Variant report

Variant	rs9303403
Chromosome Location	chr17:57219300-57219301
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:4)
CpG islands
(count:0)
Chromatin interactive
region (count:6)
LncRNA
region (count:0)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

(count:4 , 50 per page) page: 1

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	MAFF	chr17:57219226-57219518	HepG2	liver:	n/a	n/a
2	MXI1	chr17:57219255-57219569	HepG2	liver:	n/a	n/a
3	POLR2A	chr17:57219187-57219344	HepG2	liver:	n/a	n/a
4	HNF4A	chr17:57219224-57219475	HepG2	liver:	n/a	n/a

No data

(count:6 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr17:57216218..57217783-chr17:57218957..57221471,2	K562	blood:
2	chr17:57180707..57182986-chr17:57216885..57219479,2	MCF-7	breast:
3	chr17:57217370..57219452-chr17:57230547..57233288,2	K562	blood:
4	chr17:57183122..57187108-chr17:57215819..57219509,5	MCF-7	breast:
5	chr17:57182570..57184907-chr17:57219298..57221962,2	K562	blood:
6	chr17:57219134..57221741-chr17:57229323..57233283,4	MCF-7	breast:

No data

Variant related genes	Relation type
MIR454	TF binding region
ENSG00000224738	Chromatin interaction
ENSG00000182628	Chromatin interaction
ENSG00000108395	Chromatin interaction
ENSG00000068489	Chromatin interaction

Extended variants
information (count: 61 )
Associated
traits (count: 11 )

rSNPs within LD-proxies of this variant (count:34)

