Variant report

Variant	rs757132
Chromosome Location	chr7:21907991-21907992
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

Extended variants
information (count: 13 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:11)

rs_ID	r²[population]
rs10226082	0.83[CEU][hapmap]
rs10485987	0.88[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.95[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];0.80[MKK][hapmap];1.00[TSI][hapmap];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11767041	0.90[AMR][1000 genomes];0.91[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs12154430	1.00[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap]
rs12539597	0.85[CHB][hapmap];0.81[CHD][hapmap]
rs12700315	0.91[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12700316	1.00[CEU][hapmap]
rs17145743	1.00[CEU][hapmap];0.85[CHB][hapmap];0.94[JPT][hapmap];0.96[AMR][1000 genomes];0.99[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs4722066	0.83[MEX][hapmap]
rs55692559	0.90[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs6959457	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1018133	chr7:21740118-22055283	Active TSS Enhancers Strong transcription Weak transcription Flanking Active TSS Genic enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	22 gene(s)	inside rSNPs	diseases
2	nsv830922	chr7:21793386-21964675	Enhancers Weak transcription Flanking Active TSS ZNF genes & repeats Strong transcription Genic enhancers Bivalent Enhancer Active TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region miRNA target site	3 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs757132	IL6	cis	cerebellum	SCAN
rs757132	CDCA7L	cis	multi-tissue	Pritchard

Chromatin state (count:31 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr7:21904600-21910400	Enhancers	HUES64 Cell Line	embryonic stem cell
2	chr7:21904600-21910600	Enhancers	iPS-15b Cell Line	embryonic stem cell
3	chr7:21904800-21908000	Enhancers	iPS-18 Cell Line	embryonic stem cell
4	chr7:21905000-21910000	Enhancers	Cortex derived primary cultured neurospheres	brain
5	chr7:21905000-21910200	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
6	chr7:21905000-21910800	Enhancers	HUES48 Cell Line	embryonic stem cell
7	chr7:21905200-21908000	Enhancers	HUES6 Cell Line	embryonic stem cell
8	chr7:21905200-21910000	Enhancers	H9 Cell Line	embryonic stem cell
9	chr7:21905200-21910200	Enhancers	H1 Cell Line	embryonic stem cell
10	chr7:21905600-21916200	Weak transcription	Primary neutrophils fromperipheralblood	blood
11	chr7:21905800-21916200	Weak transcription	Primary hematopoietic stem cells	blood
12	chr7:21906000-21908800	Enhancers	Ganglion Eminence derived primary cultured neurospheres	brain
13	chr7:21906400-21908800	Enhancers	Brain Germinal Matrix	brain
14	chr7:21906400-21909600	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
15	chr7:21906400-21910200	Enhancers	ES-WA7 Cell Line	embryonic stem cell
16	chr7:21906600-21910600	Enhancers	ES-UCSF4 Cell Line	embryonic stem cell
17	chr7:21906600-21916200	Weak transcription	Primary hematopoietic stem cells short term culture	blood
18	chr7:21906800-21908400	Enhancers	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
19	chr7:21906800-21916200	Weak transcription	Primary B cells from cord blood	blood
20	chr7:21906800-21916200	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
21	chr7:21907000-21910000	Enhancers	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
22	chr7:21907200-21909600	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
23	chr7:21907200-21910200	Enhancers	iPS DF 6.9 Cell Line	embryonic stem cell
24	chr7:21907400-21916000	Weak transcription	Primary B cells from peripheral blood	blood
25	chr7:21907400-21937200	Weak transcription	Fetal Thymus	thymus
26	chr7:21907800-21908000	Flanking Active TSS	ES-I3 Cell Line	embryonic stem cell
27	chr7:21907800-21908400	Enhancers	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
28	chr7:21907800-21908800	Flanking Active TSS	iPS-20b Cell Line	embryonic stem cell
29	chr7:21907800-21908800	Enhancers	Fetal Intestine Small	intestine
30	chr7:21907800-21910200	Enhancers	Fetal Heart	heart
31	chr7:21907800-21916200	Weak transcription	Thymus	Thymus

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