Variant report

Variant	rs10937776
Chromosome Location	chr4:7004495-7004496
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr4:6985775..6987930-chr4:7003466..7005254,2	MCF-7	breast:
2	chr4:7003678..7005841-chr4:7015045..7016665,2	K562	blood:

Extended variants
information (count: 68 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:60)

rs_ID	r²[population]
rs10012590	1.00[CHD][hapmap];0.81[ASN][1000 genomes]
rs10025310	0.81[ASN][1000 genomes]
rs1048009	0.88[LWK][hapmap]
rs10516181	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10937772	0.82[ASN][1000 genomes]
rs10937774	0.90[CEU][hapmap];0.81[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs11732898	0.86[CEU][hapmap];1.00[CHD][hapmap];0.96[GIH][hapmap];0.84[MEX][hapmap];0.81[TSI][hapmap];0.86[YRI][hapmap];0.88[ASN][1000 genomes]
rs11934364	1.00[CHB][hapmap]
rs11938701	0.81[ASN][1000 genomes]
rs11944897	0.81[ASN][1000 genomes]
rs12503027	0.81[ASN][1000 genomes]
rs12510715	1.00[CHB][hapmap];1.00[CHD][hapmap]
rs13107989	0.81[ASN][1000 genomes]
rs13122119	0.83[CHD][hapmap]
rs13148395	0.81[ASN][1000 genomes]
rs13149923	0.81[ASN][1000 genomes]
rs2301817	0.81[ASN][1000 genomes]
rs2301818	1.00[CHB][hapmap];1.00[CHD][hapmap];0.87[ASN][1000 genomes]
rs2301819	1.00[CHB][hapmap];1.00[CHD][hapmap];0.87[ASN][1000 genomes]
rs2359194	1.00[AFR][1000 genomes];0.98[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs3188939	1.00[CHD][hapmap];0.81[ASN][1000 genomes]
rs34219101	0.91[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs34221933	0.81[ASN][1000 genomes]
rs35680216	0.81[ASN][1000 genomes]
rs3857171	1.00[AFR][1000 genomes];0.94[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs3892490	0.88[ASW][hapmap];0.91[CEU][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];0.97[LWK][hapmap];0.84[MEX][hapmap];0.89[MKK][hapmap];0.83[TSI][hapmap];0.86[YRI][hapmap];0.92[AFR][1000 genomes];0.89[AMR][1000 genomes];0.81[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs3894945	0.81[ASN][1000 genomes]
rs4234793	0.81[ASN][1000 genomes]
rs4296677	0.82[ASN][1000 genomes]
rs4428285	0.86[CEU][hapmap];1.00[CHB][hapmap]
rs4458452	0.82[ASN][1000 genomes]
rs4544710	0.81[ASN][1000 genomes]
rs4645214	0.84[CEU][hapmap];0.80[AFR][1000 genomes];0.82[ASN][1000 genomes]
rs4689059	0.82[ASW][hapmap];0.86[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];0.96[GIH][hapmap];0.95[LWK][hapmap];0.84[MEX][hapmap];1.00[YRI][hapmap];0.81[AFR][1000 genomes];0.81[AMR][1000 genomes]
rs4689568	1.00[CHD][hapmap];0.82[GIH][hapmap];0.86[YRI][hapmap];0.88[ASN][1000 genomes]
rs4689573	0.89[AFR][1000 genomes];0.89[AMR][1000 genomes];0.91[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs4689575	0.81[ASN][1000 genomes]
rs55822670	0.94[ASN][1000 genomes]
rs62289166	0.81[ASN][1000 genomes]
rs6446559	0.81[ASN][1000 genomes]
rs66841627	0.81[ASN][1000 genomes]
rs6811496	0.81[ASN][1000 genomes]
rs6816882	0.82[AFR][1000 genomes];0.87[AMR][1000 genomes];0.81[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs6818744	0.87[ASN][1000 genomes]
rs6831129	0.83[AMR][1000 genomes];0.86[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs6834102	0.81[ASN][1000 genomes]
rs6840780	0.81[ASN][1000 genomes]
rs6854776	1.00[CHD][hapmap];0.81[ASN][1000 genomes]
rs73202120	0.89[AFR][1000 genomes]
rs7655563	0.84[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs7655773	0.81[ASN][1000 genomes]
rs7658198	0.91[CEU][hapmap];0.86[YRI][hapmap];0.91[AFR][1000 genomes];0.89[AMR][1000 genomes];0.80[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs7661462	0.91[CEU][hapmap];0.83[YRI][hapmap];0.81[AMR][1000 genomes];0.86[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs7661952	0.81[ASN][1000 genomes]
rs7673901	0.81[ASN][1000 genomes]
rs7675524	1.00[CHD][hapmap]
rs7685667	0.81[ASN][1000 genomes]
rs7693321	0.97[AMR][1000 genomes];0.82[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs8180337	0.82[ASW][hapmap];0.86[CEU][hapmap];1.00[CHB][hapmap];0.85[CHD][hapmap];0.96[GIH][hapmap];0.95[LWK][hapmap];0.84[MEX][hapmap];1.00[YRI][hapmap];0.82[AFR][1000 genomes]
rs9291126	1.00[CHB][hapmap];0.85[CHD][hapmap]

