Variant report

Variant	rs7910396
Chromosome Location	chr10:27425907-27425908
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	POLR2A	chr10:27425881-27429350	K562	blood:	n/a	n/a
2	POLR2A	chr10:27424441-27430915	HepG2	liver:	n/a	n/a

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:27422874..27425974-chr10:27441725..27444427,3	K562	blood:
2	chr10:27425181..27427784-chr10:27528316..27531053,2	MCF-7	breast:

Variant related genes	Relation type
YME1L1	TF binding region
ENSG00000136758	Chromatin interaction
ENSG00000120539	Chromatin interaction
ENSG00000107897	Chromatin interaction

Extended variants
information (count: 97 )
Associated
traits (count: 5 )

rSNPs within LD-proxies of this variant (count:97)

rs_ID	r²[population]
rs10430596	0.87[ASN][1000 genomes]
rs10764673	0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10764675	0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10764678	0.89[ASN][1000 genomes]
rs10764688	0.90[ASN][1000 genomes]
rs10829183	0.81[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs10829185	0.92[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10829191	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10829192	1.00[CEU][hapmap];0.96[YRI][hapmap];0.95[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10829193	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10829194	1.00[CEU][hapmap];1.00[YRI][hapmap];1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11015508	0.83[YRI][hapmap]
rs11015511	0.90[YRI][hapmap]
rs11015529	0.86[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs11015530	0.86[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs11015532	0.86[AFR][1000 genomes];0.89[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs11015536	0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11015538	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015541	0.97[ASN][1000 genomes]
rs11015542	0.93[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015548	0.93[AFR][1000 genomes];0.91[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015553	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11015554	0.90[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015555	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015556	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015558	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015559	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015560	0.97[AFR][1000 genomes];0.91[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs11015564	1.00[CEU][hapmap];1.00[YRI][hapmap];0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015565	1.00[CEU][hapmap];1.00[YRI][hapmap];0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015566	0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015571	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11015599	0.97[ASN][1000 genomes]
rs11015604	0.87[ASN][1000 genomes]
rs11598615	0.87[ASN][1000 genomes]
rs11813670	0.95[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12255977	1.00[CEU][hapmap];1.00[YRI][hapmap];0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12259472	0.81[AFR][1000 genomes];0.86[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs12571792	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12572344	1.00[CEU][hapmap];0.96[YRI][hapmap];0.95[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12766193	0.84[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs12768114	0.86[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs12769335	0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12784464	0.94[AFR][1000 genomes];0.89[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs1557167	0.89[ASN][1000 genomes]
rs1974367	0.89[ASN][1000 genomes]
rs2274634	1.00[CEU][hapmap];0.96[YRI][hapmap];0.95[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs2274635	1.00[CEU][hapmap];0.96[YRI][hapmap];0.95[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs2274743	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs2275752	1.00[CEU][hapmap];1.00[YRI][hapmap];1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2297143	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs2297145	0.88[CEU][hapmap];0.96[YRI][hapmap];0.86[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs2297151	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs2297152	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs2368217	1.00[CEU][hapmap];1.00[YRI][hapmap];0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs35805599	0.89[ASN][1000 genomes]
rs3737054	0.88[CEU][hapmap];0.85[AMR][1000 genomes];0.83[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs3780921	1.00[CEU][hapmap];1.00[YRI][hapmap];0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs3780922	0.94[CEU][hapmap];1.00[YRI][hapmap];0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs3781100	0.84[AMR][1000 genomes]
rs3932559	1.00[CEU][hapmap];1.00[YRI][hapmap];0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs4747585	0.94[AFR][1000 genomes];0.91[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs4747589	0.89[ASN][1000 genomes]
rs4749225	0.81[AFR][1000 genomes];0.81[EUR][1000 genomes]
rs4749226	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs4749236	0.89[ASN][1000 genomes]
rs4749238	0.87[ASN][1000 genomes]
rs55741077	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs55955460	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6482602	0.87[ASN][1000 genomes]
rs6482603	0.90[ASN][1000 genomes]
rs67177346	0.81[AFR][1000 genomes];0.98[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs67425403	0.90[AFR][1000 genomes];0.90[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs7073381	0.81[AFR][1000 genomes];0.86[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs7074295	0.90[ASN][1000 genomes]
rs7075448	1.00[CEU][hapmap];1.00[YRI][hapmap];0.85[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7080173	0.89[ASN][1000 genomes]
rs7080568	0.90[ASN][1000 genomes]
rs7083768	0.88[CEU][hapmap];0.96[YRI][hapmap];0.86[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs7086311	0.88[CEU][hapmap];0.91[YRI][hapmap];0.86[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs7086820	0.84[AMR][1000 genomes]
rs7099019	0.89[ASN][1000 genomes]
rs7896012	0.90[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs7902126	0.87[ASN][1000 genomes]
rs7903590	0.88[ASN][1000 genomes]
rs7907492	0.92[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7909135	0.89[ASN][1000 genomes]
rs7909444	1.00[CEU][hapmap];1.00[YRI][hapmap];0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7910688	1.00[CEU][hapmap];0.96[YRI][hapmap];0.92[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs7914630	1.00[CEU][hapmap];1.00[YRI][hapmap];0.99[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs7921222	1.00[CEU][hapmap];1.00[YRI][hapmap];0.96[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7921980	0.93[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs7922972	0.88[ASN][1000 genomes]
rs882475	0.89[ASN][1000 genomes]
rs9651378	0.88[CEU][hapmap];0.84[AMR][1000 genomes]
rs9971193	0.97[AFR][1000 genomes];0.93[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs9971335	0.83[AFR][1000 genomes];0.89[AMR][1000 genomes];0.91[EUR][1000 genomes]

mRNA abundance (count:5)

