Variant report

Variant	rs10946203
Chromosome Location	chr6:167446735-167446736
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr6:167446559..167451164-chr6:167453044..167456262,4	K562	blood:
2	chr6:167438895..167441335-chr6:167445093..167449039,4	K562	blood:

Extended variants
information (count: 103 )
Associated
traits (count: 4 )

rSNPs within LD-proxies of this variant (count:92)

rs_ID	r²[population]
rs10455982	0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10484530	0.85[AFR][1000 genomes];0.89[AMR][1000 genomes];0.90[ASN][1000 genomes]
rs10484531	0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs1060404	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs10946204	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10946205	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs10946207	0.81[AFR][1000 genomes];0.84[AMR][1000 genomes];0.81[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10946208	0.87[AMR][1000 genomes]
rs12208359	0.92[AMR][1000 genomes];0.80[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs12209395	0.85[AFR][1000 genomes];0.90[AMR][1000 genomes];0.87[ASN][1000 genomes]
rs12212247	0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];0.95[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12213683	0.82[AMR][1000 genomes]
rs12526548	0.92[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs12528323	0.82[AMR][1000 genomes]
rs12528689	0.82[AMR][1000 genomes]
rs12529876	0.82[AMR][1000 genomes]
rs13195812	0.94[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs13204839	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs13208636	0.82[AMR][1000 genomes]
rs1322077	0.97[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs17524252	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs1794696	0.88[ASN][1000 genomes]
rs1811120	0.80[ASN][1000 genomes]
rs1894603	0.92[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs2001114	0.85[AMR][1000 genomes]
rs2038580	0.92[AMR][1000 genomes];0.99[ASN][1000 genomes]
rs2181059	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs2237272	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs2237273	0.88[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs2237276	0.93[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs2237277	0.88[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs2239826	0.81[AMR][1000 genomes];0.81[ASN][1000 genomes]
rs2239827	0.87[AMR][1000 genomes];0.81[ASN][1000 genomes]
rs2282860	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs2282861	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs2285148	0.82[AMR][1000 genomes]
rs2301436	0.92[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs239933	0.88[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs239935	0.85[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs2757042	0.80[ASN][1000 genomes]
rs2769352	0.82[ASN][1000 genomes]
rs35171809	0.91[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs364451	0.80[ASN][1000 genomes]
rs3752520	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs398278	0.83[ASN][1000 genomes]
rs404222	0.88[ASN][1000 genomes]
rs408080	0.85[ASN][1000 genomes]
rs427824	0.84[AMR][1000 genomes];0.87[ASN][1000 genomes]
rs444988	0.83[ASN][1000 genomes]
rs4710171	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs4710175	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs4710176	0.82[AMR][1000 genomes]
rs62436765	0.86[AMR][1000 genomes]
rs6456143	0.89[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs6456146	0.92[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs6456149	0.82[AMR][1000 genomes]
rs6456152	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.87[ASN][1000 genomes]
rs6900701	0.90[AMR][1000 genomes];0.94[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs6904946	0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs6909180	0.82[AMR][1000 genomes]
rs6920858	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.80[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs6921588	0.81[AMR][1000 genomes]
rs6923582	0.94[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs6929466	0.93[AMR][1000 genomes];0.94[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs7749278	0.89[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs7766242	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.83[ASN][1000 genomes]
rs916331	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs9295384	0.92[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs9295385	0.94[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9348211	0.82[ASN][1000 genomes]
rs9457249	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs9457251	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs9457252	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9457254	0.98[AFR][1000 genomes];0.96[AMR][1000 genomes];0.95[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs9457256	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs9457257	0.92[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs9457258	0.88[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs9457259	0.84[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9457260	0.87[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs9459835	0.91[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs9459836	0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];0.95[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs9459838	0.98[AFR][1000 genomes];0.99[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs9459839	0.92[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs9459840	0.94[AMR][1000 genomes];0.97[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9459841	0.94[AMR][1000 genomes];0.97[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9459842	0.89[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs9459845	0.92[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs9459846	0.92[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs9459849	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs9459854	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.87[ASN][1000 genomes]
rs9459855	0.85[AFR][1000 genomes];0.87[AMR][1000 genomes];0.88[ASN][1000 genomes]
rs9459872	0.82[AMR][1000 genomes];0.81[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:11 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv605260	chr6:166984094-167455139	Enhancers Strong transcription Weak transcription Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Active TSS Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	13 gene(s)	inside rSNPs	diseases
2	nsv1019381	chr6:167090236-167558598	Enhancers Weak transcription Bivalent Enhancer Strong transcription Flanking Bivalent TSS/Enh Active TSS Flanking Active TSS Genic enhancers ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA	14 gene(s)	inside rSNPs	diseases
3	nsv538541	chr6:167090236-167558598	Enhancers Weak transcription Active TSS Strong transcription Genic enhancers Flanking Active TSS Bivalent Enhancer Transcr. at gene 5' and 3' Bivalent/Poised TSS ZNF genes & repeats Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	14 gene(s)	inside rSNPs	diseases
4	nsv948634	chr6:167200671-167838993	Enhancers Weak transcription Strong transcription Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Flanking Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA	25 gene(s)	inside rSNPs	diseases
5	nsv482507	chr6:167282376-167474915	Strong transcription Weak transcription Enhancers ZNF genes & repeats Active TSS Genic enhancers Flanking Active TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA	11 gene(s)	inside rSNPs	diseases
6	nsv532074	chr6:167320656-167781977	Weak transcription Enhancers Active TSS Bivalent Enhancer Strong transcription Flanking Active TSS ZNF genes & repeats Genic enhancers Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	23 gene(s)	inside rSNPs	diseases
7	nsv1031039	chr6:167324021-167741439	Weak transcription Genic enhancers Strong transcription Enhancers Flanking Active TSS Active TSS Bivalent Enhancer Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA miRNA	21 gene(s)	inside rSNPs	diseases
8	nsv538543	chr6:167324021-167741439	Flanking Active TSS Weak transcription Enhancers Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Strong transcription ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA	21 gene(s)	inside rSNPs	diseases
9	nsv1026972	chr6:167335031-167671042	Weak transcription Enhancers Flanking Active TSS Strong transcription Genic enhancers Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA	19 gene(s)	inside rSNPs	diseases
10	nsv464140	chr6:167426681-167492552	Active TSS Weak transcription Strong transcription Genic enhancers Enhancers Flanking Active TSS ZNF genes & repeats Bivalent Enhancer Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	6 gene(s)	inside rSNPs	diseases
11	nsv886943	chr6:167440244-167502638	Strong transcription Flanking Active TSS Genic enhancers Weak transcription Enhancers Bivalent Enhancer Active TSS Flanking Bivalent TSS/Enh ZNF genes & repeats	Chromatin interactive region lncRNA	4 gene(s)	inside rSNPs	diseases