rs_ID	r²[population]
rs11654986	0.86[YRI][hapmap]
rs12051896	0.87[ASN][1000 genomes]
rs12051897	0.90[CHB][hapmap];0.90[CHD][hapmap];0.90[JPT][hapmap];0.90[ASN][1000 genomes]
rs12603238	0.86[YRI][hapmap]
rs12948746	0.86[YRI][hapmap]
rs35448939	0.90[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs4932693	0.86[YRI][hapmap]
rs62081890	0.96[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs62081892	0.87[AMR][1000 genomes];0.90[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs6503893	0.86[YRI][hapmap]
rs6503898	0.90[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs7208505	0.86[YRI][hapmap]
rs7213269	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.98[GIH][hapmap];0.86[JPT][hapmap];0.97[LWK][hapmap];1.00[MEX][hapmap];0.97[MKK][hapmap];0.84[TSI][hapmap];1.00[YRI][hapmap];0.88[AFR][1000 genomes];0.96[AMR][1000 genomes];0.91[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7214098	0.86[YRI][hapmap]
rs7217845	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.98[GIH][hapmap];0.86[JPT][hapmap];0.97[LWK][hapmap];1.00[MEX][hapmap];0.97[MKK][hapmap];0.87[TSI][hapmap];1.00[YRI][hapmap];0.89[AFR][1000 genomes];0.96[AMR][1000 genomes];0.95[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7223587	0.81[AFR][1000 genomes];0.85[AMR][1000 genomes];0.91[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs7342863	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.82[LWK][hapmap];1.00[MEX][hapmap];0.97[MKK][hapmap];0.95[TSI][hapmap];0.81[AFR][1000 genomes];0.97[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7502541	0.90[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs7502947	1.00[CHB][hapmap];0.95[CHD][hapmap];1.00[JPT][hapmap];1.00[ASN][1000 genomes]
rs7503190	0.86[YRI][hapmap]
rs8067264	0.86[YRI][hapmap]
rs8067682	1.00[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];0.82[LWK][hapmap];1.00[MEX][hapmap];0.97[MKK][hapmap];0.97[TSI][hapmap];0.83[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs8069033	0.86[YRI][hapmap]
rs8072182	0.88[ASW][hapmap];0.87[CEU][hapmap];0.90[CHB][hapmap];0.97[CHD][hapmap];0.89[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];0.98[MKK][hapmap];0.89[TSI][hapmap];1.00[YRI][hapmap];0.91[AFR][1000 genomes];0.90[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs8073316	0.91[CEU][hapmap];0.95[CHB][hapmap];0.97[CHD][hapmap];0.83[GIH][hapmap];1.00[JPT][hapmap];0.86[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs8073699	0.84[AMR][1000 genomes];0.91[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs8077052	0.91[CEU][hapmap];0.95[CHB][hapmap];0.97[CHD][hapmap];0.83[GIH][hapmap];0.95[JPT][hapmap];0.86[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs8081967	0.86[YRI][hapmap]
rs8082544	0.86[YRI][hapmap]
rs9892425	1.00[ASW][hapmap];0.90[CEU][hapmap];1.00[CHB][hapmap];0.97[CHD][hapmap];0.86[JPT][hapmap];0.93[LWK][hapmap];0.97[MKK][hapmap];1.00[YRI][hapmap];0.88[AFR][1000 genomes];0.96[AMR][1000 genomes];0.92[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs9909925	1.00[ASW][hapmap];0.95[CEU][hapmap];0.95[CHB][hapmap];1.00[CHD][hapmap];0.89[GIH][hapmap];1.00[JPT][hapmap];0.82[LWK][hapmap];0.86[MEX][hapmap];0.97[MKK][hapmap];0.92[TSI][hapmap];0.90[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9910629	0.90[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9911583	1.00[ASW][hapmap];0.95[CEU][hapmap];0.95[CHB][hapmap];1.00[CHD][hapmap];0.89[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];0.86[MEX][hapmap];1.00[MKK][hapmap];0.89[TSI][hapmap];1.00[YRI][hapmap];0.93[AFR][1000 genomes];0.86[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9915267	0.86[AFR][1000 genomes];0.94[AMR][1000 genomes];0.92[EUR][1000 genomes];0.94[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:27 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv908643	chr17:56803028-57249010	Bivalent/Poised TSS Weak transcription Enhancers Strong transcription Genic enhancers Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	227 gene(s)	inside rSNPs	diseases
2	nsv908644	chr17:56803028-57371432	Strong transcription Weak transcription Active TSS Enhancers Bivalent Enhancer Flanking Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	238 gene(s)	inside rSNPs	diseases
3	esv3335958	chr17:56849544-57385398	Enhancers Weak transcription Strong transcription Active TSS Flanking Active TSS Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	233 gene(s)	inside rSNPs	diseases
4	nsv1065063	chr17:56954121-57346694	Weak transcription Enhancers Strong transcription Flanking Active TSS Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	227 gene(s)	inside rSNPs	diseases
5	nsv1064384	chr17:57049519-57346694	Active TSS ZNF genes & repeats Weak transcription Enhancers Strong transcription Flanking Active TSS Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	219 gene(s)	inside rSNPs	diseases
6	nsv908646	chr17:57061238-57255810	Strong transcription Weak transcription Active TSS Enhancers Genic enhancers ZNF genes & repeats Flanking Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	206 gene(s)	inside rSNPs	diseases