SNP	Gene	Cis/trans	Tissue	Source
rs7910396	YME1L1	Cis_1M	lymphoblastoid	RTeQTL
rs7910396	MASTL	cis	Stomach	GTEx
rs7910396	MASTL	cis	Thyroid	GTEx
rs7910396	MASTL	cis	lung	GTEx
rs7910396	MASTL	cis	Skin Sun Exposed Lower leg	GTEx

Chromatin state (count:126 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:27389800-27441200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
2	chr10:27390000-27442000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
3	chr10:27390200-27435000	Weak transcription	Pancreatic Islets	Pancreatic Islet
4	chr10:27393800-27438600	Strong transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
5	chr10:27394000-27426600	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
6	chr10:27394200-27432600	Strong transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
7	chr10:27394800-27432800	Strong transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
8	chr10:27395400-27437800	Strong transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
9	chr10:27396200-27440600	Strong transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
10	chr10:27396800-27432000	Strong transcription	Foreskin Melanocyte Primary Cells skin03	Skin
11	chr10:27397600-27438600	Strong transcription	Fetal Thymus	thymus
12	chr10:27398200-27434200	Strong transcription	Ganglion Eminence derived primary cultured neurospheres	brain
13	chr10:27398400-27428400	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
14	chr10:27398400-27435200	Strong transcription	HUES64 Cell Line	embryonic stem cell
15	chr10:27398600-27426400	Strong transcription	iPS-18 Cell Line	embryonic stem cell
16	chr10:27398600-27427000	Strong transcription	GM12878-XiMat	blood
17	chr10:27398600-27427800	Strong transcription	Adipose Nuclei	Adipose
18	chr10:27398600-27431600	Strong transcription	HUES48 Cell Line	embryonic stem cell
19	chr10:27398600-27434800	Strong transcription	H9 Derived Neuron Cultured Cells	ES cell derived
20	chr10:27398600-27434800	Strong transcription	iPS-20b Cell Line	embryonic stem cell
21	chr10:27398600-27434800	Strong transcription	Primary T helper cells PMA-I stimulated	--
22	chr10:27398600-27436400	Strong transcription	Dnd41	blood
23	chr10:27398800-27426000	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
24	chr10:27398800-27427600	Strong transcription	Fetal Lung	lung
25	chr10:27398800-27438200	Strong transcription	Primary T helper cells fromperipheralblood	blood
26	chr10:27398800-27438200	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
27	chr10:27399000-27426400	Strong transcription	Osteobl	bone
28	chr10:27399000-27426800	Strong transcription	Primary B cells from peripheral blood	blood
29	chr10:27399000-27431400	Strong transcription	Placenta	Placenta
30	chr10:27399600-27435200	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
31	chr10:27399600-27438400	Strong transcription	Primary T regulatory cells fromperipheralblood	blood
32	chr10:27399800-27438600	Strong transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
33	chr10:27400000-27426000	Strong transcription	Primary hematopoietic stem cells short term culture	blood
34	chr10:27400400-27438400	Strong transcription	Liver	Liver
35	chr10:27401200-27435400	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
36	chr10:27403000-27428400	Strong transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
37	chr10:27403200-27431600	Strong transcription	NH-A	brain
38	chr10:27405800-27427600	Strong transcription	HSMM	muscle
39	chr10:27407800-27436400	Weak transcription	Right Ventricle	heart
40	chr10:27411200-27436000	Weak transcription	Esophagus	oesophagus
41	chr10:27412400-27440200	Weak transcription	Fetal Heart	heart
42	chr10:27413600-27430800	Strong transcription	Duodenum Smooth Muscle	Duodenum
43	chr10:27415400-27436200	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
44	chr10:27416800-27430800	Strong transcription	HUVEC	blood vessel
45	chr10:27417200-27426000	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
46	chr10:27418000-27436400	Weak transcription	Spleen	Spleen
47	chr10:27418200-27430000	Weak transcription	Pancreas	Pancrea
48	chr10:27419200-27426600	Strong transcription	Primary T helper memory cells from peripheral blood 1	blood
49	chr10:27419200-27438600	Strong transcription	Monocytes-CD14+_RO01746	blood
50	chr10:27419200-27438800	Strong transcription	Primary monocytes fromperipheralblood	blood

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