mRNA abundance (count:4)

SNP	Gene	Cis/trans	Tissue	Source
rs10946203	AL133458.1	cis	Whole Blood	GTEx
rs10946203	AL133458.1	cis	lung	GTEx
rs10946203	RNASET2	cis	Skin Sun Exposed Lower leg	GTEx
rs10946203	RNASET2	cis	Whole Blood	GTEx

Chromatin state (count:126 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr6:167413600-167449200	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
2	chr6:167413600-167452400	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
3	chr6:167414600-167448000	Weak transcription	Small Intestine	intestine
4	chr6:167414600-167450200	Weak transcription	Stomach Mucosa	stomach
5	chr6:167415400-167454000	Strong transcription	Fetal Thymus	thymus
6	chr6:167415400-167456600	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
7	chr6:167417200-167455400	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
8	chr6:167417600-167454800	Strong transcription	Primary hematopoietic stem cells short term culture	blood
9	chr6:167417800-167455200	Strong transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
10	chr6:167420800-167447600	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
11	chr6:167423000-167457600	Strong transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
12	chr6:167423400-167452200	Strong transcription	Monocytes-CD14+_RO01746	blood
13	chr6:167425600-167453000	Weak transcription	Brain Substantia Nigra	brain
14	chr6:167426600-167450600	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
15	chr6:167429200-167447600	Strong transcription	H9 Derived Neuron Cultured Cells	ES cell derived
16	chr6:167432200-167450200	Strong transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
17	chr6:167434200-167450600	Strong transcription	GM12878-XiMat	blood
18	chr6:167434800-167452000	Strong transcription	Primary T cells from cord blood	blood
19	chr6:167435800-167452200	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
20	chr6:167436200-167450200	Strong transcription	Rectal Mucosa Donor 29	rectum
21	chr6:167437400-167449400	Weak transcription	Fetal Brain Male	brain
22	chr6:167437400-167454200	Strong transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
23	chr6:167438000-167456200	Strong transcription	Adipose Nuclei	Adipose
24	chr6:167438400-167447600	Weak transcription	Hela-S3	cervix
25	chr6:167438600-167449000	Strong transcription	Brain Anterior Caudate	brain
26	chr6:167439200-167454000	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
27	chr6:167439600-167453200	Strong transcription	Fetal Intestine Small	intestine
28	chr6:167440200-167447400	Weak transcription	Brain Hippocampus Middle	brain
29	chr6:167440400-167459400	Weak transcription	Colon Smooth Muscle	Colon
30	chr6:167441000-167461800	Weak transcription	Pancreatic Islets	Pancreatic Islet
31	chr6:167441200-167454200	Strong transcription	Duodenum Mucosa	Duodenum
32	chr6:167441200-167456600	Strong transcription	ES-UCSF4 Cell Line	embryonic stem cell
33	chr6:167441400-167455400	Strong transcription	iPS-20b Cell Line	embryonic stem cell
34	chr6:167441400-167456200	Strong transcription	HUES64 Cell Line	embryonic stem cell
35	chr6:167441400-167473400	Weak transcription	Psoas Muscle	Psoas
36	chr6:167441600-167447600	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
37	chr6:167441600-167447600	Weak transcription	Primary T killer memory cells from peripheral blood	blood
38	chr6:167441600-167447600	Weak transcription	Fetal Kidney	kidney
39	chr6:167441600-167452200	Strong transcription	iPS-18 Cell Line	embryonic stem cell
40	chr6:167441600-167454200	Weak transcription	Primary T helper naive cells from peripheral blood	blood
41	chr6:167441600-167454600	Strong transcription	HUES6 Cell Line	embryonic stem cell
42	chr6:167441600-167455600	Strong transcription	HUES48 Cell Line	embryonic stem cell
43	chr6:167441800-167447400	Weak transcription	Colonic Mucosa	Colon
44	chr6:167441800-167456000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
45	chr6:167442000-167447600	Weak transcription	Rectal Smooth Muscle	rectum
46	chr6:167442000-167447600	Weak transcription	Right Ventricle	heart
47	chr6:167442000-167451200	Weak transcription	Placenta Amnion	Placenta Amnion
48	chr6:167442200-167447400	Weak transcription	HMEC	breast
49	chr6:167442400-167447800	Weak transcription	HSMMtube	muscle
50	chr6:167442800-167447000	Weak transcription	HSMM	muscle

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