Variant overlapped rSNPs/rCNVs (count:8 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv878530	chr4:6888932-7058473	Strong transcription Enhancers Weak transcription Genic enhancers Bivalent Enhancer Flanking Active TSS Transcr. at gene 5' and 3' Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	39 gene(s)	inside rSNPs	diseases
2	esv34033	chr4:6973270-7390621	Weak transcription Enhancers Strong transcription Flanking Active TSS Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats Active TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA miRNA target site	40 gene(s)	inside rSNPs	diseases
3	esv2757919	chr4:6988148-7269901	Genic enhancers Strong transcription Flanking Active TSS Bivalent Enhancer Weak transcription Enhancers Flanking Bivalent TSS/Enh Active TSS ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	38 gene(s)	inside rSNPs	diseases
4	esv2759221	chr4:6988148-7269901	Active TSS Weak transcription Flanking Active TSS Enhancers Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Genic enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	38 gene(s)	inside rSNPs	diseases
5	nsv428436	chr4:6988148-7269901	Bivalent Enhancer Weak transcription Bivalent/Poised TSS Active TSS Enhancers Genic enhancers Flanking Active TSS Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	38 gene(s)	inside rSNPs	diseases
6	esv3358199	chr4:7000551-7004849	Genic enhancers Weak transcription Strong transcription Enhancers Transcr. at gene 5' and 3' Flanking Active TSS	TF binding region Chromatin interactive region lncRNA	3 gene(s)	inside rSNPs	diseases
7	nsv593547	chr4:7002344-7032180	Strong transcription Enhancers Weak transcription Genic enhancers Flanking Active TSS ZNF genes & repeats Transcr. at gene 5' and 3'	Chromatin interactive region	5 gene(s)	inside rSNPs	diseases
8	nsv469847	chr4:7003525-7168441	Enhancers Flanking Active TSS Weak transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers Active TSS Strong transcription Transcr. at gene 5' and 3' Bivalent Enhancer ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	35 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10937776	GRPEL1	cis	lymphoblastoid	seeQTL

Chromatin state (count:126 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr4:6990400-7008800	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
2	chr4:6991000-7021800	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
3	chr4:6993200-7006800	Strong transcription	ES-UCSF4 Cell Line	embryonic stem cell
4	chr4:6993800-7008400	Strong transcription	iPS-20b Cell Line	embryonic stem cell
5	chr4:6994000-7005200	Strong transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
6	chr4:6994000-7008600	Strong transcription	HUES6 Cell Line	embryonic stem cell
7	chr4:6994000-7035600	Strong transcription	Fetal Stomach	stomach
8	chr4:6994000-7043200	Weak transcription	Right Atrium	heart
9	chr4:6994200-7035400	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
10	chr4:6994400-7013400	Strong transcription	Primary hematopoietic stem cells short term culture	blood
11	chr4:6994600-7006800	Strong transcription	Stomach Smooth Muscle	stomach
12	chr4:6994600-7021400	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
13	chr4:6994800-7007600	Strong transcription	Fetal Adrenal Gland	Adrenal Gland
14	chr4:6995000-7009200	Strong transcription	IMR90 fetal lung fibroblasts Cell Line	lung
15	chr4:6995000-7020800	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
16	chr4:6995200-7008400	Strong transcription	HUES48 Cell Line	embryonic stem cell
17	chr4:6995200-7008600	Strong transcription	Fetal Intestine Small	intestine
18	chr4:6995400-7005000	Strong transcription	GM12878-XiMat	blood
19	chr4:6995400-7006600	Strong transcription	Duodenum Mucosa	Duodenum
20	chr4:6995400-7007800	Strong transcription	iPS-18 Cell Line	embryonic stem cell
21	chr4:6995400-7008600	Strong transcription	Fetal Intestine Large	intestine
22	chr4:6995400-7013600	Strong transcription	Fetal Thymus	thymus
23	chr4:6995600-7006800	Strong transcription	Rectal Mucosa Donor 29	rectum
24	chr4:6995800-7006800	Strong transcription	H1 Cell Line	embryonic stem cell
25	chr4:6995800-7008200	Strong transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
26	chr4:6995800-7008400	Strong transcription	HUES64 Cell Line	embryonic stem cell
27	chr4:6995800-7032800	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
28	chr4:6996000-7004600	Strong transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
29	chr4:6996000-7006400	Strong transcription	Foreskin Fibroblast Primary Cells skin02	Skin
30	chr4:6996000-7014800	Strong transcription	Primary B cells from peripheral blood	blood
31	chr4:6996000-7035200	Strong transcription	H9 Derived Neuron Cultured Cells	ES cell derived
32	chr4:6996400-7007400	Strong transcription	Fetal Brain Female	brain
33	chr4:6996400-7034800	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
34	chr4:6996600-7005000	Strong transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
35	chr4:6996600-7005600	Strong transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
36	chr4:6996600-7021400	Strong transcription	Brain Germinal Matrix	brain
37	chr4:6997600-7006400	Strong transcription	Left Ventricle	heart
38	chr4:6997800-7013800	Strong transcription	Thymus	Thymus
39	chr4:6998000-7006800	Strong transcription	Sigmoid Colon	Sigmoid Colon
40	chr4:6998400-7004600	Strong transcription	NHLF	lung
41	chr4:6999000-7006800	Strong transcription	Lung	lung
42	chr4:7000000-7004800	Strong transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
43	chr4:7000000-7006400	Strong transcription	Colon Smooth Muscle	Colon
44	chr4:7000000-7006600	Strong transcription	Cortex derived primary cultured neurospheres	brain
45	chr4:7000200-7021600	Strong transcription	Duodenum Smooth Muscle	Duodenum
46	chr4:7000400-7004600	Strong transcription	Adipose Nuclei	Adipose
47	chr4:7000400-7006400	Strong transcription	Gastric	stomach
48	chr4:7000400-7008200	Strong transcription	HepG2	liver
49	chr4:7000600-7004800	Strong transcription	Foreskin Melanocyte Primary Cells skin01	Skin
50	chr4:7000600-7005000	Strong transcription	Osteobl	bone

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