transcription	Fetal Stomach	stomach
36	chr10:93644400-93646800	Weak transcription	Psoas Muscle	Psoas
37	chr10:93644400-93646800	Weak transcription	NHLF	lung
38	chr10:93644400-93646800	Weak transcription	Osteobl	bone
39	chr10:93644400-93647000	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
40	chr10:93644400-93647000	Weak transcription	Left Ventricle	heart
41	chr10:93644400-93647000	Weak transcription	Right Ventricle	heart
42	chr10:93644600-93646800	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
43	chr10:93644800-93646400	Enhancers	iPS DF 19.11 Cell Line	embryonic stem cell
44	chr10:93644800-93646800	Weak transcription	Breast Myoepithelial Primary Cells	Breast
45	chr10:93644800-93646800	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
46	chr10:93644800-93646800	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
47	chr10:93645000-93646400	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
48	chr10:93645000-93646800	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
49	chr10:93645000-93646800	Weak transcription	Placenta	Placenta
50	chr10:93645000-93646800	Weak transcription	NHEK	skin

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