Variant report

Variant	rs11186721
Chromosome Location	chr10:93641908-93641909
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:93638890..93643512-chr10:93665882..93670219,9	MCF-7	breast:
2	chr10:93638107..93642679-chr10:93666717..93670620,8	MCF-7	breast:

Variant related genes	Relation type
ENSG00000272817	Chromatin interaction
ENSG00000174721	Chromatin interaction

Extended variants
information (count: 34 )
Associated
traits (count: 8 )

rSNPs within LD-proxies of this variant (count:31)

rs_ID	r²[population]
rs10881973	0.83[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs10881974	0.83[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs10881978	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10881979	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10881987	0.87[AFR][1000 genomes];0.96[AMR][1000 genomes];0.95[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10881988	0.81[AFR][1000 genomes];0.96[AMR][1000 genomes];0.91[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs11186696	0.83[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs11186719	0.93[AMR][1000 genomes];0.95[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs11186722	0.82[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs11186723	0.92[AMR][1000 genomes];0.87[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs12253245	0.96[AMR][1000 genomes];0.89[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs1539042	0.91[AMR][1000 genomes];0.94[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs1770466	0.87[AMR][1000 genomes];0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1770476	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs1772179	0.84[AMR][1000 genomes];0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1772182	0.86[AMR][1000 genomes];0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1772183	0.87[AMR][1000 genomes];0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1772189	0.93[AMR][1000 genomes];0.95[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs1890896	0.88[AFR][1000 genomes];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs2153655	0.85[EUR][1000 genomes]
rs2259305	0.87[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs2994393	0.93[AMR][1000 genomes];0.95[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs3802650	0.82[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs4611111	0.81[AFR][1000 genomes];0.96[AMR][1000 genomes];0.91[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs4612711	0.81[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs4933698	0.84[AFR][1000 genomes];0.95[AMR][1000 genomes];0.98[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs7069232	0.85[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs7076687	0.83[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs7079479	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs7096581	0.82[AMR][1000 genomes]
rs7917858	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];0.82[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:3 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv7491	chr10:93626192-93671694	Enhancers Weak transcription Active TSS Flanking Active TSS Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
2	esv1819110	chr10:93634155-93643195	Weak transcription Enhancers Flanking Active TSS Bivalent Enhancer ZNF genes & repeats Active TSS	Chromatin interactive region	3 gene(s)	inside rSNPs	diseases
3	esv1842657	chr10:93634155-93668663	Flanking Active TSS Enhancers Weak transcription Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases

mRNA abundance (count:8)

SNP	Gene	Cis/trans	Tissue	Source
rs11186721	TNKS2-AS1	cis	Artery Tibial	GTEx
rs11186721	TNKS2-AS1	cis	Thyroid	GTEx
rs11186721	TNKS2-AS1	cis	Esophagus Mucosa	GTEx
rs11186721	TNKS2-AS1	cis	lung	GTEx
rs11186721	TNKS2-AS1	cis	Muscle Skeletal	GTEx
rs11186721	TNKS2-AS1	cis	Heart Left Ventricle	GTEx
rs11186721	TNKS2-AS1	cis	Adipose Subcutaneous	GTEx
rs11186721	TNKS2-AS1	cis	Skin Sun Exposed Lower leg	GTEx

Chromatin state (count:44 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:93608800-93643400	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
2	chr10:93626200-93643000	Weak transcription	HSMMtube	muscle
3	chr10:93635000-93643200	Weak transcription	Right Atrium	heart
4	chr10:93639200-93642200	Enhancers	Placenta	Placenta
5	chr10:93639400-93643200	Weak transcription	Brain Angular Gyrus	brain
6	chr10:93639800-93643000	Weak transcription	Fetal Heart	heart
7	chr10:93639800-93643200	Weak transcription	Esophagus	oesophagus
8	chr10:93639800-93643400	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
9	chr10:93640000-93643200	Weak transcription	Brain Anterior Caudate	brain
10	chr10:93640200-93643200	Weak transcription	Brain Hippocampus Middle	brain
11	chr10:93640200-93643200	Weak transcription	Stomach Mucosa	stomach
12	chr10:93640200-93643400	Weak transcription	Brain Inferior Temporal Lobe	brain
13	chr10:93640400-93643000	Weak transcription	ES-I3 Cell Line	embryonic stem cell
14	chr10:93640400-93643000	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
15	chr10:93640400-93643000	Weak transcription	iPS-15b Cell Line	embryonic stem cell
16	chr10:93640400-93643000	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
17	chr10:93640400-93643000	Weak transcription	NHDF-Ad	bronchial
18	chr10:93640400-93643200	Weak transcription	H9 Cell Line	embryonic stem cell
19	chr10:93640400-93643200	Weak transcription	Brain Cingulate Gyrus	brain
20	chr10:93640400-93643200	Weak transcription	Rectal Mucosa Donor 31	rectum
21	chr10:93640400-93643400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
22	chr10:93640400-93643400	Weak transcription	Brain Substantia Nigra	brain
23	chr10:93640600-93642800	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
24	chr10:93640600-93643000	Weak transcription	HUES48 Cell Line	embryonic stem cell
25	chr10:93640600-93643000	Weak transcription	iPS-18 Cell Line	embryonic stem cell
26	chr10:93640600-93643000	Weak transcription	Adipose Nuclei	Adipose
27	chr10:93640600-93643000	Weak transcription	Fetal Brain Male	brain
28	chr10:93640600-93643200	Weak transcription	Aorta	Aorta
29	chr10:93640600-93643200	Weak transcription	Brain Germinal Matrix	brain
30	chr10:93640600-93644800	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
31	chr10:93640800-93643000	Weak transcription	HUES64 Cell Line	embryonic stem cell
32	chr10:93640800-93643000	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
33	chr10:93640800-93643400	Weak transcription	HMEC	breast
34	chr10:93641000-93643000	Weak transcription	NHEK	skin
35	chr10:93641000-93643400	Weak transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
36	chr10:93641200-93643200	Weak transcription	Placenta Amnion	Placenta Amnion
37	chr10:93641400-93642800	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
38	chr10:93641400-93642800	Weak transcription	Ganglion Eminence derived primary cultured neurospheres	brain
39	chr10:93641400-93643000	Weak transcription	H1 Cell Line	embryonic stem cell
40	chr10:93641400-93643000	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
41	chr10:93641600-93642600	Weak transcription	Cortex derived primary cultured neurospheres	brain
42	chr10:93641600-93643000	Weak transcription	Fetal Brain Female	brain
43	chr10:93641800-93642800	Weak transcription	iPS-20b Cell Line	embryonic stem cell
44	chr10:93641800-93643000	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived

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