7	nsv833499	chr17:57070693-57288410	Enhancers Weak transcription Active TSS Flanking Active TSS Strong transcription Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	208 gene(s)	inside rSNPs	diseases
8	nsv1066388	chr17:57082013-57339981	Strong transcription Active TSS Weak transcription Flanking Active TSS Genic enhancers Enhancers ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	209 gene(s)	inside rSNPs	diseases
9	esv2758462	chr17:57082579-57425634	Enhancers Strong transcription Weak transcription Active TSS Flanking Active TSS Genic enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA	213 gene(s)	inside rSNPs	diseases
10	esv2758699	chr17:57082579-57425634	Weak transcription Strong transcription Genic enhancers Active TSS Transcr. at gene 5' and 3' Flanking Active TSS Enhancers ZNF genes & repeats Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA	213 gene(s)	inside rSNPs	diseases
11	nsv1066467	chr17:57117682-57338731	Enhancers Weak transcription Active TSS Strong transcription ZNF genes & repeats Flanking Active TSS Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	200 gene(s)	inside rSNPs	diseases
12	nsv1057209	chr17:57117682-57742240	Weak transcription Enhancers Strong transcription Flanking Active TSS Active TSS ZNF genes & repeats Bivalent/Poised TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	240 gene(s)	inside rSNPs	diseases
13	nsv543396	chr17:57117682-57742240	Weak transcription Flanking Active TSS Strong transcription Active TSS Enhancers Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	240 gene(s)	inside rSNPs	diseases
14	nsv1066788	chr17:57126446-57344129	Strong transcription Weak transcription Flanking Active TSS Enhancers Genic enhancers Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	193 gene(s)	inside rSNPs	diseases
15	nsv482858	chr17:57136446-57288615	Weak transcription Strong transcription Enhancers Flanking Active TSS Genic enhancers Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA	184 gene(s)	inside rSNPs	diseases
16	nsv908647	chr17:57165097-57290383	Weak transcription Flanking Active TSS Enhancers Active TSS Genic enhancers Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA	173 gene(s)	inside rSNPs	diseases
17	nsv908648	chr17:57165097-57322954	Weak transcription Active TSS Transcr. at gene 5' and 3' Flanking Active TSS Enhancers Strong transcription Genic enhancers ZNF genes & repeats Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	179 gene(s)	inside rSNPs	diseases
18	nsv1063542	chr17:57179669-57569673	Weak transcription ZNF genes & repeats Enhancers Flanking Active TSS Strong transcription Active TSS Genic enhancers Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	172 gene(s)	inside rSNPs	diseases
19	nsv543397	chr17:57179669-57569673	Enhancers Flanking Active TSS Weak transcription Genic enhancers Strong transcription Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	172 gene(s)	inside rSNPs	diseases
20	nsv1062959	chr17:57179669-57680772	Strong transcription Weak transcription Enhancers Genic enhancers Flanking Bivalent TSS/Enh Active TSS Flanking Active TSS Bivalent Enhancer ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	175 gene(s)	inside rSNPs	diseases
21	esv1792828	chr17:57185807-57219391	Weak transcription Strong transcription Enhancers Flanking Active TSS ZNF genes & repeats Active TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA	77 gene(s)	inside rSNPs	diseases
22	nsv1060807	chr17:57189467-57344129	Active TSS Enhancers Weak transcription Strong transcription Flanking Active TSS Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA	114 gene(s)	inside rSNPs	diseases
23	nsv1064115	chr17:57199370-57369270	Flanking Active TSS Weak transcription Active TSS Transcr. at gene 5' and 3' Genic enhancers Strong transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS ZNF genes & repeats Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA	107 gene(s)	inside rSNPs	diseases
24	esv1803083	chr17:57206124-57233048	Weak transcription Flanking Active TSS Strong transcription Genic enhancers Enhancers Active TSS Bivalent/Poised TSS Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region miRNA	87 gene(s)	inside rSNPs	diseases
25	esv1793348	chr17:57207540-57233048	Weak transcription Flanking Active TSS Enhancers Strong transcription Genic enhancers Active TSS ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region miRNA	87 gene(s)	inside rSNPs	diseases
26	esv1800539	chr17:57208752-57233048	Active TSS Flanking Active TSS Enhancers Weak transcription Strong transcription ZNF genes & repeats Genic enhancers Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region miRNA	87 gene(s)	inside rSNPs	diseases
27	nsv575802	chr17:57208752-57344181	Transcr. at gene 5' and 3' Weak transcription Flanking Active TSS Strong transcription ZNF genes & repeats Enhancers Active TSS Genic enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	102 gene(s)	inside rSNPs	diseases

