Variant report

Variant	rs10898445
Chromosome Location	chr11:85908139-85908140
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	ATF1	chr11:85907288-85908307	K562	blood:	n/a	n/a
2	IRF1	chr11:85907037-85908980	K562	blood:	n/a	n/a
3	TCF7L2	chr11:85906824-85908185	Hela-S3	cervix:	n/a	chr11:85907334-85907348 chr11:85907334-85907348 chr11:85907282-85907291 chr11:85907281-85907290
4	MYC	chr11:85907980-85908240	NB4	blood:	n/a	n/a
5	RFX5	chr11:85907994-85908892	K562	blood:	n/a	n/a
6	CCNT2	chr11:85908114-85908250	K562	blood:	n/a	n/a
7	GATA1	chr11:85907394-85909524	PBDE	blood:	n/a	chr11:85908503-85908513 chr11:85907557-85907573
8	TBL1XR1	chr11:85907184-85908948	K562	blood:	n/a	n/a
9	TBP	chr11:85907144-85908142	Hela-S3	cervix:	n/a	n/a
10	EP300	chr11:85907179-85908919	K562	blood:	n/a	chr11:85907523-85907537 chr11:85908441-85908450 chr11:85907260-85907270 chr11:85908311-85908318 chr11:85907282-85907291
11	CEBPB	chr11:85907911-85908953	K562	blood:	n/a	chr11:85908094-85908107
12	CEBPB	chr11:85906954-85908288	Hela-S3	cervix:	n/a	chr11:85907033-85907045 chr11:85908094-85908107
13	MAFF	chr11:85908019-85908894	K562	blood:	n/a	chr11:85908717-85908735
14	ARID3A	chr11:85907402-85908387	K562	blood:	n/a	n/a
15	TAL1	chr11:85907907-85908189	K562	blood:	n/a	n/a
16	EP300	chr11:85907037-85908188	Hela-S3	cervix:	n/a	chr11:85907523-85907537 chr11:85907260-85907270 chr11:85907282-85907291
17	MYC	chr11:85907933-85908777	K562	blood:	n/a	n/a
18	JUN	chr11:85907574-85909075	K562	blood:	n/a	n/a
19	JUND	chr11:85907126-85908878	K562	blood:	n/a	chr11:85907282-85907291 chr11:85907282-85907289
20	RCOR1	chr11:85907188-85908858	K562	blood:	n/a	n/a
21	IRF1	chr11:85907928-85908897	K562	blood:	n/a	n/a
22	CEBPB	chr11:85907910-85908290	K562	blood:	n/a	chr11:85908094-85908107
23	MAX	chr11:85907936-85908273	NB4	blood:	n/a	n/a

No.	Distal block	Cell Line	Cell type
1	chr11:85902463..85904724-chr11:85908007..85910447,3	K562	blood:
2	chr11:85908094..85909994-chr11:85921014..85923973,2	K562	blood:
3	chr11:85778187..85780114-chr11:85906688..85908300,2	K562	blood:
4	chr11:85894603..85896311-chr11:85907931..85910681,2	K562	blood:

Variant related genes	Relation type
ENSG00000254699	TF binding region
ENSG00000073921	Chromatin interaction
ENSG00000254699	Chromatin interaction

Extended variants
information (count: 23 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:20)

