Variant report

Variant	rs12355888
Chromosome Location	chr10:45931564-45931565
allele	G/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

Extended variants
information (count: 29 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:22)

rs_ID	r²[population]
rs1059696	0.81[EUR][1000 genomes]
rs10900215	1.00[ASN][1000 genomes]
rs10900228	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239523	1.00[ASN][1000 genomes]
rs11239524	1.00[ASN][1000 genomes]
rs11239534	0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239540	0.88[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239572	0.85[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2082109	0.82[EUR][1000 genomes]
rs2082110	0.82[EUR][1000 genomes]
rs2082111	0.82[EUR][1000 genomes]
rs28395868	1.00[ASN][1000 genomes]
rs28586924	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs56071381	1.00[ASN][1000 genomes]
rs61854092	0.81[EUR][1000 genomes]
rs61854093	0.81[EUR][1000 genomes]
rs61854113	0.81[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs61854124	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs72796464	1.00[ASN][1000 genomes]
rs72796496	1.00[ASN][1000 genomes]
rs72798218	1.00[ASN][1000 genomes]
rs72798220	1.00[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:7 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv430166	chr10:45668894-46148794	Bivalent Enhancer Strong transcription Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Flanking Active TSS Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
2	nsv993428	chr10:45742877-46224333	Enhancers Active TSS Weak transcription ZNF genes & repeats Bivalent/Poised TSS Strong transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
3	nsv895107	chr10:45850300-45953767	Strong transcription Enhancers Bivalent/Poised TSS Bivalent Enhancer Flanking Active TSS Active TSS ZNF genes & repeats Genic enhancers Weak transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	2 gene(s)	inside rSNPs	diseases
4	nsv895108	chr10:45878908-46224333	Active TSS Weak transcription Enhancers ZNF genes & repeats Strong transcription Bivalent Enhancer Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	16 gene(s)	inside rSNPs	diseases
5	nsv895109	chr10:45882741-46210665	Weak transcription Strong transcription Enhancers Active TSS Genic enhancers Flanking Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	12 gene(s)	inside rSNPs	diseases
6	nsv895110	chr10:45912771-45953767	Weak transcription Flanking Active TSS Enhancers Genic enhancers ZNF genes & repeats Active TSS Bivalent Enhancer Strong transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	2 gene(s)	inside rSNPs	diseases
7	nsv1043536	chr10:45915941-46076235	Weak transcription Enhancers Active TSS Strong transcription ZNF genes & repeats Flanking Active TSS Genic enhancers Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	5 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs12355888	ALOX5	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:21 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:45916600-45949200	Weak transcription	Gastric	stomach
2	chr10:45921400-45931600	Strong transcription	Monocytes-CD14+_RO01746	blood
3	chr10:45921800-45933800	Weak transcription	Esophagus	oesophagus
4	chr10:45925000-45940600	Weak transcription	Fetal Intestine Small	intestine
5	chr10:45925000-45949200	Weak transcription	Lung	lung
6	chr10:45925800-45936200	Weak transcription	Placenta	Placenta
7	chr10:45928800-45951000	Weak transcription	Duodenum Mucosa	Duodenum
8	chr10:45929000-45934800	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
9	chr10:45929200-45951600	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
10	chr10:45929600-45934600	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
11	chr10:45930000-45931800	Strong transcription	Primary B cells from peripheral blood	blood
12	chr10:45930200-45932400	Weak transcription	Pancreas	Pancrea
13	chr10:45930200-45934200	Weak transcription	Spleen	Spleen
14	chr10:45930200-45938400	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
15	chr10:45930400-45932400	Weak transcription	Primary monocytes fromperipheralblood	blood
16	chr10:45930400-45933200	Weak transcription	K562	blood
17	chr10:45930600-45934200	Weak transcription	Thymus	Thymus
18	chr10:45930800-45932200	ZNF genes & repeats	Primary B cells from cord blood	blood
19	chr10:45930800-45934000	ZNF genes & repeats	GM12878-XiMat	blood
20	chr10:45930800-45935200	Weak transcription	Fetal Thymus	thymus
21	chr10:45930800-45935400	Genic enhancers	Primary neutrophils fromperipheralblood	blood

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