mRNA abundance (count:11)

SNP	Gene	Cis/trans	Tissue	Source
rs9303403	BZRAP1	cis	cerebellum	SCAN
rs9303403	RAD51C	cis	parietal	SCAN
rs9303403	SUPT4H1	cis	cerebellum	SCAN
rs9303403	HSF5	cis	cerebellum	SCAN
rs9303403	RAD51C	cis	multi-tissue	Pritchard
rs9303403	F2RL1	trans	cerebellum	SCAN
rs9303403	RAD51C	cis	Adipose Subcutaneous	GTEx
rs9303403	RAD51C	cis	Esophagus Mucosa	GTEx
rs9303403	SUPT4H1	cis	parietal	SCAN
rs9303403	RAD51C	cis	lymphoblastoid	seeQTL
rs9303403	RAD51C	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:87 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr17:57184800-57231000	Weak transcription	Aorta	Aorta
2	chr17:57185000-57221600	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
3	chr17:57185000-57231000	Weak transcription	Rectal Mucosa Donor 31	rectum
4	chr17:57185000-57231200	Weak transcription	Lung	lung
5	chr17:57185200-57223000	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
6	chr17:57185200-57226200	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
7	chr17:57185200-57228400	Weak transcription	Fetal Heart	heart
8	chr17:57185600-57227800	Weak transcription	Fetal Brain Male	brain
9	chr17:57186000-57231200	Weak transcription	Colon Smooth Muscle	Colon
10	chr17:57189200-57230400	Weak transcription	Brain Inferior Temporal Lobe	brain
11	chr17:57192400-57229600	Weak transcription	Stomach Smooth Muscle	stomach
12	chr17:57193200-57219800	Weak transcription	Rectal Mucosa Donor 29	rectum
13	chr17:57193600-57223200	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
14	chr17:57194400-57231200	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
15	chr17:57195600-57230400	Weak transcription	Fetal Intestine Small	intestine
16	chr17:57196600-57226000	Weak transcription	HUVEC	blood vessel
17	chr17:57196600-57226600	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
18	chr17:57196800-57226600	Weak transcription	Primary T killer memory cells from peripheral blood	blood
19	chr17:57197600-57228400	Weak transcription	Fetal Brain Female	brain
20	chr17:57198000-57231000	Weak transcription	Primary B cells from peripheral blood	blood
21	chr17:57198200-57230800	Weak transcription	Primary monocytes fromperipheralblood	blood
22	chr17:57198800-57231000	Weak transcription	Fetal Muscle Trunk	muscle
23	chr17:57200200-57229200	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
24	chr17:57202200-57220600	Weak transcription	Primary hematopoietic stem cells	blood
25	chr17:57202200-57226000	Weak transcription	Muscle Satellite Cultured Cells	--
26	chr17:57202400-57227200	Weak transcription	Left Ventricle	heart
27	chr17:57203000-57225800	Weak transcription	NHLF	lung
28	chr17:57203000-57227200	Weak transcription	Small Intestine	intestine
29	chr17:57204000-57222800	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
30	chr17:57204600-57221600	Weak transcription	Hela-S3	cervix
31	chr17:57204600-57226400	Weak transcription	GM12878-XiMat	blood
32	chr17:57204800-57226600	Weak transcription	HSMM	muscle
33	chr17:57205200-57225800	Weak transcription	NHDF-Ad	bronchial
34	chr17:57205200-57229600	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
35	chr17:57205400-57226000	Weak transcription	Ovary	ovary
36	chr17:57205400-57227200	Weak transcription	Fetal Lung	lung
37	chr17:57205800-57221000	Weak transcription	Brain Germinal Matrix	brain
38	chr17:57205800-57227200	Weak transcription	Primary B cells from cord blood	blood
39	chr17:57205800-57230800	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
40	chr17:57206000-57220800	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
41	chr17:57206000-57230400	Weak transcription	Duodenum Smooth Muscle	Duodenum
42	chr17:57206200-57227200	Weak transcription	Primary T helper cells PMA-I stimulated	--
43	chr17:57206400-57221600	Weak transcription	A549	lung
44	chr17:57206400-57229000	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
45	chr17:57206400-57231000	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
46	chr17:57206600-57221000	Weak transcription	Fetal Muscle Leg	muscle
47	chr17:57206600-57226600	Weak transcription	Primary T regulatory cells fromperipheralblood	blood
48	chr17:57206600-57228400	Weak transcription	ES-I3 Cell Line	embryonic stem cell
49	chr17:57206600-57230600	Weak transcription	Monocytes-CD14+_RO01746	blood
50	chr17:57206600-57231400	Weak transcription	HSMMtube	muscle

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