rs_ID	r²[population]
rs10792847	0.81[CHD][hapmap]
rs10898444	0.98[EUR][1000 genomes]
rs11234577	0.88[EUR][1000 genomes]
rs11234578	0.89[EUR][1000 genomes]
rs11234582	0.84[CEU][hapmap];0.82[CHD][hapmap];0.86[TSI][hapmap]
rs11234583	0.84[CEU][hapmap]
rs12577739	0.81[CEU][hapmap]
rs1376944	0.83[CHB][hapmap]
rs167086	0.83[CHB][hapmap]
rs2600951	0.83[CHB][hapmap];0.82[CHD][hapmap]
rs2646727	0.83[CHB][hapmap];0.82[CHD][hapmap]
rs2847471	0.83[CHB][hapmap];0.82[CHD][hapmap]
rs291231	0.83[CHB][hapmap];0.89[CHD][hapmap]
rs291235	0.83[CHB][hapmap]
rs291236	0.83[CHB][hapmap];0.85[CHD][hapmap]
rs291239	0.83[CHB][hapmap]
rs291244	0.83[CHB][hapmap]
rs4424696	0.83[CHB][hapmap]
rs57902302	0.92[EUR][1000 genomes]
rs61178383	0.92[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:3 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv1050948	chr11:85756325-85968665	Active TSS Genic enhancers Transcr. at gene 5' and 3' Enhancers Flanking Active TSS Weak transcription Strong transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	43 gene(s)	inside rSNPs	diseases
2	nsv541117	chr11:85756325-85968665	Enhancers Weak transcription Flanking Active TSS Active TSS Transcr. at gene 5' and 3' Strong transcription Bivalent/Poised TSS Bivalent Enhancer Genic enhancers ZNF genes & repeats Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	43 gene(s)	inside rSNPs	diseases
3	nsv832223	chr11:85845315-86015957	Enhancers Weak transcription Active TSS Flanking Active TSS Strong transcription Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	36 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs10898445	EED	cis	parietal	SCAN
rs10898445	EED	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:43 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:85898400-85913400	Weak transcription	Left Ventricle	heart
2	chr11:85902000-85908800	Enhancers	Primary monocytes fromperipheralblood	blood
3	chr11:85904400-85913200	Weak transcription	Fetal Intestine Small	intestine
4	chr11:85905000-85912400	Weak transcription	HSMM	muscle
5	chr11:85905000-85913200	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
6	chr11:85905000-85913200	Weak transcription	Placenta	Placenta
7	chr11:85905000-85913200	Weak transcription	Fetal Stomach	stomach
8	chr11:85905200-85908200	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
9	chr11:85905200-85908400	Weak transcription	Rectal Smooth Muscle	rectum
10	chr11:85905200-85910800	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
11	chr11:85905200-85913200	Weak transcription	Stomach Mucosa	stomach
12	chr11:85905800-85911200	Weak transcription	Duodenum Smooth Muscle	Duodenum
13	chr11:85905800-85913200	Weak transcription	Duodenum Mucosa	Duodenum
14	chr11:85906600-85908800	Enhancers	Brain Substantia Nigra	brain
15	chr11:85906600-85909600	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
16	chr11:85906800-85908200	Enhancers	Brain Cingulate Gyrus	brain
17	chr11:85906800-85908200	Enhancers	Brain Inferior Temporal Lobe	brain
18	chr11:85907000-85908200	Flanking Active TSS	Hela-S3	cervix
19	chr11:85907000-85908600	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
20	chr11:85907000-85908800	Enhancers	NHEK	skin
21	chr11:85907000-85909000	Flanking Active TSS	K562	blood
22	chr11:85907000-85909600	Enhancers	Brain Hippocampus Middle	brain
23	chr11:85907200-85908200	Enhancers	Foreskin Keratinocyte Primary Cells skin02	Skin
24	chr11:85907200-85908400	Enhancers	Osteobl	bone
25	chr11:85907200-85908600	Enhancers	Brain Angular Gyrus	brain
26	chr11:85907200-85909400	Enhancers	Primary neutrophils fromperipheralblood	blood
27	chr11:85907200-85909600	Enhancers	Primary hematopoietic stem cells short term culture	blood
28	chr11:85907200-85909600	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
29	chr11:85907400-85908400	Enhancers	Ovary	ovary
30	chr11:85907400-85908600	Enhancers	Small Intestine	intestine
31	chr11:85907400-85909000	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
32	chr11:85907400-85910800	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
33	chr11:85907600-85908800	Enhancers	Brain Anterior Caudate	brain
34	chr11:85907800-85908200	Enhancers	Fetal Lung	lung
35	chr11:85907800-85911400	Weak transcription	Spleen	Spleen
36	chr11:85907800-85912400	Weak transcription	Fetal Kidney	kidney
37	chr11:85908000-85908200	Enhancers	IMR90 fetal lung fibroblasts Cell Line	lung
38	chr11:85908000-85908200	Enhancers	Skeletal Muscle Female	skeletal muscle
39	chr11:85908000-85908400	Enhancers	Stomach Smooth Muscle	stomach
40	chr11:85908000-85908600	Enhancers	Adipose Nuclei	Adipose
41	chr11:85908000-85909000	Enhancers	Primary hematopoietic stem cells	blood
42	chr11:85908000-85909400	Enhancers	Monocytes-CD14+_RO01746	blood
43	chr11:85908000-85913400	Weak transcription	Rectal Mucosa Donor 31	rectum

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